Curcumin and its derivatives in cancer therapy: Potentiating antitumor activity of cisplatin and reducing side effects

Phytotherapy Research, Journal Year: 2021, Volume and Issue: 36(1), P. 189 - 213

Published: Oct. 25, 2021

Abstract Curcumin is a phytochemical isolated from Curcuma longa with potent tumor‐suppressor activity, which has shown significant efficacy in pre‐clinical and clinical studies. stimulates cell death, triggers cycle arrest, suppresses oncogenic pathways, thereby suppressing cancer progression. Cisplatin (CP) DNA damage apoptosis chemotherapy. However, CP adverse effects on several organs of the body, drug resistance frequently observed. The purpose present review to show function curcumin decreasing CP's impacts improving its antitumor activity. administration reduces ROS levels prevent normal cells. Furthermore, can inhibit inflammation via down‐regulation NF‐κB maintain organs. nanoformulations reduce hepatoxicity, neurotoxicity, renal toxicity, ototoxicity, cardiotoxicity caused by CP. Notably, potentiates cytotoxicity mediating death arrest. Besides, STAT3 NF‐ĸB as tumor‐promoting enhance sensitivity resistance. targeted delivery tumor cells be mediated nanostructures. In addition, derivatives are also able CP‐mediated side effects, increase against various types.

Language: Английский

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Curcumin as an Enhancer of Therapeutic Efficiency of Chemotherapy Drugs in Breast Cancer

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(4), P. 2144 - 2144

Published: Feb. 15, 2022

Female breast cancer is the world’s most prevalent in 2020. Chemotherapy still remains a backbone therapy and crucial advanced metastatic treatment. The clinical efficiency of chemotherapy regimens limited due to tumor heterogeneity, chemoresistance, side effects. Chemotherapeutic drug combinations with natural products hold great promise for enhancing their anticancer efficacy. Curcumin an ideal chemopreventive agent owning its multitargeting function on various regulatory molecules, key signaling pathways, pharmacological safety. This review aimed elucidate potential role curcumin efficacy doxorubicin, paclitaxel, 5-fluorouracil, cisplatin via combinational therapy. Additionally, molecular mechanisms underlying chemosensitizing activity these have been addressed. Overall, based promising therapeutic combination conventional drugs, considerable value develop as adjunct current drugs treat cancer. Furthermore, this topic may provide frameworks future research direction curcumin–chemotherapy studies benefit development novel strategy maximize while minimizing effects

Language: Английский

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Cisplatin for cancer therapy and overcoming chemoresistance

Heliyon, Journal Year: 2022, Volume and Issue: 8(9), P. e10608 - e10608

Published: Sept. 1, 2022

Language: Английский

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A critical review on the bio-mediated green synthesis and multiple applications of magnesium oxide nanoparticles

Chemosphere, Journal Year: 2022, Volume and Issue: 312, P. 137301 - 137301

Published: Nov. 18, 2022

Language: Английский

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Magnesium Oxide (MgO) Nanoparticles: Synthetic Strategies and Biomedical Applications

Crystals, Journal Year: 2024, Volume and Issue: 14(3), P. 215 - 215

Published: Feb. 23, 2024

In recent times, there has been considerable interest among researchers in magnesium oxide (MgO) nanoparticles, due to their excellent biocompatibility, stability, and diverse biomedical uses, such as antimicrobial, antioxidant, anticancer, antidiabetic properties, well tissue engineering, bioimaging, drug delivery applications. Consequently, the escalating utilization of nanoparticles medical contexts necessitates in-depth exploration these nanoparticles. Notably, existing literature lacks a comprehensive review nanoparticles’ synthesis methods, detailed applications with mechanisms, toxicity assessments. Thus, this aims bridge gap by furnishing insight into various synthetic approaches for development MgO Additionally, it elucidates noteworthy potential mechanisms action, alongside summarizing profiles. This article also highlights challenges future prospects further exploring field. Existing indicates that synthesized demonstrate substantial biocompatibility display significant antibacterial, antifungal, antioxidant properties. intends enhance readers’ comprehension regarding advancements synthesizing through promising biomedicine.

Language: Английский

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Plant Foods and Their Bioactives as Dietary Enhancers for Colon Cancer Treatment with 5-Fluorouracil

Food Reviews International, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 50

Published: Jan. 4, 2025

Cancer is the world's second most common cause of death, with colon cancer (CC) ranking third in prevalence and cancer-related fatalities. CC originates or rectum influenced by genetic mutations, lifestyle, diet. Although chemotherapy, especially 5-fluorouracil (5-FU), fundamental to treatment has improved patient survival, its benefits are often limited significant side effects emerging drug resistance. Recently, plant-based foods have drawn interest research for their natural bioactive compounds relatively low toxicity. Certain plant not only exhibit anti-cancer activity but may also boost effectiveness 5-FU while reducing adverse effects. Despite evidence suggesting a synergistic effect between 5-FU, this area remains fragmented. This review consolidates current on including fruits, vegetables, legumes, tea bioactives treatment. Besides, it explores mechanisms through which these enhance efficacy reduce effects, evaluates clinical application prospects, identifies challenges future directions. comprehensive analysis aims provide scientific foundation integrated CC, highlighting potential enhancing chemotherapy associated toxicities.

Language: Английский

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Nanoparticles in gynecologic cancers: a bibliometric and visualization analysis

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 14

Published: Jan. 8, 2025

Gynecological cancers are characterized by uncontrolled cell proliferation within the female reproductive organs. These pose a significant threat to women's health, impacting life expectancy, quality of life, and fertility. Nanoparticles, with their small size, large surface area, high permeability, have become key focus in targeted cancer therapy. The aim this study is review recent advancements nanoparticles applied gynecologic cancers, providing valuable insights for future research. We retrieved all literature on from Web Science Core Collection (WOSCC) database between January 1, 2004, June 4, 2024. Data analysis visualization were conducted using R software (version 4.4.0), VOSviewer 1.6.19.0), CiteSpace 6.1). A total 2,843 publications 2024 searched. Over past 20 years, there has been increase publications. leading countries institutions terms productivity China Chinese Academy Sciences. most prolific author co-cited Sood, K Siegel, Rl. top journals International Journal Nanomedicine (n=97), followed ACS Applied Materials & Interfaces (n=72) Chemistry B (n=53). Keyword shows current research focuses two main areas: application drug delivery broader applications cancers. Future will likely "silver nanoparticles," "gold "green synthesis." decades, rapidly advanced field Research primarily focused applications. trends point toward optimizing synthesis techniques advancing preclinical studies clinical applications, particularly silver gold nanoparticles. findings provide scientific researchers.

Language: Английский

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Targeted Drug Delivery Systems for Curcumin in Breast Cancer Therapy

International Journal of Nanomedicine, Journal Year: 2023, Volume and Issue: Volume 18, P. 4275 - 4311

Published: July 1, 2023

Abstract: Breast cancer (BC) is the most prevalent type of in world and main reason women die from cancer. Due to significant side effects conventional treatments such as chemotherapy radiotherapy, search for supplemental alternative natural drugs with lower toxicity interest researchers. Curcumin (CUR) a polyphenol extracted turmeric. Numerous studies have demonstrated that CUR an effective anticancer drug works by modifying different intracellular signaling pathways. CUR's therapeutic utility severely constrained its short half-life vivo, low water solubility, poor stability, quick metabolism, oral bioavailability, potential gastrointestinal discomfort high doses. One practical solutions aforementioned issues development targeted delivery systems (TDDSs) based on nanomaterials. To improve targeting efficacy serve reference use TDDSs clinical setting, this review describes physicochemical properties bioavailability mechanism action BC, emphasis recent BC combination CUR, including passive TDDSs, active TDDSs. Keywords: breast cancer, curcumin, system, targeting,

Language: Английский

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A Comprehensive Overview on Chemotherapy-Induced Cardiotoxicity: Insights into the Underlying Inflammatory and Oxidative Mechanisms

Cardiovascular Drugs and Therapy, Journal Year: 2024, Volume and Issue: unknown

Published: March 16, 2024

Abstract While oncotherapy has made rapid progress in recent years, side effects of anti-cancer drugs and treatments have also come to the fore. These include cardiotoxicity, which can cause irreversible cardiac damages with long-term morbidity mortality. Despite continuous in-depth research on drugs, an improved knowledge underlying mechanisms cardiotoxicity are necessary for early detection management risk. Although most reviews focus cardiotoxic effect a specific individual chemotherapeutic agent, aim our review is provide comprehensive insight into various agents that induced their mechanisms. Characterization these underpinned by animal models clinical studies. In order gain complex mechanisms, we emphasize role inflammatory processes oxidative stress chemotherapy-induced changes. A better understanding identification interplay between chemotherapy inflammatory/oxidative hold some promise prevent or at least mitigate cardiotoxicity-associated mortality among cancer survivors.

Language: Английский

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Manganese-based nanomaterials in diagnostics and chemodynamic therapy of cancers: new development

RSC Advances, Journal Year: 2024, Volume and Issue: 14(21), P. 14722 - 14741

Published: Jan. 1, 2024

Manganese-based nanomaterials have seen rapid development in chemodynamic therapy and T 1 -enhanced MRI over the past five years, holding promising prospects various combined applications.

Language: Английский

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