The effects of nicotine on microRNA-124 expression in the bile duct ligation- induced liver fibrosis in rats DOI Creative Commons
Khalil Hajiasgharzadeh, Parviz Shahabi, Elham Karimi‐Sales

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 14, 2023

Abstract Background Smoking causes a variety of adverse effects on organs that have no direct contact with the smoke itself such as liver. Nicotine main compound smoking may exert its by changing expression microRNAs (miRNAs). This study was conducted to further investigate molecular mechanisms miRNA-dependent nicotine in an animal model liver fibrosis. Methods First, bile duct ligation (BDL) approach used male Wistar rats create Then, administration miRNA-124 expression, well fibrosis and inflammation-related genes were investigated using quantitative Real-Time PCR method. The total bilirubin enzymes activity levels measured colorimetric assay. Also, process histological studies. Results development BDL leads decrease expression. has been seen groups administered nicotine. is accompanied increase fibrotic proinflammatory genes. significant worsens administration. results studies also confirm these results. Conclusion Considering anti-inflammatory miRNA, it can be concluded due exposure inflammatory processes subsequently

Language: Английский

Chili pepper: A delve into its nutritional values and roles in food-based therapy DOI Creative Commons

Ayman Faris Faisal,

Yasser Fakri Mustafa

Food Chemistry Advances, Journal Year: 2025, Volume and Issue: 6, P. 100928 - 100928

Published: Feb. 16, 2025

Language: Английский

Citations

1
The association of exposure to polychlorinated biphenyls with lipid profile and liver enzymes in umbilical cord blood samples DOI
Ahmed Hjazi, Chou‐Yi Hsu,

Wafaa M. Al-Attar

et al.

Chemosphere, Journal Year: 2024, Volume and Issue: 350, P. 141096 - 141096

Published: Jan. 2, 2024

Language: Английский

Citations

5
Application of thermo-responsive polymers as smart biomaterials in wound dressing DOI
Iman Rad, Elaheh Esmaeili,

Behnoosh Bahadori Jahromi

et al.

Polymer Bulletin, Journal Year: 2024, Volume and Issue: 81(13), P. 11399 - 11420

Published: April 23, 2024

Language: Английский

Citations

4
Unveiling the Effect of Particle Incorporation in PEO Coatings on the Corrosion and Wear Performance of Magnesium Implants DOI Creative Commons
Yasir Q. Аlmajidi,

Eyhab Ali,

Madiha Fouad Jameel

et al.

Lubricants, Journal Year: 2023, Volume and Issue: 11(12), P. 519 - 519

Published: Dec. 8, 2023

Magnesium has been a focal point of significant exploration in the biomedical engineering domain for many years due to its exceptional attributes, encompassing impressive specific strength, low density, excellent damping abilities, biodegradability, and sought-after quality biocompatibility. The primary drawback associated with magnesium-based implants is their susceptibility corrosion wear physiological environments, which represents limitation. Research findings have established that plasma electrolytic oxidation (PEO) induces substantial modifications surface characteristics behavior magnesium alloy counterparts. By subjecting high voltages, porous ceramic coating formed, resulting not only altered properties resistance, but also enhanced resistance. However, PEO process excessive pore formation porosity within shell could potentially undermine coating’s resistances. Altering electrolyte conditions by introducing micro- nano-particles can serve as valuable approach decrease enhance ultimate characteristics. This paper evaluates particle adhesion, composition, corrosion, performances particle-incorporated coatings applied alloys through method.

Language: Английский

Citations

10
Exploring the therapeutic potential of chlorogenic acid in alleviating olanzapine-induced metabolic syndrome in rats: a key role of hypothalamic satiety proteins DOI

Zeinab Ebrahimian,

Bibi Marjan Razavi, Seyed Ali Mousavi Shaegh

et al.

Nutritional Neuroscience, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 20

Published: Feb. 9, 2025

Objectives: Olanzapine (Olz) is an effective antipsychotic medication for schizophrenia; however, its use associated with weight gain and metabolic disorders. Chlorogenic acid (CGA), a dietary polyphenol, has promising potential the treatment of obesity, diabetes, hypertension. This study aimed to determine whether CGA could effectively manage Olz-induced syndrome (MetS) in rat model, metformin (Met) as positive control.Methods: Female Wistar rats were divided into seven groups: control; Olz (5 mg/kg/day, IP); (20, 40, 80 gavage) plus Olz; Met (100 (80 30 days. Metabolic parameters including body weight, fasting blood glucose, triglycerides, pressure assessed. focused on evaluating serum levels leptin adiponectin, well hypothalamic protein expression pro-opiomelanocortin (POMC), neuropeptide Y (NPY), AMP-activated kinase (AMPK), 5-HT2C receptors (5-HT2CR), which are known influence energy balance potentially play role abnormalities.Results: caused substantial hyperphagia, gain, hypertension, liver damage, along elevated levels. mitigated these effects, although elevation adiponectin remained unaffected by either treatment. Mechanistically, reduced 5-HT2CR levels, trend that was observed therapy groups. also enhanced NPY pAMPK/AMPK ratio while lowering POMC These alterations reversed administered or Met.Discussion: findings suggest attenuated adverse consequences modulating leptin, NPY, POMC, AMPK CGA's therapeutic highlights intervention managing antipsychotic-induced disturbances.

Language: Английский

Citations

0
The effects of propolis supplementation on lipid profiles in adults with metabolic syndrome and related disorders: A systematic review and meta-analysis of randomized controlled trials DOI Creative Commons
Yasmin Basheer Ahmed, Saade Abdalkareem Jasim, Yasser Fakri Mustafa

et al.

Human Nutrition & Metabolism, Journal Year: 2024, Volume and Issue: 37, P. 200276 - 200276

Published: June 13, 2024

Findings on the effects of propolis supplementation lipid profile in adults with metabolic syndrome (MetS) and related disorders are conflicting. The current comprehensive systematic review meta-analysis aimed to summarize available evidence this regard. Online databases including PubMed, Scopus, Web Science, Cochrane Library were searched up May 2024 for randomized controlled trials (RCTs) that examined effect MetS disorders. data was pooled using a random-effects model is presented as weighted mean difference (WMD) 95 % confidence interval (CI). Ten RCTs involving total 683 subjects included meta-analysis. combined results revealed led significant decrease low-density lipoprotein cholesterol (LDL-C) levels (WMD: −7.97 mg/dL, CI: −13.11 −2.83, P = 0.002; I2 69.9 %) increase high-density (HDL-C) 2.85 0.41 5.28, 0.02; 82.2 %). However, there no impact triglyceride −9.12 −22.84 4.59, 0.19; 0.0 0.69 mg/dL; −4.79 6.18, 0.80; 81.9 This suggests improves serum LDL-C HDL-C levels, which could delay progression heart disease. these based limited RCTs, further clinical needed exclusively study individuals dyslipidemia confirm our findings.

Language: Английский

Citations

3
Dietary caffeine intake is associated with favorable metabolic profile among apparently healthy overweight and obese individuals DOI Creative Commons
Shadia Hamoud Alshahrani,

Yasir Atia,

Raheem Atiya Badir

et al.

BMC Endocrine Disorders, Journal Year: 2023, Volume and Issue: 23(1)

Published: Oct. 20, 2023

Recent studies have revealed some conflicting results about the health effects of caffeine. These are inconsistent in terms design and population source consumed In current study, we aimed to evaluate possible dietary caffeine intake among overweight obese individuals.In this cross-sectional 488 apparently healthy individuals with obesity were participated. Dietary was assessed by a Food Frequency Questionnaire (FFQ) amount calculated. Body composition determined bioelectrical impedance analysis (BIA). Enzymatic methods used serum lipid, glucose, insulin concentrations.Those at highest tertile had lower percentage fat mass, higher free mass appetite score (P < 0.05). Also, total cholesterol (TC) low density lipoprotein (LDL-c) observed tertiles compared tertiles. multinomial adjusted models, those second more likely = 0.04) homeostatic model assessment resistance (HOMA-IR) values first 0.03) crude model. While, age, body index (BMI), sex, physical activity, socio-economic status (SES) energy -adjusted (Model III), third LDL concentrations [odds ratio (OR) 0.957; CI 0.918-0.997; P 0.04]. With further adjustment vegetable, fiber grain intake, systolic blood pressure (SBP), high HDL levels 0.05).High intakes associated LDL, SBP, individuals. However, due observational causal inference is impossible warranted confirm our findings.

Language: Английский

Citations

7
Effects of nicotine on microRNA-124 expression in bile duct ligation-induced liver fibrosis in rats DOI Creative Commons
Khalil Hajiasgharzadeh, Parviz Shahabi, Elham Karimi‐Sales

et al.

BMC Pharmacology and Toxicology, Journal Year: 2024, Volume and Issue: 25(1)

Published: March 28, 2024

Abstract Background Nicotine, the main compound of smoking may exert its effects by changing expression microRNAs (miRNAs). This study was conducted to further investigate molecular mechanisms miRNA-dependent nicotine in an animal model liver fibrosis. Methods The bile duct ligation (BDL) approach used create a Twenty-four male Wistar rats were study. administration on miRNA-124 expression, as well alpha-smooth muscle actin (liver fibrosis marker) and chemokine ligand 2 (an inflammatory chemokine), investigated using RT-qPCR. In addition, mRNA protein signal transducer activator transcription 3 (STAT-3; potential target for miRNA-124) RT-qPCR immunofluorescence, respectively. Liver enzyme activity levels measured colorimetric assay. process with histological studies. Results development BDL led decrease expression. is accompanied increase fibrotic proinflammatory genes. Also, STAT-3 observed that received nicotine. significant bilirubin enzymes worsens administration. results studies also confirm these results. Conclusion Considering anti-inflammatory miRNA, it can be concluded due exposure leads processes subsequently

Language: Английский

Citations

2
Soluble receptor for advanced glycation end products (sRAGE) is associated with obesity rates: a systematic review and meta-analysis of cross-sectional study DOI Creative Commons
Nahla A. Tayyib, Pushpamala Ramaiah, Shadia Hamoud Alshahrani

et al.

BMC Endocrine Disorders, Journal Year: 2023, Volume and Issue: 23(1)

Published: Dec. 15, 2023

Several studies have highlighted the possible positive effects of soluble receptor for advanced glycation end products (sRAGE) against obesity. However, due to their inconsistent results, this systematic review and meta-analysis aimed quantitatively evaluate critically results evaluating relationship between sRAGE with obesity among adult population.In search, eligibility criteria were as follows: conducted a cross-sectional design, included apparently healthy adults, adults obesity, or obesity-related disorders, aged over 18 years, evaluated association general central indices sRAGE.Our search in electronic databases, including PubMed, Scopus, Embase up 26 October, 2023 yielded total 21,612 articles. After removing duplicates, screening titles abstracts, reading full texts, 13 manuscripts final meta-analysis. According our those at highest category circulating concentration median values 934.92 pg/ml sRAGE, had 1.9 kg/m2 lower body mass index (BMI) (WMD: -1.927; CI: -2.868, -0.986; P < 0.001) compared lowest 481.88 pg/ml. Also, being 1302.3 was accompanied near 6 cm waist circumference (WC) -5.602; -8.820, -2.383; 0.001 86.4% heterogeneity I2) 500.525 Individuals significantly concentrations -135.105; -256.491, -13.72; = 0.029; 79.5% I2). subgrouping meta-regression country baseline BMI sources. Begg's Egger's tests funnel plots there no publication bias.According higher associated WC adults. Further randomized clinical trials are warranted identification causal associations.

Language: Английский

Citations

6
Screening of pslA and pelB Biofilm-Producing Genes from Pseudomonas Isolated from Clinical Samples DOI

Zahra Soleymani-Fard,

Mehdi Hassanshahian, Saade Abdalkareem Jasim

et al.

Proceedings of the National Academy of Sciences India Section B Biological Sciences, Journal Year: 2024, Volume and Issue: 94(3), P. 519 - 525

Published: April 2, 2024

Language: Английский

Citations

2