Research Square (Research Square),
Journal Year:
2023,
Volume and Issue:
unknown
Published: Nov. 14, 2023
Abstract
Background
Smoking
causes
a
variety
of
adverse
effects
on
organs
that
have
no
direct
contact
with
the
smoke
itself
such
as
liver.
Nicotine
main
compound
smoking
may
exert
its
by
changing
expression
microRNAs
(miRNAs).
This
study
was
conducted
to
further
investigate
molecular
mechanisms
miRNA-dependent
nicotine
in
an
animal
model
liver
fibrosis.
Methods
First,
bile
duct
ligation
(BDL)
approach
used
male
Wistar
rats
create
Then,
administration
miRNA-124
expression,
well
fibrosis
and
inflammation-related
genes
were
investigated
using
quantitative
Real-Time
PCR
method.
The
total
bilirubin
enzymes
activity
levels
measured
colorimetric
assay.
Also,
process
histological
studies.
Results
development
BDL
leads
decrease
expression.
has
been
seen
groups
administered
nicotine.
is
accompanied
increase
fibrotic
proinflammatory
genes.
significant
worsens
administration.
results
studies
also
confirm
these
results.
Conclusion
Considering
anti-inflammatory
miRNA,
it
can
be
concluded
due
exposure
inflammatory
processes
subsequently
BMC Endocrine Disorders,
Journal Year:
2023,
Volume and Issue:
23(1)
Published: Nov. 27, 2023
Abstract
Background
The
health
benefits
of
dietary
polyphenol
intake
(DPI)
including
improved
lipid
profiles,
blood
pressure,
insulin
resistance,
and
reduced
systemic
inflammation
has
revealed
previously.
However,
the
results
numerous
studies
are
not
consistent
it
seems
that
these
effects
attributed
to
some
DPI.
In
current
research,
we
evaluated
DPI
on
metabolic
markers
glycemic
among
overweight
obese
individuals.
Methods
this
cross-sectional
study,
487
individuals
with
obesity
were
participated.
Dietary
was
assessed
by
a
Food
Frequency
Questionnaire
(FFQ)
amount
calculated
based
information
derived
from
Phenol-Explorer
database
(
www.phenolexplorer.eu/contents
).
Bioelectrical
impedance
analysis
(BIA)
used
measure
body
composition.
Systolic
diastolic
pressures
measured
sphygmomanometer.
Biochemical
assays
fasting
sugar,
serum
lipids’
concentrations
enzymatic
methods.
Results
According
our
results,
males
more
likely
be
at
highest
tertile
P
=
0.04).
Also,
those
had
higher
fat
free
mass
physical
activity
level
<
0.05).
Lower
TG
in
crude
model
also
observed,
but,
lost
its
significant
threshold
after
adjustment
for
confounders.
Subjects
second
have
lower
systolic
pressure
sex
age
adjusted
[OR
0.970;
CI
0.940-1.000;
0.049].
For
other
biochemical
variables,
no
association
observed.
Conclusion
total
associated
SBP
Further
warranted
better
elucidate
observed
results.
Complementary Therapies in Medicine,
Journal Year:
2024,
Volume and Issue:
82, P. 103041 - 103041
Published: April 21, 2024
The
effects
of
jujube
(Ziziphus
jujube)
consumption
on
metabolic
and
mental
health
outcomes
in
subjects
diagnosed
with
syndrome
(MetS)
is
unknown
remains
to
be
examined.
Hence,
we
carried
out
a
parallel-group,
randomized
controlled
trial
investigate
this
issue.
Eligible
participants
were
randomly
assigned
the
intervention
(n=30)
or
control
groups
receive
either
placebo
for
eight
weeks.
Subjects
provided
30
g
dried
powder
asked
consume
half
at
10
a.m.
rest
4
p.m.
Lipid
profile,
fasting
blood
glucose
(FBG),
waist
circumference
(WC),
pressure
evaluated
as
primary
outcomes.
Secondary
collected
measures
(e.g.,
depression,
anxiety,
stress).
Jujube
failed
decrease
FBG,
total
cholesterol,
low-density
lipoprotein
pressure,
well
depression
anxiety
scores
(P>0.05).
However,
between-group
comparison
revealed
significant
improvement
WC
(-3.98
vs.
-0.51,
P=0.01),
triglyceride
(TG)
(-24.96
-0.73,
P=0.03),
high-density
cholesterol
(HDL-C)
(2.83
0.40,
P=0.01)
group
compared
placebo.
In
addition,
group,
led
score
stress
(-5.80
-2.86,
P=0.01).
only
had
beneficial
WC,
TG,
HDL-C
MetS.
current
study
has
methodological
weaknesses
blinding
herb
purity/potency
testing,
which
should
addressed
future
studies.
Iranian
Registry
Clinical
Trials
(registration
number:
IRCT20180201038585N10;
registration
date:
11
April
2021),
https://www.irct.ir/trial/55287.
Environmental Sciences Europe,
Journal Year:
2024,
Volume and Issue:
36(1)
Published: May 2, 2024
Abstract
Polycyclic
aromatic
hydrocarbons
(PAHs)
are
ubiquitous
environmental
pollutants
with
significant
adverse
effects
on
human
health,
particularly
concerning
fetal
development
during
pregnancy.
This
study
investigates
the
relationship
between
maternal
exposure
to
particulate
matter-bound
(PM-bound)
PAHs
and
potential
alterations
in
renal
function.
A
cross-sectional
investigation
was
conducted
450
mother-pair
newborns
from
June
2019
August
2021.
Exposure
PM-bound
estimated
at
residential
address
using
spatiotemporal
models
based
data
30
monitoring
stations
across
area.
Umbilical
cord
blood
samples
were
collected
post-delivery
for
biochemical
analysis
of
function
markers,
including
creatinine
(Cr),
urea
nitrogen
(BUN),
glomerular
filtration
rate
(eGFR).
Multivariable
regression
used
assess
each
compound
Moreover,
mixture
assessed
quantile
g-computation
analysis.
Increased
concentrations
various
PAH
compounds
correlated
raised
levels
umbilical
BUN
Cr,
suggesting
impairment.
Notably,
certain
demonstrated
statistically
negative
associations
eGFR
levels.
An
increment
one
quartile
a
rise
1.08
mg/dL
(95%
CI
0.04,
2.11,
p
=
0.04)
0.02
−
0.00,
0.05,
0.05)
increase
respectively.
one-quartile
associated
1.09
mL/min/1.73
m
2
2.03,
0.14,
0.02)
decrease
eGFR.
These
findings
highlight
impact
underscore
importance
considering
exposures
assessing
neonatal
health
outcomes.
Phytotherapy Research,
Journal Year:
2024,
Volume and Issue:
38(7), P. 3583 - 3593
Published: May 8, 2024
In
recent
years,
an
increase
in
the
incidence
of
liver
diseases
has
been
reported
all
over
world.
This
study
aims
to
comprehensively
summarize
and
quantitatively
analyze
existing
evidence
concerning
effectiveness
grape-derived
products
on
enzymes
through
a
systematic
review
meta-analytic
approach.
PubMed,
Scopus,
Cochrane
Library,
ISI
Web
Science
were
searched
until
January
2024.
Articles
that
effect
serum
aspartate
aminotransferase
(AST),
alanine
(ALT),
alkaline
phosphatase
(ALP)
levels
included.
Weighted
mean
differences
(WMDs)
pooled
using
random-effects
model.
Nine
studies
included
meta-analysis.
The
results
revealed
did
not
significantly
change
concentrations
ALT
(WMD:
-2.70
IU/L,
95%
CI:
-6.14
0.75,
p
=
0.12),
AST
-1.42
-3.54
0.70,
0.18).
However,
significant
reduction
was
observed
ALP
-5.49
-9.57
-1.4,
0.008).
present
findings
suggest
positively
influence
among
adults.
more
comprehensive
decision
necessitates
additional
studies.
Research Square (Research Square),
Journal Year:
2023,
Volume and Issue:
unknown
Published: Nov. 14, 2023
Abstract
Background
Smoking
causes
a
variety
of
adverse
effects
on
organs
that
have
no
direct
contact
with
the
smoke
itself
such
as
liver.
Nicotine
main
compound
smoking
may
exert
its
by
changing
expression
microRNAs
(miRNAs).
This
study
was
conducted
to
further
investigate
molecular
mechanisms
miRNA-dependent
nicotine
in
an
animal
model
liver
fibrosis.
Methods
First,
bile
duct
ligation
(BDL)
approach
used
male
Wistar
rats
create
Then,
administration
miRNA-124
expression,
well
fibrosis
and
inflammation-related
genes
were
investigated
using
quantitative
Real-Time
PCR
method.
The
total
bilirubin
enzymes
activity
levels
measured
colorimetric
assay.
Also,
process
histological
studies.
Results
development
BDL
leads
decrease
expression.
has
been
seen
groups
administered
nicotine.
is
accompanied
increase
fibrotic
proinflammatory
genes.
significant
worsens
administration.
results
studies
also
confirm
these
results.
Conclusion
Considering
anti-inflammatory
miRNA,
it
can
be
concluded
due
exposure
inflammatory
processes
subsequently
