Applied Physics B, Journal Year: 2025, Volume and Issue: 131(6)
Published: May 10, 2025
Language: Английский
ACS Sensors, Journal Year: 2024, Volume and Issue: 9(9), P. 4469 - 4494
Published: Sept. 9, 2024
Lung cancer remains a global health concern, demanding the development of noninvasive, prompt, selective, and point-of-care diagnostic tools. Correspondingly, breath analysis using nanobiosensors has emerged as promising noninvasive nose-on-chip technique for early detection lung through monitoring diversified biomarkers such volatile organic compounds/gases in exhaled breath. This comprehensive review summarizes state-of-the-art breath-based diagnosis employing chemiresistive-module supported by theoretical findings. It unveils fundamental mechanisms biological basis biomarker generation associated with cancer, technological advancements, clinical implementation nanobiosensor-based analysis. explores merits, challenges, potential alternate solutions implementing these settings, including standardization, biocompatibility/toxicity analysis, green sustainable technologies, life-cycle assessment, scheming regulatory modalities. highlights nanobiosensors' role facilitating precise, real-time, on-site leading to improved patient outcomes, enhanced management, remote personalized monitoring. Additionally, integrating biosensors artificial intelligence, machine learning, Internet-of-things, bioinformatics, omics technologies is discussed, providing insights into prospects intelligent sniffing nanobiosensors. Overall, this consolidates knowledge on breathomic biosensor-based screening, shedding light its significance applications advancing medical diagnostics reduce burden hospitals save human lives.
Language: Английский
Citations
30
Microchemical Journal, Journal Year: 2024, Volume and Issue: 205, P. 111307 - 111307
Published: July 27, 2024
Language: Английский
Citations
19
Talanta, Journal Year: 2025, Volume and Issue: 287, P. 127693 - 127693
Published: Feb. 4, 2025
Language: Английский
Citations
4
Microchimica Acta, Journal Year: 2024, Volume and Issue: 191(5)
Published: April 8, 2024
Language: Английский
Citations
16
Food Control, Journal Year: 2024, Volume and Issue: 161, P. 110399 - 110399
Published: Feb. 24, 2024
Language: Английский
Citations
15
ECS Journal of Solid State Science and Technology, Journal Year: 2024, Volume and Issue: 13(4), P. 047004 - 047004
Published: April 1, 2024
Early diagnosis through noninvasive tools is a cornerstone in the realm of personalized and medical healthcare, averting direct/indirect infection transmission directly influencing treatment outcomes patient survival rates. In this context, optical biochip breathomic sensors integrated with nanomaterials, microfluidics, artificial intelligence exhibit potential to design next-generation intelligent diagnostics. This cutting-edge tool offers variety advantages, including being economical, compact, smart, point care, highly sensitive, noninvasive. makes it an ideal avenue for screening, diagnosing, prognosing various high-risk diseases/disorders by detecting associated breath biomarkers. The underlying detection mechanism relies on interaction biomarkers sensors, which causes modulations fundamental attributes, such as surface plasmon resonance, fluorescence, reflectance, absorption, emission, phosphorescence, refractive index. Despite these remarkable commercial development faces challenges, insufficient support from clinical trials, concerns about cross-sensitivity, challenges related production scalability, validation issues, regulatory compliance, contrasts conventional perspective article sheds light state disease diagnosis, addresses proposes alternative solutions, explores future avenues revolutionize healthcare
Language: Английский
Citations
14
Plasmonics, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 28, 2024
Language: Английский
Citations
10
Journal of Biotechnology, Journal Year: 2025, Volume and Issue: 400, P. 29 - 47
Published: Feb. 15, 2025
Language: Английский
Citations
2
ACS Chemical Neuroscience, Journal Year: 2025, Volume and Issue: 16(5), P. 895 - 907
Published: Feb. 20, 2025
Ischemic stroke remains a leading cause of morbidity and mortality worldwide, early diagnosis is critical for improving clinical outcomes. This paper presents an optical design framework combining speckle contrast spectroscopy (SCOS) with multiwavelength reflectance to monitor subtle changes in cerebral blood flow during ischemic events. The research aims enable precise tissue interrogation using high-resolution, low-scatter imaging. Key the system's accuracy 1.55 μm small beam waist, grating density 1300 grooves/mm, 15.53 depth focus. calculated effective focal length 8333.33 enhances resolution 4.07 μm, detection minor properties. We investigate sensitivity various near-infrared wavelengths (660, 785, 800, 976 nm) ischemic-induced changes, particular emphasis on nm wavelength, which demonstrates superior penetration increased variations perfusion ischemia. Optical markers such as spot-size widening, spatial intensity shifts, central decrease are identified reliable indicators Our findings suggest that analysis, particularly range, provides practical, noninvasive approach continuously monitoring strokes. technique indicates potential real-time perfusion, allows continuous, management strokes, patient outcomes decision-making.
Language: Английский
Citations
2
Journal of environmental chemical engineering, Journal Year: 2025, Volume and Issue: unknown, P. 115714 - 115714
Published: Feb. 1, 2025
Language: Английский
Citations
1