Risk for newly diagnosed diabetes after COVID-19: a systematic review and meta-analysis

BMC Medicine, Journal Year: 2022, Volume and Issue: 20(1)

Published: Nov. 15, 2022

Abstract Background There is growing evidence that patients recovering after a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection may have variety of sequelae including newly diagnosed diabetes. However, the risk diabetes in post-acute phase unclear. To solve this question, we aimed to determine if there was any association between status post-coronavirus disease (COVID-19) and new diagnosis Methods We performed systematic review meta-analysis cohort studies assessing new-onset COVID-19. PubMed, Embase, Web Science, Cochrane databases were all searched from inception June 10, 2022. Three evaluators independently extracted individual study data assessed bias. Random-effects models estimated pooled incidence relative (RR) compared non-COVID-19 Results Nine with nearly 40 million participants included. Overall, COVID-19 15.53 (7.91–25.64) per 1000 person-years, elevated (RR 1.62 [1.45–1.80]). The type 1 RR=1.48 (1.26–1.75) RR=1.70 (1.32–2.19), patients. At ages, statistically significant positive diabetes: <18 years: RR=1.72 (1.19–2.49), ≥18 RR=1.63 (1.26–2.11), >65 RR=1.68 (1.22–2.30). different gender groups about (males: RR=2.08 [1.27–3.40]; females: RR=1.99 [1.47–2.80]). increased 1.17-fold (1.02–1.34) general upper tract infections. Patients at higher (RR=1.67 [1.25–2.23]) (RR=1.95 [1.85–2.06]) highest first 3 months These results remained taking confounding factors into account. Conclusions After COVID-19, ages genders had an for Particular attention should be paid during follow-up

Language: Английский

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The global impact of COVID‐19 pandemic on the incidence of pediatric new‐onset type 1 diabetes and ketoacidosis: A systematic review and meta‐analysis

Journal of Medical Virology, Journal Year: 2022, Volume and Issue: 94(11), P. 5112 - 5127

Published: July 14, 2022

Viral infections may increase the risk of developing type 1 diabetes (T1D), and recent reports suggest that Coronavirus Disease 2019 (COVID-19) might have increased incidence pediatric T1D and/or diabetic ketoacidosis (DKA). Therefore, this meta-analysis aims to estimate global new-onset T1D, DKA, severe DKA before after COVID-19 pandemic. A systematic search MEDLINE/PubMed, CINAHL, Scopus, EMBASE was conducted for articles published up March 2022. random-effects performed compare relative among patients with between pre-pandemic pandemic periods. We also compared glucose HbA1c values in children who were newly diagnosed The rate period 19.73 per 100 000 32.39 2020 period. Compared pre-COVID-19 pandemic, number worldwide during first year by 9.5%, 25%, 19.5%, respectively. levels, median glucose, 6.43% 6.42%, has significantly DKA. Moreover, higher mandates targeted measures raise public physician awareness.

Language: Английский

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Effects of COVID‐19 vaccination during pregnancy on SARS‐CoV‐2 infection and maternal and neonatal outcomes: A systematic review and meta‐analysis

Reviews in Medical Virology, Journal Year: 2023, Volume and Issue: 33(3)

Published: March 10, 2023

SARS-CoV-2 infection during pregnancy is associated with adverse maternal and neonatal outcomes, but no systematic synthesis of evidence on COVID-19 vaccination against these outcomes has been undertaken. Thus, we aimed to assess the collective effects outcomes. PubMed/MEDLINE, CENTRAL, EMBASE were systematically searched for articles published up 1 November 2022. A review meta-analysis performed calculate pooled size 95% confidence interval (CI). We evaluated 30 studies involving 862,272 individuals (308,428 vaccinated 553,844 unvaccinated). Overall analyses in pregnant women showed reduced risks by 60% (41%-73%), hospitalisation 53% (31%-69%), intensive care unit (ICU) admission 82% (12%-99%). Neonates 1.78 folds more likely acquire first 2, 4 6 months life Omicron period. The risk stillbirth was 45% (17%-63%) association (vs. vaccination) pregnancy. decrease 15% (3%-25%), 33% (14%-48%), (17%-46%) odds preterm births before 37, 32 28 weeks' gestation pregnancy, respectively. ICU significantly lower 20% following (16%-24%). There a higher including miscarriage, gestational diabetes, hypertension, cardiac problems, oligohydramnios, polyhydramnios, unassisted vaginal delivery, cesarean postpartum haemorrhage, age at placental abruption, Apgar score 5 min below 7, low birthweight (<2500 g), very (<1500 small age, foetal abnormalities. safe highly effective preventing without increasing reduction stillbirth, births, admission. Importantly, did not reduce

Language: Английский

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New‐onset neurodegenerative diseases as long‐term sequelae of SARS‐CoV‐2 infection: A systematic review and meta‐analysis

Journal of Medical Virology, Journal Year: 2023, Volume and Issue: 95(7)

Published: July 1, 2023

Abstract The association between SARS‐CoV‐2 infection with increased risk for new‐onset neurodegenerative diseases remains unclear. Therefore, this meta‐analysis aims to elucidate whether are long‐term sequelae of infection. PubMed/MEDLINE, CENTRAL, and EMBASE were systematically searched articles published up January 10, 2023. A systematic review performed calculate the pooled effect size, expressed as hazard ratios (HR) corresponding 95% confidence interval (CI) each outcome. Twelve studies involving 33 146 809 individuals (2 688 417 post‐COVID‐19 cases 30 458 392 controls) included in present meta‐analysis. analyses compared control groups showed a significant Alzheimer's disease (HR = 1.50, CI 1.22–1.85, I 2 97%), dementia 1.66, 1.42–1.94, 91%), Parkinson's 1.44, 1.06–1.95, 86%) among COVID‐19 survivors. may be associated higher recovered patients. Future warranted determine biological mechanisms underlying consequences

Language: Английский

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Baseline physical activity is associated with reduced mortality and disease outcomes in COVID‐19: A systematic review and meta‐analysis

Reviews in Medical Virology, Journal Year: 2022, Volume and Issue: 32(5)

Published: April 13, 2022

Abstract Among coronavirus disease 2019 (COVID‐19) patients, physically active individuals may be at lower risk of fatal outcomes. However, to date, no meta‐analysis has been carried out investigate the relationship between physical activity (PA) and outcomes in patients with COVID‐19. Therefore, this aims explore hospitalisation, intensive care unit (ICU) admissions, mortality rates COVID‐19 a history PA participation before onset pandemic, evaluate reliability evidence. A systematic search MEDLINE/PubMed, Cumulative Index Nursing Allied Health Literature, Scopus, medRxiv was conducted for articles published up January 2022. random‐effects performed compare severity inactive cases. Twelve studies involving 1,256,609 (991,268 265,341 cases) COVID‐19, were included pooled analysis. The overall compared controls showed significant associations reduction hospitalisation (risk ratio (RR) = 0.58, 95% confidence intervals (CI) 0.46–0.73, P 0.001), ICU admissions (RR 0.65, CI 0.52–0.81, 0.001) 0.47, 0.38–0.59, 0.001). protective effect on could attributable types exercise such as resistance 0.27, 0.15–0.49, endurance 0.41, 0.23–0.74, 0.003), respectively. Physical is associated decreased Moreover, exercises experience rate mortality, Further are warranted determine biological mechanisms underlying these findings.

Language: Английский

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The Key Drivers of Brain Injury by Systemic Inflammatory Responses after Sepsis: Microglia and Neuroinflammation

Molecular Neurobiology, Journal Year: 2022, Volume and Issue: 60(3), P. 1369 - 1390

Published: Nov. 29, 2022

Abstract Sepsis is a leading cause of intensive care unit admission and death worldwide. Most surviving patients show acute or chronic mental disorders, which are known as sepsis-associated encephalopathy (SAE). Although accumulating studies in the past two decades focused on pathogenesis SAE, systematic review retrospective exclusively focuses inflammatory mechanisms SAE has been lacking yet. This summarizes recent advance field neuroinflammation sheds light activation microglia SAE. Activation predominates neuroinflammation. As gene expression profile changes, heterogeneous characterizations throughout all stages Here, we summarize systemic inflammation following sepsis also relationship microglial diversity Moreover, collection neuroinflammation-related dysfunction reviewed to illustrate possible for In addition, promising pharmacological non-pharmacological therapeutic strategies, especially those target microglia, concluded final part this review. Collectively, clarification vital between SAE-related disorders would significantly improve our understanding pathophysiological therefore provide potential targets therapies aimed at inhibiting

Language: Английский

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The effect of adherence to high‐quality dietary pattern on COVID‐19 outcomes: A systematic review and meta‐analysis

Journal of Medical Virology, Journal Year: 2022, Volume and Issue: 95(1)

Published: Nov. 11, 2022

Dietary quality and patterns may influence SARS-CoV-2 infection outcomes, but scientific data evidence to support such a role are lacking. Therefore, this meta-analysis aims elucidate the effect of prepandemic diet on risk COVID-19 hospitalization. PubMed/MEDLINE, CENTRAL, Scopus, EMBASE were systematically searched for articles published up September 1, 2022. A systematic review performed calculate each outcome's ratio (RR) 95% confidence interval (CI). Five studies including 4 023 663 individuals (3 149 784 high-quality 873 881 controls) included in present meta-analysis. The effectiveness dietary pattern against hospitalization was 28% (95% CI 19%-36%) 62% 25%-80%); respectively. Subgroup analysis based different levels showed no difference between middle high reducing infection. Interestingly, subgroup types diets revealed that plant-based 50% 30%-65%); while Mediterranean 22% 12%-31%). Adherence is associated with lower More required confirm these findings, future should determine biological mechanisms underlying association

Language: Английский

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Physical activity lowers the risk for acute respiratory infections: Time for recognition

Journal of sport and health science/Journal of Sport and Health Science, Journal Year: 2022, Volume and Issue: 11(6), P. 648 - 655

Published: Aug. 20, 2022

Physical inactivity is a well-established risk factor for chronic diseases, such as cardiovascular disease, cancer, and diabetes mellitus. There growing awareness that physical should also be regarded acute respiratory infections (ARIs). ARIs, the common cold, influenza, pneumonia, coronavirus disease 2019 (COVID-19), are among most pervasive diseases on earth cause widespread morbidity mortality. Evidence in support of linkage between ARIs has been strengthened during COVID-19 pandemic because increased scientific scrutiny. Large-scale studies have consistently reported severe outcomes elevated cohorts with low activity and/or fitness, even after adjusting other factors. The lowered physically active groups attributed to exercise-induced immunoprotective effects, including enhanced surveillance key immune cells reduced inflammation. Scientific consensus groups, those who submitted Activity Guidelines Americans, not yet given this area research respect due. It time add "reduced ARIs" "Exercise Medicine" list activity-related health benefits.

Language: Английский

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Effects of physical rehabilitation interventions in COVID-19 patients following discharge from hospital: A systematic review

Journal of Integrative Medicine, Journal Year: 2023, Volume and Issue: 21(2), P. 149 - 158

Published: Jan. 20, 2023

Language: Английский

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The efficacy of extracorporeal shock wave therapy for knee osteoarthritis : an umbrella review

International Journal of Surgery, Journal Year: 2024, Volume and Issue: 110(4), P. 2389 - 2395

Published: Jan. 18, 2024

Background: An umbrella review was conducted to compare the effectiveness of extracorporeal shock wave therapy (ESWT) versus non-ESWT in treatment knee osteoarthritis (KOA). Materials and methods: Three databases including PubMed, Embase Web science were searched up September 2023. Literature screening, quality evaluation, data extraction performed according inclusion exclusion criteria. Meta-analysis outcome indicators using Revman 5.4 software. Results: A total eight meta-analysis included this review. All graded against a Measurement Tool Assess Systematic Reviews 2 (AMSTAR 2) scored between 8 11. Compared sham group, ESWT group showed better results WOMAC (Western Ontario McMaster Universities Arthritis Index) [mean difference (MD)=−2.94, 95% CI: −5.52, −0.37, P =0.03, I²=60%], Visual Analog Scale (VAS) (MD=−2.0, −2.5, −1.5, <0.01, I²=0%), range motion (ROM) (MD=17.55, 13.49, 21.61, <0.00001, Lequesne index (MD=−2.85, −3.64, −2.07, I²=48%). Conclusion: Based on our analysis, is now an effective for improving pain function patients with KOA.

Language: Английский

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