The anti-inflammatory effects of exercise on autoimmune diseases: A 20-year systematic review

Journal of sport and health science/Journal of Sport and Health Science, Journal Year: 2024, Volume and Issue: 13(3), P. 353 - 367

Published: Feb. 9, 2024

The anti-inflammatory effect of exercise may be an underlying factor in improving several autoimmune diseases. aim this systematic review was to examine the evidence on role training mitigating inflammation adolescents and adults with disease. PubMed, Web Science, Embase databases were systematically reviewed for related studies published between January 1, 2003 August 31, 2023. All randomized non-randomized controlled trials interventions disease study participants that evaluated inflammation-related biomarkers included. quality assessed using Tool assEssment Study qualiTy reporting Exercise (TESTEX) scale Cochrane bias risk tool. A total 14,565 records identified. After screening titles, abstracts, full texts, 87 eligible review. These conducted 25 different countries included a 2779 (patients disease, or control groups). Overall, suggests markers such as C-reactive protein (CRP), interleukin 6 (IL-6), tumor necrosis α (TNF-α) reduced by regular interventions. Regular combined multiple modes associated greater benefits. patients exerts influence. This provides support promotion development clinical intervention programs Most can safely adopt moderate protocols, but changes will modest at best. Acute are ineffective even modestly transiently pro-inflammatory.

Language: Английский

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Physical Activity: An Immunity Booster for Treating Respiratory Diseases

IntechOpen eBooks, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 9, 2025

The interplay between physical activity and the immune system has garnered significant attention, especially in context of respiratory diseases. Understanding this relationship is crucial, given global burden conditions such as COVID-19, influenza, other upper tract infections (URTIs). This proposal aims to explore how can serve an immunity booster its potential treating immunopathological COVID-19 pandemic further underscored importance maintaining mitigate adverse effects prolonged inactivity on system. Immobilization due hospitalization quarantine downregulate responses, making individuals more susceptible severe outcomes from infections. research inform public health recommendations clinical practices aimed at leveraging a non-pharmacological intervention boost manage By establishing clear connection exercise function, study will contribute development holistic treatment approaches for conditions, ultimately improving patient reducing healthcare burdens.

Language: Английский

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Correlation between physical activity and acute respiratory infections in preschool children

Medicinski Glasnik, Journal Year: 2025, Volume and Issue: 22(1), P. 173 - 178

Published: Jan. 19, 2025

To analyse a correlation between physical activity (PA) and acute respiratory infections (ARIs) in preschool children aged 5 to 7 years. Data on both ARIs, sedentary behaviour (SB) PA were obtained through specially created questionnaires for this study relationships them examined. A total of 129 with an average age 72.2±4.2 months, slightly higher number males, 65 (50.4%), have participated the study. Upper tract (URTIs) significantly negative frequency training weekdays (p=0.041) weekends (p=0.005). Lower (LRTIs) had positive usage electronic gaming devices (p=0.034), significant spending time nature (p=0.036). ARIs (p=0.025) An increase SB reduced level showed impact increase. It is recommended introduce programs among young children.

Language: Английский

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Impact of coronavirus (COVID-19) pandemic on physical activity levels in different sub-populations of Iranians: a national survey

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 24, 2025

During the COVID-19 pandemic, level of physical activity (PA) has been reported to decrease worldwide. A sedentary lifestyle is widely recognized as a significant risk factor for various diseases, necessitating extensive big data analysis uncover diverse aspects linked pandemic. Therefore, aim this study was investigate impact pandemic on PA levels across population subsets in Iran and identify barriers during fifth wave outbreak. Data from 7810 individuals (50.8% male, 54.8% married, 69.6% 18–49 years) were collected using standardized questionnaire comprising demographic details, high, moderate, low PA, daily time, at home, PA. The distributed online via social platforms such Telegram, WhatsApp, Instagram. obtained analyzed Chi-Square goodness-of-fit test significance α < 0.05. there number days/week dedicated well reduction duration each session compared pre-pandemic (p 0.001). Conversely, particularly exceeding 5 h, significantly increased post-outbreak Notably, lack appropriate space time constraints identified primary In nationally representative study, findings underscore substantial decline sub-populations an increase behaviors crisis.

Language: Английский

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Association of memory function with COVID-19 outcomes in adults aged 50 years and older: Analysis of three prospective cohorts

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

Abstract Background Patients with Alzheimer’s disease or dementia are at increased risk for COVID-19 hospitalization and mortality. However, no study has examined whether memory function is associated outcomes in general older adults. Methods Data were obtained from SHARE (the Survey of Health, Ageing Retirement Europe), HRS Health Study), ELSA English Longitudinal Study Ageing), three prospective representative cohorts non-institutionalized adults aged 50 years 25 European countries plus Israel, the United States, Kingdom, respectively. Memory was measured immediate delayed 10-words recall tests. Associations mortality assessed using logistic models adjusted age, sex, race, body mass index, smoking, physical activity, household income, education level, chronic conditions. Results A total 4062 participants infection SHARE, 1349 HRS, 278 included analysis. 610 (15.0%) 142 (10.5%) 39 (14.0%) hospitalized, 102 (2.5%) died related complications SHARE. The odds ratios (aORs) 1.15 (95% CI, 1.09-1.22) 1.07 0.94-1.21) 1.34 1.02-1.77) ELSA, per word decrease recall. For recall, corresponding aORs 1.11 1.06-1.17), 1.12 1.01-1.24), 1.25 1.01-1.55), 1.14 1.01-1.28) relatively robust to missing data covariates, exclusion cases based on symptoms alone, dementia. Conclusions This shows that low performance, as by independently an older.

Language: Английский

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Sexually distinct multi-omic responses to progressive endurance exercise training in the rat lung—Findings from MoTrPAC

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: April 16, 2025

Abstract Despite the lungs being essential for ventilation and aerobic exercise capacity, conventionally are not thought to adapt training. Endurance is key pulmonary rehabilitation programs, which also displays sex-specific differences in therapeutic efficacy. Given molecular underpinnings of lung adaptations endurance uncharacterized, we used a multi-omics approach study sex 6-month-old Fischer 344 rats response an 8 week progressive treadmill training protocol. This was accomplished by reannotating publicly accessible data from Molecular Transducers Physical Activity Consortium (MoTrPAC) integrating newly-analyzed acetylome assess multi-omic sedentary progressively trained states. Female displayed enrichment immune-related features pathways at transcriptome proteome level that were maintained with Conversely, male rat there overall decrease immune following weeks Sexually conserved responses included increased transcriptomic related type I alveoli proteomic cilia, decreased mitochondrial protein acetylation. In both sexes, known be enriched diseases attenuated Together our findings provide novel insight into specific may offer translational disease pathogenesis treatment.

Language: Английский

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Why Are Obese People Predisposed to Severe Disease in Viral Respiratory Infections?

Obesities, Journal Year: 2023, Volume and Issue: 3(1), P. 46 - 58

Published: Feb. 13, 2023

Obesity is one of the most pressing healthcare concerns twenty-first century. prevalence has risen dramatically in recent decades, and 2016, more than 1.9 billion adults were overweight (BMI ≥ 25 kg/m2) 650 million obese 30 kg/m2). About 50% world’s population anticipated to be obese/overweight within next decade. a major risk factor for variety non-communicable diseases, including type 2 diabetes mellitus, cardiovascular disease, non-alcoholic fatty liver malignancies. emerged as substantial hospitalization death from viral respiratory infections such influenza A ongoing pandemic SARS-CoV-2. Several independent studies have indicated that patients are at higher severe disease these diseases. Excess fat, particularly visceral contributes development metabolic disorders, persistent systemic inflammation decreased immunological function. As result, response infectious pathogens weakened, resulting poorer outcomes post-infection. Additionally, poor lung mechanics associated with obesity may increase serious infections. In this review, we address likely mechanism(s) predispose people diseases caused by

Language: Английский

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Environmental Preferences and Concerns of Recreational Trail Runners

International Journal of Environmental Research and Public Health, Journal Year: 2024, Volume and Issue: 21(1), P. 97 - 97

Published: Jan. 16, 2024

Trail running is a fast-growing sport, linked to improvements in both physical and psychological well-being. Despite its popularity, the preferences of trail runners are not well known. The objective this study was examine environmental concerns with respect age gender. We conducted cross-sectional survey recreational runners. A total 548 people responded, which 50.1% respondents were women 44.2% men. sample distributed relatively evenly across groups, up 54 years; over 55 represented only 9.4% sample. Comparisons runner characteristics by gender indicated significant differences (p < 0.05) according age, distance run per week, number days week. Certain also differed significantly gender, including importance around others, type races they seek, whether or like seek “vert” elevation their runs. Major for genders while included lack cell reception (Men: 33.8%; Women: 50.8%) getting lost 26.8%; 35.5%). results help strengthen our understanding runners’ can be used guide future design maintenance environments encourage greater participation sport.

Language: Английский

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Demystifying roles of exercise in immune response regulation against acute respiratory infections: A narrative review

Sports Medicine and Health Science, Journal Year: 2024, Volume and Issue: 6(2), P. 139 - 153

Published: Jan. 21, 2024

The benefits of physical activity and exercise, especially those classified as moderate-to-vigorous (MVPA), have been well-established in preventing non-communicable diseases mental health problems healthy adults. However, the relationship between exercise prevention management acute respiratory infection (ARI), a global high-burden disease, has inconclusive. There debates disagreements among scientific publications regarding immune response against causative agents ARI. This narrative review aims to explore theory that sufficiently explains correlation response, potential root causes discrepancies come from research associated with "open window" hypothesis. studies several limitations, future improvements address them are urgently needed study design, data collection, intervention, subject recruitment, biomarkers for inflammation, nutritional metabolism status, addressing confounding variables. In conclusion, support clinical advantages regulatory contribution toward improving which turn potentially protects humans hypothesis related its negative effect must be adopted cautiously.

Language: Английский

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Replacement of sedentary behavior with various physical activities and the risk of all-cause and cause-specific mortality

BMC Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: Sept. 12, 2024

Sedentary behavior (SB) has emerged as a significant health concern that deserves attention. This study aimed to examine the associations between prolonged sedentary and risk of all-cause cause-specific mortality well explore desirable alternatives sitting in terms physical activity (PA).

Language: Английский

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