A Low Number of Baselines γδ T Cells Increases the Risk of SARS-CoV-2 Post-Vaccination Infection DOI Creative Commons
Juan Carlos Andreu‐Ballester, Lorena Galindo-Regal, Carmen Cuéllar

et al.

Vaccines, Journal Year: 2024, Volume and Issue: 12(5), P. 553 - 553

Published: May 18, 2024

Background: The COVID-19 pandemic is the biggest global health problem in last hundred years. efficacy of vaccine to protect against severe disease estimated be 70–95% according studies carried out, although there are aspects immune response that remain unclear. Methods: Humoral and cellular immunity after administration three doses Pfizer–BioNTech Oxford AstraZeneca vaccines SARS-CoV-2 over one year appearance post-vaccination were studied. IgG IgA antibodies, αβ γδ T-cell subsets, their differentiation stages apoptosis analyzed. Results: Anti-SARS-CoV-2 antibodies showed a progressive increase throughout duration study. This was greatest third dose. highest levels observed subjects who had anti-SARS-CoV-2 prior vaccination. There an CD4+ αβ, CD8+ TEM T cells, decrease CD56+ cells. Post-vaccination infection greater than 60%. symptoms very mild related cell deficit, specifically TEMRA TEM, as well lower pre-vaccine levels. Conclusions: results unveil important role cells SARS-CoV-2-vaccine-mediated protection from disease.

Language: Английский

A delicate balance between antibody evasion and ACE2 affinity for Omicron BA.2.75 DOI Creative Commons
Jiandong Huo, Aiste Dijokaite-Guraliuc, Chang Liu

et al.

Cell Reports, Journal Year: 2022, Volume and Issue: 42(1), P. 111903 - 111903

Published: Dec. 14, 2022

Variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have caused successive global waves infection. These variants, with multiple mutations in the spike protein, are thought to facilitate escape from natural and vaccine-induced immunity often increase affinity for ACE2. The latest variant cause concern is BA.2.75, identified India where it now dominant strain, evidence wider dissemination. BA.2.75 derived BA.2 contains four additional receptor-binding domain (RBD). Here, we perform an antigenic biophysical characterization revealing interesting balance between humoral evasion ACE2 receptor affinity. increased 9-fold compared BA.2; there also immune serum, particularly that induced by Delta infection, which may explain rapid spread India, a high background appears be prioritized over greater escape.

Language: Английский

Citations

56
Growing attention of immunogenicity among patients with autoimmune diseases post-SARS-CoV-2 vaccination: meta-analysis and systematic reviews of the current studies DOI Creative Commons
Chao Zhang, Yuqiang Zhang,

Run-Ben Liu

et al.

Annals of Medicine, Journal Year: 2025, Volume and Issue: 57(1)

Published: March 26, 2025

This study aimed to identify the optimal strategy for patients with autoimmune diseases by comparing immunoreaction and effectiveness of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines between healthy individuals patients. The PubMed, Embase, Cochrane Library were searched eligible studies on SARS-CoV-2 in published until October 07, 2022. quality each included was evaluated independent reviewers using National Institutes Health assessment tool, STATA 15.0 software used all statistical analyses. A total 84 publications analyzed this meta-analysis, favoring controls regarding serological response (risk ratio, RR=0.88, 95% CI (confidence interval): 0.86-0.91), antibody (RR=0.90, 95%CI: 0.87-0.94), incidence seropositive immunoglobulin G (IgG) (RR=0.74, 0.69-0.80) than post-vaccination. Patients developed lower IgG (standard mean difference, SMD=-0.64 -0.84 -0.43) titer level (SMD=-1.39, -2.30 -0.49) AU/ml. Stratified analyses conducted further according various potential factors full-text studies. who are immunocompromised received more demonstrated poorer humoral responses after vaccination individuals. Despite lack observable favor diseases, trend is close that populations. should be provided a better schedule, considering vaccine subtypes, dose(s), variants concern, immunoassays.

Language: Английский

Citations

1
Variants of SARS-CoV-2: Influences on the Vaccines’ Effectiveness and Possible Strategies to Overcome Their Consequences DOI Creative Commons
Ali A. Rabaan,

Shamsah H. Al-Ahmed,

Hawra Albayat

et al.

Medicina, Journal Year: 2023, Volume and Issue: 59(3), P. 507 - 507

Published: March 5, 2023

The immune response elicited by the current COVID-19 vaccinations declines with time, especially among immunocompromised population. Furthermore, emergence of novel SARS-CoV-2 variants, particularly Omicron variant, has raised serious concerns about efficacy currently available vaccines in protecting most vulnerable people. Several studies have reported that vaccinated people get breakthrough infections amid cases. So far, five variants concern (VOCs) been reported, resulting successive waves infection. These shown a variable amount resistance towards neutralising antibodies (nAbs) either through natural infection or vaccination. spike (S) protein, membrane (M) and envelope (E) protein on viral surface N-nucleocapsid core ribonucleoprotein are major structural vaccine target proteins against COVID-19. Among these targets, S Protein extensively exploited to generate effective Hence, SARS-CoV-2, we discussed their impact vaccines. We also potential roles development vaccination approaches contain negative consequences variants’ acquisition mutations SARS-CoV-2. Moreover, implications SARS-CoV-2’s were terms elicit an response.

Language: Английский

Citations

14
COVID-19 Vaccine Acceptance and Hesitancy among Healthcare Workers in Lusaka, Zambia; Findings and Implications for the Future DOI Creative Commons
Steward Mudenda, Victor Daka, Scott Kaba Matafwali

et al.

Vaccines, Journal Year: 2023, Volume and Issue: 11(8), P. 1350 - 1350

Published: Aug. 9, 2023

The uptake of COVID-19 vaccines is critical to address the severe consequences disease. Previous studies have suggested that many healthcare workers (HCWs) are hesitant receive vaccine, further enhancing hesitancy rates within countries. vaccine acceptance and levels currently unknown among HCWs in Zambia, which a concern given burden infectious diseases country. Consequently, this study assessed Lusaka, Zambia. A cross-sectional was conducted 240 between August September 2022, using semi-structured questionnaire. Multivariable analysis used determine key factors associated with HCWs. Of who participated, 54.2% were females. total 72.1% would accept being vaccinated, while 27.9% hesitant. Moreover, 93.3% had positive attitudes towards vaccines, medical doctors having highest mean attitude score (82%). Encouragingly, reduced odds (AOR = 0.02, 95% CI: 0.01-0.11,

Language: Английский

Citations

13
Publication trends of research on COVID-19 and host immune response: A bibliometric analysis DOI Creative Commons
Yun Xia, Ren-qi Yao, Peng-yue Zhao

et al.

Frontiers in Public Health, Journal Year: 2022, Volume and Issue: 10

Published: Aug. 8, 2022

Introduction As the first bibliometric analysis of COVID-19 and immune responses, this study will provide a comprehensive overview latest research advances. We attempt to summarize scientific productivity cooperation across countries institutions using methodology. Meanwhile, clustering keywords, we revealed evolution hotspots predicted future focuses, thereby providing valuable information for follow-up studies. Methods selected publications on response our pre-designed search strategy. Web Science was applied screen eligible subsequent analyses. GraphPad Prism 8.0, VOSviewer, CiteSpace were analyze trends compared contributions countries, authors, institutions, journals global in field. Results identified 2,200 published between December 1, 2019, April 25, 2022, with total 3,154 citations. The United States (611), China (353), Germany (209) ranked top three terms number publications, accounting 53.3% articles. Among 15 publishing articles area, four from France, States, China. journal Frontiers Immunology most (178) related response. Alessandro Sette (31 publications) productive influential scholar field, whose citation frequency (3,633). Furthermore, development evaluation vaccines might become hotspot relevant scope. Conclusions makes indispensable contribution field publication numbers, citations, H-index. Although also take lead regarding quality quantity, their international preclinical need be further strengthened. Regarding articles, progress tracked top-ranking By analyzing chronological order appearance retrieved speculated that vaccine-related novel focus

Language: Английский

Citations

17
Multiplicity of infection and culture medium on the SARS-CoV-2 virus like-particles production by baculovirus/insect system DOI

Luis Giovani de Oliveira Guardalini,

Felipe Moura Dias,

Samanta Omae Camalhonte

et al.

Biotechnology Letters, Journal Year: 2025, Volume and Issue: 47(2)

Published: March 6, 2025

Language: Английский

Citations

0
Spike protein-related proteinopathies: a focus on the neurological side of spikeopathies DOI Creative Commons
Andreas Posa

Annals of Anatomy - Anatomischer Anzeiger, Journal Year: 2025, Volume and Issue: unknown, P. 152662 - 152662

Published: April 1, 2025

Language: Английский

Citations

0
In-depth review of delivery carriers associated with vaccine adjuvants: current status and future perspectives DOI Creative Commons

Yarong Zeng,

Feihong Zou,

Ningshao Xia

et al.

Expert Review of Vaccines, Journal Year: 2023, Volume and Issue: 22(1), P. 681 - 695

Published: July 27, 2023

Introduction Vaccines are powerful tools for controlling microbial infections and preventing epidemics. To enhance the immune response to antigens, effective subunit vaccines or mRNA often require combination of adjuvants delivery carriers. In recent years, with rapid development mechanism research nanotechnology, various studies based on optimization traditional novel carriers have been intensified, construction vaccine adjuvant systems (VADS) both activity antigen has become more important in research.

Language: Английский

Citations

8
Longitudinal Analysis of SARS-CoV-2-Specific Cellular and Humoral Immune Responses and Breakthrough Infection following BNT162b2/BNT162b2/BNT162b2 and ChAdOx1/ChAdOx1/BNT162b2 Vaccination: A Prospective Cohort in Naive Healthcare Workers DOI Creative Commons

Geon Young Ko,

Ji Hyun Lee, Hyunjoo Bae

et al.

Vaccines, Journal Year: 2023, Volume and Issue: 11(10), P. 1613 - 1613

Published: Oct. 19, 2023

Assessing immune responses post-SARS-CoV-2 vaccination is crucial for optimizing vaccine strategies. This prospective study aims to evaluate and breakthrough infection in 235 infection-naïve healthcare workers up 13-15 months after initial two groups (108 BNT/BNT/BNT 127 ChAd/ChAd/BNT). Immune were assessed using the interferon-gamma enzyme-linked immunospot (ELISPOT) assay, total immunoglobulin, neutralizing activity through surrogate virus neutralization test at nine different time points. Both exhibited peak one second or third dose, followed by gradual declines over six months. Notably, ChAd group a increase ELISPOT results, but their antibody levels declined more rapidly reaching response compared BNT group. Six both had substantial cellular responses, with superior humoral (p < 0.05). As many as 55 participants displayed higher activities against Omicron variants, similar individuals, suggesting cross-immunity. Distinct classifications (<30%, >80% inhibition) correlated results. Our reveals diverse patterns based on strategies infections, emphasizing importance of understanding these dynamics optimized decisions.

Language: Английский

Citations

8
Current Advances in Viral Nanoparticles for Biomedicine DOI

Xianxun Sun,

Tao Tian,

Yindong Lian

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 9, 2024

Viral nanoparticles (VNPs) have emerged as crucial tools in the field of biomedicine. Leveraging their biological and physicochemical properties, VNPs exhibit significant advantages prevention, diagnosis, treatment human diseases. Through techniques such chemical bioconjugation, infusion, genetic engineering, encapsulation, these been endowed with multifunctional capabilities, including display functional peptides or proteins, encapsulation therapeutic drugs inorganic particles, integration imaging agents, conjugation bioactive molecules. This review provides an in-depth analysis biomedicine, elucidating diverse types, distinctive features, production methods, complex design principles behind VNPs. It highlights recent innovative research various applications, covering roles imaging, drug delivery, therapeutics, gene vaccines, immunotherapy, tissue regeneration. Additionally, assessment safety biocompatibility discusses challenges future opportunities field, underscoring vast potential evolving nature VNP research.

Language: Английский

Citations

3