Published: Jan. 1, 2023
Language: Английский
ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(1)
Published: Jan. 2, 2024
Abstract In this research, design and synthesis of the magnetic nanoparticle, coated by a silica shell modified with dicationic ionic liquid are described. The characterization Fe 3 O 4 @SiO 2 ⋅ DIL was done means techniques such as XRD, FTIR, SEM, EDX, TEM, TGA. catalytic activity new nanocatalyst tested in one‐pot tree‐component 1,8‐dioxodecahydroacridines. To achieve higher yield products, factors reaction temperature, time, amount solvent were studied, optimized conditions investigated. results indicated that time for aromatic aldehydes bearing substituent at para position is shorter yields products obtained these substrates. Short high easy purification recoverable catalyst without significantly loss its main advantages process presented. clearly showed existing system could be eco‐friendly economical to carry out reaction.
Language: Английский
Citations
2
Molecules, Journal Year: 2022, Volume and Issue: 27(14), P. 4486 - 4486
Published: July 13, 2022
Four commercial immobilized lipases biocatalysts have been submitted to modifications with different metal (zinc, cobalt or copper) phosphates check the effects of this modification on enzyme features. The lipase preparations were Lipozyme®TL (TLL-IM) (lipase from Thermomyces lanuginose), Lipozyme®435 (L435) B Candida antarctica), Lipozyme®RM (RML-IM), and LipuraSelect (LS-IM) (both Rhizomucor miehei). greatly altered specificity, increasing activity versus some substrates (e.g., TLL-IM modified zinc phosphate in hydrolysis triacetin) while decreasing other (the same preparation R- S- methyl mandelate). Enantiospecificity was also drastically after these modifications, e.g., LS-IM increased R isomer S when treated copper phosphate. Regarding stability, it significantly improved using octyl-agarose-lipases. Using all biocatalysts, no significant positive found; fact, a decrease stability usually detected. results point towards possibility battery including many immobilization protocols, being good opportunity tune features, possibilities having that may be suitable for specific process.
Language: Английский
Citations
10
International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(15), P. 8819 - 8819
Published: Aug. 8, 2022
An enzymatic route for phosphorous-carbon bond formation was developed by discovering new promiscuous activity of lipase. We reported a metal-free biocatalytic method the synthesis pharmacologically relevant β-phosphonomalononitriles via lipase-catalyzed one-pot Knoevenagel-phospha-Michael reaction. carefully analyzed best conditions given reaction: type enzyme, temperature, and solvent. A series target compounds synthesized, with yields ranging from 43% to 93% reaction Candida cylindracea (CcL) lipase as recyclable and, few times, reusable catalyst. The advantages this protocol are excellent yields, mild conditions, low costs, sustainability. applicability same catalyst in β-phosphononitriles is also described. Further, obtained were validated potential antimicrobial agents characteristic E. coli bacterial strains. pivotal role such group phosphonate derivatives on inhibitory against selected pathogenic strains revealed. observed results especially important case increasing resistance bacteria various drugs antibiotics. impact β-phosphono malonate chemical structure demonstrated. crucial substituents attached aromatic ring action Among tested compounds, four β-phosphonate showed an profile similar that currently used antibiotics ciprofloxacin, bleomycin, cloxacillin. In addition, constitute convenient platform further functionalization, allowing change their biological profile. It should be noted cost low, which may attractive alternative agents. because
Language: Английский
Citations
10
The Journal of Supercritical Fluids, Journal Year: 2023, Volume and Issue: 203, P. 106085 - 106085
Published: Oct. 4, 2023
Language: Английский
Citations
4
Molecules, Journal Year: 2022, Volume and Issue: 27(22), P. 7798 - 7798
Published: Nov. 12, 2022
Organophosphorus compounds are the core structure of many active natural products. The synthesis these is generally achieved by metal catalysis requiring specifically functionalized substrates or harsh conditions. Herein, we disclose phospha-Michael addition reaction biphenyphosphine oxide with various substituted β-nitrostyrenes benzylidene malononitriles. This biocatalytic strategy provides a direct route for C-P bonds good functional group compatibility and simple practical operation. Under optimal conditions (styrene (0.5 mmol), Novozym 435 (300 U), EtOH (1 mL)), lipase leads to formation organophosphorus in yields up 94% at room temperature. Furthermore, confirm role catalytic triad this reaction. new system will have broad applications organic synthesis.
Language: Английский
Citations
5
Catalysts, Journal Year: 2023, Volume and Issue: 13(12), P. 1493 - 1493
Published: Dec. 6, 2023
Disulfides, as fundamental scaffolds, are widely present in peptides, natural products, and pharmaceutical molecules. However, traditional synthesis of disulfides often involves the utilization toxic reagents or environmentally unfriendly reaction conditions. In this work, a green efficient method was developed for synthesizing pyrrole using β-ketothioamides ethyl cyanoacetate substrates, with lipase serving catalyst. Under optimal conditions (β-Ketothioamides (1 mmol), PPL (200 U), EtOH (5 mL)), leads to formation yields up 88% at 40 °C. The related mechanism is also speculated paper. This approach not only presents new application enzyme catalytic promiscuity, but offers significant advancement synthetic pathway aligns current mainstream research direction chemistry, contributing further development friendly biocatalytic processes.
Language: Английский
Citations
1
Published: Jan. 1, 2023
Language: Английский
Citations
0