Therapeutic Nanoparticles and Their Targeted Delivery Applications

Molecules, Journal Year: 2020, Volume and Issue: 25(9), P. 2193 - 2193

Published: May 8, 2020

Nanotechnology offers many advantages in various fields of science. In this regard, nanoparticles are the essential building blocks nanotechnology. Recent advances nanotechnology have proven that acquire a great potential medical applications. Formation stable interactions with ligands, variability size and shape, high carrier capacity, convenience binding both hydrophilic hydrophobic substances make favorable platforms for target-specific controlled delivery micro- macromolecules disease therapy. Nanoparticles combined therapeutic agents overcome problems associated conventional therapy; however, some issues like side effects toxicity still debated should be well concerned before their utilization biological systems. It is therefore important to understand specific properties strategies. Here, we provide an overview on unique features We emphasize type clinically used specificity applications, as current strategies diseases such cancer, infectious, autoimmune, cardiovascular, neurodegenerative, ocular, pulmonary diseases. Understanding characteristics environment will enable us establish novel treatment, prevention, diagnosis diseases, particularly untreatable ones.

Language: Английский

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Multifunctional GelMA platforms with nanomaterials for advanced tissue therapeutics

Bioactive Materials, Journal Year: 2021, Volume and Issue: 8, P. 267 - 295

Published: July 6, 2021

Polymeric hydrogels are fascinating platforms as 3D scaffolds for tissue repair and delivery systems of therapeutic molecules cells. Among others, methacrylated gelatin (GelMA) has become a representative hydrogel formulation, finding various biomedical applications. Recent efforts on GelMA-based have been devoted to combining them with bioactive functional nanomaterials, aiming provide enhanced physicochemical biological properties GelMA. The benefits this approach multiple: i) reinforcing mechanical properties, ii) modulating viscoelastic property allow printability bio-inks, iii) rendering electrical/magnetic produce electro-/magneto-active the specific tissues (e.g., muscle, nerve), iv) providing stimuli-responsiveness actively deliver molecules, v) endowing capacity in process antioxidant effects). nanomaterial-combined GelMA shown significantly extraordinary behaviors (bone, skin, cardiac, nerve) that rarely observable Here we systematically review these recent nanomaterials-combined considered next-generation multifunctional therapeutics. approaches used can also apply other existing polymeric systems.

Language: Английский

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Photoluminescent Nanoparticles for Chemical and Biological Analysis and Imaging

Chemical Reviews, Journal Year: 2021, Volume and Issue: 121(15), P. 9243 - 9358

Published: July 20, 2021

Research related to the development and application of luminescent nanoparticles (LNPs) for chemical biological analysis imaging is flourishing. Novel materials new applications continue be reported after two decades research. This review provides a comprehensive heuristic overview this field. It targeted both newcomers experts who are interested in critical assessment LNP materials, their properties, strengths weaknesses, prospective applications. Numerous cataloged by fundamental descriptions identities physical morphology, quantitative photoluminescence (PL) PL mechanisms, surface chemistry. These include various semiconductor quantum dots, carbon nanotubes, graphene derivatives, nanodiamonds, metal nanoclusters, lanthanide-doped upconversion downshifting nanoparticles, triplet–triplet annihilation persistent-luminescence conjugated polymer semiconducting multi-nanoparticle assemblies, doped labeled including but not limited those based on polymers silica. As an exercise these ranked several application-related functional criteria. Additional sections highlight recent examples advances analysis, point-of-care diagnostics, cellular, tissue, vivo theranostics. drawn from literature organized material particular properties that leveraged advantage. Finally, perspective what comes next field offered.

Language: Английский

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Quantum sensors for biomedical applications

Nature Reviews Physics, Journal Year: 2023, Volume and Issue: 5(3), P. 157 - 169

Published: Feb. 3, 2023

Quantum sensors are finding their way from laboratories to the real world, as witnessed by increasing number of start-ups in this field. The atomic length scale quantum and coherence properties enable unprecedented spatial resolution sensitivity. Biomedical applications could benefit these technologies, but it is often difficult evaluate potential impact techniques. This Review sheds light on questions, presenting status sensing discussing path towards commercialization. focus two promising platforms: optically pumped magnetometers, nitrogen–vacancy centres diamond. broad spectrum biomedical highlighted four case studies ranging brain imaging single-cell spectroscopy. new possibilities due high In Review, presented, real-world molecular, cellular organism evaluated.

Language: Английский

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Nanotechnology for the development of new cosmetic formulations

Expert Opinion on Drug Delivery, Journal Year: 2019, Volume and Issue: 16(4), P. 313 - 330

Published: March 1, 2019

Introduction Nanotechnology is an increasingly widespread area of research for its various applications and advantages. Accordingly, nanotechnology has been the focus investment in different areas science, namely as a technological strategy development cosmetics formulations. Nanosystems allow profit skin penetration effective release profile ingredients, which contributes to superior cosmetic effects. The nanocosmetics are numerous, from anti-aging care, make-up, nails, deodorants, oral sunscreens, hair care. However, emerging knowledge, it now begun encourage investigations into toxicology profile, particularly regarding health damage environmental pollution. Also, regulatory saw adaptation concerning use formulations containing nanotechnology.Areas covered A description nanosystems so far applied presented. Moreover, outline lipid-based-nanosystems, polymeric-based nanoparticles, metal-based silica additional (dendrimers, nanocrystals, fullerenes, nanodiamonds, cyclodextrins) towards obtainment outcomes addressed. toxicological well aspects also discussed.Expert opinion This innovative timely review emphasizes that constitute highly promising technology ground-breaking

Language: Английский

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Nanosensors for diagnosis with optical, electric and mechanical transducers

RSC Advances, Journal Year: 2019, Volume and Issue: 9(12), P. 6793 - 6803

Published: Jan. 1, 2019

Nanosensors with high sensitivity utilize electrical, optical, and acoustic properties to improve the detection limits of analytes.

Language: Английский

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Toward Quantitative Bio-sensing with Nitrogen–Vacancy Center in Diamond

ACS Sensors, Journal Year: 2021, Volume and Issue: 6(6), P. 2077 - 2107

Published: May 26, 2021

The long-dreamed-of capability of monitoring the molecular machinery in living systems has not been realized yet, mainly due to technical limitations current sensing technologies. However, recently emerging quantum sensors are showing great promise for detection and imaging. One such qubits is nitrogen-vacancy (NV) center, a photoluminescent impurity diamond lattice with unique room-temperature optical spin properties. This atomic-sized emitter ability quantitatively measure nanoscale electromagnetic fields via means at ambient conditions. Moreover, unlimited photostability NV centers, combined excellent biocompatibility possibility nanoparticles internalization into cells, makes NV-based one most promising versatile platforms various life-science applications. In this review, we will summarize latest developments focus on biomedical applications, including measurements magnetic biomaterials, intracellular temperature, localized physiological species, action potentials, electronic nuclear spins. We also outline main unresolved challenges provide future perspectives many aspects bio-sensing.

Language: Английский

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Zero-Dimensional Carbon Nanomaterials for Fluorescent Sensing and Imaging

Chemical Reviews, Journal Year: 2023, Volume and Issue: 123(18), P. 11047 - 11136

Published: Sept. 7, 2023

Advances in nanotechnology and nanomaterials have attracted considerable interest play key roles scientific innovations diverse fields. In particular, increased attention has been focused on carbon-based exhibiting extended structures unique properties. Among these materials, zero-dimensional structures, including fullerenes, carbon nano-onions, nanodiamonds, dots, possess excellent bioaffinities superior fluorescence properties that make suitable for application to environmental biological sensing, imaging, therapeutics. This review provides a systematic overview of the classification structural properties, design principles preparation methods, optical sensing applications nanomaterials. Recent interesting breakthroughs sensitive selective imaging heavy metal pollutants, hazardous substances, bioactive molecules as well information encryption, super-resolution photoacoustic phototherapy nanomedicine delivery are main focus this review. Finally, future challenges prospects materials highlighted envisaged. presents comprehensive basis directions designing, developing, applying fascinating fluorescent sensors fabricated based specific requirements numerous research

Language: Английский

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Corrosion and corrosion-fatigue behavior of magnesium metal matrix composites for bio-implant applications: A review

Journal of Magnesium and Alloys, Journal Year: 2023, Volume and Issue: 11(4), P. 1125 - 1161

Published: April 1, 2023

Recently, the topic of bioresorbable metals, with much focus on magnesium for bone implant applications, has been an area considerable investigation. Indeed, it could be argued that is most promising biodegradable material currently being studied use as orthopedic skeletal fixation and joint replacement hardware. However, fast degradation rate magnesium-based materials in physiological environment negatively affects their mechanical integrity hence limits biomedical use. The critical conditions may occur when subjected to a corrosive fluctuating load during daily activities. Hence, numerous studies have published synthesis, alloying, coating control increase strength durability. Among strategies employed achieve these goals, biocomposites exhibited superior properties acceptable biocompatibility. there lack understanding corrosion corrosion-fatigue behavior. Such necessary qualify new various bio-implant applications. To this end, paper reviews recent advances behavior biocomposites. It also provides comprehensive discussion different factors influence biocompatibility, corrosion, fatigue, potential materials. This study emphasizes despite abundance biocomposites, imperative need more fatigue studies.

Language: Английский

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Autophagy inhibitors for cancer therapy: Small molecules and nanomedicines

Pharmacology & Therapeutics, Journal Year: 2023, Volume and Issue: 249, P. 108485 - 108485

Published: July 3, 2023

Language: Английский

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