OPSALC: On-Particle Solvent-Assisted Lipid Coating to Create Erythrocyte Membrane-like Coatings with Improved Hemocompatibility DOI Creative Commons
Francisca L. Gomes, Dorothee Wasserberg,

Rick Edelbroek

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: March 13, 2025

Particles are essential building blocks in nanomedicine and cell engineering. Their administration often involves blood contact, which demands a hemocompatible material profile. Coating particles with isolated membranes is common strategy to improve hemocompatibility, but this solution nonscalable potentially immunogenic. Cell membrane-like lipid coatings promising alternative, as lipids can be synthesized on large scale used create safe supported bilayers. However, method controllably scalably lipid-coat wide range of has remained elusive. Here, an on-particle solvent-assisted coating (OPSALC) introduced innovative technique endow various types coatings. formation efficiency shown depend concentration, buffer addition rate, solvent:buffer ratio, these parameters determine assembly lipid–surface interactions. Four formulations levels erythrocyte membrane mimicry explored terms demonstrating reduced particle-induced hemolysis plasma coagulation time. Interestingly, higher show the lowest complement activation highest colloidal stability. Overall, OPSALC represents simple yet scalable facilitate blood-contact applications.

Language: Английский

A review of nanomaterials for biosensing applications DOI
Lei Li, Tianshu Wang, Yuting Zhong

et al.

Journal of Materials Chemistry B, Journal Year: 2023, Volume and Issue: 12(5), P. 1168 - 1193

Published: Dec. 21, 2023

A biosensor is a device that reacts with the analyte to be analyzed, detects its concentration, and generates readable information, which plays an important role in medical diagnosis, detection of physiological indicators, disease prevention. Nanomaterials have received increasing attention fabrication improvement biosensors due their unique physicochemical optical properties. In this paper, properties nanomaterials such as size effect, electrical properties, advantages field biosensing are briefly summarized, application can effectively improve sensitivity reduce limit biosensors. The commonly used gold nanoparticles (AuNPs), carbon nanotubes (CNTs), quantum dots (QDs), graphene, magnetic nanobeads for applications also reviewed. Besides, two main types using involved construction working principles described, toxicity biocompatibility future direction nanomaterial discussed.

Language: Английский

Citations

52
Optimization of Graphene-Based Square Slotted Surface Plasmon Resonance Refractive Index Biosensor for Accurate Detection of Pregnancy DOI
Abdulkarem H. M. Almawgani, Jacob Wekalao, Shobhit K. Patel

et al.

Plasmonics, Journal Year: 2024, Volume and Issue: unknown

Published: April 11, 2024

Language: Английский

Citations

33
Nanotechnology: Current applications and future scope in food packaging systems DOI Creative Commons
Rakesh Kumar Gupta,

Fatma Abd El Gawad,

Elsayed A.E. Ali

et al.

Measurement Food, Journal Year: 2023, Volume and Issue: 13, P. 100131 - 100131

Published: Dec. 31, 2023

Food packaging has shown a considerable deal of interest in the use nanotechnology. The current landscape nanotechnology food involves incorporation nanomaterials, such as nanoparticles and nanocomposites, into materials to achieve specific functionalities. These functionalities include improved barrier properties, antimicrobial activity, sensing capabilities. Nanoparticles, silver titanium dioxide, have been utilized impart thereby reducing risk contamination extending shelf life perishable foods. So, enhanced presentation, innovative packaging, smart packaging—all which support preservation quality traceability throughout supply chain—are developed using nanoparticles. Therefore, this article primarily emphasized on synthesis various techniques including, electrospinning, mechanical milling, etching laser ablation etc., characterization based organic inorganic sources. Additionally, nanoemulsion their application covered study. Apart from this, toxicological effect investigated with associated product. when developing materials, it's critical investigate migration interactions polymer matrix since high surface area volume ratio might sometimes be cause nanoparticle toxicity.

Language: Английский

Citations

40
Shape dependent protein‐induced stabilization of gold nanoparticles: From a protein corona perspective DOI Creative Commons
Anastasiia Tukova, Yihan Nie, Mohammad Tavakkoli Yaraki

et al.

Aggregate, Journal Year: 2023, Volume and Issue: 4(4)

Published: Feb. 22, 2023

Abstract Gold nanoparticles (AuNPs) are promising materials for many bioapplications. However, upon contacting with biological media, AuNPs undergo changes. The interaction proteins results in the so‐called protein corona (PC) around AuNPs, leading to new bioidentity and optical properties. Understanding mechanisms of PC formation its functions can help us utilise benefits avoid drawbacks. To date, most previous works aimed understand governing focused on spherical nanoparticles, although non‐spherical designed a wide range applications biosensing. In this work, we investigated differences anisotropic (nanostars particular) from joint experimental (extinction spectroscopy, zeta potential surface‐enhanced Raman scattering [SERS]) computational methods (the finite element method molecular dynamics [MD] simulations). We discovered that does not fully cover surface leaving SERS hot‐spots at tips high curvature edges ‘available’ analyte binding (no signal after pre‐incubation protein) while providing protein‐induced stabilization (indicated by extinction spectroscopy) layer particle's core. findings confirmed our MD simulations, adsorption energy significantly decreases increased radius curvature, so (adsorption energy: 2762.334 kJ/mol) would be least preferential site compared core 11819.263 kJ/mol). These observations will development nanostructures improved sensing targeting ability.

Language: Английский

Citations

25
Advances and significances of gold nanoparticles in cancer treatment: A comprehensive review DOI Creative Commons
Amran Hossain,

Md. Thohid Rayhan,

Md Hosne Mobarak

et al.

Results in Chemistry, Journal Year: 2024, Volume and Issue: 8, P. 101559 - 101559

Published: May 24, 2024

This comprehensive review examines the diverse range of uses gold nanoparticles across numerous disciplines, focusing on their distinctive characteristics in catalysis, thermal conductivity, optical properties, electrical and biological interactions. work emphasizes crucial significance progression cancer treatment, demonstrating multifunctionality areas drug transport, photothermal therapy, bioimaging, diagnostic applications. Gold have demonstrated utility improving accuracy effectiveness treatments, presenting innovative approaches to address clinical obstacles. Nevertheless, research also discusses notable challenges, including apprehensions over toxicity, influence nanoparticle size, potential environmental repercussions. These issues emphasize necessity responsible administration fully exploit capabilities context therapy. Notwithstanding these obstacles, ultimately underscores profound domains such as monitoring, renewable energy, healthcare, cosmetics, biotechnology. highlights capacity mold future through inventive adaptable means

Language: Английский

Citations

15
Enhancing H. pylori detection: ultrasensitive electrochemical aptasensor with Au-doped CQDs and polythiophene conjugation DOI

Seyed Saber Mirzaei,

Mehrab Pourmadadi,

Amin Foroozandeh

et al.

Journal of Applied Electrochemistry, Journal Year: 2024, Volume and Issue: 54(8), P. 1887 - 1900

Published: Feb. 16, 2024

Language: Английский

Citations

14
Recent Advancements and Unexplored Biomedical Applications of Green Synthesized Ag and Au Nanoparticles: A Review DOI Creative Commons
Shahbaz Ahmad, Shujaat Ahmad, Shujat Ali

et al.

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 3187 - 3215

Published: April 1, 2024

Abstract: Green synthesis of silver (Ag) and gold (Au) nanoparticles (NPs) has acquired huge popularity owing to their potential applications in various fields. A large number research articles exist the literature describing green Ag Au NPs for biomedical applications. However, these findings are scattered, making it time-consuming researchers locate promising advancements unexplored Unlike other review articles, this systematic study not only highlights recent but also explores The article discusses approaches highlighting emerging developments novel strategies. Then, reviews important synthesized by critically evaluating expected advantages. To expose future direction field, describes NPs. Finally, discuss challenges limitations This will serve as a valuable reference researchers, working on Keywords: nanoparticles, environmental-friendly, applications, potentials

Language: Английский

Citations

12
Advances in smart nanotechnology-supported photodynamic therapy for cancer DOI Creative Commons
Guangyao Li, Cong Wang,

Bing‐Hui Jin

et al.

Cell Death Discovery, Journal Year: 2024, Volume and Issue: 10(1)

Published: Nov. 11, 2024

Cancer has emerged as a formidable challenge in the 21st century, impacting society, public health, and economy. Conventional cancer treatments often exhibit limited efficacy considerable side effects, particularly managing advanced stages of disease. Photodynamic therapy (PDT), contemporary non-invasive therapeutic approach, employs photosensitizers (PS) conjunction with precise light wavelengths to selectively target diseased tissues, inducing generation reactive oxygen species ultimately leading cell apoptosis. In contrast conventional therapies, PDT presents lower incidence effects greater precision targeting. The integration intelligent nanotechnology into markedly improved its effectiveness, evidenced by remarkable synergistic antitumor observed utilization multifunctional nanoplatforms PDT. This paper provides concise overview principles underlying PS PDT, while also delving nanomaterial-based context treatment.

Language: Английский

Citations

11
Aptamer-conjugated gold nanoparticles for portable, ultrasensitive naked-eye detection of C-reactive protein based on the Tyndall effect DOI Creative Commons
Alexandru-Milentie Hada, Sorina Suarasan, Mara Muntean

et al.

Analytica Chimica Acta, Journal Year: 2024, Volume and Issue: 1307, P. 342626 - 342626

Published: April 22, 2024

C-reactive protein (CRP) represents an early clinical biomarker that indicates the presence of inflammatory or infectious conditions in human body. Today's procedures approved by Food and Drug Administration (FDA) imply expensive equipment highly trained personnel to perform test. Therefore, a new diagnostic method with high detection efficiency less cost is urgently needed for delivering rapid timely results point-of-care (POC) service.

Language: Английский

Citations

10
Recent Trends and Innovations in Bead-Based Biosensors for Cancer Detection DOI Creative Commons

Hui-Pin Cheng,

Tai‐Hua Yang,

Jhih-Cheng Wang

et al.

Sensors, Journal Year: 2024, Volume and Issue: 24(9), P. 2904 - 2904

Published: May 1, 2024

Demand is strong for sensitive, reliable, and cost-effective diagnostic tools cancer detection. Accordingly, bead-based biosensors have emerged in recent years as promising platforms based on wide-ranging biomarkers owing to the versatility, high sensitivity, flexibility perform multiplexing of beads. This comprehensive review highlights trends innovations development cancer-biomarker We introduce various types such optical, electrochemical, magnetic biosensors, along with their respective advantages limitations. Moreover, summarizes latest advancements, including fabrication techniques, signal-amplification strategies, integration microfluidics nanotechnology. Additionally, challenges future perspectives field detection are discussed. Understanding these can greatly contribute improvements diagnostics, thereby facilitating early personalized treatments.

Language: Английский

Citations

9