Immunogenic Cell Death Activates the Tumor Immune Microenvironment to Boost the Immunotherapy Efficiency

Advanced Science, Journal Year: 2022, Volume and Issue: 9(22)

Published: June 2, 2022

Abstract Tumor immunotherapy is only effective in a fraction of patients due to low response rate and severe side effects, these challenges clinics can be addressed through induction immunogenic cell death (ICD). ICD elicited from many antitumor therapies release danger associated molecular patterns (DAMPs) tumor‐associated antigens facilitate maturation dendritic cells (DCs) infiltration cytotoxic T lymphocytes (CTLs). The process reverse the tumor immunosuppressive microenvironment improve sensitivity immunotherapy. Nanostructure‐based drug delivery systems (NDDSs) are explored induce by incorporating therapeutic molecules for chemotherapy, photosensitizers (PSs) photodynamic therapy (PDT), photothermal conversion agents (PTT), radiosensitizers radiotherapy (RT). These NDDSs loaded at right dose place time, resulting greater effectiveness lower toxicity. Immunotherapeutic also combined with achieve synergic effect multi‐modality approach. In this review, harnessed load multiple PDT, PTT, RT combination promote reduce effects cancer treatment.

Language: Английский

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Metal-based anticancer agents as immunogenic cell death inducers: the past, present, and future

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(4), P. 1212 - 1233

Published: Jan. 1, 2022

Cancer is the deadliest disease in world behind heart disease. Sadly, this remains true even as we suffer ravages of Covid-19 pandemic. Whilst current chemo- and radiotherapeutic treatment strategies have significantly improved patient survival rate, reoccurrence continues to pose a deadly risk for all too many patients. Incomplete removal tumour cells from body increases chances metastasis developing resistance against treatments. Immunotherapy represents therapeutic modality that has helped overcome these limitations recent decades. However, further progress needed. So-called immunogenic cell death (ICD) recently discovered unique mode could trigger necessary progress. ICD involves stimulation tumour-specific immune response downstream effect. Facilitated by certain modalities, undergoing can IFN-γ mediated involving cytotoxic T (CTLs) γδ eradicate residual cells. In years, there been significant increase number small-molecules being tested potential inducers. A large inducers are metal-based complexes. fact, anticancer metal drugs based on Pt, Ru, Ir, Cu, Au now known give rise an result ICD. Advances also made terms exploiting combinatorial delivery strategies. favourable cases, approaches shown efficacy otherwise "silent" Taken concert, rationally designed novel complexes act show promise new immunotherapies neoplastic This Tutorial Review will allow readers assess fast-evolving field thus setting stage future advances.

Language: Английский

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Immunogenic Cell Death Augmented by Manganese Zinc Sulfide Nanoparticles for Metastatic Melanoma Immunotherapy

ACS Nano, Journal Year: 2022, Volume and Issue: 16(9), P. 15471 - 15483

Published: Aug. 18, 2022

Both T-cell deprivation and insufficient tumor immunogenicity seriously hinder the efficacy of immune-mediated destruction in melanoma. In this work, an amphiphilic polyethylene glycol-poly(2-hexoxy-2-oxo-1,3,2-dioxaphospholane) copolymer with a thermally sensitive flowable core (mPEG-b-PHEP) was chosen to incorporate IR780 dye manganese zinc sulfide nanoparticles (ZMS) form polymer micelles (denoted PPIR780-ZMS), which precisely controlled release ZMS after being triggered by near-infrared light (NIR). Mn2+-mediated chemodynamic therapy (CDT) photothermal trigger boosted generation reactive oxygen species (ROS), making PPIR780-ZMS smart bomblets vivo. It demonstrated that could maximize immunogenic cell death (ICD) cancer, is characterized abundant damage-associated molecular pattern (DAMP) exposure. As result, cytotoxic T cells (CD8+) helper (CD4+) expanded infiltrated neoplastic foci, further reprogrammed suppressive microenvironment (TME) against primary pulmonary metastases safe systemic cytokine expression. addition, cGAS-STING signaling pathway activation enhanced antitumor immunity nanocomposite, providing practical strategy for expanding use Mn-based nanostructures.

Language: Английский

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Mixed‐Metal MOF‐Derived Hollow Porous Nanocomposite for Trimodality Imaging Guided Reactive Oxygen Species‐Augmented Synergistic Therapy

Advanced Functional Materials, Journal Year: 2021, Volume and Issue: 31(37)

Published: June 26, 2021

Abstract Here an excellent trimodality imaging‐guided synergistic photothermal therapy (PTT)/photodynamic (PDT)/chemodynamic (CDT) is proposed. To this end, a mixed‐metal Cu/Zn‐metal‐organic framework (MOF) first assembled at room temperature on nano‐scale. Interestingly, heating the MOF results in Cu +/2+ ‐coexisting hollow porous structure. Subsequent treatment used to integrate Mn 2+ and MnO 2 presence of manganese(II) acetylacetonate. The composite achieves efficient loading photosensitizer, indocyanine green (ICG). Under laser irradiation, aggregated ICG imaging PTT. Once released tumor site, exhibits fluorescence PDT capacity. + /Mn ions perform Fenton‐like reaction with H O produce cytotoxic •OH for enhanced CDT. /MnO scavenge glutathione improve reactive oxygen species‐based therapy, while formed enable “turn on” magnetic resonance imaging. Significantly, produced from catalytic decomposition endogenous ICG‐mediated PDT. Moreover, photothermal‐induced local hyperthermia accelerates generation enhance This drug‐free antitumor strategy realizes high efficacy low side effects normal tissues. Thus, realize structures multi‐function integration therapeutic

Language: Английский

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Immunogenic Cell Death Inducing Metal Complexes for Cancer Therapy

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(21)

Published: Feb. 21, 2023

Cancer is one of the deadliest diseases worldwide. Recent statistics have shown that metastases and tumor relapse are leading causes cancer-associated deaths. While traditional treatments able to efficiently remove primary tumor, secondary tumors remain poorly accessible. Capitalizing on this there an urgent need for novel treatment modalities. Among most promising approaches, increasing research interest has been devoted immunogenic cell death inducing agents trigger localized cancer cells as well induce immune response inside whole organism. Preliminary studies compounds could be overcome metastatic relapsing tumors. Herein, application metal complexes systematically reviewed.

Language: Английский

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Recent progress of metal‐based nanomaterials with anti‐tumor biological effects for enhanced cancer therapy

Exploration, Journal Year: 2023, Volume and Issue: 3(5)

Published: June 30, 2023

Abstract Metal‐based nanomaterials have attracted broad attention recently due to their unique biological physical and chemical properties after entering tumor cells, namely effects. In particular, the abilities of Ca 2+ modulate T cell receptors activation, K + regulate stem differentiation, Mn activate STING pathway, Fe 2+/3+ induce ferroptosis enhance catalytic therapy, make metal ions metal‐based play crucial roles in cancer treatments. Therefore, superior advantages characteristics microenvironment, we will summarize recent progress anti‐tumor effects nanomaterials. Based on different this review mainly focuses following five aspects: (1) metal‐enhanced radiotherapy sensitization, (2) (3) ferroptosis, (4) pyroptosis, (5) immunotherapy. At same time, shortcomings therapy are also discussed, future research directions been prospected. The highlights promising biosafety, potent efficacy for in‐depth various mechanism studies provide novel ideas application

Language: Английский

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Reactive oxygen species-powered cancer immunotherapy: Current status and challenges

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 356, P. 623 - 648

Published: March 21, 2023

Language: Английский

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Cope with copper: From copper linked mechanisms to copper-based clinical cancer therapies

Cancer Letters, Journal Year: 2023, Volume and Issue: 561, P. 216157 - 216157

Published: April 1, 2023

Language: Английский

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Radiation‐Induced Immunogenic Cell Death for Cancer Radioimmunotherapy

Small Methods, Journal Year: 2023, Volume and Issue: 7(5)

Published: Feb. 21, 2023

Abstract In cancer treatment, traditional radiotherapy (RT) is routinely conducted in local tumors and limited by radioresistance, while recently emerged immunotherapy confronted with low response rate, high cost, cytokine release syndrome. Logically, the combination of two therapeutic modalities into radioimmunotherapy promising to complement each other for systemic elimination cells specificity, efficiency, safety. Especially, RT‐induced immunogenic cell death (ICD) plays an imperative role evoke immune against cancer, including elevating immunity tumor antigens, recruiting activating antigen‐presenting cells, priming cytotoxic T lymphocytes tumoral infiltration eradication. This review first retrospects origin concept ICD, summarizes major damage‐associated molecular patterns signaling pathways, highlights characteristics ICD. Subsequently, strategies enhancing ICD are reviewed from perspectives RT itself, treatments, stimulating holistic system. On basis these published research underlying mechanism, this work attempts forecast possible directions enhancement promote clinical applications.

Language: Английский

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Mechanisms and applications of radiation-induced oxidative stress in regulating cancer immunotherapy

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Aug. 4, 2023

Radiotherapy (RT) is an effective treatment option for cancer patients, which induces the production of reactive oxygen species (ROS) and causes oxidative stress (OS), leading to death tumor cells. OS not only apoptosis, autophagy ferroptosis, but also affects immune response. The combination RT immunotherapy has revolutionized management various cancers. In this process, caused by ROS plays a critical role. Specifically, RT-induced can promote release tumor-associated antigens (TAAs), regulate infiltration differentiation cells, manipulate expression checkpoints, change microenvironment (TME). review, we briefly summarize several ways in IR cell discuss interrelationship between antitumor immunity, with focus on interaction ferroptosis immunogenic death. We potential mechanisms regulates checkpoint expression, cells activity, differentiation. addition, conclude therapeutic opportunity improving radiotherapy regulating OS, may be beneficial clinical treatment.

Language: Английский

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