Nanoparticles in tumor microenvironment remodeling and cancer immunotherapy

Journal of Hematology & Oncology, Journal Year: 2024, Volume and Issue: 17(1)

Published: April 2, 2024

Abstract Cancer immunotherapy and vaccine development have significantly improved the fight against cancers. Despite these advancements, challenges remain, particularly in clinical delivery of immunomodulatory compounds. The tumor microenvironment (TME), comprising macrophages, fibroblasts, immune cells, plays a crucial role response modulation. Nanoparticles, engineered to reshape TME, shown promising results enhancing by facilitating targeted These nanoparticles can suppress fibroblast activation, promote M1 macrophage polarization, aid dendritic cell maturation, encourage T infiltration. Biomimetic further enhance increasing internalization agents cells such as cells. Moreover, exosomes, whether naturally secreted body or bioengineered, been explored regulate TME immune-related affect cancer immunotherapy. Stimuli-responsive nanocarriers, activated pH, redox, light conditions, exhibit potential accelerate co-application with checkpoint inhibitors is an emerging strategy boost anti-tumor immunity. With their ability induce long-term immunity, nanoarchitectures are structures development. This review underscores critical overcoming current driving advancement modification.

Language: Английский

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Managing the immune microenvironment of osteosarcoma: the outlook for osteosarcoma treatment

Bone Research, Journal Year: 2023, Volume and Issue: 11(1)

Published: Feb. 27, 2023

Osteosarcoma, with poor survival after metastasis, is considered the most common primary bone cancer in adolescents. Notwithstanding efforts of researchers, its five-year rate has only shown limited improvement, suggesting that existing therapeutic strategies are insufficient to meet clinical needs. Notably, immunotherapy certain advantages over traditional tumor treatments inhibiting metastasis. Therefore, managing immune microenvironment osteosarcoma can provide novel and valuable insight into multifaceted mechanisms underlying heterogeneity progression disease. Additionally, given advances nanomedicine, there exist many advanced nanoplatforms for enhanced satisfactory physiochemical characteristics. Here, we review classification, characteristics, functions key components osteosarcoma. This also emphasizes application, progress, prospects discusses several nanomedicine-based options enhance efficiency treatment. Furthermore, examine disadvantages standard present future perspectives immunotherapy.

Language: Английский

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Genetically Engineering Cell Membrane‐Coated BTO Nanoparticles for MMP2‐Activated Piezocatalysis‐Immunotherapy

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(18)

Published: Feb. 21, 2023

Tumor immunotherapy based on immune checkpoint blockade (ICB) still suffers from low host response rate and non-specific distribution of inhibitors, greatly compromising the therapeutic efficiency. Herein, cellular membrane stably expressing matrix metallopeptidase 2 (MMP2)-activated PD-L1 blockades is engineered to coat ultrasmall barium titanate (BTO) nanoparticle for overcoming immunosuppressive microenvironment tumors. The resulting M@BTO NPs can significantly promote BTO's tumor accumulation, while masking domains antibodies are cleaved when exposure MMP2 highly expressed in tumor. With ultrasound (US) irradiation, simultaneously generate reactive oxygen species (ROS) O2 BTO mediated piezocatalysis water splitting, promoting intratumoral infiltration cytotoxic T lymphocytes (CTLs) improving therapy tumor, effective growth inhibition lung metastasis suppression a melanoma mouse model. This nanoplatform combines MMP2-activated genetic editing cell with US responsive both stimulation specific inhibition, providing safe robust strategy enhancing against

Language: Английский

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Augmenting Immunotherapy via Bioinspired MOF‐Based ROS Homeostasis Disruptor with Nanozyme‐Cascade Reaction

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(49)

Published: Sept. 10, 2023

Despite its remarkable clinical breakthroughs, immune checkpoint blockade (ICB) therapy remains limited by the insufficient response in "cold" tumor. Nanozyme-based antitumor catalysis is associated with precise activation tumor microenvironment (TME). In this study, a cascade-augmented nanoimmunomodulator (CMZM) multienzyme-like activities, which includes superoxide dismutase (SOD), catalase (CAT), peroxidase (POD), and glutathione oxidase (GSHOx), that dissociates under an acidic abundant GSH TME, proposed for multimodal imaging-guided chemodynamic (CDT)/photodynamic (PDT) enhanced immunotherapy. Vigorous activities can not only produce O2 to alleviate hypoxia promote polarization of M2 M1 macrophages, but also generate ROS (•OH 1 ) deplete TME expose necrotic cell fragments reverse immunosuppressive eliciting maturation dendritic cells infiltration cytotoxic T lymphocytes (CTLs) tumors. Therefore, inhibitory effects on both primary distant tumors are achieved through synergy α-PD-L1 blocking antibody. This cascade multienzyme-based nanoplatform provides smart strategy highly efficient ICB immunotherapy against revising TME.

Language: Английский

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Nano-drug delivery system targeting tumor microenvironment: A prospective strategy for melanoma treatment

Cancer Letters, Journal Year: 2023, Volume and Issue: 574, P. 216397 - 216397

Published: Sept. 18, 2023

Language: Английский

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Sodium Bicarbonate Nanoparticles for Amplified Cancer Immunotherapy by Inducing Pyroptosis and Regulating Lactic Acid Metabolism

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(40)

Published: Aug. 17, 2023

Abstract Although immunotherapy has a broad clinical application prospect, it is still hindered by low immune responses and immunosuppressive tumor microenvironment. Herein, simple drug‐free inorganic nanomaterial, alkalescent sodium bicarbonate nanoparticles (NaHCO 3 NPs), prepared via fast microemulsion method for amplified cancer immunotherapy. The obtained NaHCO regulates lactic acid metabolism through acid‐base neutralization so as to reverse the mildly acidic environment. Additionally, can further release high amounts of Na + ions inside cells induce surge in intracellular osmolarity, thus activate pyroptosis pathway immunogenic cell death (ICD), damage‐associated molecular patterns (DAMPs) inflammatory factors, improve responses. Collectively, NPs observably inhibit primary/distal growth metastasis remitted immunosuppression induced activation, showing an enhanced antitumor immunity efficiency. This work provides new paradigm mediated treatment, which potential

Language: Английский

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Interrelation between Programmed Cell Death and Immunogenic Cell Death: Take Antitumor Nanodrug as an Example

Small Methods, Journal Year: 2023, Volume and Issue: 7(5)

Published: Jan. 27, 2023

Abstract Programmed cell death (PCD, mainly including apoptosis, necrosis, ferroptosis, pyroptosis, and autophagy) immunogenic (ICD), as important mechanisms, are widely reported in cancer therapy, understanding the relationship between two is significant for clinical tumor treatments. Considering that vast nanodrugs developed to induce PCD ICD simultaneously, this review, interrelationship described using nanomedicines examples. First, an overview of patterns focus on morphological differences interconnections among them provided. Then apoptosis terms endoplasmic reticulum stress by introducing various treatments recent developments with inducible immunogenicity. Next, crosstalk non‐apoptotic (including signaling pathways introduced their through examples further illustrated. Finally, its application prospects development new nanomaterials summarized. This review believed deepen ICD, extend biomedical applications nanodrugs, promote progress therapy.

Language: Английский

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Delivering metal ions by nanomaterials: Turning metal ions into drug-like cancer theranostic agents

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 494, P. 215332 - 215332

Published: July 17, 2023

Language: Английский

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Strategies for the development of metalloimmunotherapies

Nature Biomedical Engineering, Journal Year: 2024, Volume and Issue: 8(9), P. 1073 - 1091

Published: June 24, 2024

Language: Английский

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Metal‐based smart nanosystems in cancer immunotherapy

Exploration, Journal Year: 2024, Volume and Issue: 4(6)

Published: March 22, 2024

Abstract Metals are an emerging topic in cancer immunotherapy that have shown great potential modulating immunity cycle and promoting antitumor by activating the intrinsic immunostimulatory mechanisms which been identified recent years. The main challenge of metal‐assisted lies fact free metals as ion forms easily cleared during circulation, even cause systemic metal toxicity due to off‐target effects. With rapid development nanomedicine, metal‐based smart nanosystems (MSNs) with unique controllable structure become one most promising delivery carriers solve issue, owing their various endogenous/external stimuli‐responsiveness release ions for metalloimmunotherapy. In this review, state‐of‐the‐art research progress metal‐related is comprehensively summarized. First, mainstream MSNs‐assisted will be delineated. immunological effects certain categorization MSNs different characters compositions then provided, followed representative exemplar applications treatment, synergistic combination immunotherapy. Finally, we conclude review a summary remaining challenges associated provide authors' perspective on further advances.

Language: Английский

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