Recent progress of metal‐based nanomaterials with anti‐tumor biological effects for enhanced cancer therapy

Exploration, Journal Year: 2023, Volume and Issue: 3(5)

Published: June 30, 2023

Abstract Metal‐based nanomaterials have attracted broad attention recently due to their unique biological physical and chemical properties after entering tumor cells, namely effects. In particular, the abilities of Ca 2+ modulate T cell receptors activation, K + regulate stem differentiation, Mn activate STING pathway, Fe 2+/3+ induce ferroptosis enhance catalytic therapy, make metal ions metal‐based play crucial roles in cancer treatments. Therefore, superior advantages characteristics microenvironment, we will summarize recent progress anti‐tumor effects nanomaterials. Based on different this review mainly focuses following five aspects: (1) metal‐enhanced radiotherapy sensitization, (2) (3) ferroptosis, (4) pyroptosis, (5) immunotherapy. At same time, shortcomings therapy are also discussed, future research directions been prospected. The highlights promising biosafety, potent efficacy for in‐depth various mechanism studies provide novel ideas application

Language: Английский

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Multifunctional Mesoporous Polydopamine‐Based Systematic Delivery of STING Agonist for Enhanced Synergistic Photothermal‐Immunotherapy

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 34(1)

Published: Sept. 15, 2023

Abstract The therapeutic application of STING agonists in various malignancies has been limited by factors such as the inability systemic administration and immunosuppressive tumor microenvironment. Herein, this work reports a mesoporous polydopamine‐based multifunctional nanoplatform loaded with agonist MSA‐2 chelated Mn 2+ for synergistic photothermal activation‐based immunotherapy. effectively delivers to site intelligently releases its contents through acid degradation, facilitated effect. Additionally, thermal ablation tissue can induce immunogenic cell death, which helps alleviate microenvironment, thereby enhancing efficacy MSA‐2. Furthermore, works dual‐acting sensitizer MRI contrast agent not only boosts immune response but also allows real‐time tracking nanoplatform. This strategy is proved highly efficacious both impeding primary/metastatic eliciting robust tumor‐specific response. Collectively, an effective delivery synergized therapy pathway activation‐mediated immunotherapy highlighted here provide new ideas strategies optimizing combination cancer treatment.

Language: Английский

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Coordination Self-Assembled AuTPyP-Cu Metal–Organic Framework Nanosheets with pH/Ultrasound Dual-Responsiveness for Synergistically Triggering Cuproptosis-Augmented Chemotherapy

ACS Nano, Journal Year: 2024, Volume and Issue: 18(12), P. 9100 - 9113

Published: March 13, 2024

Reactive oxygen species (ROS) mediated tumor cell death is a powerful anticancer strategy. Cuproptosis copper-dependent and ROS-mediated prospective therapy However, the complex microenvironment (TME), low specificity, poor efficiency, lack of imaging capability impair output current cuproptosis drugs. Herein, we designed dual-responsive two-dimensional metal–organic framework (2D MOF) nanotheranostic via coordination self-assembly strategy using Au(III) tetra-(4-pyridyl) porphine (AuTPyP) as ligand copper ions (Cu2+) nodes. The dual-stimulus combined with protonation pyridyl group in AuTPyP deep-penetration ultrasound (US) together triggered controlled release an acidic TME. ultrathin structure (3.0 nm) nanotheranostics promoted process. released Cu2+ was reduced to Cu+ by depleting overexpressed glutathione (GSH) tumor, which not only activated Ferredoxin 1 (FDX1)-mediated but also catalyzed hydrogen peroxide (H2O2) into reactive Fenton-like reaction. Simultaneously, could specifically bind thioredoxin reductase activate redox imbalance cells. These selectively induced significant mitochondrial vacuoles prominent did damage normal fluorescence magnetic resonance (MRI) results verified this target HeLa greatly promote self-enhanced effect chemotherapy/cuproptosis inhibition efficiency. work helped elucidate assembly multiresponsive high-specificity ROS regulation for application therapy.

Language: Английский

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Succinate Nanomaterials Boost Tumor Immunotherapy via Activating Cell Pyroptosis and Enhancing MHC-I Expression

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 2, 2025

Despite the promising clinical applications of immunotherapy, its effectiveness is often limited by low immune responses and tumor escape. In this study, we introduce a simple drug-free inorganic nanomaterial, sodium succinate (C4H4Na2O4 NPs), prepared using rapid microemulsion method to enhance cancer immunotherapy. The synthesized C4H4Na2O4 NPs can release high concentrations Na+ ions into cells, leading an increase in intracellular osmolarity. This triggers pyroptosis pathway, resulting cellular contents, inflammatory factors, damage-associated molecular patterns, which ultimately boost responses. Furthermore, inhibit escape through upregulating major histocompatibility complex-I (MHC-I) expression. Collectively, significantly growth metastasis pyroptosis-induced activation MHC-I expression upregulation-remitted research offers novel approach treatment that leverages pyroptosis, demonstrating potential for application

Language: Английский

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Self-Cascaded Pyroptosis-STING Initiators for Catalytic Metalloimmunotherapy

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 17, 2025

Gasdermin (GSDM)-mediated pyroptosis involves the induction of mitochondrial damage and subsequent release DNA (mtDNA), which is anticipated to activate cGAS-STING pathway, thereby augmenting antitumor immune response. However, challenges lie in effectively triggering cancer cells subsequently enhancing activation with specificity. Herein, we developed intelligent self-cascaded pyroptosis-STING initiators cobalt fluoride (CoF2) nanocatalysts for catalytic metalloimmunotherapy. CoF2 a semiconductor structure enzyme-like activity generated substantial amount reactive oxygen species (ROS) under stimulation by endogenous H2O2 exogenous ultrasound. Importantly, discovered that Co-based nanomaterials themselves induce cells. Therefore, initially acted as inducers, caspase-1/GSDMD-dependent via Co2+ ROS, leading mtDNA release. Subsequently, were further utilized STING agonists specifically capable detecting pathway. These cascade events triggered robust response, modulating immunosuppressive tumor microenvironment into an immune-supportive state, providing favorable support therapy. This innovative strategy not only significantly impeded growth primary but also elicited response augment efficacy checkpoint inhibitors preventing distant progression. Overall, this study proposed self-cascade activating amplifying pathway specificity mediated pyroptosis, representing valuable avenue future

Language: Английский

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Engineered Silicon-Titania heterojunction elicits catalytic cancer cell death

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 159226 - 159226

Published: Jan. 1, 2025

Language: Английский

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Mannose-Modified Multifunctional Iron-Based Nanozyme for Hepatocellular Carcinoma Treatment by Remodeling the Tumor Microenvironment

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: 250, P. 114548 - 114548

Published: Feb. 3, 2025

Language: Английский

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Selenium electrophilic center shuttles active electrons to boost mitochondrial electron leakage

Published: Feb. 1, 2025

Language: Английский

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Dual Starvations Induce Pyroptosis for Orthotopic Pancreatic Cancer Therapy through Simultaneous Deprivation of Glucose and Glutamine

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(26), P. 17854 - 17865

Published: May 22, 2024

Pancreatic cancer is a highly fatal disease, and existing treatment methods are ineffective, so it urgent to develop new effective strategies. The high dependence of pancreatic cells on glucose glutamine suggests that disrupting this dependency could serve as an alternative strategy for therapy. We identified the vital genes transporter 1 (GLUT1) alanine-serine-cysteine 2 (ASCT2) through bioinformatics analysis, which regulate metabolism in cancer, respectively. Human serum albumin nanoparticles (HSA NPs) delivery GLUT1 ASCT2 inhibitors, BAY-876/V-9302@HSA NPs, were prepared by self-assembly process. This nanodrug inhibits uptake released BAY-876 V-9302, leading nutrition deprivation oxidative stress. inhibition leads synthesis glutathione, further aggravates Both them lead significant increase reactive oxygen species, activating caspase GSDMD finally inducing pyroptosis. study provides orthotopic dual starvation-induced screening metabolic targets using analysis followed constructing nanodrugs loaded with inhibitors will inspire future targeted therapy cancer.

Language: Английский

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Mild near-infrared laser-triggered photo-immunotherapy potentiates immune checkpoint blockade via an all-in-one theranostic nanoplatform

Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 678, P. 1088 - 1103

Published: Sept. 6, 2024

Language: Английский

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