Engineering nanomedicines for immunogenic eradication of cancer cells: Recent trends and synergistic approaches DOI Creative Commons
Ahmed O. Elzoghby, Omar Samir,

Hagar E. Emam

et al.

Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 14(6), P. 2475 - 2504

Published: March 20, 2024

Resistance to cancer immunotherapy is mainly attributed poor tumor immunogenicity as well the immunosuppressive microenvironment (TME) leading failure of immune response. Numerous therapeutic strategies including chemotherapy, radiotherapy, photodynamic, photothermal, magnetic, chemodynamic, sonodynamic and oncolytic therapy, have been developed induce immunogenic cell death (ICD) cells thereby elicit boost antitumor However, many challenges hamper clinical application ICD inducers resulting in modest Here, we outline current state using nanomedicines for boosting cells. Moreover, synergistic approaches used combination with inducing remodeling TME

Language: Английский

Recent advances in the metal/organic hybrid nanomaterials for cancer theranostics DOI
Zhaoyi Ye, Ying Bao, Zefeng Chen

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 504, P. 215654 - 215654

Published: Jan. 20, 2024

Language: Английский

Citations

20
Inhalable metal–organic framework-mediated cuproptosis combined with PD-L1 checkpoint blockade for lung metastasis synergistic immunotherapy DOI Creative Commons

Chongzheng Yan,

Y Liu, Guozhi Zhao

et al.

Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 14(5), P. 2281 - 2297

Published: Feb. 6, 2024

Cuproptosis shows enormous application prospects in lung metastasis treatment. However, the glycolysis, Cu+ efflux mechanisms, and insufficient drug accumulation severely restrict cuproptosis efficacy. Herein, an inhalable poly(2-(N-oxide-N,N-diethylamino)ethyl methacrylate) (OPDEA)-coated copper-based metal–organic framework encapsulating pyruvate dehydrogenase kinase 1 siRNA (siPDK) is constructed for mediating subsequently promoting immunotherapy, namely OMP. After inhalation, OMP highly efficient long-term retention, ascribing to OPDEA-mediated pulmonary mucosa penetration. Within tumor cells, degraded release Cu2+ under acidic condition, which will be reduced toxic induce glutathione (GSH) regulation. Meanwhile, siPDK released from inhibits intracellular glycolysis adenosine-5ʹ-triphosphate (ATP) production, then blocking protein ATP7B, thereby rendering cells more sensitive OMP-mediated cuproptosis. Moreover, triggers immunogenic cell death (ICD) promote dendritic (DCs) maturation CD8+ T infiltration. Notably, OMP-induced up-regulates membrane-associated programmed death-ligand (PD-L1) expression induces soluble PD-L1 secretion, thus synergizes with anti-PD-L1 antibodies (aPD-L1) reprogram immunosuppressive microenvironment, finally yielding improved immunotherapy Overall, may serve as nanoplatform afford preferable efficacy against through inducing combining aPD-L1.

Language: Английский

Citations

18
Emerging role of immunogenic cell death in cancer immunotherapy: Advancing next-generation CAR-T cell immunotherapy by combination DOI
Zhaokai Zhou, Yumiao Mai, Ge Zhang

et al.

Cancer Letters, Journal Year: 2024, Volume and Issue: 598, P. 217079 - 217079

Published: June 25, 2024

Language: Английский

Citations

17
Development of nanotechnology-mediated precision radiotherapy for anti-metastasis and radioprotection DOI Creative Commons
Yuan‐Bo Pan, Wei Tang, Wenpei Fan

et al.

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(23), P. 9759 - 9830

Published: Jan. 1, 2022

Radiotherapy (RT), including external beam RT and internal radiation therapy, uses high-energy ionizing to kill tumor cells.

Language: Английский

Citations

68
High‐Z‐Sensitized Radiotherapy Synergizes with the Intervention of the Pentose Phosphate Pathway for In Situ Tumor Vaccination DOI
Yuxiang Wang, Jing Chen,

R. Duan

et al.

Advanced Materials, Journal Year: 2022, Volume and Issue: 34(13)

Published: Feb. 1, 2022

In situ tumor vaccination is preliminarily pursued to strengthen antitumor immune response. Immunogenic cell death spontaneously releases abundant antigens and adjuvants for activation of dendritic cells, providing a paragon opportunity establishing efficient in vaccination. Herein, Phy@PLGdH nanosheets are constructed by integrating physcion (Phy, an inhibitor the pentose phosphate pathway (PPP)) with layered gadolinium hydroxide (PLGdH) boost radiation-therapy (RT)-induced immunogenic (ICD) potent It first observed that sheet-like PLGdH can present superior X-ray deposition penetrability, exhibiting improved radiosensitization vitro vivo. Moreover, destruction cellular nicotinamide adenine dinucleotide (NADPH) nucleotide homeostasis Phy-mediated PPP intervention further amplify PLGdH-sensitized RT-mediated oxidative stress DNA damage, which correspondingly results effective ICD enhance immunogenicity irradiated cells. Consequently, Phy@PLGdH-sensitized RT successfully primes robust CD8+ -T-cell-dependent immunity potentiate checkpoint blockade immunotherapies against primary metastatic tumors.

Language: Английский

Citations

64
Polymeric nanoparticle-based nanovaccines for cancer immunotherapy DOI
Yongxin Zhang, Jiajing Chen, Linqi Shi

et al.

Materials Horizons, Journal Year: 2022, Volume and Issue: 10(2), P. 361 - 392

Published: Nov. 29, 2022

Polymeric nanoparticle-based cancer vaccines with the components of antigens ( ex vivo and in situ ) different immune adjuvants.

Language: Английский

Citations

52
Restoration of the Immunogenicity of Tumor Cells for Enhanced Cancer Therapy via Nanoparticle‐Mediated Copper Chaperone Inhibition DOI

Feixiang Ding,

Fei Li, Dongsheng Tang

et al.

Angewandte Chemie International Edition, Journal Year: 2022, Volume and Issue: 61(31)

Published: June 1, 2022

Recent progress in studying copper-dependent targets and pathways the context of tumor treatment has provided new insights into therapeutic strategies leveraging disease vulnerabilities pharmacological manipulation intratumor copper transportation to improve chemotherapy. Here, we developed reactive oxygen species (ROS)-sensitive nanoparticles loaded with chaperone inhibitor DC_AC50 cisplatin(IV) prodrug. The released can promote a remarkable accumulation intracellular cisplatin through inhibition Atox1-ATPase pathways, thereby enhancing chemotherapeutic effect inducing significant ROS generation. Excessive then elicits intense endoplasmic reticulin (ER) stress which facilitates immunogenic cell death (ICD) spurring sustained immune response. Our study suggests that nanoparticle-mediated via restore immunogenicity cells for enhanced chemotherapy cancer immunotherapy.

Language: Английский

Citations

51
Nanomedicine embraces cancer radio-immunotherapy: mechanism, design, recent advances, and clinical translation DOI
Haonan Li, Qiang Luo, Hu Zhang

et al.

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 52(1), P. 47 - 96

Published: Nov. 25, 2022

This review overviews the landscape of nanomedicine-aided cancer radio-immunotherapy in a “from bench to clinic” manner.

Language: Английский

Citations

44
The programmed site-specific delivery of LY3200882 and PD-L1 siRNA boosts immunotherapy for triple-negative breast cancer by remodeling tumor microenvironment DOI
Pan Zhang, Chao Qin, Nan Liu

et al.

Biomaterials, Journal Year: 2022, Volume and Issue: 284, P. 121518 - 121518

Published: April 12, 2022

Language: Английский

Citations

41
Copper-instigated modulatory cell mortality mechanisms and progress in oncological treatment investigations DOI Creative Commons
Lei Gao, Anqi Zhang

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Aug. 2, 2023

Copper, a transition metal, serves as an essential co-factor in numerous enzymatic active sites and constitutes vital trace element the human body, participating crucial life-sustaining activities such energy metabolism, antioxidation, coagulation, neurotransmitter synthesis, iron tetramer deposition. Maintaining equilibrium of copper ions within biological systems is paramount importance prevention atherosclerosis associated cardiovascular diseases. Copper induces cellular demise through diverse mechanisms, encompassing reactive oxygen species responses, apoptosis, necrosis, pyroptosis, mitochondrial dysfunction. Recent research has identified dubbed novel regulatory cell death modality—”cuprotosis”—wherein bind to acylated proteins tricarboxylic acid cycle respiration, resulting protein aggregation, subsequent downregulation iron-sulfur cluster expression, induction proteotoxic stress, eventual death. Scholars have synthesized complexes by combining with various ligands, exploring their significance applications cancer therapy. This review comprehensively examines multiple pathways copper-induced death, current status treatment.

Language: Английский

Citations

40