Bacterial carrier-mediated drug delivery systems: a promising strategy in cancer therapy DOI Creative Commons
Shaomin Yan, Yu Gan, Huizhe Xu

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 8, 2025

Cancer is a major killer threatening modern human health and leading cause of death worldwide. Due to the heterogeneity complexity cancer, traditional treatments have limited effectiveness. To address this problem, an increasing number researchers medical professionals are working develop new ways treat cancer. Bacteria chemotaxis that can target colonize tumor tissue, as well activate anti-tumor immune responses, which makes them ideal for biomedical applications. With rapid development nanomedicine synthetic biology technologies, bacteria extensively used carriers drug delivery tumors, holds promise overcoming limitations conventional cancer treatment regimens. This paper summarizes examples anti-cancer drugs delivered by bacterial carriers, their strengths weaknesses. Further, we emphasize carrier systems in clinical translation.

Language: Английский

Manganese Dioxide Coated Piezoelectric Nanosonosensitizer for Cancer Therapy with Tumor Microenvironment Remodeling and Multienzyme‐Like Catalysis DOI

Zhaoyang Yue,

Qinyu Zhao, Shaobo Wang

et al.

Small Methods, Journal Year: 2024, Volume and Issue: unknown

Published: April 1, 2024

Abstract Sonodynamic therapy (SDT) as an emerging method for cancer has encountered difficulty in insufficient production of reactive oxygen species (ROS), especially tumor microenvironment (TME) with elevated antioxidants and hypoxic conditions. In this work, the authors have fabricated heterostructured manganese dioxide (MnO 2 )‐coated BaTiO 3 nanoparticles (BTO@M NPs) a piezoelectric sonosensitizer, which exhibits capacity remodeling TME multienzyme‐like catalysis boosting SDT. Benefitting from piezotronic effect, formation p ‐ n junction between MnO BTO built‐in electric field band bending efficiently promotes separation charge carriers, facilitating generation superoxide anion (•O − ) hydroxyl radical (•OH) under ultrasound (US) stimulation. Moreover, BTO@M NPs can catalyze overexpressed hydrogen peroxide (H O to produce replenishing gas source SDT, also deplete antioxidant glutathione (GSH), realizing remodeling. During process, reduced Mn(II) convert H into •OH, further amplifying cellular oxidative damage. With these combination effects, versatile exhibit prominent cytotoxicity growth inhibition against 4T1 breast cancer. This work provides feasible strategy constructing high‐efficiency sonosensitizers

Language: Английский

Citations

19
Targeted antibacterial photodynamic therapy with aggregation‐induced emission photosensitizers DOI Creative Commons
B Wu,

Kenry Kenry,

Fang Hu

et al.

Deleted Journal, Journal Year: 2024, Volume and Issue: 2(1)

Published: Jan. 1, 2024

Abstract With the increasing prevalence of infectious diseases caused by drug‐resistant bacteria, there is an urgent need to develop innovative therapies alternative antibiotics. Among these alternatives, aggregation‐induced emission (AIE) photosensitizers (PSs) stand out with their integrated imaging and therapeutic functionalities, allowing for early monitoring image‐guided ablation bacteria. AIE fluorescent probes unique optical properties excel in selective bacterial imaging. Furthermore, AIE‐enabled reactive oxygen species (ROS)‐mediated antibacterial photodynamic therapy can operate on multiple targets oxidize Also, as they are able specifically target PSs ameliorate limitations small‐scale action ROS. This review methodically discusses different strategies that be employed using targeting including sheltered The challenges future opportunities this emerging field also briefly discussed.

Language: Английский

Citations

16
Employing Piezoelectric Mg2+‐Doped Hydroxyapatite to Target Death Receptor‐Mediated Necroptosis: A Strategy for Amplifying Immune Activation DOI Creative Commons

Jiani Yang,

Yaqian Du,

Yuanfei Yao

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(13)

Published: Jan. 22, 2024

Abstract Although immunogenic cell death (ICD) inducers evidently enhance the effectiveness of immunotherapy, their potential is increasingly restricted by development apoptosis resistance in tumor cells, poor immunogenicity, and low T‐cell immune responsiveness. In this study, for first time, piezoelectrically catalyzed Mg 2+ ‐doped hydroxyapatite (Mg‐HAP) nanoparticles, which are coated with a mesoporous silica layer loaded ONC201 as an agonist to specifically target receptor DR5 on ultimately developing Mg‐HAP@MS/ONC201 nanoparticle (MHMO NP) system, engineered. Owing its excellent piezoelectric properties, MHMO facilitates release significant amount reactive oxygen species Ca within effectively promoting upregulation expression inducing necroptosis overcome resistance. Concurrently, released microenvironment promotes CD8 + T activation response antitumor reaction induced ICD. Using RNA‐seq analysis, it elucidated that can activate NF‐κB pathway under catalysis, thus M1‐type macrophage polarization. summary, dual‐targeting therapy system targets both cells catalysis designed. This holds substantial advancements immunotherapy.

Language: Английский

Citations

16
Sono‐Piezo Dynamic Therapy: Utilizing Piezoelectric Materials as Sonosensitizer for Sonodynamic Therapy DOI Creative Commons
Zhiguang Chen, Liang Sang, Yanjun Liu

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 8, 2025

Sonodynamic therapy (SDT) represents a promising approach for cancer treatment. Compared to photodynamic therapy, SDT offers increased penetration depth and higher precision. However, the practical application of is constrained by low water solubility, poor tumor specificity, metabolic susceptibility most sonosensitizers. Recent research has explored use piezoelectric materials as sonosensitizers in treatment inhibition bacterial growth. Upon ultrasound excitation, separation electron-hole (e--h+) pairs occurs within material. By improving crystal structure material or incorporating other nanoparticles prevent rapid recombination e--h+ pairs, accumulates charges conduction band valence band, achieving redox potential O2/·O2 -. This enables serve sonosensitizer, leading concept termed Sono-Piezo Dynamic Therapy (SPDT). review aims define SPDT, provide systematic overview historical development SDT, elucidate mechanisms which act Importantly, various will be discussed terms their feasibility, advantages, disadvantages sonosensitizers, offering new perspectives identifying

Language: Английский

Citations

3
Bacterial carrier-mediated drug delivery systems: a promising strategy in cancer therapy DOI Creative Commons
Shaomin Yan, Yu Gan, Huizhe Xu

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 8, 2025

Cancer is a major killer threatening modern human health and leading cause of death worldwide. Due to the heterogeneity complexity cancer, traditional treatments have limited effectiveness. To address this problem, an increasing number researchers medical professionals are working develop new ways treat cancer. Bacteria chemotaxis that can target colonize tumor tissue, as well activate anti-tumor immune responses, which makes them ideal for biomedical applications. With rapid development nanomedicine synthetic biology technologies, bacteria extensively used carriers drug delivery tumors, holds promise overcoming limitations conventional cancer treatment regimens. This paper summarizes examples anti-cancer drugs delivered by bacterial carriers, their strengths weaknesses. Further, we emphasize carrier systems in clinical translation.

Language: Английский

Citations

2