Artificial Nonenzymatic Antioxidant MXene Nanosheet-Anchored Injectable Hydrogel as a Mild Photothermal-Controlled Oxygen Release Platform for Diabetic Wound Healing

ACS Nano, Journal Year: 2022, Volume and Issue: 16(5), P. 7486 - 7502

Published: May 9, 2022

Hypoxia, excessive reactive oxygen species (ROS), impaired angiogenesis, lasting inflammation, and bacterial infection, are key problems impeding diabetic wound healing. Particularly, controllable release ROS scavenging capacities critical during the healing process. Here, an injectable hydrogel based on hyaluronic acid-graft-dopamine (HA-DA) polydopamine (PDA) coated Ti3C2 MXene nanosheets is developed catalytically cross-linked by oxyhemoglobin/hydrogen (HbO2/H2O2) system combined with mild photothermal stimulation for HbO2 not only acts as a horseradish peroxidase-like to catalyze formation but also carrier controllably when activated heat produced from near-infrared (NIR) irradiation. Specifically, can provide repeatedly binding in air NIR off. The stable photoresponsive heating behavior of ensures repeatable release. Additionally, artificial nonenzymatic antioxidant proposed scavenge nitrogen including H2O2, O2•-, •OH, keeping intracellular redox homeostasis alleviating oxidative stress, eradicate bacteria avoid infection. antibacterial abilities further improved PDA coating, which promotes cross-linking into network hydrogel. HA-DA molecules endow capacity regulate macrophage polarization M1 M2 achieve anti-inflammation. More importantly, MXene-anchored multifunctions tissue adhesion, self-healing, injectability, hemostasis, stimulation, greatly human umbilical vein endothelial cell proliferation migration notably facilitates infected

Language: Английский

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Tailored Hydrogel Delivering Niobium Carbide Boosts ROS‐Scavenging and Antimicrobial Activities for Diabetic Wound Healing

Small, Journal Year: 2022, Volume and Issue: 18(27)

Published: June 9, 2022

Abstract The treatment of diabetic wounds remains challenging due to the excess levels oxidative stress, vulnerability bacterial infection, and persistent inflammation response during healing. development hydrogel wound dressings with ideal anti‐inflammation, antioxidant, anti‐infective properties is an urgent clinical requirement. In present study, injectable thermosensitive niobium carbide (Nb 2 C)‐based C@Gel) antioxidative antimicrobial activity developed promote Nb C@Gel system composed C a PLGA‐PEG‐PLGA triblock copolymer. fabricated nanosheets (NSs) show good biocompatibility in vitro cytotoxicity hemocompatibility assays vivo toxicity assays. experiments that NSs can efficiently eliminate reactive oxygen species (ROS), thus protecting cells from stress damage. Meanwhile, also exhibit near‐infrared (NIR) photothermal against both Staphylococcus aureus Escherichia coli . results demonstrate promotes healing by attenuating ROS levels, reducing damage, eradicating infection under NIR irradiation, accelerating angiogenesis. To summarize, system, its ROS‐scavenging, hemostatic activities, be promising effective strategy for wounds.

Language: Английский

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Recent Advances in the Development and Antimicrobial Applications of Metal–Phenolic Networks

Advanced Science, Journal Year: 2022, Volume and Issue: 9(27)

Published: July 25, 2022

Due to the abuse of antibiotics and emergence multidrug resistant microorganisms, medical devices, related biomaterials are at high risk microbial infection during use, placing a heavy burden on patients healthcare systems. Metal-phenolic networks (MPNs), an emerging organic-inorganic hybrid network system developed gradually in recent years, have exhibited excellent multifunctional properties such as anti-inflammatory, antioxidant, antibacterial by making use coordination between phenolic ligands metal ions. Further, MPNs received widespread attention antimicrobial infections due their facile synthesis process, biocompatibility, brought about polyphenols In this review, different categories based (nanoparticles, coatings, capsules, hydrogels) fabrication strategies summarized, research advances applications biomedical fields (e.g., skin repair, bone regeneration, etc.) highlighted.

Language: Английский

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pH-Activatable Organic Nanoparticles for Efficient Low-Temperature Photothermal Therapy of Ocular Bacterial Infection

ACS Nano, Journal Year: 2022, Volume and Issue: 16(7), P. 11136 - 11151

Published: June 24, 2022

Low-temperature photothermal therapy (PTT) systems constructed by integrating organic agents with other bactericidal components that initiate bacterial apoptosis at low hyperthermia possess a promising prospect. However, these multicomponent low-temperature PTT nanoplatforms have drawbacks in terms of the tedious construction process, suboptimal synergy effect diverse antibacterial therapies, and high laser dose needed, compromising their biosafety ocular infection treatment. Herein, mild nanotherapeutic platform is formulated via self-assembly pH-responsive phenothiazinium dye. These nanoparticles conversion efficiency up to 84.5% necessitate only an ultralow light 36 J/cm2 achieve efficient inhibition pH 5.5 under 650 nm irradiation. In addition, this intelligent nanoplatform undergoes negative positive charge reversion acid biofilms, exhibiting good penetration highly elimination drug-resistant E. coli biofilms photoirradiation. Further vivo animal tests demonstrated inflammatory mitigation as well superior biocompatibility Overall, single-component system featuring simple processes holds great potential for wide application clinical transformation.

Language: Английский

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Polysaccharide-based hydrogel with photothermal effect for accelerating wound healing

Carbohydrate Polymers, Journal Year: 2022, Volume and Issue: 299, P. 120228 - 120228

Published: Oct. 14, 2022

Language: Английский

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NIR-II Responsive Nanohybrids Incorporating Thermosensitive Hydrogel as Sprayable Dressing for Multidrug-Resistant-Bacteria Infected Wound Management

ACS Nano, Journal Year: 2023, Volume and Issue: 17(12), P. 11253 - 11267

Published: June 14, 2023

Developing an effective dressing against bacterial infection and synchronously addressing wound complications, such as bleeding, long-term inflammation, reinfection, are highly desirable in clinical practice. In this work, a second near-infrared (NIR-II) responsive nanohybrid consisting of imipenem encapsulated liposome with gold-shell lipopolysaccharide (LPS)-targeting aptamer, namely ILGA, is constructed for bacteria elimination. Benefiting from the delicate structure, ILGA exhibits strong affinity reliable photothermal/antibiotic therapeutic effect toward multidrug-resistant Pseudomonas aeruginosa (MDR-PA). Furthermore, by incorporating thermosensitive hydrogel poly(lactic-co-glycolic acid)-polyethylene glycol-poly(lactic-co-glycolic acid) (PLGA-PEG-PLGA), sprayable ILGA@Gel was prepared, which enables quick on-demand gelation (10 s) hemostasis offers excellent efficacy to sterilize infected wound. Additionally, provides satisfactory wound-healing environments reeducating wound-associated macrophages inflammation alleviation forming gel layer block exogenous reinfection. This biomimetic reveals eradication recovery effectiveness, demonstrating its promising potential managing complicated wounds.

Language: Английский

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Three‐Step Regenerative Strategy: Multifunctional Bilayer Hydrogel for Combined Photothermal/Photodynamic Therapy to Promote Drug‐Resistant Bacteria‐Infected Wound Healing

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 34(2)

Published: Sept. 27, 2023

Abstract The drug‐resistant bacterial‐infected skin wound is still a severe healthcare problem. Uncontrolled bacterial infection, abundant reactive oxygen species (ROS) content, and prolonged inflammatory response are detrimental to healing. Moreover, excessive vessel growth can result in unsatisfactory scar formation. Herein, three‐step regenerative strategy based on bilayered gelatin/acryloyl β ‐cyclodextrin (BGACD) hydrogel containing physical host–guest complexations chemical crosslinks proposed. loaded with humic acids (HAs) astragaloside IV (AS) the lower layer verteporfin (Vt) upper layer. Different ratios endow layers of different degradation rates. Under light irradiation, combination HAs‐induced photothermal therapy (PTT) verteporfin‐induced photodynamic effectively inhibits MRSA growth. HAs released from scavenge ROS promote M2 macrophage polarization angiogenesis during inflammation early proliferation phases, while releases suppress late remodeling phases. HAs‐AS@Vt@BGACD successfully achieves rapid scarless healing an MRSA‐infected model rats. Therefore, shows promising potential for treatment bacteria‐infected

Language: Английский

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Progress in nanomaterial-based synergistic photothermal-enhanced chemodynamic therapy in combating bacterial infections

Progress in Materials Science, Journal Year: 2024, Volume and Issue: 144, P. 101292 - 101292

Published: April 6, 2024

The prevalence of multidrug-resistant (MDR) bacterial infections has emerged as a serious threat to clinical treatment and global human health, become one the most important challenges in therapy. Hence, there is an urgent need develop safe, effective, new antibacterial strategies based on multifunctional nanomaterials for accurate detection MDR infections. Chemodynamic therapy (CDT) emerging therapeutic strategy that uses Fenton/Fenton-like metal-based nanocatalysts convert hydrogen peroxide (H2O2) into hydroxyl radicals (OH) destroy Despite enormous potential CDT, single CDT limitations such low catalytic efficacy insufficient production H2O2. In this regard, can be combined with other strategies, photothermal (PTT), which effectively enhanced by PTT heating effect. Thus, rational combination nanoplatform been demonstrated highly efficient achieving better This review summarizes discusses latest advances photothermal-enhanced (PT/CDT) infection theranostics well advantages, challenges, future research directions applications, will inspire development PT/CDT

Language: Английский

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Stimuli‐Responsive Hydrogels for Antibacterial Applications

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(22)

Published: May 9, 2024

Hydrogels have emerged as promising candidates for biomedical applications, especially in the field of antibacterial therapeutics, due to their unique structural properties, highly tunable physicochemical and excellent biocompatibility. The integration stimuli-responsive functions into hydrogels holds potential enhance properties therapeutic efficacy, dynamically responding different external or internal stimuli, such pH, temperature, enzymes, light. Therefore, this review describes applications hydrogel dressings responsive stimuli therapy. collaborative interaction between materials is discussed. This synergistic approach, contrast conventional materials, not only amplifies effect but also alleviates adverse side effects diminishes incidence multiple infections drug resistance. provides a comprehensive overview current challenges outlines future research directions hydrogels. It underscores imperative ongoing interdisciplinary aimed at unraveling mechanisms wound healing. understanding crucial optimizing design implementation Ultimately, aims offer scientific guidance development practical clinical application dressings.

Language: Английский

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H2O2 self-supplying and GSH-depleting nanosystem for amplified NIR mediated-chemodynamic therapy of MRSA biofilm-associated infections

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: March 16, 2024

Abstract Reactive oxygen species (ROS) has emerged as potent therapeutic agents for biofilm-associated bacterial infections. Chemodynamic therapy (CDT), involving the generation of high-energy ROS, displays great potential in However, challenges such insufficient hydrogen peroxide (H 2 O ) and over-expressed glutathione (GSH) levels within microenvironment biofilms severely limit antibacterial efficacy CDT. Herein, we have developed a multifunctional nanoplatform (CuS@CaO @Dex) by integrating copper sulfide (CuS) calcium (CaO into dextran (Dex)-coated nanoparticles. This innovative platform enhanced ROS highly efficient biofilm elimination simultaneously supplying H depleting GSH. The Dex-coating facilitated penetrability CuS@CaO @Dex biofilms, while CaO generated substantial amount acidic microenvironment. CuS, through Fenton-like reaction, catalyzed conversion self-supplied hydroxyl radicals (•OH) consumed overexpressed Additionally, incorporation near-infrared II (NIR II) laser irradiation photothermal properties improving catalytic efficiency reaction effects. In vivo experiments demonstrated that exhibited remarkable antibiofilm efficacy, exceptional wound healing capabilities, notable biosafety. summary, Dex-coated proposed this study, with its self-sterilization capability holds significant future biomedical applications.

Language: Английский

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