Bioactive Materials,
Journal Year:
2023,
Volume and Issue:
30, P. 129 - 141
Published: July 28, 2023
In
clinical
applications,
there
is
a
lack
of
wound
dressings
that
combine
efficient
resistance
to
drug-resistant
bacteria
with
good
self-healing
properties.
this
study,
series
adhesive
conductive
antibacterial
hydrogel
based
on
oxidized
sodium
alginate-grafted
dopamine/carboxymethyl
chitosan/Fe3+
(OSD/CMC/Fe
hydrogel)/polydopamine-encapsulated
poly(thiophene-3-acetic
acid)
(OSD/CMC/Fe/PA
hydrogel)
were
prepared
for
the
repair
infected
wound.
The
Schiff
base
and
Fe3+
coordination
bonds
structure
are
dynamic
can
be
repaired
automatically
after
network
disrupted.
Macroscopically,
exhibits
properties,
allowing
dressing
adapt
complex
surfaces.
OSD/CMC/Fe/PA
showed
conductivity
photothermal
properties
under
near-infrared
(NIR)
light
irradiation.
addition,
hydrogels
exhibit
tunable
rheological
suitable
mechanical
antioxidant
tissue
adhesion
hemostatic
Furthermore,
all
improved
healing
in
full-thickness
defect
skin
test
mice.
size
by
OSD/CMC/Fe/PA3
+
NIR
was
much
smaller
(12%)
than
control
group
treated
Tegaderm™
film
14
days.
conclusion,
have
high
efficiency,
conductivity,
great
biocompatibility,
hemostasis
making
them
promising
candidates
treatment
wounds.
Materials Today Bio,
Journal Year:
2023,
Volume and Issue:
19, P. 100582 - 100582
Published: Feb. 16, 2023
Hydrogels
are
essential
biomaterials
due
to
their
favorable
biocompatibility,
mechanical
properties
similar
human
soft
tissue
extracellular
matrix,
and
repair
properties.
In
skin
wound
repair,
hydrogels
with
antibacterial
functions
especially
suitable
for
dressing
applications,
so
novel
hydrogel
dressings
have
attracted
widespread
attention,
including
the
design
of
components,
optimization
preparation
methods,
strategies
reduce
bacterial
resistance,
etc.
this
review,
we
discuss
fabrication
challenges
associated
crosslinking
methods
chemistry
materials.
We
investigated
advantages
limitations
(antibacterial
effects
mechanisms)
different
components
in
achieve
good
properties,
response
stimuli
such
as
light,
sound,
electricity
resistance.
Conclusively,
provide
a
systematic
summary
findings
(crosslinking
methods)
an
outlook
on
long-lasting
effects,
broader
spectrum,
diversified
forms,
future
development
prospects
field.
Advanced Healthcare Materials,
Journal Year:
2023,
Volume and Issue:
13(1)
Published: Sept. 13, 2023
Abstract
The
healing
of
diabetic
wounds
is
hindered
by
various
factors,
including
bacterial
infection,
macrophage
dysfunction,
excess
proinflammatory
cytokines,
high
levels
reactive
oxygen
species,
and
sustained
hypoxia.
These
factors
collectively
impede
cellular
behaviors
the
process.
Consequently,
this
review
presents
intelligent
hydrogels
equipped
with
multifunctional
capacities,
which
enable
them
to
dynamically
respond
microenvironment
accelerate
wound
in
ways,
stimuli
‐responsiveness,
injectable
self‐healing,
shape
‐memory,
conductive
real‐time
monitoring
properties.
relationship
between
multiple
functions
also
discussed.
Based
on
wounds,
antibacterial,
anti‐inflammatory,
immunomodulatory,
antioxidant,
pro‐angiogenic
strategies
are
combined
hydrogels.
application
repair
systematically
discussed,
aiming
provide
guidelines
for
fabricating
exploring
role
therapeutic
processes.
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
36(8)
Published: Sept. 19, 2023
Abstract
Nanozymes,
as
one
of
the
most
efficient
reactive
oxygen
species
(ROS)‐scavenging
biomaterials,
are
receiving
wide
attention
in
promoting
diabetic
wound
healing.
Despite
recent
attempts
at
improving
catalytic
efficiency
Pt‐based
nanozymes
(e.g.,
PtCu,
best
systems),
they
still
display
quite
limited
ROS
scavenging
capacity
and
ROS‐dependent
antibacterial
effects
on
bacteria
or
immunocytes,
which
leads
to
uncontrolled
poor
Hence,
a
new
class
multifunctional
PtCuTe
nanosheets
with
excellent
catalytic,
ROS‐independent
antibacterial,
proangiogenic,
anti‐inflammatory,
immuno‐modulatory
properties
for
boosting
healing,
is
reported.
The
show
stronger
better
than
PtCu.
It
also
revealed
that
can
enhance
vascular
tube
formation,
stimulate
macrophage
polarization
toward
M2
phenotype
improve
fibroblast
mobility,
outperforming
conventional
Moreover,
promotes
crosstalk
between
different
cell
types
form
positive
feedback
loop.
Consequently,
stimulates
proregenerative
environment
relevant
populations
ensure
normal
tissue
repair.
Utilizing
mouse
model,
it
demonstrated
significantly
facilitated
regeneration
highly
vascularized
skin,
percentage
closure
being
over
90%
8th
day,
among
reported
comparable
biomaterials.
Advanced Science,
Journal Year:
2023,
Volume and Issue:
10(22)
Published: May 18, 2023
Abstract
Treatment
of
infected
wounds
remains
a
challenge
owing
to
antibiotic
resistance;
thus,
developing
smart
biomaterials
for
the
healing
is
urgently
needed.
In
this
study,
microneedle
(MN)
patch
system
with
antimicrobial
and
immunomodulatory
properties
developed
promote
accelerate
wound
healing.
MN
(termed
PFG/M
MNs),
nanoparticle
polydopamine
(PDA)‐loaded
iron
oxide
grafted
glucose
oxidase
(GOx)
hyaluronic
acid
(HA)
then
integrated
into
tips,
amine‐modified
mesoporous
silica
nanoparticles
(AP‐MSNs)
are
incorporated
bases.
Results
show
that
MNs
eradicate
bacterial
infections
modulate
immune
microenvironment,
combining
advantages
chemodynamic
therapy,
photothermal
M2
macrophage
polarization
from
Fe/PDA@GOx@HA
in
tips
as
well
anti‐inflammatory
effect
AP‐MSNs
Thus,
promising
clinical
candidate
promoting
Advanced Science,
Journal Year:
2023,
Volume and Issue:
10(17)
Published: April 19, 2023
Chronic
wounds
in
diabetic
patients
are
challenging
because
their
prolonged
inflammation
makes
healing
difficult,
thus
burdening
patients,
society,
and
health
care
systems.
Customized
dressing
materials
needed
to
effectively
treat
such
that
vary
shape
depth.
The
continuous
development
of
3D-printing
technology
along
with
artificial
intelligence
has
increased
the
precision,
versatility,
compatibility
various
materials,
providing
considerable
potential
meet
abovementioned
needs.
Herein,
functional
inks
comprising
DNA
from
salmon
sperm
DNA-induced
biosilica
inspired
by
marine
sponges,
developed
for
machine
learning-based
wound
dressings.
biomineralized
silica
incorporated
into
hydrogel
a
fast,
facile
manner.
3D-printed
generates
provided
appropriate
porosity,
characterized
effective
exudate
blood
absorption
at
sites,
mechanical
tunability
indicated
good
fidelity
printability
during
optimized
3D
printing.
Moreover,
act
as
nanotherapeutics,
enhancing
biological
activity
dressings
terms
reactive
oxygen
species
scavenging,
angiogenesis,
anti-inflammation
activity,
thereby
accelerating
acute
healing.
These
bioinspired
hydrogels
produce
using
biomineralization
strategy
an
excellent
platform
clinical
applications
chronic
repair.
ACS Applied Materials & Interfaces,
Journal Year:
2023,
Volume and Issue:
15(15), P. 18608 - 18619
Published: April 10, 2023
Bacterial
infection
and
excess
reactive
oxygen
species
are
key
factors
that
lead
to
slow
or
substantially
delayed
wound
healing.
It
is
crucial
design
develop
new
nanomaterials
with
antibacterial
antioxidative
capabilities
for
Here,
positively
charged
carbon
dots
(CDs)
rationally
designed
synthesized
from
p-phenylenediamine
polyethyleneimine
by
a
facile
one-pot
solvothermal
method,
which
show
good
biocompatibility
in
vitro
cytotoxicity,
hemolysis
assays,
vivo
toxicity
evaluation.
The
CDs
superior
antimicrobial
effect
against
Staphylococcus
aureus
(S.
aureus)
at
very
low
concentrations,
reducing
the
risk
of
infection.
At
same
time,
surface
defects
unpaired
electrons
can
effectively
scavenge
free
radicals
reduce
oxidative
stress
damage,
accelerate
inflammation-proliferation
transition,
promote
mouse
model
skin
demonstrates
healing
without
obvious
side
effects
simply
dropping
spraying
onto
wound.
We
believe
prepared
have
satisfactory
biocompatibility,
antioxidant
capacity,
excellent
activity
great
application
potential
