AAPS Open, Journal Year: 2025, Volume and Issue: 11(1)
Published: March 17, 2025
Language: Английский
ACS Materials Au, Journal Year: 2023, Volume and Issue: 3(6), P. 600 - 619
Published: Aug. 21, 2023
Over the past decade, therapeutic potential of nanomaterials as novel drug delivery systems complementing conventional pharmacology has been widely acknowledged. Among these nanomaterials, lipid-based nanoparticles (LNPs) have shown remarkable pharmacological performance and promising outcomes, thus gaining substantial interest in preclinical clinical research. In this review, we introduce main types LNPs used formulations such liposomes, nanoemulsions, solid lipid nanoparticles, nanostructured carriers, polymer hybrid focusing on their physicochemical properties potential. We discuss computational studies modeling techniques to enhance understanding how interact with cargo predict effectiveness interactions applications. also analyze benefits drawbacks various LNP production nanoprecipitation, emulsification, evaporation, thin film hydration, microfluidic-based methods, an impingement jet mixer. Additionally, major challenges associated industrial development, including stability sterilization, storage, regulatory compliance, reproducibility, quality control. Overcoming facilitating compliance represent key steps toward LNP's successful commercialization translation into settings.
Language: Английский
Citations
179
RSC Advances, Journal Year: 2023, Volume and Issue: 13(26), P. 17685 - 17704
Published: Jan. 1, 2023
Interactions between surfactants and drugs.
Language: Английский
Citations
58
Advances in Colloid and Interface Science, Journal Year: 2023, Volume and Issue: 318, P. 102957 - 102957
Published: June 27, 2023
Enzymes are widely used in industry due to their high efficiency and selectivity. However, low stability during certain industrial processes can result a significant loss of catalytic activity. Encapsulation is promising technique that stabilize enzymes by protecting them from environmental stresses such as extreme temperature pH, mechanical force, organic solvents, proteases. Alginate alginate-based materials have emerged effective carriers for enzyme encapsulation biocompatibility, biodegradability, ability form gel beads through ionic gelation. This review presents various systems stabilization explores applications different industries. We discuss the preparation methods alginate encapsulated analyze release mechanisms materials. Additionally, we summarize characterization techniques enzyme-alginate composites. provides insights into use means stabilizing highlights potential benefits applications.
Language: Английский
Citations
44
Chemical Engineering Science, Journal Year: 2024, Volume and Issue: 293, P. 120028 - 120028
Published: March 24, 2024
Language: Английский
Citations
32
Lab on a Chip, Journal Year: 2024, Volume and Issue: 24(5), P. 1154 - 1174
Published: Jan. 1, 2024
The current landscape of microfluidic technologies for lipid nanoparticle production, size control, scaling, and nanomedicine post-processing is described in a review this evolving field.
Language: Английский
Citations
27
Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 14(8), P. 3432 - 3456
Published: May 13, 2024
The advent of cancer immunotherapy has imparted a transformative impact on treatment paradigms by harnessing the power immune system. However, challenge practical and precise targeting malignant cells persists. To address this, engineered nanoparticles (NPs) have emerged as promising solution for enhancing targeted drug delivery in immunotherapeutic interventions, owing to their small size, low immunogenicity, ease surface modification. This comprehensive review delves into contemporary research at nexus NP engineering immunotherapy, encompassing an extensive spectrum morphologies strategies tailored toward optimizing tumor augmenting therapeutic effectiveness. Moreover, it underscores mechanisms that NPs leverage bypass numerous obstacles encountered regimens probes combined potential when co-administered with both established novel modalities. Finally, evaluates existing limitations platforms which could shape path future advancements this field.
Language: Английский
Citations
23
Drug Discovery Today, Journal Year: 2024, Volume and Issue: 29(4), P. 103936 - 103936
Published: Feb. 29, 2024
This review highlights the transformative impact of microfluidic technology on personalized drug delivery. Microfluidics addresses issues in traditional synthesis, providing precise control and scalability nanoparticle fabrication, platforms show high potential for versatility, offering patient-specific dosing real-time monitoring capabilities, all integrated into wearable technology. Covalent conjugation antibodies to nanoparticles improves bioactivity, driving innovations targeting. The integration microfluidics with sensor technologies artificial intelligence facilitates feedback autonomous adaptation delivery systems. Key challenges, such as droplet polydispersity fluidic handling, along future directions focusing reliability, are essential considerations advancing
Language: Английский
Citations
20
Nano Letters, Journal Year: 2024, Volume and Issue: 24(4), P. 1081 - 1089
Published: Jan. 16, 2024
Oral administration of probiotics orchestrates the balance between intestinal microbes and immune response. However, effective delivery in situ colonization are limited by harsh environment gastrointestinal tract. Herein, we provide a microfluidics-derived encapsulation strategy to address this problem. A novel synergistic system composed EcN Nissle 1917 prebiotics, including alginate sodium inulin gel, for treating inflammatory bowel disease colitis-associated colorectal cancer is proposed. We demonstrated that EcN@AN microparticles yielded promising resistance on-demand probiotic colon-retentive capability. efficiently ameliorated inflammation modulated gut microbiome experimental colitis. Moreover, prebiotic composition enhanced fermentation relative short-chain fatty acid metabolites, kind postbiotics, exert anti-inflammatory tumor-suppressive effects murine models. This microfluidcis-based approach coordinated prebiotics may have broad implications bacteriotherapy applications.
Language: Английский
Citations
17
ACS Biomaterials Science & Engineering, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 8, 2025
Nanomedicine is revolutionizing precision medicine, providing targeted, personalized treatment options. Lipid-based nanomedicines offer distinct benefits including high potency, targeted delivery, extended retention in the body, reduced toxicity, and lower required doses. These characteristics make lipid-based nanoparticles ideal for drug delivery areas such as gene therapy, cancer treatment, mRNA vaccines. However, traditional bulk synthesis methods LNPs often produce larger particle sizes, significant polydispersity, low encapsulation efficiency, which can reduce therapeutic effectiveness. issues primarily result from uneven mixing limited control over formation during synthesis. Microfluidic technology has emerged a solution, precise size, uniformity, efficiency. In this mini review, we introduce state-of-the-art microfluidic systems nanoparticle functionalization. We include working principles of different types systems, use LNP synthesis, cargo encapsulation, nanomedicine delivery. end, briefly discuss clinical enabled by devices.
Language: Английский
Citations
2
Pharmaceutics, Journal Year: 2022, Volume and Issue: 14(9), P. 1940 - 1940
Published: Sept. 14, 2022
Nanoparticulate technologies have revolutionized drug delivery allowing for passive and active targeting, altered biodistribution, controlled release (temporospatial or triggered), enhanced stability, improved solubilization capacity, a reduction in dose adverse effects. However, their manufacture remains immature, challenges exist on an industrial scale due to high batch-to-batch variability hindering clinical translation. Lipid-based nanomedicines remain the most widely approved nanomedicines, current manufacturing methods discontinuous face several problems such as affecting critical quality attributes (CQAs) of product, laborious multistep processes, need expert workforce, not being easily amenable scale-up involving typically complex process control. Several techniques emerged recent years nanomedicine manufacture, but paradigm shift occurred when microfluidic strategies able mix fluids channels with dimensions tens micrometers small volumes liquid reagents highly manner form nanoparticles tunable reproducible structure were employed. In this review, we summarize advancements lipid-based using microfluidics particular emphasis parameters that govern control CQAs final nanomedicines. The impact environments formation dynamics nanomaterials, application microdevices platforms nanomaterial screening are also discussed.
Language: Английский
Citations
40