Enhancing Drug Solubility, Bioavailability, and Targeted Therapeutic Applications through Magnetic Nanoparticles

Molecules, Journal Year: 2024, Volume and Issue: 29(20), P. 4854 - 4854

Published: Oct. 13, 2024

Biological variability poses significant challenges in the development of effective therapeutics, particularly when it comes to drug solubility and bioavailability. Poor across varying physiological conditions often leads reduced absorption inconsistent therapeutic outcomes. This review examines how nanotechnology, especially through use nanomaterials magnetic nanoparticles, offers innovative solutions enhance comprehensive focuses on recent advancements approaches nanotechnology. We highlight both successes remaining this field, emphasizing role continued innovation. Future research should prioritize developing universal solutions, conducting interdisciplinary research, leveraging personalized nanomedicine address biological variability.

Language: Английский

---

Advancing neurological disorders therapies: Organic nanoparticles as a key to blood-brain barrier penetration

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: 670, P. 125186 - 125186

Published: Jan. 8, 2025

The blood-brain barrier (BBB) plays a vital role in protecting the central nervous system (CNS) by preventing entry of harmful pathogens from bloodstream. However, this also presents significant obstacle when it comes to delivering drugs for treatment neurodegenerative diseases and brain cancer. Recent breakthroughs nanotechnology have paved way creation wide range nanoparticles (NPs) that can serve as carriers diagnosis therapy. Regarding their promising properties, organic NPs potential be used effective drug delivery across BBB based on recent advancements. These remarkable ability penetrate using various mechanisms. This review offers comprehensive examination intricate structure distinct properties BBB, emphasizing its crucial function preserving balance regulating transport ions molecules. disruption conditions such stroke, Alzheimer's disease, Parkinson's disease highlights importance developing creative approaches drugs. Through encapsulation therapeutic molecules precise targeting processes vasculature, NP formulations present hopeful strategy improve BBB. We explore changes pathological investigate factors affect successful into brain. In addition, we most systems associated with shown positive results treating ischemic disorders. opens up new possibilities nanotechnology-based therapies cerebral diseases.

Language: Английский

---

Direct preparation of two-dimensional platelets from polymers enabled by accelerated seed formation

Nature Synthesis, Journal Year: 2025, Volume and Issue: unknown

Published: March 14, 2025

Language: Английский

---

Liposome–Hydrogel Composites for Controlled Drug Delivery Applications

Gels, Journal Year: 2024, Volume and Issue: 10(4), P. 284 - 284

Published: April 22, 2024

Various controlled delivery systems (CDSs) have been developed to overcome the shortcomings of traditional drug formulations (tablets, capsules, syrups, ointments, etc.). Among innovative CDSs, hydrogels and liposomes shown great promise for clinical applications thanks their cost-effectiveness, well-known chemistry synthetic feasibility, biodegradability, biocompatibility responsiveness external stimuli. To date, several liposomal- hydrogel-based products approved treat cancer, as well fungal viral infections, hence integration into has attracted increasing attention because benefit from both them a single platform, resulting in multifunctional formulation, which is essential develop efficient CDSs. This short review aims present an updated report on advancements liposome-hydrogel purposes.

Language: Английский

---

Advances in Starch-Based Nanocomposites for Functional Food Systems: Harnessing AI and Nuclear Magnetic Resonance Technologies for Tailored Stability and Bioactivity

Foods, Journal Year: 2025, Volume and Issue: 14(5), P. 773 - 773

Published: Feb. 24, 2025

Starch-based nanocomposites (SNCs) are at the forefront of innovations in food science, offering unparalleled opportunities for enhancing stability, bioactivity, and overall functionality systems. This review delves into potential SNCs to address contemporary challenges formulation, focusing on synergistic effects their components. By integrating cutting-edge technologies, such as artificial intelligence (AI) nuclear magnetic resonance (NMR), we explore new avenues precision, predictability, SNCs. AI is applied optimize design SNCs, leveraging predictive modeling fine-tune material properties streamline production processes. The role NMR also critically examined, with particular emphasis its capacity provide high-resolution structural insights, monitor stability over time, elucidate molecular interactions within matrices. Through detailed examples, highlights impact unraveling complex behaviors bioactive compounds encapsulated Additionally, discuss integration functional assays AI-driven analytics assessing bioactivity sensory these systems, providing a robust framework rational advanced products. synergy between AI, NMR, opens pathways developing tailored, high-performance formulations that both health consumer preferences.

Language: Английский

---

Zweifach–Fung Microfluidic Device for Efficient Microparticle Separation: Cost-Effective Fabrication Using CO2 Laser-Ablated PMMA

Micromachines, Journal Year: 2024, Volume and Issue: 15(7), P. 932 - 932

Published: July 22, 2024

Microfluidic separators play a pivotal role in the biomedical and chemical industries by enabling precise fluid manipulations. Traditional fabrication of these devices typically requires costly cleanroom facilities, which limits their broader application. This study introduces novel microfluidic device that leverages passive Zweifach–Fung principle to overcome financial barriers. Through Lagrangian computational simulations, we optimized an eleven-channel configuration achieved perfect 100% recall rate for particles following specified normal distribution. Experimental evaluations determined 2 mL/h as optimal total flow (TFR), under showcased exceptional performance enhancements precision micrometer-sized particles, achieving overall accuracy 94% ± 3%. Fabricated using cost-effective, non-cleanroom method, this approach represents significant shift from conventional practices, dramatically reducing production costs while maintaining high operational efficacy. The cost each chip is less than USD 0.90 cents manufacturing process takes only 15 min. development not makes technology more accessible but also sets new standard future advancements field.

Language: Английский

---

Biotechnological Tools Boost the Functional Diversity of DNA-based Data Storage Systems

Computational and Structural Biotechnology Journal, Journal Year: 2025, Volume and Issue: 27, P. 624 - 630

Published: Jan. 1, 2025

DNA-based data storage has emerged as a groundbreaking solution to the growing demand for efficient, high-density, and long-term storage. It is attracting many researchers' attention, who are implementing functions such random access, searching, operations apart from existing capabilities, including reading writing. We summarize recent progress of how biotechnological tools, based on sequence specificity, encapsulation, high-dimensional structures DNA molecules, facilitate implementation various functions. The limitations using biochemical reactions that hinder development more precise efficient information systems also discussed. Future advancements in molecular biology nanotechnology expected improve architecture, scalability, efficiency storage, positioning it sustainable dynamic alternative conventional systems.

Language: Английский

---

Microfluidic confined acoustic streaming vortex for liposome synthesis

Lab on a Chip, Journal Year: 2024, Volume and Issue: 24(10), P. 2802 - 2810

Published: Jan. 1, 2024

An acoustofluidic platform for controllable size liposome synthesis using microfluidic confined acoustic streaming vortex. It combines the features of both hydrodynamic flow focusing and rapid micro-mixing.

Language: Английский

---

Transforming Nanomaterial Synthesis through Advanced Microfluidic Approaches: A Review on Accessing Unrestricted Possibilities

Journal of Composites Science, Journal Year: 2024, Volume and Issue: 8(10), P. 386 - 386

Published: Sept. 25, 2024

The inception of microfluidic devices marks a confluence diverse scientific domains, including physics, biology, chemistry, and fluid mechanics. These multidisciplinary roots have catalyzed the evolution devices, which serve as versatile platforms for various chemical biological processes. Notably, garnered attention efficient reactors, offering distinct benefits such minimized spatial requirements reactions, reduced equipment costs, accelerated residence times. advantages, among others, ignited compelling interest in harnessing technology conception, refinement, production nanomaterials nanocomposites, pivotal within both industrial medicinal sectors. This comprehensive exposition delves into multifaceted aspects nanomaterial synthesis, underscoring transformative role methodologies departure from conventional techniques. discourse navigates through intricate considerations surrounding preparation nanomaterials, elucidating how paradigm has emerged promising alternative. paper serves an illuminating exploration juncture between innovation synthesis. It traverses potential microfluidics revolutionizing traditional approaches, heralding new era precision engineering advanced materials with applications spanning to domains.

Language: Английский

---

Enhancing Magnetic Micro- and Nanoparticle Separation with a Cost-Effective Microfluidic Device Fabricated by Laser Ablation of PMMA

Micromachines, Journal Year: 2024, Volume and Issue: 15(8), P. 1057 - 1057

Published: Aug. 22, 2024

Superparamagnetic iron oxide micro- and nanoparticles have significant applications in biomedical chemical engineering. This study presents the development evaluation of a novel low-cost microfluidic device for purification hyperconcentration these magnetic particles. The device, fabricated using laser ablation polymethyl methacrylate (PMMA), leverages precise control over fluid dynamics to efficiently separate particles from non-magnetic ones. We assessed device’s performance through Multiphysics simulations empirical tests, focusing on separation magnetite blue carbon dots microparticles polystyrene at various total flow rates (TFRs). For nanoparticle separation, achieved recall up 93.3 ± 4% precision 95.9 1.2% an optimal TFR 2 mL/h, significantly outperforming previous models, which only 50% recall. Microparticle demonstrated accuracy 98.1 1% mL/h both experimental conditions. Lagrangian model effectively captured microparticle microparticles, with close agreement between simulated results. Our findings underscore robust capability distinguishing nanoscales. highlights potential low-cost, non-cleanroom manufacturing techniques produce high-performance devices, thereby expanding their accessibility applicability industrial research settings. integration continuous magnet, as opposed segmented magnets designs, was identified key factor enhancing efficiency.

Language: Английский

---