Journal of Materials Chemistry B,
Journal Year:
2023,
Volume and Issue:
11(9), P. 1829 - 1848
Published: Jan. 1, 2023
Although
degradable
nanomaterials
have
been
widely
designed
and
applied
for
cancer
bioimaging
various
treatments,
few
reviews
of
biodegradable
reported.
Herein,
we
summarized
the
representative
research
advances
with
respect
to
mechanism
degradation
their
application
in
tumor
imaging
therapy.
First,
four
kinds
microenvironment
(TME)
responsive
are
presented,
including
pH,
glutathione
(GSH),
hypoxia
matrix
metalloproteinase
(MMP)
degradation.
Second,
external
stimulation
is
briefly.
Next,
outlined
applications
bioimaging.
Finally,
focused
on
some
typical
examples
radiotherapy
(RT),
photothermal
therapy
(PTT),
starvation
therapy,
photodynamic
(PDT),
chemotherapy,
chemodynamic
(CDT),
sonodynamic
(SDT),
gene
immunotherapy
combination
RSC Advances,
Journal Year:
2024,
Volume and Issue:
14(21), P. 14722 - 14741
Published: Jan. 1, 2024
Manganese-based
nanomaterials
have
seen
rapid
development
in
chemodynamic
therapy
and
T
1
-enhanced
MRI
over
the
past
five
years,
holding
promising
prospects
various
combined
applications.
Small,
Journal Year:
2022,
Volume and Issue:
18(52)
Published: Nov. 4, 2022
Abstract
Photodynamic
therapy
(PDT)
has
been
showing
great
potential
in
cancer
treatment.
However,
the
efficacy
of
PDT
is
always
limited
by
intrinsic
hypoxic
tumor
microenvironment
(TME)
and
low
accumulation
efficiency
photosensitizers
tumors.
To
address
issue,
a
multifunctional
hollow
multilayer
nanoplatform
(H‐MnO
2
@TPyP@Bro)
comprising
manganese
dioxide,
porphyrin
(TPyP)
bromelain
(Bro),
developed
for
enhanced
photodynamic
therapy.
MnO
catalyzes
intracellular
hydrogen
peroxide
(H
O
)
to
produce
oxygen
(O
),
reversing
TME
vivo.
The
generated
converted
into
singlet
(
1
TPyP
shell
under
near‐infrared
light,
which
can
inhibit
proliferation.
Meanwhile,
Bro
digest
collagen
extracellular
matrix
around
tumor,
promote
H‐MnO
@TPyP@Bro
deeper
tissue,
further
improving
therapeutic
effect
PDT.
In
addition,
react
with
overexpressed
glutathione
release
Mn
2+
.
Consequently,
not
only
induces
chemo‐dynamic
based
on
Fenton
reaction
converting
H
hydroxyl
radicals,
but
also
activates
‐based
magnetic
resonance
imaging.
Therefore,
effectively
modulate
unfavorable
overcome
limitations
conventional
diagnostic
therapeutic.
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
35(33)
Published: May 24, 2023
Abstract
Ultrasound
(US)‐triggered
cascade
amplification
of
nanotherapies
has
attracted
considerable
attention
as
an
effective
strategy
for
cancer
treatment.
With
the
remarkable
advances
in
materials
chemistry
and
nanotechnology,
a
large
number
well‐designed
nanosystems
have
emerged
that
incorporate
presupposed
processes
can
be
activated
to
trigger
therapies
such
chemotherapy,
immunotherapy,
ferroptosis,
under
exogenous
US
stimulation
or
specific
substances
generated
by
actuation,
maximize
antitumor
efficacy
minimize
detrimental
effects.
Therefore,
summarizing
corresponding
applications
based
on
US‐triggered
is
essential.
This
review
comprehensively
summarizes
highlights
recent
design
intelligent
modalities,
consisting
unique
components,
distinctive
properties,
processes.
These
ingenious
strategies
confer
unparalleled
potential
ultrasound‐triggered
provide
superior
controllability,
thus
overcoming
unmet
requirements
precision
medicine
personalized
Finally,
challenges
prospects
this
emerging
are
discussed
it
expected
encourage
more
innovative
ideas
promote
their
further
development.
Journal of Materials Chemistry B,
Journal Year:
2023,
Volume and Issue:
11(9), P. 1829 - 1848
Published: Jan. 1, 2023
Although
degradable
nanomaterials
have
been
widely
designed
and
applied
for
cancer
bioimaging
various
treatments,
few
reviews
of
biodegradable
reported.
Herein,
we
summarized
the
representative
research
advances
with
respect
to
mechanism
degradation
their
application
in
tumor
imaging
therapy.
First,
four
kinds
microenvironment
(TME)
responsive
are
presented,
including
pH,
glutathione
(GSH),
hypoxia
matrix
metalloproteinase
(MMP)
degradation.
Second,
external
stimulation
is
briefly.
Next,
outlined
applications
bioimaging.
Finally,
focused
on
some
typical
examples
radiotherapy
(RT),
photothermal
therapy
(PTT),
starvation
therapy,
photodynamic
(PDT),
chemotherapy,
chemodynamic
(CDT),
sonodynamic
(SDT),
gene
immunotherapy
combination
