ACS Applied Nano Materials,
Journal Year:
2023,
Volume and Issue:
7(1), P. 1450 - 1461
Published: Dec. 14, 2023
Hypoxia,
a
distinct
feature
of
breast
cancer,
can
affect
the
effectiveness
cancer
therapy.
To
alleviate
hypoxic
state
tumor
microenvironment
and
achieve
synergistic
starvation-photodynamic
therapy
(PDT),
we
have
developed
simple
effective
multifunctional
nanoplatform.
Spherical
silica
(SiO2)
serves
as
template
for
synthesis
hollow
mesoporous
MnO2
(H-MnO2)
nanoparticles,
which
act
carriers
chlorin
e6
(Ce6)
glucose
oxidase
(GOx).
Subsequently,
particles
are
modified
with
surfactant
Pluronic
F-127,
leading
to
formation
H-MnO2/Ce6/GOx/F-127
(MCGF)
During
treatment,
pH/glutathione/H2O2-responsive
MCGF
allows
controlled
release
encapsulated
Ce6
GOx,
avoiding
pre-exposure
body
fluids.
Upon
release,
GOx
oxidizes
endogenous
generate
H2O2
gluconic
acid.
The
catalase-like
H-MnO2
reacts
glucose-oxidation-generated
produce
O2.
Reinforcement
between
these
catalytic
reactions
promotes
O2-dependent
Ce6-mediated
PDT
GOx-induced
starvation
Moreover,
T1-weighted
magnetic
resonance
imaging
(MRI)
Mn2+,
is
produced
by
degradation,
real-time
monitoring.
Both
in
vitro
vivo
experiments
demonstrate
that
nanoplatform
MRI
monitoring
achieves
efficient
starvation/PDT
effects
treatment.
We
believe
our
findings
will
contribute
development
nanotheranostic
platforms
starvation/PDT.
Theranostics,
Journal Year:
2023,
Volume and Issue:
13(6), P. 1974 - 2014
Published: Jan. 1, 2023
Chemodynamic
therapy
(CDT)
is
well-known
for
using
the
tumor
microenvironment
to
activate
Fenton
reaction
or
Fenton-like
generate
strong
oxidative
hydroxyl
radicals
tumor-specific
treatment.
It
highly
selective
and
safe,
without
depth
limitation
of
tissue
penetration,
shows
its
potential
as
a
new
green
therapeutic
method
with
great
clinical
application.
However,
catalytic
efficiency
reagents
involved
in
severely
affected
by
inherent
microenvironmental
limitations
tumors
strict
reaction-dependent
conditions.
With
increasing
application
nanotechnology
medical
field,
combined
therapies
based
on
different
types
functional
nanomaterials
have
opened
up
avenues
development
next-generation
CDT-enhanced
system.
This
review
will
comprehensively
exemplify
representative
results
CDT
other
antitumor
such
chemotherapy,
phototherapy,
sonodynamic
therapy,
radiation
magnetic
hyperthermia
immunotherapy,
starvation
gas
gene
oncosis
combination
thereof
improving
from
hundreds
latest
literature,
introduce
strategies
ingenious
design
nanomedicines
regulations
enhance
further
summarize
challenges
future
perspective
CDT-based
multimodal
anticancer
therapy.
MedComm – Oncology,
Journal Year:
2024,
Volume and Issue:
3(1)
Published: March 1, 2024
Abstract
Rapid
growth
in
nanoparticles
(NPs)
as
delivery
systems
holds
vast
promise
to
promote
therapeutic
approaches
for
cancer
treatment.
Presently,
a
diverse
array
of
NPs
with
unique
properties
have
been
developed
overcome
different
challenges
and
achieve
sophisticated
routes
enhancement
series
therapies.
Inspiring
advances
achieved
the
field
therapy
using
NPs.
In
this
review,
we
aim
summarize
up‐to‐date
progression
addressing
various
challenges,
expect
elicit
novel
potential
opportunities
alternatively.
We
first
introduce
sorts
NP
technologies,
illustrate
their
mechanisms,
present
applications.
Then,
achievements
made
by
break
obstacles
delivering
cargoes
specific
sites
through
particular
are
highlighted,
including
long‐circulation,
tumor
targeting,
responsive
release,
subcellular
localization.
subsequently
retrospect
recent
research
treatments
from
single
therapy,
like
chemotherapy,
combination
chemoradiotherapy,
integrative
therapy.
Finally,
perspectives
impact
on
oncology
discussed.
believe
review
can
offer
deeper
understanding
Small,
Journal Year:
2024,
Volume and Issue:
20(32)
Published: March 20, 2024
Abstract
The
combination
of
ferroptosis
and
innovative
tumor
therapy
methods
offers
another
promising
answer
to
the
problem
tumors.
In
order
generate
effective
in
cells,
iron‐based
nanomaterials
are
commonly
utilized
introduce
foreign
iron
as
a
trigger
for
ferroptosis.
However,
this
usually
necessitates
injection
larger
doses
into
body.
These
exogenous
increases
likely
create
concealed
concerns
symptoms
such
liver
damage
allergy.
Herein,
an
iron‐free
radiosensitizer
is
introduced,
oxygen‐vacancy‐rich
MnO
2
nanoflowers
(
ovs
‐MnO
),
that
promotes
modifies
microenvironment
assist
radiotherapy.
with
enriched
oxygen
vacancies
on
surface
induces
release
intracellular
free
(Fe
2+
which
functions
activator
Fenton
reaction
enhances
accumulation
reactive
species.
On
other
hand,
Fe
also
triggers
lipid
peroxides.
Subsequently,
depletion
glutathione
peroxidation
cells
leads
inactivation
peroxidase
4
(GPX4)
ferroptosis,
thereby
enhancing
therapeutic
efficacy
nanoplatform
provides
novel
strategy
generating
nanomedicines
ferroptosis‐assisted
Signal Transduction and Targeted Therapy,
Journal Year:
2025,
Volume and Issue:
10(1)
Published: March 19, 2025
Abstract
Nanoparticle-based
drug
delivery
system
remains
a
significant
challenge
in
the
current
treatment
of
solid
tumors,
primarily
due
to
their
limited
penetration
capabilities.
Herein,
we
successfully
engineer
photodynamic
gel-bombs
(DCM@OPR)
capable
penetrating
deeply
into
tumor
tissues
utilizing
photodynamic-triggered
explosive
energy
and
receptor-mediated
transcytosis,
significantly
enhancing
therapeutic
efficacy
breast
cancer.
The
were
fabricated
by
loading
powerful
components
chlorin
e6
MnO
2
nanoparticles,
as
well
Doxorubicin,
crosslinked
Ca
2+
-gel.
Upon
exposure
laser
irradiation,
obtained
are
generating
energy,
resulting
fragmentation
numerous
nanofragments.
subsequently
drives
these
nanofragments
penetrate
through
gap
leakage
among
cells.
In
addition,
also
promotes
escape
those
(including
e6,
doxorubicin)
from
lysosomes.
subsequent
stages,
exhibit
excellent
transcytosis
capacity,
facilitating
deep
tissues.
As
expected,
enhanced
accumulation
can
be
achieved,
anti-proliferation
capacity
against
Materials Horizons,
Journal Year:
2024,
Volume and Issue:
11(23), P. 5815 - 5842
Published: Jan. 1, 2024
The
current
state-of-the
art
on
NIR-II-activated
photosensitizers
and
their
applications
for
the
deep
tumor
treatment,
as
well
recent
efforts
that
combine
NIR-II
activated
PDT
with
other
complementary
therapeutic
routes.
Advanced Science,
Journal Year:
2024,
Volume and Issue:
11(33)
Published: July 2, 2024
In
situ
cancer
vaccination
is
an
attractive
strategy
that
stimulates
protective
antitumor
immunity.
Cytotoxic
T
lymphocytes
(CTLs)
are
major
mediators
of
the
adaptive
immune
defenses,
with
critical
roles
in
response
and
establishing
memory,
consequently
extremely
important
for
vaccines
to
generate
systemic
lasting
efficacy.
However,
dense
extracellular
matrix
hypoxia
solid
tumors
severely
impede
infiltration
function
CTLs,
ultimately
compromising
efficacy
vaccines.
To
address
this
issue,
a
robust
vaccine,
Au@MnO
Biomaterials Science,
Journal Year:
2024,
Volume and Issue:
12(14), P. 3622 - 3632
Published: Jan. 1, 2024
Metal
nanoenzymes
(HMnO
2
@CDDP)
that
can
degrade
to
produce
Mn
2+
exhibit
Fenton-like,
GSH-peroxidase-like
activity.
Treatment
with
increased
intratumor
Pt-DNA
content,
leading
the
up-regulation
of
γ-H2Aχ
and
an
increase
in
tumor
damage.
