Revolutionizing adjuvant development: harnessing AI for next-generation cancer vaccines DOI Creative Commons
Wei Zhang, Xiaoli Zheng, Paolo Coghi

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 14, 2024

With the COVID-19 pandemic, importance of vaccines has been widely recognized and led to increased research development efforts. Vaccines also play a crucial role in cancer treatment by activating immune system target destroy cells. However, enhancing efficacy remains challenge. Adjuvants, which enhance response antigens improve vaccine effectiveness, have faced limitations recent years, resulting few novel adjuvants being identified. The advancement artificial intelligence (AI) technology drug provided foundation for adjuvant screening application, leading diversification adjuvants. This article reviews significant tumor basic clinical explores use AI screen from databases. findings this review offer valuable insights new next-generation vaccines.

Language: Английский

Nanomaterials for photothermal cancer therapy DOI Creative Commons

Shufan Duan,

Yanling Hu, Ying Zhao

et al.

RSC Advances, Journal Year: 2023, Volume and Issue: 13(21), P. 14443 - 14460

Published: Jan. 1, 2023

This review summarizes the common inorganic and organic photothermal nanoagents their applications in tumor therapy. Additionally, challenges future prospects of nanomaterial-based therapy cancer treatment are discussed.

Language: Английский

Citations

77
Bacterial outer membrane vesicle based versatile nanosystem boosts the efferocytosis blockade triggered tumor-specific immunity DOI Creative Commons

Wanru Zhuang,

Yunfeng Wang, Weidong Nie

et al.

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: March 25, 2023

Efferocytosis inhibition is emerging as an attractive strategy for antitumor immune therapy because of the subsequent leak abundant immunogenic contents. However, practical efficacy seriously impeded by immunosuppressive tumor microenvironments. Here, we construct a versatile nanosystem that can not only inhibit efferocytosis but also boost following immunity. MerTK inhibitor UNC2025 loaded into bacterial outer membrane vesicles (OMVs), which are then modified with maleimide (mU@OMVs). The prepared mU@OMVs effectively inhibits promoting uptake while preventing phosphorylation associated macrophages, and captures released antigens through forming universal thioether bonds. obtained in situ vaccine transfers to lymph nodes virtue intrinsic features OMVs, provokes intense responses efficiently prevent growth, metastasis recurrence tumors mice, providing generalizable cancer immunotherapy.

Language: Английский

Citations

57
Biomimetic Nano-Drug Delivery System: An Emerging Platform for Promoting Tumor Treatment DOI Creative Commons
Xiujuan Han, Chunai Gong,

Qingru Yang

et al.

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 571 - 608

Published: Jan. 1, 2024

Abstract: With the development of nanotechnology, nanoparticles (NPs) have shown broad prospects as drug delivery vehicles. However, they exhibit certain limitations, including low biocompatibility, poor physiological stability, rapid clearance from body, and nonspecific targeting, which hampered their clinical application. Therefore, novel systems with improved biocompatibility high target specificity remains a major challenge. In recent years, biofilm mediated biomimetic nano-drug system (BNDDS) has become research hotspot focus in field life sciences. This new platform uses bio-nanotechnology to encapsulate synthetic NPswithin membrane, organically integrating immunogenicity, toxicity, tumor good adjustability versatility nanocarrier, shows promising applications precision therapy. this review, we systematically summarize progress BNDDS used for optimizing delivery, providing theoretical reference designing safe efficient treatment strategies improve outcomes. Keywords: nanoparticles, cell targeted therapy

Language: Английский

Citations

37
Surface Mineralization of Engineered Bacterial Outer Membrane Vesicles to Enhance Tumor Photothermal/Immunotherapy DOI
Xue Chen,

Puze Li,

Ban Luo

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(2), P. 1357 - 1370

Published: Jan. 2, 2024

Gram-negative bacteria can naturally produce nanosized spherical outer membrane vesicles (OMVs) with a lipid bilayer membrane, possessing immunostimulatory capabilities to be potentially applied in tumor therapy. However, the systemic toxicity induced by pathogen-associated molecular patterns (PAMPs) of OMVs is main obstacle for their clinical translation. Herein, melanin-loaded were produced genetic engineering strategy and further coated calcium phosphate (CaP) reduce enhance treatment effects. Wild-type bacterium Escherichia coli Nissle 1917 (EcN) was genetically engineered highly express tyrosinase catalyze intracellular synthesis melanin, giving (OMVMel). To therapy, OMVMel CaP surface mineralization obtain OMVMel@CaP. In comparison OMVMel, OMVMel@CaP showed lower inflammatory responses healthy mice less damage liver, spleen, lung, kidney, so administration dose could increased antitumor effect. acidic microenvironment, shell disintegrated release trigger immune responses. Under costimulation acting as immunoadjuvants damage-associated (DAMPs) released photothermal effect, efficiency photothermal/immunotherapy largely boosted through promoting infiltration matured DCs, M1 macrophages, activated CD8+ T cells, decreasing ratio MDSCs tumors.

Language: Английский

Citations

33
Engineered bacterial outer membrane vesicles: a versatile bacteria-based weapon against gastrointestinal tumors DOI Creative Commons

Keshuang Zheng,

Yongpu Feng,

Lie Li

et al.

Theranostics, Journal Year: 2024, Volume and Issue: 14(2), P. 761 - 787

Published: Jan. 1, 2024

Outer membrane vesicles (OMVs) are nanoscale lipid bilayer structures released by gram-negative bacteria.They share composition and properties with their originating cells, making them adept at traversing cellular barriers.These OMVs have demonstrated exceptional stability, immunogenicity, safety, penetration, tumor-targeting properties, which been leveraged in developing vaccines drug delivery systems.Recent research efforts focused on engineering to increase production yield, reduce cytotoxicity, improve the safety efficacy of treatment.Notably, gastrointestinal (GI) tumors proven resistant several traditional oncological treatment strategies, including chemotherapy, radiotherapy, targeted therapy.Although immune checkpoint inhibitors some patients, usage as monotherapy remains limited tumor heterogeneity individual variability.The immunogenic modifiable nature makes an ideal design platform for individualized GI tumors.OMV-based therapy enables combination optimization anti-tumor effects.This review comprehensively summarizes recent advances OMV discusses challenges clinical translation emerging OMV-based therapies.

Language: Английский

Citations

18
Advancing nanotechnology for neoantigen-based cancer theranostics DOI Creative Commons
Jianhua Zou, Yu Zhang,

Yuanbo Pan

et al.

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(7), P. 3224 - 3252

Published: Jan. 1, 2024

Neoantigens play a pivotal role in the field of tumour therapy, encompassing stimulation anti-tumour immune response and enhancement targeting capability. Nonetheless, numerous factors directly influence effectiveness neoantigens bolstering responses, including neoantigen quantity specificity, uptake rates by antigen-presenting cells (APCs), residence duration within microenvironment (TME), their ability to facilitate maturation APCs for activation. Nanotechnology assumes significant several aspects, facilitating release, promoting delivery cells, augmenting dendritic shielding from protease degradation, optimizing interactions between system. Consequently, development nanotechnology synergistically enhances efficacy cancer theranostics. In this review, we provide an overview sources, mechanisms neoantigen-induced evolution precision neoantigen-based nanomedicine. This encompasses various therapeutic modalities, such as immunotherapy, phototherapy, radiotherapy, chemotherapy, chemodynamic other strategies tailored augment therapeutics. We also discuss current challenges prospects application nanomedicine, aiming expedite its clinical translation.

Language: Английский

Citations

16
Invasion and metastasis in cancer: molecular insights and therapeutic targets DOI Creative Commons

Yongxing Li,

Fengshuo Liu,

Qingjin Cai

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)

Published: Feb. 20, 2025

The progression of malignant tumors leads to the development secondary in various organs, including bones, brain, liver, and lungs. This metastatic process severely impacts prognosis patients, significantly affecting their quality life survival rates. Research efforts have consistently focused on intricate mechanisms underlying this corresponding clinical management strategies. Consequently, a comprehensive understanding biological foundations tumor metastasis, identification pivotal signaling pathways, systematic evaluation existing emerging therapeutic strategies are paramount enhancing overall diagnostic treatment capabilities for tumors. However, current research is primarily metastasis within specific cancer types, leaving significant gaps our complex cascade, organ-specific tropism mechanisms, targeted treatments. In study, we examine sequential processes elucidate driving organ-tropic systematically analyze tumors, those tailored organ involvement. Subsequently, synthesize most recent advances technologies challenges opportunities encountered pertaining bone metastasis. Our objective offer insights that can inform future practice crucial field.

Language: Английский

Citations

3
Bacterial extracellular vesicles-based therapeutic strategies for bone and soft tissue tumors therapy DOI Creative Commons
Han Liu, Hao Zhang, Yafei Han

et al.

Theranostics, Journal Year: 2022, Volume and Issue: 12(15), P. 6576 - 6594

Published: Jan. 1, 2022

Bone and soft tissue tumors are complex mesenchymal neoplasms that seriously endanger human health. Over the past decade, relationship between microorganisms health diseases is getting more attention. The extracellular vesicles derived from bacteria have been shown to regulate bacterial-host cell communication by transferring their contents, including nucleic acids, proteins, metabolites, lipopolysaccharides, peptidoglycans. Bacteria (BEVs) promising lipid-bilayer nanocarriers for treatment of many due low toxicity, drug loading capacity, ease modification industrialization. Specially, BEVs-based cancer therapy has attracted much attention because ability effectively stimulate immune responses. In this review, we provide an overview biogenesis, composition, isolation, classification, internalization BEVs. We then comprehensively summarize sources BEVs in BEVs-related strategies. further highlight great potential bone tumors. Finally, conclude major advantages challenges therapy. believe comprehensive understanding field will generate innovative solutions achieve clinical applications.

Language: Английский

Citations

59
Engineered bacterial extracellular vesicles for osteoporosis therapy DOI Creative Commons
Han Liu, Mengmeng Li, Tao Zhang

et al.

Chemical Engineering Journal, Journal Year: 2022, Volume and Issue: 450, P. 138309 - 138309

Published: July 30, 2022

Osteoporosis (OP) is a systemic bone disease characterized by reduction of mass and destruction structure, which can easily lead to fragility fractures. Over the past decade, an expanding body study suggests that gut microbiota (GM) plays important role in homeostasis pathogenesis OP. The communication mechanism between GM OP has received increasing attention. Bacterial extracellular vesicles (BEVs) are irreproducible phospholipid bilayer nanocarriers with sizes ranging from 20 400 nm, mediate delivering various bioactive molecules. BEVs have emerged as promising platform for treatment due their nanosized structures, low toxicity, drug loading capacity, good biocompatibility, ease modification industrialization. Here, we summarize overview BEVs, including biogenies, classes, compositions, internalization, isolation BEVs. We then focus on applications natural Subsequently, present two major engineering strategies, parental strain after isolation, modifying treatment. Finally, provide outlook challenges future prospects hope comprehensive understanding engineered will new solutions

Language: Английский

Citations

52
In situ photothermal nano-vaccine based on tumor cell membrane-coated black phosphorus-Au for photo-immunotherapy of metastatic breast tumors DOI

Deqiu Huang,

Tong Wu,

Siyuan Lan

et al.

Biomaterials, Journal Year: 2022, Volume and Issue: 289, P. 121808 - 121808

Published: Sept. 16, 2022

Language: Английский

Citations

44