Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 156383 - 156383
Published: Oct. 1, 2024
Language: Английский
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: July 11, 2024
Alternative splicing (AS) functions as a crucial program in transcriptional modulation, leading to proteomic diversity and functional alterations of proteins. These actions induce various neoantigens that hold prognostic significance contribute aspects cancer progression, including immune responses against cancer. The advent immunotherapy has remarkably revolutionized tumor therapy. In this regard, AS-derived are potent targets for vaccines chimeric antigen receptor (CAR) T cell therapies. review, we outline serve promising immunotherapeutic guide strategies. This evidence contributes deeper comprehension the complexity provides novel perspectives techniques precision medicine immunotherapy. Moreover, underscore obstacles awaited be addressed approach become clinically applicable.
Language: Английский
Citations
11
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 15
Published: Jan. 7, 2025
Virus-like particles (VLPs), as a unique form of nanocarrier, predominantly encompass hollow protein shells that exhibit analogous morphology and structure to naturally occurring viruses, yet devoid genetic material. VLPs are considered safe, easily modifiable, stable, making them suitable for preparation in various expression systems. They serve precise biological instruments with broad applications the field medical biology. Leveraging their structural attributes facile modification capabilities, can an effective platform delivery tumor antigens, thereby stimulating immune system facilitating eradication cells.
Language: Английский
Citations
1
Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 12, 2025
Abstract Uveal melanoma (UM) is a highly aggressive ocular malignancy associated with poor prognosis and significant resistance to conventional therapies, including surgical resection, chemotherapy, radiotherapy, which are often limited by their efficacy adverse side effects. Energy‐conversion‐based nanodynamic therapy, facilitates the generation of reactive oxygen species (ROS), has emerged as promising approach for cancer treatment. Here, development high‐performance multifunctional thermoelectric nanocatalysts, specifically Cu 5 FeS 3.6 Se 0.4 nanoparticles, optimized effective synergistic treatment UM reported. These nanoparticles exhibit remarkable photothermal, thermoelectric, chemodynamic properties that enhance therapeutic efficacy. Under near‐infrared light irradiation, generate localized hyperthermia, not only induces direct tumor cell ablation but also produces potentials facilitate ROS generation. Additionally, hyperthermia induced photothermal effects these accelerates Fenton‐like reaction, leading formation hydroxyl radicals therapy. The resultant induce oxidative stress within cells, promoting mechanisms such cuproptosis pyroptosis. integration effects, potentials, therapy single nanoplatform represents an efficient strategy treatment, addressing shortcomings traditional therapies offering means managing this cancer.
Language: Английский
Citations
1
Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 23, 2025
Abstract Engineered modifications of nanomaterials inspired by nature hold great promise for disease‐specific imaging and therapies. However, conventional polyethylene glycol modification is limited immune system rejection. The manipulation gold nanorods (Au NRs) modified endogenous proteins (eP@Au) reported as an engineered biomodulator enhanced breast tumor therapy. results show that eP@Au NRs neither activate inflammatory factors in vitro nor elicit rejection responses vivo. Tumor‐specific exhibit a dual‐modal capability trigger mild photothermal effect under near‐infrared light irradiation, enabling highly efficient therapy tumors. Transcriptome sequencing confirmatory experiments reveal the antitumor mainly attributed to repression PI3K‐Akt/MAPK signaling pathways at molecular level. This powerful surprising situ eP‐regulated biomodulation demonstrates advantages convenient fabrication, inert immunogenicity, biocompatibility, providing alternative strategy biomedical
Language: Английский
Citations
1
Journal for ImmunoTherapy of Cancer, Journal Year: 2025, Volume and Issue: 13(2), P. e010150 - e010150
Published: Feb. 1, 2025
Background Enhancing antigen cross-presentation is essential for the development of a tumor neoantigen vaccine. One approach to stimulate antigen-presenting cells (APCs) uptake neoantigens. Mycobacterium tuberculosis (MTb) contains pathogen-associated molecular patterns (PAMPs) recognized by APCs and adhesion molecules that facilitate MTb invasion APCs. Therefore, we suggest using as carrier enhance APC phagocytosis neoantigens, thereby promoting cross-presentation. Methods The successful preparation (phMTb) was confirmed through electron confocal microscopy. Fluorescence microscopy used detect PAMPs on phMTb well observe its role in aiding dendritic (DCs) into endosomes or lysosomes. Flow cytometry assess retention phMTb, investigate DCs, evaluate their activation maturation status, examine presentation analyze immune draining lymph nodes tissues. efficacy vaccine formulations combination with anti-programmed cell death protein 1 (PD-1) antibody therapy assessed MC38 mouse models. Adverse effects were evaluated H&E staining major organs, assessment reproductive capability detection biochemical indices. Results engineered porous hollow successfully encapsulated model without adjuvant CpG. retained surface, similar parental MTb, enhancing DC containing neoantigens Vaccines formulated facilitated maturation, activation, promoted migration phMTb-laden DCs nodes, effector memory CD8 + T lymphocyte function. In murine models, immunization phMTb-formulated vaccines elicited robust tumor-specific cytotoxic response minimal adverse effects. Additionally, vaccination effectively reversed tumor’s immune-suppressive microenvironment. Concurrent administration PD-1 exhibited significant synergistic therapeutic Conclusions results our study highlight potential clinical translation personalized carrier.
Language: Английский
Citations
1
Cancer Letters, Journal Year: 2025, Volume and Issue: unknown, P. 217616 - 217616
Published: March 1, 2025
Language: Английский
Citations
1
Small, Journal Year: 2024, Volume and Issue: 20(45)
Published: July 25, 2024
Abstract Immune checkpoint inhibitors (ICIs) offer promise in breaking through the treatment and survival dilemma of triple‐negative breast cancer (TNBC), yet only immunomodulatory subtype ≈5% TNBC patients respond as monotherapy due to lack effector immune cells (internal problem) physical barrier (external limitation) formed by cancer‐associated fibroblasts (CAFs). A hydrogel drug‐delivery platform, ALG@TBP‐2/Pt(0)/nintedanib (ALG@TPN), is designed induce strong functions dual elimination internal external tumor microenvironment (TME). Activated white light, type I II photodynamic therapy (PDT), TBP‐2 generates large amounts reactive oxygen species (ROS) intracellularly, oxidizing mitochondrial DNA (mtDNA). The unique catalase activity Pt(0) converts endogenous H 2 O , reducing anoxia‐limiting PDT enhancing ROS generation efficacy. Abundant can oxidize cytotoxic Pt(II), damaging nuclear (nDNA). Dual damage mtDNA nDNA might bi‐directionally activate cGAS/STING pathway enhance cell response. Besides, nintedanib demonstrates a significant inhibitory effect on CAFs, weakening deepening infiltration. Overall, study provides self‐oxygenating with “PDT/chemotherapy/anti‐CAFs” effect, triggering reshape TME. Both interventions increase anti‐TNBC responses.
Language: Английский
Citations
5
Proceedings of the National Academy of Sciences, Journal Year: 2025, Volume and Issue: 122(11)
Published: March 11, 2025
Pancreatic ductal adenocarcinoma (PDAC) is notoriously immune-resistant, limiting the clinical efficacy of single-agent immune modulators and thereby necessitating exploration multimodal immunotherapy combinations. Traditional approaches combining conventional checkpoint inhibitors with neoantigen vaccines have shown some promise in treating PDAC but are often compromised by intratumoral T lymphocyte exhaustion systemic toxicity. Hence, novel needed to address these challenges. Herein, we demonstrate that mRNA polymeric nanoparticles encoding anti-PD-1 antibodies situ at tumor site enhance therapeutic neoantigen-based vaccine for PDAC. This mRNA-based, antibody production strategy also protects tumor-infiltrating cells from PD-1 inhibition, potentially reducing toxicities induced inhibition. Our study may provide an innovative dual nanoparticle effective immunotherapy, as well cancer combination therapy other clinically approved drugs (e.g., β-elemene).
Language: Английский
Citations
0
Pathology - Research and Practice, Journal Year: 2025, Volume and Issue: 270, P. 155983 - 155983
Published: April 18, 2025
Language: Английский
Citations
0
Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11
Published: July 29, 2024
Polyphenols are a group of naturally occurring compounds that possess range biological properties capable potentially mitigating or preventing the progression age-related cognitive decline and Alzheimer's disease (AD). AD is chronic neurodegenerative known as one fast-growing diseases, especially in elderly population. Moreover, primary etiology dementia, it poses challenges for both familial societal structures, while also imposing significant economic strain. There currently no pharmacological intervention has demonstrated efficacy treating AD. While polyphenols have exhibited potential inhibiting pathological hallmarks AD, their limited bioavailability challenge therapeutic application. Furthermore, order to address constraints, several polymer nanoparticles being explored improved delivery systems optimize pharmacokinetic characteristics polyphenols. Polymer advantageous facilitating across blood-brain barrier, resulting efficient distribution within brain. This review focuses on amyloid-related diseases role them, addition discussing anti-amyloid effects applications polyphenol-based nanoparticles.
Language: Английский
Citations
3