Perspectives on recent advancements in energy harvesting, sensing and bio-medical applications of piezoelectric gels

Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(17), P. 6191 - 6220

Published: Jan. 1, 2023

This review highlights the recent progress in piezoelectric gels (also known as PiezoGels) comprised of polymers, ceramic oxides and supramolecular materials used for energy harvesting, sensing wound dressing.

Language: Английский

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Fundamental properties of smart hydrogels for tissue engineering applications: A review

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 254, P. 127882 - 127882

Published: Nov. 10, 2023

Language: Английский

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Dynamic matrices with DNA-encoded viscoelasticity for cell and organoid culture

Nature Nanotechnology, Journal Year: 2023, Volume and Issue: 18(12), P. 1463 - 1473

Published: Aug. 7, 2023

Abstract Three-dimensional cell and organoid cultures rely on the mechanical support of viscoelastic matrices. However, commonly used matrix materials lack control over key cell-instructive properties. Here we report fully synthetic hydrogels based DNA libraries that self-assemble with ultrahigh-molecular-weight polymers, forming a dynamic DNA-crosslinked (DyNAtrix). DyNAtrix enables computationally predictable systematic its viscoelasticity, thermodynamic kinetic parameters by changing sequence information. Adjustable heat activation allows homogeneous embedding mammalian cells. Intriguingly, stress-relaxation times can be tuned four orders magnitude, recapitulating characteristics living tissues. is self-healing, printable, exhibits high stability, cyto- haemocompatibility, controllable degradation. DyNAtrix-based human mesenchymal stromal cells, pluripotent stem canine kidney cysts trophoblast organoids show viability, proliferation morphogenesis. thus represents programmable versatile precision for advanced approaches to biomechanics, biophysics tissue engineering.

Language: Английский

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Plasma‐Enabled Graphene Quantum Dot Hydrogels as Smart Anticancer Drug Nanocarriers

Small, Journal Year: 2023, Volume and Issue: 19(20)

Published: Feb. 2, 2023

Abstract One of the major challenges on way to low‐cost, simple, and effective cancer treatments is lack smart anticancer drug delivery materials with requisite site‐specific microenvironment‐responsive properties. This work reports development plasma‐engineered nanocarriers (SDNCs) containing chitosan nitrogen‐doped graphene quantum dots (NGQDs) for in a pH‐responsive manner. Through customized microplasma processing, highly cross‐linked SDNC only 4.5% NGQD ratio can exhibit enhanced toughness up threefold higher than control group, avoiding commonly used high temperatures toxic chemical cross‐linking agents. The SDNCs demonstrate improved loading capability doxorubicin (DOX) via π–π interactions stable solid‐state photoluminescence monitor DOX release through Förster resonance energy transfer (FRET) mechanism. Moreover, loaded exhibits effects against cells during cytotoxicity tests at minimum concentration. Cellular uptake studies confirm that be successfully internalized into nucleus after 12 h incubation period. provides new insights smart, environmental‐friendly, biocompatible nanographene hydrogels next‐generation biomedical applications.

Language: Английский

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Targeted therapy of kidney disease with nanoparticle drug delivery materials

Bioactive Materials, Journal Year: 2024, Volume and Issue: 37, P. 206 - 221

Published: March 21, 2024

With the development of nanomedicine, nanomaterials have been widely used, offering specific drug delivery to target sites, minimal side effects, and significant therapeutic effects. The kidneys filtration reabsorption functions, with various potential cell types a complex structural environment, making strategies for kidney function protection recovery after injury complex. This also lays foundation application nanomedicine in diseases. Currently, evidence preclinical clinical settings supports feasibility targeted therapy diseases using based on nanomaterials. prerequisite treating is use carriers good biocompatibility, including nanoparticles, hydrogels, liposomes, micelles, dendrimer polymers, adenoviruses, lysozymes, elastin-like polypeptides. These precise renal uptake, longer half-life, organ distribution, protecting improving efficacy drugs they carry. Additionally, attention should be paid toxicity solubility carriers. While mentioned above used studies both vivo vitro, extensive trials are still needed ensure short-term long-term effects nano human body. review will discuss advantages limitations nanoscale carrier materials diseases, provide more comprehensive catalog nanocarrier materials, offer prospects their drug-loading applications.

Language: Английский

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A Label-Free Photoelectrochemical Biosensor Based on CRISPR/Cas12a System Responsive Deoxyribonucleic Acid Hydrogel and “Click” Chemistry

ACS Sensors, Journal Year: 2022, Volume and Issue: 7(10), P. 3153 - 3160

Published: Oct. 11, 2022

A novel label-free photoelectrochemical (PEC) biosensor is presented in this work. As a barrier, the DNA hydrogel could block coupling between g-C3N4 and CdS quantum dots (QDs). Therefore, extremely low photocurrent signals were obtained. The presence of target microRNA-21 can initiate rolling circle amplification (RCA) reaction, which turn produces many repeated sequences to activate CRISPR/Cas12a system. trans-cleavage activity system led degradation hydrogels efficiently. result, g-C3N4/CdS QDs heterojunction was formed through "click" chemistry. Through RCA system, sensitivity PEC improved significantly with detection limit 3.2 aM. proposed sensor also showed excellent selectivity be used detect actual samples. In addition, modular design facilitate different objects. Thus, responsive provides simple, sensitive, flexible way for analysis.

Language: Английский

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Recent advance in bioactive hydrogels for repairing spinal cord injury: material design, biofunctional regulation, and applications

Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)

Published: July 24, 2023

Abstract Functional hydrogels show potential application in repairing spinal cord injury (SCI) due to their unique chemical, physical, and biological properties functions. In this comprehensive review, we present recent advance the material design, functional regulation, SCI repair applications of bioactive hydrogels. Different from previously released reviews on three-dimensional scaffolds for repair, work focuses strategies design biologically regulation hydrogels, specifically aiming how these significant efforts can promoting performance SCI. We demonstrate various methods techniques fabrication with components such as DNA, proteins, peptides, biomass polysaccharides, biopolymers obtain including cell biocompatibility, self-healing, anti-bacterial activity, injectability, bio-adhesion, bio-degradation, other multi-functions The drugs/growth factors, polymers, nanoparticles, one-dimensional materials, two-dimensional materials highly effective treating are introduced discussed detail. This shows new viewpoints ideas synthesis state-of-the-art knowledges science nanotechnology, will bridge connection biomedicine, further inspire clinical biomedical fields.

Language: Английский

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Rational Design of DNA Hydrogels Based on Molecular Dynamics of Polymers

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(7)

Published: Oct. 11, 2023

Abstract In recent years, DNA has emerged as a fascinating building material to engineer hydrogel due its excellent programmability, which gained considerable attention in biomedical applications. Understanding the structure–property relationship and underlying molecular determinants of is essential precisely tailor macroscopic properties at level. this review, rational design principles networks based on dynamics polymers temporal scale, can be engineered via backbone rigidity crosslinking kinetics, are highlighted. By elucidating mechanisms theories, it aimed provide comprehensive overview how tunable kinetics lead desirable hydrogels, including mechanical properties, diffusive permeability, swelling behaviors, dynamic features. Furthermore, also discussed make hydrogels promising candidates for applications, such cell culture, tissue engineering, bio‐sensing, drug delivery.

Language: Английский

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Nonreleasing AgNP Colloids Composite Hydrogel with Potent Hemostatic, Photodynamic Bactericidal and Wound Healing-Promoting Properties

ACS Applied Materials & Interfaces, Journal Year: 2023, Volume and Issue: 15(14), P. 17742 - 17756

Published: April 3, 2023

Reactive oxygen species (ROS) produced by noble metallic nanoparticles under visible light is an effective way to combat drug-resistant bacteria colonized on the wound. However, photocatalytic efficiency of limited its self-aggregation in water media. Moreover, fast release ions from might engender cellular toxicity and hazardous environmental issues. Herein, we chose AgNPs, most common plasmonic nanoparticles, as example, modifying surface AgNPs with oleic acid n-butylamine imbedded them into calcium alginate (CA) hydrogel that holds tissue adhesion, rapid hemostatic, sunlight-sensitive antibacterial anti-inflammatory abilities, thus effectively promotes healing wounds. Unlike conventional AgNP-based materials, constrain colloids networks hinders leach Ag+. Nonetheless, CA/Ag hydrogels exhibit on-demand photodynamic efficacy due generation ROS light. In addition, can stop hemorrhage a mouse liver bleeding model their skin-adaptive flexibility adhesiveness. The potent sunlight-responsive activity kill multidrug-resistant both vitro (>99.999%) vivo (>99.9%), while diminished Ag+ guarantees biocompatibility. significantly wound process downregulation proinflammatory cytokines (TNF-α IL-6) rodent full-thickness cutaneous model. Overall, proposed multifunctional nanocomposite has excellent prospects advanced dressing.

Language: Английский

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Stimuli‐Responsive Self‐Degradable DNA Hydrogels: Design, Synthesis, and Applications

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(16)

Published: Jan. 28, 2023

Abstract DNA hydrogels play an increasingly important role in biomedicine and bioanalysis applications. Due to their high programmability, multifunctionality biocompatibility, they are often used as effective carriers for packing drugs, cells, or other bioactive cargoes vitro vivo. However, the stability of prevents in‐demand rapid release achieve a full therapeutic effect time. For bioanalysis, generation signals sometimes needs hydrogel be rapidly degraded when sensing target molecules. To meet these requirements, stimulus‐responsive designed. By responding different stimuli, self‐degradable can switch from gel solution quantitative precision cargo delivery. This review summarizes recently developed innovative methods designing stimuli‐responsive showed applications biomedicines fields. Challenges, well prospects, also discussed.

Language: Английский

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