A Whole‐Course‐Repair System Based on Neurogenesis‐Angiogenesis Crosstalk and Macrophage Reprogramming Promotes Diabetic Wound Healing

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(19)

Published: Feb. 22, 2023

Diabetic wound (DW) therapy is currently a big challenge in medicine and strategies to enhance neurogenesis angiogenesis have appeared be promising direction. However, the current treatments failed coordinate simultaneously, leading an increased disability rate caused by DWs. Herein, whole-course-repair system introduced hydrogel concurrently achieve mutually supportive cycle of neurogenesis-angiogenesis under favorable immune-microenvironment. This can first one-step packaged syringe for later situ local injections cover wounds long-termly accelerated healing via synergistic effect magnesium ions (Mg2+ ) engineered small extracellular vesicles (sEVs). The self-healing bio-adhesive properties make it ideal physical barrier At inflammation stage, formulation recruit bone marrow-derived mesenchymal stem cells sites stimulate them toward neurogenic differentiation, while providing immune microenvironment macrophage reprogramming. proliferation stage repair, robust occurs newly differentiated neural released Mg2+ , allowing regenerative take place at site. provides novel platform combined DW therapy.

Language: Английский

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Ultrasound-Augmented Multienzyme-like Nanozyme Hydrogel Spray for Promoting Diabetic Wound Healing

ACS Nano, Journal Year: 2023, Volume and Issue: 17(16), P. 15962 - 15977

Published: Aug. 3, 2023

Treatment of diabetic foot ulcers (DFU) needs to reduce inflammation, relieve hypoxia, lower blood glucose, promote angiogenesis, and eliminate pathogenic bacteria, but the therapeutic efficacy is greatly limited by diversity synergy drug functions as well DFU microenvironment itself. Herein, an ultrasound-augmented multienzyme-like nanozyme hydrogel spray was developed using hyaluronic acid encapsulated l-arginine ultrasmall gold nanoparticles Cu1.6O coloaded phosphorus doped graphitic carbon nitride nanosheets (ACPCAH). This possesses five types enzyme-like activities, including superoxide dismutase (SOD)-, catalase (CAT)-, glucose oxidase (GOx)-, peroxidase (POD)-, nitric oxide synthase (NOS)-like activities. The kinetics reaction mechanism sonodynamic/sonothermal synergistic enhancement SOD-CAT-GOx-POD/NOS cascade ACPCAH are fully investigated. Both in vitro vivo tests demonstrate that this can be activated thus accelerating wound healing effectively. study highlights a competitive approach based on nanozymes for development all-in-one therapies.

Language: Английский

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Engineered Living Materials for Advanced Diseases Therapy

Advanced Materials, Journal Year: 2023, Volume and Issue: unknown

Published: July 12, 2023

Abstract Natural living materials serving as biotherapeutics exhibit great potential for treating various diseases owing to their immunoactivity, tissue targeting, and other biological activities. In this review, the recent developments in engineered materials, including mammalian cells, bacteria, viruses, fungi, microalgae, plants, active derivatives that are used summarized. Further, future perspectives challenges of such material‐based discussed provide considerations advances biomedical applications.

Language: Английский

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Zinc‐Based Tannin‐Modified Composite Microparticulate Scaffolds with Balanced Antimicrobial Activity and Osteogenesis for Infected Bone Defect Repair

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(20)

Published: March 25, 2023

Treatment of infected bone defects is a major clinical challenge; bioactive materials combining sufficient antimicrobial activity and favorable osteogenic ability are urgently needed. In this study, through facile one-pot hydrothermal reaction zinc acetate in the presence tannic acid (TA), with or without silver nitrate (AgNO3 ), used to synthesize TA nanoparticles (Ag NPs) bulk-modified oxide (ZnO) (ZnO-TA ZnO-TA-Ag), which further composited zein fabricate porous microparticulate scaffolds for defect repair. Bulk modification significantly improves release rate antibacterial metal ions (Zn2+ >100 times that ZnO). Fast long-lasting (>35 d) Zn2+ Ag+ guaranteed capability excellent properties promoting differentiation marrow mesenchymal stem cells endogenous citric production mineralization providing considerable immunomodulatory M2 polarization macrophages. At same time, synchronously-released could scavenge reactive oxygen species (ROS) ROS produced by ions, effectively balancing osteogenesis sufficiently control infection while protecting surrounding tissue from damage, thus

Language: Английский

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Bioinspired wet adhesive carboxymethyl cellulose-based hydrogel with rapid shape adaptability and antioxidant activity for diabetic wound repair

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 334, P. 122014 - 122014

Published: March 4, 2024

Language: Английский

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Stimuli‐Responsive Hydrogels for Antibacterial Applications

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(22)

Published: May 9, 2024

Hydrogels have emerged as promising candidates for biomedical applications, especially in the field of antibacterial therapeutics, due to their unique structural properties, highly tunable physicochemical and excellent biocompatibility. The integration stimuli-responsive functions into hydrogels holds potential enhance properties therapeutic efficacy, dynamically responding different external or internal stimuli, such pH, temperature, enzymes, light. Therefore, this review describes applications hydrogel dressings responsive stimuli therapy. collaborative interaction between materials is discussed. This synergistic approach, contrast conventional materials, not only amplifies effect but also alleviates adverse side effects diminishes incidence multiple infections drug resistance. provides a comprehensive overview current challenges outlines future research directions hydrogels. It underscores imperative ongoing interdisciplinary aimed at unraveling mechanisms wound healing. understanding crucial optimizing design implementation Ultimately, aims offer scientific guidance development practical clinical application dressings.

Language: Английский

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All‐in‐One Self‐Powered Microneedle Device for Accelerating Infected Diabetic Wound Repair

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(13)

Published: Feb. 7, 2024

Abstract Diabetic wound healing remains a significant clinical challenge due to the complex microenvironment and attenuated endogenous electric field. Herein, novel all‐in‐one self‐powered microneedle device (termed TZ@mMN‐TENG) is developed by combining multifunctional carried tannin@ZnO microparticles (TZ@mMN) with triboelectric nanogenerator (TENG). In addition delivery of tannin Zn 2+ , TZ@mMN also effectively conducts electrical stimulation (ES) infected diabetic wounds. As device, TENG can convert biomechanical motion into exogenous ES accelerate healing. vitro experiment demonstrated that shows excellent conductive, high antioxidant ability, effective antibacterial properties against both Staphylococcus aureus Escherichia coli (>99% rates). Besides, TZ@mMN‐TENG promote cell proliferation migration. rat full‐thickness skin model eliminate bacteria, epidermal growth (regenerative epidermis: ≈303.3 ± 19.1 µm), enhance collagen deposition, inhibit inflammation (lower TNF‐α IL‐6 expression), angiogenesis (higher CD31 VEGF expression) repair. Overall, provides promising strategy for application in

Language: Английский

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Dextran‐Based Antibacterial Hydrogel Dressings for Accelerating Infected Wound Healing by Reducing Inflammation Levels

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(22)

Published: May 27, 2024

Infected wounds pose challenges such as exudate management, bacterial infections, and persistent inflammation, making them a significant challenge for modern dressings. To address these issues in infected more effectively, aerogel-hydrogel biphase gels based on dextran are developed. The gel introduced this study exhibits antibacterial anti-inflammatory properties the process of wound therapy, contributing to accelerated healing. aerogel phase exceptional water-absorption capabilities, rapidly soaking up from wound, thereby fostering clean hygienic healing microenvironment. Concurrently, is enriched with hydrogen sulfide donors. Following water absorption formation hydrogel phase, it enables sustained release around sites. experiments confirm that sulfide, by promoting M2 macrophage differentiation reducing levels inflammatory factors, effectively diminishes local inflammation at site. Furthermore, sodium copper chlorophyllin component within demonstrates effective through photodynamic antimicrobial providing viable solution infection challenges.

Language: Английский

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Recent advances of hydrogels as smart dressings for diabetic wounds

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(5), P. 1126 - 1148

Published: Jan. 1, 2024

This review highlights the latest progress of smart hydrogel dressings for bandaging, monitoring and therapy diabetic wounds.

Language: Английский

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Stimuli-responsive hydrogel dressing for wound healing

APL Materials, Journal Year: 2025, Volume and Issue: 13(1)

Published: Jan. 1, 2025

Wound healing is a complex, variable, and time-dynamic repair process. Wounds can be classified as acute wounds or chronic wounds, effective wound management still major challenge in clinical nursing settings. The microenvironment collectively regulated by internal biomolecules, external drugs, sanitation. Traditional dressings (powders, bandages, sponges, etc.) often have poor therapeutic effects during processes because they cannot respond to the dynamic changes over long-term. Stimulus-responsive biomaterials, which are activated various factors intrinsic influences, hold great promise for precise drug delivery controlled release. Various stimulus-responsive hydrogels been developed recent years, exhibiting range of “smart” properties, such interacting with wound, sensing conditions environmental changes, responding accordingly, thereby effectively promoting healing. This review discusses latest advancements used We introduce design scheme stimulus-response detail based on local biological/biochemical peculiarities (pH, reactive oxygen species glucose, enzymes, physical microenvironments (temperature, light, ultrasound, electric fields, etc.). Furthermore, we explore several promising tissue-engineered constructs (nanofibers, scaffolds, microneedles, microspheres). Finally, summarize basis active research challenges, current progress, development trends field.

Language: Английский

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