International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 12221 - 12255
Published: Nov. 1, 2024
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) enters the nasal cavity, penetrates epithelial cells through interaction of its spike protein with host cell receptor angiotensin-converting enzyme (ACE2) and then triggers a cytokine storm. We aimed to assess biocompatibility fullerenol nanoparticles C
Language: Английский
Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 501, P. 215550 - 215550
Published: Nov. 24, 2023
Language: Английский
Citations
25
Advanced Energy Materials, Journal Year: 2023, Volume and Issue: 13(46)
Published: Oct. 27, 2023
Abstract Buckminsterfullerene (C 60 ) and derivatives are significant in the synthesis of efficient electrocatalysts photocatalysts. This is because electron acceptor properties distinctive heterostructure(s) physicochemical characteristics. High‐performance photocatalysts important therefore conversions for clean energy. Here a critical assessment advances use C as heterostructures “electron buffers” catalysts reported. Methodologies preparing composite assessed categorized microscopic mechanisms boosting catalytic performance through materials including, semiconductors, carbon‐based metal‐free materials, metal nanoclusters, single atoms, metal–organic skeletons established. Important characterizations used with derivative composites contrasted practical challenges to development determined. A prospective on future directions likely outcomes high efficiency provided. It concluded that advantageous advanced structural integrity boosted transport. The findings expected be interest benefit researchers manufacturers formation buffer areas significantly performance.
Language: Английский
Citations
17
Advanced Materials, Journal Year: 2024, Volume and Issue: 36(32)
Published: May 30, 2024
Mucus is a dynamic biological hydrogel, composed primarily of the glycoprotein mucin, exhibits unique biophysical properties and forms barrier protecting cells against broad-spectrum viruses. Here, this work develops polyglycerol sulfate-based dendronized mucin-inspired copolymer (MICP-1) with ≈10% repeating units activated disulfide as cross-linking sites. Cryo-electron microscopy (Cryo-EM) analysis MICP-1 reveals an elongated single-chain fiber morphology. shows potential inhibitory activity many viruses such herpes simplex virus 1 (HSV-1) SARS-CoV-2 (including variants Delta Omicron). produces hydrogels viscoelastic similar to healthy human sputum tuneable microstructures using linear branched polyethylene glycol-thiol (PEG-thiol) cross-linkers. Single particle tracking microrheology, electron paramagnetic resonance (EPR) cryo-scanning (Cryo-SEM) are used characterize network structures. The synthesized exhibit self-healing properties, along that through reduction. A transwell assay investigate hydrogel's protective viral infection HSV-1. Live-cell confirms these can protect underlying from by trapping virus, due both morphology anionic multivalent effects. Overall, novel generates mucus-mimetic on multi-gram scale. These be models for disulfide-rich airway mucus research, biomaterials.
Language: Английский
Citations
6
Deleted Journal, Journal Year: 2023, Volume and Issue: 2(1), P. 34 - 57
Published: May 10, 2023
In December 2019, an outbreak of unknown pneumonia emerged in Wuhan City, Hubei Province, China. It was later identified as the SARS-CoV-2 virus and has since infected over 9 million people more than 213 countries worldwide. Massive papers on topic that have already been published are necessary to be analyzed discussed. This paper used combination systematic literature network analysis content develop a comprehensive discussion related use nanotechnology materials environmental human protection. Its is shown various efforts made control transmission this pandemic. Nanotechnology plays crucial role modern vaccine design, nanomaterials essential tools for antigen delivery, adjuvants, mimics viral structures. addition, also reported protection defence treating To eradicate pandemics now future, successful treatments must enable rapid discovery, scalable manufacturing, global distribution. review, we discuss current approaches COVID-19 development highlight critical combating body environment.
Language: Английский
Citations
16
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(38)
Published: June 18, 2024
Abstract In the antimicrobial resistance era, carbon‐based nanomaterials (CBNs) such as fullerenes, carbon dots, graphene, and their derivatives are promising therapeutic tools in combating viral diseases. This review shows that these materials have broad‐spectrum antiviral activity against 33 viruses belonging to different Baltimore groups. CBNs also exhibit bacteria fungi possess a low risk of selecting for resistance, since primary mode action involves physically damaging microbes. offer additional properties, including enhanced effectiveness under diverse types irradiation facilitating immune responses. Their potential agents is still its infancy future research should focus on toxicity, mechanisms, pharmacokinetics, bioavailability. They preventing transmission diseases use face masks, shields, hospital airport surfaces, elevators, among others. It anticipated will play an increasingly significant role fight infectious
Language: Английский
Citations
5
JACS Au, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 6, 2025
Interactions of polyelectrolytes (PEs) with proteins play a crucial role in numerous biological processes, such as the internalization virus particles into host cells. Although docking, machine learning methods, and molecular dynamics (MD) simulations are utilized to estimate binding poses free energies small-molecule drugs proteins, quantitative prediction thermodynamics PE-based presents significant obstacle computer-aided drug design. This is due sluggish PEs caused by their size strong charge-charge correlations. In this paper, we introduce advanced sampling methods based on force-spectroscopy setup theoretical modeling overcome barrier. We exemplify our method explicit solvent all-atom MD interactions between anionic that show antiviral properties, namely heparin linear polyglycerol sulfate (LPGS), SARS-CoV-2 spike protein receptor domain (RBD). Our for free-energy LPGS wild-type RBD matches experimentally measured dissociation constants within thermal energy, k B T, correctly reproduces experimental PE-length dependence. find binds Delta-variant an additional gain 2.4 compared RBD, presence two mutated cationic residues contributing electrostatic energy gain. LPGS-RBD dominated enthalpy driven, though large entropy-enthalpy compensation. applicable general polymer adsorption phenomena predicts precise reconfigurational friction needed drug-delivery
Language: Английский
Citations
0
iScience, Journal Year: 2025, Volume and Issue: 28(3), P. 111944 - 111944
Published: Feb. 4, 2025
Membrane technology, through innovative approaches such as nanocomposite membranes, membrane bioreactors, and electrocatalytic reactors, offers a synergistic platform for pathogen removal. This review examines recent advancements in modifications aimed at optimizing virus removal efficiency. It outlines various mechanisms employed these innovations, including size exclusion, electronic interactions, hydrophobic hydrophilic inactivation. By systematically discussing the intrinsic properties of viruses that affect their interactions with highlights potential advanced functional materials tailored to specific processes. Emphasis is placed on necessity adjusting pore sizes enhancing other physical chemical (e.g., electrochemical oxidation performance) improve efficacy. Overall, this comprehensively assesses technologies, comparing effectiveness providing theoretical insights practical guidance utilizing safeguard water against viral contaminants.
Language: Английский
Citations
0
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(19), P. 14471 - 14471
Published: Sept. 23, 2023
The disease of SARS-CoV-2 has caused considerable morbidity and mortality globally. Spike proteins on the surface allow it to bind with human cells, leading infection. Fullerenes their derivatives are promising inhibitors drug-delivery vehicles. In this study, Gaussian accelerated molecular dynamics simulations Markov state model were employed delve into inhibitory mechanism Fullerene–linear-polyglycerol-b-amine sulfate (F–LGPS) spike proteins. During was discovered that fullerene can operate at interface receptor-binding domain (RBD) N-terminal (NTD), keeping structural domains in a downward conformation. It also observed F-LGPS demonstrated superior effects XBB variant comparison wild-type variant. This study yielded invaluable insights for potential development efficient therapeutics targeting protein SARS-CoV-2.
Language: Английский
Citations
7
Microporous and Mesoporous Materials, Journal Year: 2023, Volume and Issue: 367, P. 112975 - 112975
Published: Dec. 30, 2023
Language: Английский
Citations
7
Smart Medicine, Journal Year: 2023, Volume and Issue: 2(4)
Published: Nov. 1, 2023
Fullerenes are a class of carbon nanomaterials that find wide range applications in biomedical fields, especially for photodynamic cancer therapy because its photosensitive effect. However, hydrophobic fullerenes can only be dispersed organic solvents which hinders their applications. Here, we report facile method to prepare highly water-dispersible fullerene (C
Language: Английский
Citations
6