Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(5), P. 1364 - 1364
Published: April 28, 2023
Polysaccharides
are
naturally
occurring
complex
molecules
with
exceptional
physicochemical
properties
and
bioactivities.
They
originate
from
plant,
animal,
microbial-based
resources
processes
can
be
chemically
modified.
The
biocompatibility
biodegradability
of
polysaccharides
enable
their
increased
use
in
nanoscale
synthesis
engineering
for
drug
encapsulation
release.
This
review
focuses
on
sustained
release
studies
the
fields
nanotechnology
biomedical
sciences.
Particular
emphasis
is
placed
kinetics
relevant
mathematical
models.
An
effective
model
used
to
envision
behavior
specific
polysaccharide
matrices
reduce
impending
experimental
trial
error,
saving
time
resources.
A
robust
also
assist
translating
vitro
vivo
experiments.
main
aim
this
demonstrate
that
any
study
establishes
should
accompanied
by
a
detailed
analysis
modeling
since
not
only
involves
diffusion
degradation
but
surface
erosion,
complicated
swelling
dynamics,
crosslinking,
drug-polymer
interactions.
As
such,
first
part,
we
discuss
classification
role
various
applications
later
elaborate
pharmaceutical
ionic
gelling,
stabilization,
cross-linking,
grafting,
drugs.
We
document
several
models
applied
hydrogels,
nanofibers,
nanoparticles
conclude
that,
at
times,
more
than
one
accurately
describe
profiles,
indicating
existence
mechanisms
running
parallel.
Finally,
future
opportunities
advanced
nanoengineered
theranostic
aptitudes
clinical
applications.
Biomedicine & Pharmacotherapy,
Journal Year:
2023,
Volume and Issue:
170, P. 115976 - 115976
Published: Dec. 3, 2023
T
helper
(Th)
cells
have
received
extensive
attention
owing
to
their
indispensable
roles
in
anti-tumor
immune
responses.
Th1
and
Th2
are
two
key
subsets
of
Th
that
exist
relative
equilibrium
through
the
secretion
cytokines
suppress
respective
response.
When
type
cytokine
tumor
microenvironment
is
altered,
this
may
be
disrupted,
leading
a
shift
from
Th1/Th2
imbalance
one
decisive
factors
development
malignant
tumors.
Therefore,
focusing
on
balance
responses
enable
future
breakthroughs
cancer
immunotherapy.
Polysaccharides
can
regulate
between
characteristic
profiles,
thereby
improving
microenvironment.
To
our
knowledge,
study
most
comprehensive
assessment
regulation
by
polysaccharides.
Herein,
we
systematically
summarized
intrinsic
molecular
mechanisms
polysaccharides
provide
new
perspective
potential
target
drugs
for
improved
immunity
delayed
progression.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(34)
Published: May 28, 2024
Abstract
T
lymphocytes
play
a
central
role
in
immunotherapy,
utilizing
physical
interactions
to
actively
inhibit
the
development
of
metastases.
However,
tumor
immune
privilege
and
heterogeneity
pose
challenges
by
protecting
against
attacks
limiting
cell
infiltration
into
tumors,
particularly
invasive
metastatic
clusters.
Here,
penetrating
magnetic
particles
(TUP)
containing
cascade‐responsive
membrane‐mimetic
copolymer
(zwitterionic
2‐methacryloyloxyethyl
phosphorylcholine‐co‐3‐hydroxypyridin‐4‐one,
PH)
cuproptosis
molecules
(elesclomol‐copper,
EsCu)
for
programming
is
developed.
The
intravenously
injected
TUP
accumulates
at
via
charge
conversion
PH
hyperthermia
effects
TUP.
In
clusters,
ES
Cu,
triggered
intracellular
environments
hyperthermia,
are
readily
released.
Cu
simultaneously
induce
cancer
cells
stimulate
responses.
This
process
destroys
self‐defense
mechanisms
exacerbates
cytotoxicity.
therapies
facilitate
release
tumor‐associated
antigens,
including
neoantigens
damage‐associated
molecular
patterns.
Following
this,
3‐hydroxypyridin‐4‐one
groups
on
act
as
antigen
reservoirs,
transporting
autologous
antigens
dendritic
cells,
thereby
inducing
prolonged
activation.
acts
an
reservoir
copper
apoptosis‐mediated
lung
metastasis,
promoting
accumulation
clusters
effectively
preventing
progression
tumors.
Pharmaceutics,
Journal Year:
2025,
Volume and Issue:
17(3), P. 375 - 375
Published: March 15, 2025
Recent
progress
in
material
science
has
led
to
the
development
of
new
drug
delivery
systems
that
go
beyond
conventional
approaches
and
offer
greater
accuracy
convenience
application
therapeutic
agents.
This
review
discusses
evolutionary
role
nanocarriers,
hydrogels,
bioresponsive
polymers
enhanced
release,
target
accuracy,
bioavailability.
Oncology,
chronic
disease
management,
vaccine
are
some
applications
explored
this
paper
show
how
these
materials
improve
results,
counteract
multidrug
resistance,
allow
for
sustained
localized
treatments.
The
also
translational
barriers
bringing
advanced
into
clinical
setting,
which
include
issues
biocompatibility,
scalability,
regulatory
approval.
Methods
overcome
challenges
surface
modifications
reduce
immunogenicity,
scalable
production
methods
such
as
microfluidics,
harmonization
systems.
In
addition,
convergence
artificial
intelligence
(AI)
machine
learning
(ML)
is
opening
frontiers
personalized
medicine.
These
technologies
predictive
modeling
real-time
adjustments
optimize
needs
individual
patients.
use
can
be
applied
rare
underserved
diseases;
thus,
strategies
gene
therapy,
orphan
drugs
development,
global
distribution
may
hopes
millions
