Nanoformulations in Pharmaceutical and Biomedical Applications: Green Perspectives

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(11), P. 5842 - 5842

Published: May 27, 2024

This study provides a brief discussion of the major nanopharmaceuticals formulations as well impact nanotechnology on future pharmaceuticals. Effective and eco-friendly strategies biofabrication are also highlighted. Modern approaches to designing pharmaceutical nanoformulations (e.g., 3D printing, Phyto-Nanotechnology, Biomimetics/Bioinspiration, etc.) outlined. paper discusses need use natural resources for “green” design new with therapeutic efficiency. Nanopharmaceuticals research is still in its early stages, preparation nanomaterials must be carefully considered. Therefore, safety long-term effects not overlooked. The testing represents an essential point their further applications. Vegetal scaffolds obtained by decellularizing plant leaves represent valuable, bioinspired model nanopharmaceutical that avoids using animals. Nanoformulations critical various fields, especially pharmacy, medicine, agriculture, material science, due unique properties advantages over conventional allows improved solubility, bioavailability, targeted drug delivery, controlled release, reduced toxicity. have transitioned from experimental stages being vital component clinical practice, significantly improving outcomes medical fields cancer treatment, infectious diseases, neurological disorders, personalized advanced diagnostics. Here key points highlighting importance. significant challenges, opportunities, directions mentioned final section.

Language: Английский

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Smart Nano-Hybrid Metal-Organic Frameworks: Revolutionizing Advancements, Applications, and Challenges in Biomedical Therapeutics and Diagnostics

Hybrid Advances, Journal Year: 2025, Volume and Issue: unknown, P. 100406 - 100406

Published: Feb. 1, 2025

Language: Английский

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Brain-specific targeted delivery of therapeutic agents using metal–organic framework-based nanomedicine

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 514, P. 215926 - 215926

Published: May 9, 2024

Language: Английский

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Nanomaterials that Aid in the Diagnosis and Treatment of Alzheimer's Disease, Resolving Blood–Brain Barrier Crossing Ability

Advanced Science, Journal Year: 2024, Volume and Issue: 11(38)

Published: Aug. 5, 2024

As a form of dementia, Alzheimer's disease (AD) suffers from no efficacious cure, yet AD treatment is still imperative, as it ameliorates the symptoms or prevents deteriorating maintains current status to longest extent. The human brain most sensitive and complex organ in body, which protected by blood-brain barrier (BBB). This induces difficulty curing drugs nanomaterials that are much inhibited reaching lesion site. Thus, BBB crossing capability drug delivery system remains significant challenge development neurological therapeutics. Fortunately, nano-enabled systems possess promising potential achieve multifunctional diagnostics/therapeutics against various targets owing their intriguing advantages nanocarriers, including easy multifunctionalization on surfaces, high surface-to-volume ratio with large payloads, ability cross BBB, making them capable conquering limitations conventional candidates. review, focuses diagnosis treatment, will provide an insightful vision conducive AD-related nanomaterials.

Language: Английский

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Advances in metal-organic framework-based drug delivery systems

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125380 - 125380

Published: Feb. 1, 2025

Language: Английский

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An investigation on the structural stability of ZIF-8 in water versus water-derived oxidative species in aqueous environment

Microporous and Mesoporous Materials, Journal Year: 2023, Volume and Issue: 366, P. 112934 - 112934

Published: Dec. 22, 2023

Language: Английский

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Metal–Organic Frameworks for Nerve Repair and Neural Stem Cell Therapy

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 34(3)

Published: Oct. 15, 2023

Abstract Recently, neurological disorders have led to a growing global burden of fatalities and disabilities. The limited capacity for natural self‐regeneration poses significant challenge in repairing nervous system injuries, which is closely related the complex microenvironment nonregenerative nature neurons. Metal–organic frameworks (MOFs), with their distinctive structure properties including high surface area, porosity, tunability, stimuli‐responsive behavior, biocompatibility, biodegradability, stand as an auspicious platform devising therapeutic strategies aiming at nerve regeneration repair. By taking advantage these characteristics, researchers opportunity explore innovative methods endogenous stimulation, magnetic response therapy, phototherapy, ultrasound drug delivery systems treatment diseases. Moreover, MOFs‐based stem cell therapy also developed inhibit neuroinflammation oxidative stress, promote axon growth, regulate differentiation, regeneration, finally restore function injured nerves. In this paper, preparation strategy biological characteristics MOFs, highlighting applications injuries treating neural cells presented. Finally, outlook on future development challenges field neuroscience concerning MOFs provided.

Language: Английский

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Amyloid detection in neurodegenerative diseases using MOFs

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(19), P. 4553 - 4573

Published: Jan. 1, 2024

Neurodegenerative diseases (amyloid such as Alzheimer's and Parkinson's), stemming from protein misfolding aggregation, encompass a spectrum of disorders with severe systemic implications. Timely detection is pivotal in managing these owing to their significant impact on organ function high mortality rates. The diverse array amyloid disorders, spanning localized manifestations, underscores the complexity conditions highlights need for advanced methods. Traditional approaches have focused identifying biomarkers using imaging techniques (PET MRI) or invasive procedures. However, recent efforts use metal-organic frameworks (MOFs), versatile class materials known unique properties, revolutionizing disease detection. porosity, customizable structures, biocompatibility MOFs enable integration biomolecules, laying groundwork highly sensitive specific biosensors. These sensors been employed electrochemical photophysical that target species under neurodegenerative conditions. adaptability allows precise quantification proteins, offering potential advancements early diagnosis management. This review article delves into how contribute detecting by categorizing uses based different sensing methods, (EC), electrochemiluminescence (ECL), fluorescence, Förster resonance energy transfer (FRET), up-conversion luminescence (ULRET), photoelectrochemical (PEC) sensing. drawbacks MOF biosensors challenges encountered field are also briefly explored our perspective.

Language: Английский

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Advance in metal–organic frameworks hybrids-based biosensors

Microchemical Journal, Journal Year: 2024, Volume and Issue: 206, P. 111441 - 111441

Published: Aug. 16, 2024

Language: Английский

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Modification sub-nano Zn-Co Metal-Organic framework for electrochemical detection of neurotransmitter

Microchemical Journal, Journal Year: 2023, Volume and Issue: 197, P. 109852 - 109852

Published: Dec. 26, 2023

Language: Английский

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