Cytotoxicity and Biocompatibility of Metal-Organic Frameworks DOI
Bahareh Farasati Far, Shaghayegh AdibAmini, Ali Pourmolaei

et al.

ACS symposium series, Journal Year: 2024, Volume and Issue: unknown, P. 69 - 105

Published: March 5, 2024

Metal-organic frameworks (MOFs) have garnered significant attention as versatile materials with diverse applications in various scientific domains. Their unique structural characteristics and tunable properties make them promising candidates for biomedical such drug delivery, imaging, tissue engineering. However, the cytotoxicity biocompatibility of MOFs are critical con­sid­er­a­tions that must be thoroughly evaluated to ensure their safe effective use biological systems. The impact MOF physicochemical on cellular uptake mechanisms intracellular fate is examined, shedding light underlying MOF-cell interactions. Moving beyond vitro evaluations, chapter delves into vivo studies elucidate biodistribution, clearance, long-term effects living organisms. Furthermore, examines strategies enhancing through surface modifications, encapsulation, co-delivery approaches. integration computational modeling predicting behavior within systems also discussed, offering insights rational design principles minimizing cytotoxic effects. In conclusion, this underscores significance understanding context applications. As continue advance frontier nanomedicine, safety profile remains paramount. A comprehensive evaluation interactions, combined innovative strategies, will pave way development MOF-based therapeutics diagnostics offer efficacious bio­com­pat­ible solutions pressing medical challenges.

Language: Английский

Nanoformulations in Pharmaceutical and Biomedical Applications: Green Perspectives DOI Open Access
Sanja Petrović, Bogdan Biță, Marcela Elisabeta Barbinta-Patrascu

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(11), P. 5842 - 5842

Published: May 27, 2024

This study provides a brief discussion of the major nanopharmaceuticals formulations as well impact nanotechnology on future pharmaceuticals. Effective and eco-friendly strategies biofabrication are also highlighted. Modern approaches to designing pharmaceutical nanoformulations (e.g., 3D printing, Phyto-Nanotechnology, Biomimetics/Bioinspiration, etc.) outlined. paper discusses need use natural resources for “green” design new with therapeutic efficiency. Nanopharmaceuticals research is still in its early stages, preparation nanomaterials must be carefully considered. Therefore, safety long-term effects not overlooked. The testing represents an essential point their further applications. Vegetal scaffolds obtained by decellularizing plant leaves represent valuable, bioinspired model nanopharmaceutical that avoids using animals. Nanoformulations critical various fields, especially pharmacy, medicine, agriculture, material science, due unique properties advantages over conventional allows improved solubility, bioavailability, targeted drug delivery, controlled release, reduced toxicity. have transitioned from experimental stages being vital component clinical practice, significantly improving outcomes medical fields cancer treatment, infectious diseases, neurological disorders, personalized advanced diagnostics. Here key points highlighting importance. significant challenges, opportunities, directions mentioned final section.

Language: Английский

Citations

22
Smart Nano-Hybrid Metal-Organic Frameworks: Revolutionizing Advancements, Applications, and Challenges in Biomedical Therapeutics and Diagnostics DOI Creative Commons
Dilip Kumar Chandra, Awanish Kumar, Chinmaya Mahapatra

et al.

Hybrid Advances, Journal Year: 2025, Volume and Issue: unknown, P. 100406 - 100406

Published: Feb. 1, 2025

Language: Английский

Citations

2
Brain-specific targeted delivery of therapeutic agents using metal–organic framework-based nanomedicine DOI
Zongsu Han, Muzhaozi Yuan, Nguyen Nguyen

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 514, P. 215926 - 215926

Published: May 9, 2024

Language: Английский

Citations

10
Nanomaterials that Aid in the Diagnosis and Treatment of Alzheimer's Disease, Resolving Blood–Brain Barrier Crossing Ability DOI Creative Commons

Qingting Song,

Junyou Li, Ting Li

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(38)

Published: Aug. 5, 2024

As a form of dementia, Alzheimer's disease (AD) suffers from no efficacious cure, yet AD treatment is still imperative, as it ameliorates the symptoms or prevents deteriorating maintains current status to longest extent. The human brain most sensitive and complex organ in body, which protected by blood-brain barrier (BBB). This induces difficulty curing drugs nanomaterials that are much inhibited reaching lesion site. Thus, BBB crossing capability drug delivery system remains significant challenge development neurological therapeutics. Fortunately, nano-enabled systems possess promising potential achieve multifunctional diagnostics/therapeutics against various targets owing their intriguing advantages nanocarriers, including easy multifunctionalization on surfaces, high surface-to-volume ratio with large payloads, ability cross BBB, making them capable conquering limitations conventional candidates. review, focuses diagnosis treatment, will provide an insightful vision conducive AD-related nanomaterials.

Language: Английский

Citations

6
Metal–Organic Frameworks for Nerve Repair and Neural Stem Cell Therapy DOI

Ling Meng,

Na Ren,

Mengwei Dong

et al.

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 34(3)

Published: Oct. 15, 2023

Abstract Recently, neurological disorders have led to a growing global burden of fatalities and disabilities. The limited capacity for natural self‐regeneration poses significant challenge in repairing nervous system injuries, which is closely related the complex microenvironment nonregenerative nature neurons. Metal–organic frameworks (MOFs), with their distinctive structure properties including high surface area, porosity, tunability, stimuli‐responsive behavior, biocompatibility, biodegradability, stand as an auspicious platform devising therapeutic strategies aiming at nerve regeneration repair. By taking advantage these characteristics, researchers opportunity explore innovative methods endogenous stimulation, magnetic response therapy, phototherapy, ultrasound drug delivery systems treatment diseases. Moreover, MOFs‐based stem cell therapy also developed inhibit neuroinflammation oxidative stress, promote axon growth, regulate differentiation, regeneration, finally restore function injured nerves. In this paper, preparation strategy biological characteristics MOFs, highlighting applications injuries treating neural cells presented. Finally, outlook on future development challenges field neuroscience concerning MOFs provided.

Language: Английский

Citations

13
Amyloid detection in neurodegenerative diseases using MOFs DOI

Ketan Maru,

Amarendra Singh, Ritambhara Jangir

et al.

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(19), P. 4553 - 4573

Published: Jan. 1, 2024

Neurodegenerative diseases (amyloid such as Alzheimer's and Parkinson's), stemming from protein misfolding aggregation, encompass a spectrum of disorders with severe systemic implications. Timely detection is pivotal in managing these owing to their significant impact on organ function high mortality rates. The diverse array amyloid disorders, spanning localized manifestations, underscores the complexity conditions highlights need for advanced methods. Traditional approaches have focused identifying biomarkers using imaging techniques (PET MRI) or invasive procedures. However, recent efforts use metal-organic frameworks (MOFs), versatile class materials known unique properties, revolutionizing disease detection. porosity, customizable structures, biocompatibility MOFs enable integration biomolecules, laying groundwork highly sensitive specific biosensors. These sensors been employed electrochemical photophysical that target species under neurodegenerative conditions. adaptability allows precise quantification proteins, offering potential advancements early diagnosis management. This review article delves into how contribute detecting by categorizing uses based different sensing methods, (EC), electrochemiluminescence (ECL), fluorescence, Förster resonance energy transfer (FRET), up-conversion luminescence (ULRET), photoelectrochemical (PEC) sensing. drawbacks MOF biosensors challenges encountered field are also briefly explored our perspective.

Language: Английский

Citations

5
An investigation on the structural stability of ZIF-8 in water versus water-derived oxidative species in aqueous environment DOI Creative Commons
Niladri Talukder, Yudong Wang, Bharath Babu Nunna

et al.

Microporous and Mesoporous Materials, Journal Year: 2023, Volume and Issue: 366, P. 112934 - 112934

Published: Dec. 22, 2023

Language: Английский

Citations

11
Applications of 2D Nanomaterials in Neural Interface DOI Open Access

Shuchun Gou,

Siyi Yang,

Yuhang Cheng

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(16), P. 8615 - 8615

Published: Aug. 7, 2024

Neural interfaces are crucial conduits between neural tissues and external devices, enabling the recording modulation of activity. However, with increasing demand, simple no longer adequate to meet requirements for precision, functionality, safety. There three main challenges in fabricating advanced interfaces: sensitivity, heat management, biocompatibility. The electrical, chemical, optical properties 2D nanomaterials enhance sensitivity various types interfaces, while newly developed do not exhibit adverse reactions terms management Additionally, can further improve functionality these including magnetic resonance imaging (MRI) compatibility, stretchability, drug delivery. In this review, we examine recent applications focusing on their contributions enhancing performance functionality. Finally, summarize advantages disadvantages nanomaterials, analyze importance biocompatibility testing propose that improving developing composite material structures interface will continue lead forefront field.

Language: Английский

Citations

4
Advance in metal–organic frameworks hybrids-based biosensors DOI
Wei Chen,

Yushuo Tan,

Haonan Zheng

et al.

Microchemical Journal, Journal Year: 2024, Volume and Issue: 206, P. 111441 - 111441

Published: Aug. 16, 2024

Language: Английский

Citations

4
Antioxidant Activity of Metal-Organic Frameworks DOI
Bahareh Farasati Far

ACS symposium series, Journal Year: 2024, Volume and Issue: unknown, P. 107 - 146

Published: March 5, 2024

Metal–organic frameworks (MOFs) have emerged as a captivating class of porous materials with diverse applications in various scientific domains. This chapter focuses on understanding the antioxidant activity MOFs, novel aspect that has received much interest recent years. Antioxidants are critical reducing oxidative stress and its adverse effects biological systems. their complicated structure customizable characteristics, provide platform for developing materials. The starts an overview human health environment. It then delves into unique structural characteristics MOFs contribute to potential effective antioxidants. design strategies tailoring properties discussed, encompassing incorporation transition metals, organic ligands, functional groups. Moreover, methodologies employed evaluating critically examined, both vitro vivo approaches.

Language: Английский

Citations

3