ACS Applied Bio Materials,
Journal Year:
2024,
Volume and Issue:
7(11), P. 7535 - 7543
Published: Oct. 12, 2024
The
search
for
drug
nanocarriers
with
stimuli-responsive
properties
and
high
payloads
targeted
delivery
precision
medicine
is
currently
a
focal
point
of
biomedical
research,
but
this
endeavor
still
encounters
various
challenges.
Herein,
porous
organic
cage
(POC)
applied
to
paclitaxel
(PTX)
cancer
therapy
the
first
time.
Specifically,
water-soluble,
stable,
biocompatible
POC-based
nanocapsules
(PTX@POC@RH40)
PTX
encapsulation
efficiency
over
98%
can
be
synthesized
by
simply
grafting
nonionic
surfactant
(Polyoxyl
40
hydrogenated
castor
oil,
RH40)
on
POC
surface.
These
PTX@POC@RH40
demonstrate
remarkable
stability
more
than
week
without
aggregation
exhibit
pH-responsive
behavior
under
acidic
conditions
(pH
5.5)
display
sustained
release
at
both
pH
7.4
5.5.
Intravenous
administration
led
3.5-fold
increase
in
bioavailability
compared
free
group
rats.
Moreover,
vivo
mouse
model
experiments
involving
4T1
subcutaneous
breast
tumors
revealed
that
exhibited
enhanced
anticancer
efficacy
minimal
toxicity
PTX.
findings
underscore
potential
POCs
as
promising
therapeutic
applications.
Molecules,
Journal Year:
2023,
Volume and Issue:
28(23), P. 7750 - 7750
Published: Nov. 24, 2023
Advances
in
nanotechnology
have
brought
innovations
to
cancer
therapy.
Nanoparticle-based
anticancer
drugs
achieved
great
success
from
bench
bedside.
However,
insufficient
therapy
efficacy
due
various
physiological
barriers
the
body
remains
a
key
challenge.
To
overcome
these
biological
and
improve
therapeutic
of
cancers,
multistage
self-assembled
nanomaterials
with
advantages
stimuli-responsiveness,
programmable
delivery,
immune
modulations
provide
opportunities.
In
this
review,
we
describe
typical
for
nanomedicines,
discuss
recent
achievements
stimuli-responsive
drug
highlighting
delivery
nanomaterials,
situ
transformable
immune-reprogramming
nanomaterials.
Ultimately,
perspective
future
opportunities
challenges
immunotherapy.
Alexandria Engineering Journal,
Journal Year:
2024,
Volume and Issue:
99, P. 271 - 281
Published: May 13, 2024
Lung
cancer
remains
as
the
leading
cause
of
cancer-related
fatalities
globally,
posing
significant
challenges
to
conventional
treatment
methods,
particularly
in
advanced
stages
where
limitations
and
adverse
effects
are
prevalent.
Nanotechnology
offers
promising
solutions
enhance
lung
therapy.
Inorganic
nanomaterials,
such
metal
nanoparticles,
rare
earth
elements,
carbonaceous
materials,
exhibit
unique
properties
that
can
address
these
challenges.
Metal
nanoparticles
facilitate
targeted
drug
delivery,
biosensing,
imaging,
while
elements
demonstrate
selective
cytotoxic
imaging
capabilities.
Carbonaceous
materials
find
applications
biosensing
including
carbon
ion
radiotherapy.
These
advancements
inorganic
nanomaterials
present
an
opportunity
revolutionize
treatment,
potentially
improved
outcomes
better
patient
well-being.
This
paper
focuses
on
recent
progress
utilizing
for
treating
cancer,
aiming
provide
a
clearer
understanding
their
benefits
compared
treatments,
along
with
in-depth
examination
associated
effects.
The Analyst,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 1, 2024
The
multi-module
biosensing
applications
based
on
metal
nanoparticles
in
terms
of
sensing
principle,
sensitivity,
and
accuracy
are
summarized
visualized.
American Journal of Cancer Research,
Journal Year:
2024,
Volume and Issue:
14(8), P. 3935 - 3961
Published: Jan. 1, 2024
The
nuclear
factor-erythroid
2-related
factor
2
(Nrf2)
is
able
to
control
the
redox
balance
in
cells
responding
oxidative
damage
and
other
stress
signals.
Nrf2
upregulation
can
elevate
levels
of
antioxidant
enzymes
support
against
death.
In
spite
protective
function
physiological
conditions,
stimulation
cancer
has
been
favour
tumorigenesis.
Since
dysregulation
molecular
pathways
mutations/deletions
are
common
tumors,
be
a
promising
therapeutic
target.
overexpression
prevent
cell
death
tumor
by
increasing
survival
rate
cells,
ensures
carcinogenesis.
Moreover,
induction
promote
invasion
metastasis
cells.
stimulates
EMT
increase
metastasis.
Furthermore,
regarding
Nrf2,
its
triggers
chemoresistance.
natural
products
regulate
therapy
reverse
drug
resistance.
nanostructures
specifically
target
signaling
therapy.
current
review
discusses
potential
proliferation,
Then,
capacity
for
suppressing
Nrf2-mediated
progression
discussed.
ACS Applied Bio Materials,
Journal Year:
2024,
Volume and Issue:
7(11), P. 7535 - 7543
Published: Oct. 12, 2024
The
search
for
drug
nanocarriers
with
stimuli-responsive
properties
and
high
payloads
targeted
delivery
precision
medicine
is
currently
a
focal
point
of
biomedical
research,
but
this
endeavor
still
encounters
various
challenges.
Herein,
porous
organic
cage
(POC)
applied
to
paclitaxel
(PTX)
cancer
therapy
the
first
time.
Specifically,
water-soluble,
stable,
biocompatible
POC-based
nanocapsules
(PTX@POC@RH40)
PTX
encapsulation
efficiency
over
98%
can
be
synthesized
by
simply
grafting
nonionic
surfactant
(Polyoxyl
40
hydrogenated
castor
oil,
RH40)
on
POC
surface.
These
PTX@POC@RH40
demonstrate
remarkable
stability
more
than
week
without
aggregation
exhibit
pH-responsive
behavior
under
acidic
conditions
(pH
5.5)
display
sustained
release
at
both
pH
7.4
5.5.
Intravenous
administration
led
3.5-fold
increase
in
bioavailability
compared
free
group
rats.
Moreover,
vivo
mouse
model
experiments
involving
4T1
subcutaneous
breast
tumors
revealed
that
exhibited
enhanced
anticancer
efficacy
minimal
toxicity
PTX.
findings
underscore
potential
POCs
as
promising
therapeutic
applications.
