Cited by Enhancing the Treating Efficacy of Immunotherapy through the Restructure of Tumor Microenvironment

Advanced application of nanotechnology in active constituents of Traditional Chinese Medicines DOI

Chong Qiu,

Jun Zhe Zhang,

Bo Wu

et al.

Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)

Published: Nov. 29, 2023

Abstract Traditional Chinese Medicines (TCMs) have been used for centuries the treatment and management of various diseases. However, their effective delivery to targeted sites may be a major challenge due poor water solubility, low bioavailability, potential toxicity. Nanocarriers, such as liposomes, polymeric nanoparticles, inorganic nanoparticles organic/inorganic nanohybrids based on active constituents from TCMs extensively studied promising strategy improve achieve higher therapeutic effect with fewer side effects compared conventional formulations. This review summarizes recent advances in nanocarrier-based systems types TCMs, including terpenoids, polyphenols, alkaloids, flavonoids, quinones, different natural sources. covers design preparation nanocarriers, characterization, vitro/vivo evaluations. Additionally, this highlights challenges opportunities field suggests future directions research. Nanocarrier-based shown great improving efficacy serve comprehensive resource researchers field. Graphical abstract

Language: Английский

Citations

Self-assembled nanodrug delivery systems for anti-cancer drugs from traditional Chinese medicine DOI

Li Qiao,

Yuan Lianghao,

Gao Shijie

et al.

Biomaterials Science, Journal Year: 2024, Volume and Issue: 12(7), P. 1662 - 1692

Published: Jan. 1, 2024

In this review, we have summarized the common self-assembled mechanism of NSMs-based SANDDSs. Meanwhile, potential applications for cancer treatment and future development prospects are also prospected.

Language: Английский

Citations

Collision of herbal medicine and nanotechnology: a bibliometric analysis of herbal nanoparticles from 2004 to 2023 DOI

Sinan Ai,

Yake Li,

Huijuan Zheng

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: April 1, 2024

Abstract Background Herbal nanoparticles are made from natural herbs/medicinal plants, their extracts, or a combination with other nanoparticle carriers. Compared to traditional herbs, herbal lead improved bioavailability, enhanced stability, and reduced toxicity. Previous research indicates that medicine nanomaterials rapidly advancing making significant progress; however, bibliometric analysis knowledge mapping for currently lacking. We performed by retrieving publications related the Web of Science Core Collection (WoSCC) database spanning 2004 2023. Data processing was using R package Bibliometrix, VOSviewers, CiteSpace. Results In total, 1876 articles were identified, originating various countries, China being primary contributing country. The number in this field increases annually. Beijing University Chinese Medicine, Shanghai Traditional Saveetha India prominent institutions domain. Journal “International Nanomedicine” has highest publications. authors these reached 8234, Yan Zhao, Yue Zhang, Huihua Qu most prolific Zhao frequently cited author. “Traditional medicine,” “drug delivery,” “green synthesis” main focal points. Themes such as synthesis,” “curcumin,” “wound healing,” “carbon dots” may represent emerging areas. Conclusions Our study findings assist identifying latest frontiers hot topics, providing valuable references scholars investigating role nanotechnology medicine. Graphical

Language: Английский

Citations

A review on ferroptosis and photodynamic therapy synergism: Enhancing anticancer treatment DOI

Qihang Chang,

Peiru Wang, Qingyu Zeng

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(7), P. e28942 - e28942

Published: March 31, 2024

Ferroptosis is an iron-dependent programmed cell death modality, which has showed great potential in anticancer treatment. Photodynamic therapy (PDT) widely used clinic as therapy. PDT combined with ferroptosis-promoting been found to be a promising strategy improve anti-cancer efficacy. Fenton reaction ferroptosis can provide oxygen for PDT, and produce reactive species enhance ferroptosis. In this review, we briefly present the importance of treatment, mechanism ferroptosis, researches on induced synergistic effect cancer killing.

Language: Английский

Citations

Self‐Delivered Transformable Nanosystem Capable of Enhancing Photodynamic Effectiveness and Multi‐Target Ameliorating Immunosuppression for Treatment of Breast Cancer and Lung Metastasis DOI

Ruyi Lin,

Jia Yan,

Bokai Gong

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: May 9, 2024

Abstract Homogeneous distribution and adequate accumulation of photosensitizer in tumor are essential for effective photodynamic therapy (PDT). However, the intricate microenvironment (TME) often poses great challenges to deep penetration retention therapeutic agents tumor. Moreover, important effect PDT induce specific antitumor immune response is impeded by multiple immunosuppressive mechanisms within TME. Confronting these issues, here a rationally designed nanosystem (SUN‐NPA) with acid‐responsive sphere‐to‐fiber transformation ability leveraging characters drug molecules proposed achieve self‐delivery Chlorin e6 (Ce6) two small‐molecule immunomodulators, metformin (MET) sunitinib (SUN). The spatiotemporal controlled enables homogeneous high drugs enduring complete elimination. Meanwhile, co‐delivered MET SUN alleviate immunosuppression from aspects, effectively synergizing ignite potent host long‐lasting immunological memory against cells. artful integration enhanced activated immunity realized SUN‐NPA leads significant inhibition growth metastasis, exhibiting potential oncotherapy.

Language: Английский

Citations

Dual-responsive supramolecular photodynamic nanomedicine with activatable immunomodulation for enhanced antitumor therapy DOI

Siqin He,

Lulu Wang, Dongxu Wu

et al.

Acta Pharmaceutica Sinica B, Journal Year: 2023, Volume and Issue: 14(2), P. 765 - 780

Published: Oct. 19, 2023

A major challenge facing photodynamic therapy (PDT) is that the activity of immune-induced infiltrating CD8+ T cells subject to regulatory lymphocytes (Tregs), leaving tumor at risk recurrence and metastasis after initial ablation. To augment antitumor response reprogram immunosuppressive microenvironment (TME), a supramolecular nanoparticle (DACss) constructed by host-guest interaction between demethylcantharidin-conjugated β-cyclodextrin (DMC-CD) amantadine-terminated disulfide-conjugated FFVLGGGC peptide with chlorin e6 decoration (Ad-ss-pep-Ce6) achieve intelligent delivery photosensitizer immunomodulator for breast cancer treatment. The acid-labile β-carboxamide bond DMC-CD hydrolyzed in acidic TME, resulting localized release DMC subsequent inhibition Tregs. guest molecule Ad-ss-pep-Ce6 can be cleaved high level intracellular GSH, reducing toxicity increasing retention tumor. With significant increase CTL/Treg ratio, combination Ce6-based PDT DMC-mediated immunomodulation adequately achieved spatiotemporal regulation remodeling as well improved primary situ lung suppression aid PD-1 antibody.

Language: Английский

Citations

Photodynamic Therapy Combined with Ferroptosis Is a Synergistic Antitumor Therapy Strategy DOI

Yun-peng Huang, Xiaoyu Li, Zijian Zhang

et al.

Cancers, Journal Year: 2023, Volume and Issue: 15(20), P. 5043 - 5043

Published: Oct. 19, 2023

Ferroptosis is a programmed death mode that regulates redox homeostasis in cells, and recent studies suggest it promising of tumor cell death. regulated by iron metabolism, lipid intracellular reducing substances, which the mechanism basis its combination with photodynamic therapy (PDT). PDT generates reactive oxygen species (ROS) 1O2 through type I II photochemical reactions, subsequently induces ferroptosis Fenton reaction peroxidation membrane lipids. kills cells generating excessive cytotoxic ROS. Due to limited laser depth photosensitizer enrichment, systemic treatment effect not good. Combining can compensate for these shortcomings. Nanoparticles constructed photosensitizers agonists are widely used field therapy, their targeting biological safety be improved modification. These nanoparticles only directly kill but also further exert synergistic activating antitumor immunity, improving hypoxia microenvironment, inhibiting angiogenesis. Ferroptosis-agonist-induced chemotherapy PDT-induced ablation have good clinical application prospects. In this review, we summarize current research progress on how promote each other.

Language: Английский

Citations

Reactive oxygen species-responsive supramolecular deucravacitinib self-assembly polymer micelles alleviate psoriatic skin inflammation by reducing mitochondrial oxidative stress DOI

Leiqing Yao,

Faming Tian, Qinqin Meng

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: May 10, 2024

Introduction The new topical formula is urgent needed to meet clinical needs for majority mild patients with psoriasis. Deucravacitinib exerts outstanding anti-psoriatic capacity as an oral TYK2 inhibitor; however, single therapy insufficient target the complicated psoriatic skin, including excessive reactive oxygen species (ROS) and persistent inflammation. To address this need, engineered smart nano-therapeutics hold potential delivery of deucravacitinib. Methods hydrophobic was loaded into polyethylene glycol block-polypropylene sulphide (PEG-b-PPS) transdermal in treatment oxidative stress model HaCaT psoriasis established by TNF-α IL-17A vitro . JC-1 assay, DCFH-DA staining mtDNA copy number were utilized assess mitochondrial function. 0.75% Carbopol ® 934 incorporated SPMs produce hydrogels Rhb labeled monitor penetration Immunofluorescence. In vivo , we IMQ-induced evaluate therapeutic effect Car@Deu@PEPS. Results Deu@PEPS exerted effects restoring DNA membrane HaCaT. Car@Deu@PEPS supramolecular micelle had longer retention time dermis ROS microenvironment. Topical application significantly restored normal epidermal architecture skin abrogation splenomegaly dermatitis model. inhibited STAT3 signaling cascade a corresponding decrease levels differentiation proliferative markers Keratin 17 Cyclin D1, respectively. Meanwhile, alleviated generation subsequent NLRP3 inflammasome-mediated pyroptosis. Conclusion prominent anti-inflammatory anti-oxidative effects, which may offers more patient-acceptable fewer adverse compared

Language: Английский

Citations

Rolling Circle Amplification-Based Self-Assembly to Form a “GPS-Nanoconveyor” for In Vitro Targeted Imaging and Enhanced Gene/Chemo (CRISPR/DOX) Synergistic Therapy DOI

Huan Du, Fang Wang, Ruyan Zhang

et al.

Biomacromolecules, Journal Year: 2024, Volume and Issue: 25(8), P. 4991 - 5007

Published: Aug. 1, 2024

The GPS-Nanoconveyor (MA-NV@DOX-Cas13a) is a targeted nanoplatform designed for the imaging and gene/chemotherapy synergistic treatment of melanoma. It utilizes rolling circle amplification (RCA) products as scaffold to construct DNA "Nanoconveyor" (NV), which incorporates multivalent aptamer (MA) "GPS", encapsulates doxorubicin (DOX) in transporter, equips it with CRISPR/Cas13a ribonucleoproteins (Cas13a RNP). Carrying MA enhances ability recognize overexpressed receptor nucleolin on B16 cells, enabling precise delivery MA-NV@DOX-Cas13a through receptor-mediated endocytosis. activation signal transducer activator transcription 3 (STAT3) cancer cells triggers cis-cleavage CRISPR/Cas13a, initiating its trans-cleavage function. Additionally, deoxyribonuclease I (DNase I) degrades MA-NV, releasing DOX intracellular chemotherapeutic agent. Experiments demonstrate superior capabilities this versatile cellular co-treatment while highlighting advantages these nanodrug systems mitigating side effects.

Language: Английский

Citations

Spatial‐Constraint Modulation of Intra/Extracellular Reactive Oxygen Species by Adaptive Hybrid Materials for Boosting Pyroptosis and Combined Immunotherapy of Breast Tumor DOI

Luoli Zhou,

Sheng Zhao,

Yijing Xu

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 28, 2025

Abstract Pyroptosis‐immunotherapy has potential for triple‐negative breast cancer treatment, but its efficacy is limited by insufficient pyroptosis activation and the need phased, balanced, spatially controlled of active species during long‐term treatment. To reconcile intracellular/extracellular demands in tumor ablation, a nanoparticle‐hydrogel hybrid enabling spatiotemporal reactive oxygen (ROS) modulation engineered. An open‐shell sonosensitizer with unpaired electrons molecular orbitals prepared chelating Cu 2 ⁺ TCPP. These sonosensitizers are undergoing bovine serum albumin mediated biomineralization to form calcium phosphate particles incorporated into an injectable hydrogel through Schiff base crosslinking between dopamine‐functionalized oxidized hyaluronic acid gallic acid‐modified chitosan. After intratumoral injection, nanoparticles endocytosed cells undergo acidic degradation, releasing ions GSH‐activatable sonosensitizers. Calcium overload synergizes ultrasound‐mediated oxidative stress induce mitochondrial damage pyroptosis, while adhesive hydrogels retained extracellular matrix control excessive secondary ROS levels protect oxidation‐sensitive entities. This dual‐action mechanism enhances overall therapeutic effect combining immediate killing immune activation. study provides new route material design, addressing conflicting short‐term ablation activation, overcoming limitations current pyroptosis‐based immunotherapies.

Language: Английский

Citations