Steering Piezocatalytic Therapy for Optimized Tumoricidal Effect

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(33)

Published: May 16, 2024

Abstract Piezocatalysts, because of their mechano‐electrical conversion properties, are exploited for various medical applications, such as sterilization, tissue engineering, biosensing, and disease theranostics. In particular, based on the unique advantage piezoelectric effect, piezocatalytic therapy (PCT) has been developed a novel promising candidate tumor therapy. To optimize utilization piezocatalysts in therapy, comprehensive understanding antitumor mechanism associated with these materials is imperative. Here, action principle elucidated by investigating piezocatalysts, reactants, energy inputs, products. Subsequently, mechanisms PCT have extensively discussed recapitulative follows: restraining cell proliferation, inducing programmed death, hindering metastasis, inhibiting angiogenesis, enhancing immunity. Additionally, optimized therapeutic outcomes PCT‐centric synergistic cancer systematically described. Finally, main challenges future research directions piezocatalysis applied envisioned. It believed that will serve new‐generation ingenious tool treatment.

Language: Английский

---

Revolutionary Energy Harvesting: Gravity‐Driven Piezocatalysts for Sustainable Hydrogen Production in MoS₂@Mo₂CT_x Systems

Advanced Energy Materials, Journal Year: 2024, Volume and Issue: 14(39)

Published: July 11, 2024

Abstract Hydrogen (H 2 ) is mainly produced using steam methane reforming, electrolysis, and gasification, which require external energy special catalysts. A new catalyst by combining MoS nanoflowers (NFs) with metal carbide/nitride nanosheets (Mo CTx MXene) to create a nanosheet bending moment. The @Mo CT x heterostructures achieve production rate of 1164.8 µmol g −1 h under an application mechanical force, 4.01 3.06 times higher than Mo alone, due enhanced charge transfer from 's piezoelectricity conductivity. This study introduces pioneering methodology that harnesses gravitational as continuous simulated peristaltic pump, drive the piezocatalytic hydrogen evolution reaction (HER), achieving notable 454.1 over 24 hours demonstrating sustained capability for generation. theoretical calculation results validate piezoelectric potential in water‐flow‐pressure triggered HER systems. system, assuming powered Hoover Dam, will produce 290.9 kmoles per ton daily, equivalent utilizing 19 150 kWh electrocatalytic system. gravity‐driven water flow piezocatalysts H generation demonstrates superior efficiency eliminating common thermal conversion losses, marking significant breakthrough sustainable technologies.

Language: Английский

---

Ultrasound-Responsive Nanobubbles for Breast Cancer: Synergistic Sonodynamic, Chemotherapy, and Immune Activation through the cGAS-STING Pathway

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: March 24, 2025

Breast cancer remains the leading cause of cancer-related deaths among women worldwide, necessitating more effective treatment strategies. Chemotherapy combined with immunotherapy is first-line for breast cancer, but it still suffers from limited therapeutic efficiency and serious side effects, which are usually due to poor delivery efficiency, drug resistance tumor cells, immunosuppressive microenvironment. This study explores development ultrasound-responsive nanobubbles (Ce6/PTX Nbs) targeted imaging sonoimmunotherapy in treatment. By integrating sonodynamic therapy (SDT), chemotherapy, immunotherapy, aim address challenges such as delivery, systemic toxicity, immune suppression conventional therapies. The nanobubbles, composed sonosensitizer chlorin e6 (Ce6)-modified phospholipid loaded chemotherapeutic agent paclitaxel (PTX) enhancing drug-loading capacity, designed precisely target sites via cyclic-RGD peptides. Upon ultrasound activation, Ce6 induces reactive oxygen species (ROS), promoting immunogenic cell death (ICD), while PTX disrupts mitosis, response. nanobubbles' responsiveness facilitates real-time controlled release, maximizing efficacy minimizing effects. Key findings demonstrate that Ce6/PTX Nbs significantly reduced growth a 4T1 model, enhanced activation cGAS-STING pathway, increased infiltration CD8+ T cells both primary distant tumors. In combination anti-PD-L1 checkpoint inhibitors, achieved substantial metastasis. innovative approach offers highly targeted, effective, minimally toxic potential clinical translation its dual capabilities.

Language: Английский

---

Recent Development and Application of “Nanozyme” Artificial Enzymes—A Review

Biomimetics, Journal Year: 2023, Volume and Issue: 8(5), P. 446 - 446

Published: Sept. 21, 2023

Nanozymes represent a category of nano-biomaterial artificial enzymes distinguished by their remarkable catalytic potency, stability, cost-effectiveness, biocompatibility, and degradability. These attributes position them as premier biomaterials with extensive applicability across medical, industrial, technological, biological domains. Following the discovery ferromagnetic nanoparticles peroxidase-mimicking capabilities, research endeavors have been dedicated to advancing nanozyme utilization. Their capacity emulate functions natural has captivated researchers, prompting in-depth investigations into potential applications. This exploration yielded insights innovations in various areas, including detection mechanisms, biosensing techniques, device development. exhibit diverse compositions, sizes, forms, resembling molecular entities such proteins tissue-based glucose. rapid impact on body necessitates comprehensive understanding intricate interplay. As each day witnesses emergence novel methodologies technologies, integration nanozymes continues surge, promising enhanced comprehension times ahead. review centers expansive deployment advancement materials, encompassing biomedical, biotechnological, environmental contexts.

Language: Английский

---

Fine‐Tuning Electron Transfer for Nanozyme Design

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: July 17, 2024

Nanozymes, with their versatile composition and structural adaptability, present distinct advantages over natural enzymes including heightened stability, customizable catalytic activity, cost-effectiveness, simplified synthesis process, making them as promising alternatives in various applications. Recent advancements nanozyme research have shifted focus from serendipitous discovery toward a more systematic approach, leveraging machine learning, theoretical calculations, mechanistic explorations to engineer nanomaterial structures tailored functions. Despite its pivotal role, electron transfer, fundamental process catalysis, has often been overlooked previous reviews. This review comprehensively summarizes recent strategies for modulating transfer processes fine-tune the activity specificity of nanozymes, electron-hole separation carrier transfer. Furthermore, bioapplications these engineered antimicrobial treatments, cancer therapy, biosensing are also introduced. Ultimately, this aims offer invaluable insights design nanozymes enhanced performance, thereby advancing field research.

Language: Английский

---

Cobalt Single‐Atom Intercalation in Molybdenum Disulfide Enhances Piezocatalytic and Enzyodynamic Activities for Advanced Cancer Therapeutics

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 14, 2025

Abstract Piezoelectric semiconductor nanomaterials have attracted considerable interest in piezocatalytic tumor treatment. However, therapy encounters obstacles such as suboptimal piezoelectric responses, rapid electron‐hole recombination, inefficient energy harvesting, and the complexities of microenvironment. In this study, sulfur vacancy‐engineered cobalt (Co) single‐atom doped molybdenum disulfide (SA‐Co@MoS 2 ) nanoflowers are strategically designed, which exhibit enhanced effects. Specifically, introduction Co single atom not only induces lattice distortion out‐of‐plane polarization but also leads to formation numerous vacancies. These changes collectively narrow intrinsic bandgap material, facilitating effective separation migration charge carriers, enabling efficient production reactive oxygen species under ultrasound stimulation. Additionally, SA‐Co@MoS demonstrate improved enzymatic activity glutathione depletion capabilities attributed mixed valence states Co, intensifying oxidative stress cells, leading cell cycle arrest apoptosis, while inactivation peroxidase 4 ferroptosis. Both vitro vivo results indicate that can significantly eliminate cells. This study offers valuable insights into exploration doping‐enhanced sonosensitizers for cancer treatment, potentially paving way advancements field synergistic enzyodynamic therapy.

Language: Английский

---

State‐of‐the‐Art Two‐Dimensional Metal Phosphides for High Performance Lithium‐ion Batteries: Progress and Prospects

ChemSusChem, Journal Year: 2023, Volume and Issue: 17(5)

Published: Nov. 13, 2023

Abstract Lithium‐ion batteries (LIBs) with high energy density, long cycle life and safety have earned recognition as outstanding storage devices, been used in extensive applications, such portable electronics new vehicles. However, traditional graphite anodes deliver low specific capacity inferior rate performance, which is difficult to satisfy ever‐increasing demands LIBs. Very recently, two‐dimensional metal phosphides (2D MPs) emerge the cutting‐edge materials LIBs due their overwhelming advantages including theoretical capacity, excellent conductivity short lithium diffusion pathway. This review summarizes up‐to‐date advances of 2D MPs from typical structures, main synthesis methods applications. The corresponding mechanism, relationship between structure performance deeply discussed provide enlightening insights application for Several potential challenges inspiring outlooks are highlighted guidance future research applications MPs.

Language: Английский

---

Ultrasound‐Triggered Piezoelectric Catalysis of Zinc Oxide@Glucose Derived Carbon Spheres for the Treatment of MRSA Infected Osteomyelitis

Small, Journal Year: 2024, Volume and Issue: unknown

Published: May 19, 2024

Currently, methicillin-resistant Staphylococcus aureus (MRSA)-induced osteomyelitis is a clinically life-threatening disease, however, long-term antibiotic treatment can lead to bacterial resistance, posing huge challenge and public health. In this study, glucose-derived carbon spheres loaded with zinc oxide (ZnO@HTCS) are successfully constructed. This composite demonstrates the robust ability generate reactive oxygen species (ROS) under ultrasound (US) irradiation, eradicating 99.788% ± 0.087% of MRSA within 15 min effectively treating MRSA-induced infection. Piezoelectric force microscopy tests finite element method simulations reveal that ZnO@HTCS exhibits superior piezoelectric catalytic performance compared pure ZnO, making it unique sonosensitizer. Density functional theory calculations formation Mott-Schottky heterojunction an internal field interface accelerates electron transfer separation electron-hole pairs. Concurrently, surface vacancies enable adsorption greater amount oxygen, enhancing effect generating substantial quantity ROS. work not only presents promising approach for augmenting catalysis through construction Schottky but also provides novel, efficient therapeutic strategy osteomyelitis.

Language: Английский

---

Catalytic Biomaterials‐Activated In Situ Chemical Reactions: Strategic Modulation and Enhanced Disease Treatment

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 5, 2024

Abstract Chemical reactions underpin biological processes, and imbalances in critical biochemical pathways within organisms can lead to the onset of severe diseases. Within this context, emerging field “Nanocatalytic Medicine” leverages nanomaterials as catalysts modulate fundamental chemical specific microenvironments This approach is designed facilitate targeted synthesis localized accumulation therapeutic agents, thus enhancing treatment efficacy precision while simultaneously reducing systemic side effects. The effectiveness these nanocatalytic strategies critically hinges on a profound understanding kinetics intricate interplay particular pathological ensure effective catalytic actions. review methodically explores situ their associated biomaterials, emphasizing regulatory that control responses. Furthermore, discussion encapsulates crucial elements‐reactants, catalysts, reaction conditions/environments‐necessary for optimizing thermodynamics reactions, rigorously addressing both biophysical dimensions disease enhance outcomes. It seeks clarify mechanisms underpinning biomaterials evaluate potential revolutionize across various conditions.

Language: Английский

---

Sonocatalytic cancer therapy: theories, advanced catalysts and system design

Nanoscale, Journal Year: 2023, Volume and Issue: 15(48), P. 19407 - 19422

Published: Jan. 1, 2023

Sonocatalytic cancer therapy has emerged as a promising strategy through the combination of ultrasound waves and catalytic materials to selectively target destroy cells.

Language: Английский

---