Harnessing External Irradiation for Precise Activation of Metal‐Based Agents in Cancer Therapy DOI
Yuting Wang,

Liling Meng,

Fang Zhao

et al.

ChemBioChem, Journal Year: 2024, Volume and Issue: 25(16)

Published: June 3, 2024

Abstract Cancer is a significant global health issue. Platinum‐based chemotherapy drugs, including cisplatin, are crucial in clinical anti‐cancer treatment. However, these drugs have limitations such as drug resistance, non‐specific distribution, and irreversible toxic side effects. In recent years, the development of metal‐based agents has led to discovery other effects beyond chemotherapy. Precise spatiotemporal controlled external irradiation can activate at specific sites play different role from traditional These strategies not only enhance efficiency, but also show fewer non‐cross‐drug which ideal approaches solve problems caused by platinum‐based drugs. this review, we focus on various agent‐mediated cancer therapies that activated three types irradiation: near‐infrared (NIR) light, ultrasound (US), X‐ray, give some prospects. We hope review will promote generation new kinds agents.

Language: Английский

Rational Design of Nanozymes for Engineered Cascade Catalytic Cancer Therapy DOI

Xiuna Jia,

Erkang Wang, Jin Wang

et al.

Chemical Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 27, 2025

Nanozymes have shown significant potential in cancer catalytic therapy by strategically catalyzing tumor-associated substances and metabolites into toxic reactive oxygen species (ROS) situ, thereby inducing oxidative stress promoting cell death. However, within the complex tumor microenvironment (TME), rational design of nanozymes factors like activity, reaction substrates, TME itself significantly influence efficiency ROS generation. To address these limitations, recent research has focused on exploring that affect activity developing nanozyme-based cascade systems, which can trigger two or more processes tumors, producing therapeutic achieving efficient stable with minimal side effects. This area remarkable progress. Perspective provides a comprehensive overview nanozymes, covering their classification fundamentals. The regulation nanozyme strategies are discussed detail. Furthermore, representative paradigms for successful construction systems treatment summarized focus revealing underlying mechanisms. Finally, we current challenges future prospects development biomedical applications.

Language: Английский

Citations

3
Peptide-Hitchhiking for the Development of Nanosystems in Glioblastoma DOI Creative Commons
Francisco Branco, Joana Cunha, Maria Mendes

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(26), P. 16359 - 16394

Published: June 11, 2024

Glioblastoma (GBM) remains the epitome of aggressiveness and lethality in spectrum brain tumors, primarily due to blood–brain barrier (BBB) that hinders effective treatment delivery, tumor heterogeneity, presence treatment-resistant stem cells contribute recurrence. Nanoparticles (NPs) have been used overcome these obstacles by attaching targeting ligands enhance therapeutic efficacy. Among ligands, peptides stand out their ease synthesis high selectivity. This article aims review single multiligand strategies critically. In addition, it highlights other integrate effects external stimuli, biomimetic approaches, chemical approaches as nanocatalytic medicine, revealing significant potential treating GBM with peptide-functionalized NPs. Alternative routes parenteral administration, specifically nose-to-brain delivery local within resected cavity, are also discussed. Finally, an overview them discussed provide a perspective on this promising field therapy.

Language: Английский

Citations

12
Nanotechnology-based in situ cancer vaccines: Mechanisms, design, and recent advances DOI

Gaoli Niu,

Hong Wang, Yanhong Zhai

et al.

Nano Today, Journal Year: 2024, Volume and Issue: 56, P. 102286 - 102286

Published: May 6, 2024

Language: Английский

Citations

7
Oral Heterojunction Coupling Interventional Optical Fiber Mediates Synergistic Therapy for Orthotopic Rectal Cancer DOI
Ruiyan Li,

Dianxun Fu,

Yuan Xue

et al.

Small, Journal Year: 2024, Volume and Issue: 20(43)

Published: June 20, 2024

Catalytic therapy has shown great potential for clinical application. However, conventional catalytic therapies rely on reactive oxygen species (ROS) as "therapeutic drugs," which have limitations in effectively inhibiting tumor recurrence and metastasis. Here, a biomimetic heterojunction catalyst is developed that can actively target orthotopic rectal cancer after oral administration. The composed of quatrefoil star-shaped BiVO

Language: Английский

Citations

5
Injectable self-healing hydrogel as a rising therapeutic strategy for the loco-regional management of cancer DOI

Shruti Srivastav,

Abhilasha Singh, Manjul Pratap Singh

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 98, P. 105913 - 105913

Published: June 26, 2024

Language: Английский

Citations

5
Advances in Sonodynamic Therapy: Focus on Ferroptosis DOI

Wen‐Qing Su,

Hao Wang,

Juhong Pan

et al.

Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 10, 2025

Ferroptosis is a nonapoptotic form of cell death discovered in 2012. Noninvasive treatments regulating ferroptosis are important for wide range diseases. Among the noninvasive treatments, sonodynamic therapy (SDT) has become promising due to its strong tissue penetration and few side effects. In recent years, targeted drug delivery platforms constructed on basis SDT have provided an efficient mode regulation ferroptosis. Based latest research reports, this Perspective introduces basic mechanism influencing factors therapeutic effects, elucidates significance ferroptosis-targeted SDT, summarizes studies through different pathways. We also present innovative composite ultrasound-responsive platforms. Finally, brief summary outlook based current presented.

Language: Английский

Citations

0
Preparation of La2(WO4)3/CuWO4 composite nanomaterials with enhanced sonodynamic anti-glioma activity DOI Creative Commons
Fang-Yu Liu, Xin Wang,

Ye-Fu Liu

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13

Published: March 20, 2025

Introduction Sonodynamic therapy (SDT) is an innovative way to treat tumors by activating sonosensitizers via ultrasound (US). The development of with high sonodynamic activity the key promote clinical application SDT. Methods In this study, a novel sonosensitizer, La 2 (WO 4 ) 3 /CuWO composite LC-10, was prepared two-step hydrothermal method and characterized. addition, antitumor LC-10 investigated using u251 glioma cells as model. Results Discussion results showed that compared CuWO , had better activity, good biosafety at concentrations below 50 μg/mL. After formed composite, recombination electron-hole ( e − – h + pairs were effectively inhibited, more strongly oxidizing ROS produced, inducing apoptosis cells. which, singlet oxygen 1 O hydroxyl radical (·OH), especially production ⋅OH, played important role in mediated SDT process. study would offer foundation for design base nano-sonosensitizers its further antitumor. it also provided new strategy excellent activity.

Language: Английский

Citations

0
Low-intensity pulsed ultrasound affects proliferation and migration of human hepatocellular carcinoma cells DOI Creative Commons
Mingzhen Yang, Zhihui Lu, Bangzhong Liu

et al.

Journal of Cancer Research and Clinical Oncology, Journal Year: 2025, Volume and Issue: 151(4)

Published: April 10, 2025

Low-intensity pulsed ultrasound (LIPUS) is an effective ancillary treatment modality for various malignancies. However, the mechanisms underlying role of LIPUS in cancer have not been fully elucidated. We investigated effects and mechanism on proliferation, apoptosis, migration, invasion hepatocellular carcinoma (HCC) cells. The HCC cell lines SMMC7721 HCCLM3 were exposed to 1 MHz at intensities 0.5, 1.0, 1.5 W/cm2 60 s. Cell morphology, viability, colony formation, assessed. Intracellular reactive oxygen species (ROS) levels mitochondrial membrane potential evaluated using a ROS assay kit JC-1 staining kit. Western blotting was performed quantify changes matrix metallopeptidases epithelial-mesenchymal transition-related proteins. Orthotopic Hep3B-Luc tumor-bearing mice treated with or 0 growth trend measured. results showed that different affected cellular activity, inhibited proliferation cloning, facilitated intracellular cytoskeletal protein reorganization, induced particularly intensity W/cm2, through ROS/mitochondria pathway. enhanced SMCC7721 migration dose-dependent manner by regulating In vivo experiments confirmed inhibitory effect tumor growth. Although apoptosis it also promoted metastasis cells under certain conditions, which related regulation

Language: Английский

Citations

0
Nanomedical Sonocatalyst Tailored for Enhanced Hypoxic Tumor Therapy Based on Crystal Facet Engineering Strategy DOI
Meng Yuan, Zhuang Yang,

Ziyong Cheng

et al.

ACS Materials Letters, Journal Year: 2024, Volume and Issue: 6(6), P. 2381 - 2391

Published: May 17, 2024

Strategically exposing active crystal facets significantly enhances the catalytic performance of catalyst. Here, we design ultrathin BiOCl nanosheets (NSs) with nearly completely exposed (001) and investigate facet-dependent activity underlying mechanism. With exposure extent increased, defect type changed from single atom Bi vacancy to adjacent Bi–O–Bi triatom association vacancy. These associates provide sites for adsorption activation substrate on surface, which promotes reaction. Meanwhile, adjustment surface electronic structure band is conducive decrease charge transfer barrier enhancement carrier separation ability. In a mouse breast cancer model, ultrasound-mediated NSs facilitated trimodal synergistic treatment regimen comprising carbon monoxide gas therapy, sonodynamic starvation therapy effectively inhibit hypoxic tumor growth proliferation.

Language: Английский

Citations

3
Synthesis of biowaste derived carbon nanomaterials: efficiency, quality, and environmental impact DOI
Shivani Sharma,

Ravi Kumar,

Kuldeep Kumar

et al.

Indian Chemical Engineer, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 20

Published: Dec. 23, 2024

This comprehensive review examines various methods for synthesising carbon nanomaterials (CNMs) derived from biowaste, focusing on their efficiency, product quality, and environmental impact. The study covers traditional approaches like chemical vapour deposition (CVD), which uses heat chemicals to create nanomaterials, as well pyrolysis, involves burning materials without oxygen. It also explores that combine water, using templates or special chemicals, innovative techniques integrate heat, biological processes. Each method has its advantages disadvantages: some are efficient mass production, others more environmentally friendly but costly, certain offer better control over the properties of nanomaterials. Factors temperature, pressure, acidity significantly impact production process, interestingly, waste plants animals can be used source material. Future research aims develop cheaper, friendly, effective making these materials, have potential applications in medicine, computing, energy storage. evolving field continues drive innovation nanoscience technology.

Language: Английский

Citations

2