Natural Products from Herbal Medicine Self‐Assemble into Advanced Bioactive Materials

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: July 21, 2024

Novel biomaterials are becoming more crucial in treating human diseases. However, many materials require complex artificial modifications and synthesis, leading to potential difficulties preparation, side effects, clinical translation. Recently, significant progress has been achieved terms of direct self-assembly natural products from herbal medicine (NPHM), an important source for novel medications, resulting a wide range bioactive supramolecular including gels, nanoparticles. The NPHM-based produced renewable resources, simple prepare, have demonstrated multi-functionality slow-release, smart-responsive release, especially possess powerful biological effects treat various In this review, revealed as emerging, revolutionary, promising strategy. development, advantages, limitations NPHM, well the advantageous position materials, first reviewed. Subsequently, systematic comprehensive analysis strategies specific seven major classes NPHM is highlighted. Insights into influence structural features on formation also provided. Finally, drivers preparations summarized, emphasizing biomedical applications, future scientific challenges, opportunities, with hope igniting inspiration research applications.

Language: Английский

---

Research progress of natural polysaccharide-based and natural protein-based hydrogels for bacteria-infected wound healing

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 496, P. 153803 - 153803

Published: July 6, 2024

Language: Английский

---

Recent advances in self-targeting natural product-based nanomedicines

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 20, 2025

Language: Английский

---

Tuning Ligands Ratio Allows for Controlling Gold Nanocluster Conformation and Activating a Nonantimicrobial Thiol Fragrance for Effective Treatment of MRSA‐Induced Keratitis

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(40)

Published: July 29, 2023

Bacterial keratitis is a serious ocular disease that affects millions of people worldwide each year, among which ≈25% are caused by Staphylococcus aureus. With the spread bacterial resistance, refractory methicillin-resistant S. aureus (MRSA) ≈120 000-190 000 annually and significant cause infectious blindness. Atomically precise gold nanoclusters (GNCs) recently emerged as promising antibacterial agents; although how GNC structure capping ligands control properties remains largely unexplored. In this study, adjusting ratio "bulky" thiol fragrance to linear zwitterionic ligand, conformation transformed from Au25 (SR)18 Au23 (SR)16 species, simultaneously converting both inactive into potent nanomaterials. Surprisingly, mixed-ligand capped GNCs exhibit superior potency compared their monoligand counterparts. The optimal highly against MRSA, showing >1024-fold lower minimum inhibitory concentration than corresponding free ligands. Moreover, it displays excellent in treating MRSA-induced mice with greatly accelerated corneal recovery (by approximately ninefold). Thus, study establishes feasible method synthesize ligand active non-antibacterial ligands, thereby increasing repertoires for combating multidrug-resistant infections.

Language: Английский

---

Polydopamine-armored zeolitic imidazolate framework-8-incorporated zwitterionic hydrogel with multifunctional properties for infected wound healing

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 274, P. 133464 - 133464

Published: June 28, 2024

Language: Английский

---

Coordination of Functional Oligonucleotides Yields a Versatile Nanocomposite Microneedle Patch to Facilitate Local Wound Microenvironment Remodeling via Systemic Hyperglycemia Regulation

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

Abstract Hyperglycemia exacerbates bacterial infections, disrupts angiogenesis, and perpetuates chronic inflammation in the wound. Therefore, effective management of diabetic wounds necessitates a synergistic approach that integrates local wound microenvironment remodeling with systemic hyperglycemia regulation. Herein, an unprecedented hierarchical cobalt pyrophosphate/DNA (Co 2 PPi/DNA) nanocomposite is reported for this purpose. Unlike stereotypical assembly either enzymatically polymerized ultralong nucleic acids Mg PPi nanosheets at low ratios or commercial homo‐oligonucleotides devoid biofunctionalities presence metal ions, study represents first demonstration on coordination‐driven high‐efficiency co‐assembly biofunctional hetero‐oligonucleotides non‐Mg nanosheets, specifically glucagon receptor (GCGR) aptamer Co nanosheets. To improve bioavailability nanocomposites, dissolvable microneedle patch applied their delivery. Thereafter, nanocomposites dissociate sustained release 2+ ions GCGR aptamer, from which eliminate colonized bacteria promote angiogenesis through stabilizing HIF‐1α, meanwhile, after circulating to liver reduces blood glucose levels by binding hepatocyte GCGR. Importantly, hypoglycemic effect promotes antibacterial pro‐angiogenic efficacy alleviates inflammatory responses. This work highlights significant advancements coordination into versatile architecture remodel pathological facilitated factor

Language: Английский

---

Antimicrobial Peptides and Their Mimetics: Promising Candidates of Next‐Generation Therapeutic Agents Combating Multidrug‐Resistant Bacteria

Advanced Biology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 6, 2025

Abstract The increasing morbidity and mortality caused by multidrug‐resistant bacteria alerts human beings to the fact that conventional antibiotics are no longer reliable effective alternatives imperatively needed. Owing wide range of sources, diverse structures, unique mode action, antimicrobial peptides have been highly anticipated extensively studied in recent years. Besides, integration artificial intelligence helps researchers gain access vast unexplored chemical space, which opens more opportunities for optimization design novel structures. Moreover, Due advances chemistry synthetic biology, also begun focus on potential mimetics peptides. In this review, a comprehensive discussion about natural synthesized as well their is made, so provide summary field inspire follow‐up research.

Language: Английский

---

Antimicrobial and Anticancer Activity of Gallic Acid–Cu(II) Hybrid Nanoflowers and Gallic Acid–Zn(II) Hybrid Nanoflowers

Journal of Inorganic and Organometallic Polymers and Materials, Journal Year: 2024, Volume and Issue: unknown

Published: June 25, 2024

Abstract Herein, synthesis and characterization of hybrid nanoflowers (hNFs) using gallic acid as organic components, Cu(II), Zn(II) ions which were involved the inorganic component was carried out. In first part study, morphologies synthesized hNFs investigated SEM, EDX, XRD, FT-IR, mapping. second antimicrobial activities examined. Antimicrobial systematically studied against Staphylococcus aureus , Escherichia coli P. aeruginosa Candida albicans with broth microdilution short time-kill assay. addition, anticancer activity For this, A549 MCF7 cell lines used. Graphical

Language: Английский

---

A glutathione-activated bismuth-gallic acid metal-organic framework nano-prodrug for enhanced sonodynamic therapy of breast tumor

Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 679, P. 214 - 223

Published: Sept. 29, 2024

Language: Английский

---

Zn@TA assisted dual cross-linked 3D printable glycol grafted chitosan hydrogels for robust antibiofilm and wound healing

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 344, P. 122522 - 122522

Published: July 22, 2024

Language: Английский

---