Current advances in nanozyme-based nanodynamic therapies for cancer

Acta Biomaterialia, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Language: Английский

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Turning Threat to Therapy: A Nanozyme‐Patch in Surgical Bed for Convenient Tumor Vaccination by Sustained In Situ Catalysis

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(13)

Published: Feb. 1, 2024

Complete surgical resection of tumor is difficult as the invasiveness cancer, making residual a lethal threat to patients. The situation deteriorated by immune suppression state after surgery, which further nourishes recurrence and metastasis. Immunotherapy promising combat metastasis, but limited severe toxicity traditional immunostimulants complexity multiple functional units. Here, it reported that simple "trans-surgical bed" delivery Cu

Language: Английский

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NIR Light‐Activated Conversion Nanomaterials for Photothermal/Immunotherapy

Published: Jan. 3, 2025

Photothermal therapy (PTT), particularly nanomaterial-based PTT, has emerged as a promising approach for cancer tumor ablation. PTT utilizes photothermal agents to convert light energy into heat, facilitating the eradication of primary tumors and triggering subsequent antitumor immune responses. However, cannot completely cure due recurrence distal metastasis. When used in combination with immunotherapy, efficacy can be improved. In this chapter, focusing on latest developments inorganic nanomaterials we first introduced light-to-heat conversion mechanism nanomaterials. Second, summarized application common nanomaterials, such noble metal nanoparticles, semiconductor carbon-based materials. addition, against was also expounded. Finally, recent advances immunotherapy discussed challenges future outlook.

Language: Английский

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Cu-Doped MnO₂ Nanoparticles Loaded with Docetaxel Synergistically Enhance Chemodynamic Therapy through Ferroptosis and Cuproptosis

ACS Applied Nano Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 17, 2025

We have developed an innovative Cu-doped and DTX-loaded Cu-MnO2@DTX@FA (MCDF) nanodrug designed to strategically alter tumor microenvironment (TME) by harnessing the synergistic effects of chemodynamic therapy (CDT), chemotherapeutic agents, induction ferroptosis cuproptosis. The MCDF efficiently degrades, releasing abundant Mn4+, Cu2+, DTX. conversion Cu2+ Cu+ facilitated FDX1 initiates cuproptosis, while, similar Mn2+, reacts with hydrogen peroxide (H2O2) generate hydroxyl radicals (·OH). Mn4+ oxidize glutathione (GSH), significantly depleting GSH levels in cells inactivating GPX4, which further promotes ferroptosis. release intensifies DTX effectively disrupts cell division cycle, thereby inhibiting proliferation spread cells. FA-modified is evade immune detection while selectively targeting tissues, ensuring precision treatment delivery. This cutting-edge material not only provides a multifunctional therapeutic strategy but also sets stage for next generation tumor-targeting nanomedicines.

Language: Английский

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Nanozyme-Based Strategies in Cancer Immunotherapy: Overcoming Resistance to Enhance Therapeutic Efficacy

Aging and Disease, Journal Year: 2025, Volume and Issue: unknown, P. 0 - 0

Published: Jan. 1, 2025

Nanozymes, which are nanomaterials that replicate the catalytic activities of natural enzymes in biological systems, have recently demonstrated considerable potential improving cancer immunotherapy by altering tumor microenvironment. Nanozyme-driven immune responses represent an innovative therapeutic modality with high effectiveness and minimal side effects. These nanozymes activate system to specifically recognize destroy cells. Combined immunotherapeutic agents, can amplify anti-cancer integrating remodeling immunogenic cell death (ICD). This review offers a thorough discussion about various involved immunity, including those mimicking catalase (CAT), superoxide dismutase (SOD), peroxidase (POD), oxidase (OXD). It also discusses challenges future directions for translating nanozyme platforms into clinical applications, enhancing susceptibility cells immunotherapy. Nanozyme-based strategies substantial oncology, offering new effective options management.

Language: Английский

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Self‐Accelerated Nanoregulators for Positive Feedback Ferroptosis‐Immunotherapy

Small, Journal Year: 2025, Volume and Issue: unknown

Published: March 3, 2025

Abstract Activating specific immunity through intelligent delivery of chemotherapeutic drugs shows great potential for effective tumor therapy. However, conventional microenvironment‐responsive nanomedicines are often difficult to achieve both specificity and sensitivity, leading severe adverse effects or limited drug release efficiency. Furthermore, the immunosuppressive microenvironment will also seriously restrict treatment efficacy. In this work, a cascade‐responsive multi‐polyprodrug nanoregulator is developed. Under with high hydrogen peroxide level, nanoregulators can simultaneously (doxorubicin), indoleamine 2,3‐dioxygenase 1 inhibitor (1‐methyl‐tryptophan) cinnamaldehyde in self‐accelerating manner. The combination reactive oxygen species‐induced ferroptosis doxorubicin‐induced apoptosis synergistically enhance immunogenic cell death activate immune response. released1‐methyl‐tryptophan promote cytotoxic T lymphocyte activation reduce escape by inhibiting tryptophan conversion. Meanwhile, it enhances species scavenging cystine/glutamate antiporter expression, achieving positive feedback ferroptosis‐immunotherapy. This work provides self‐accelerated strategy cooperation mode synergistic immunotherapy based on ferroptosis‐apoptosis.

Language: Английский

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Subcellular organelle targeted tumor phototherapy

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 535, P. 216635 - 216635

Published: March 26, 2025

Language: Английский

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Synergizing Catalysis with Post-catalysis Pseudo-Iron Release by Building Dynamic Catalytic Active Sites in Diatomic Nanozymes for Boosting Cancer Therapy

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown

Published: April 25, 2025

Biomimetic nanozymes hold considerable promise for cancer therapy, but their therapeutic potential is often constrained by limited catalytic activity. Here, we present a Ga/Zn diatomic nanozyme (Ga/Zn-NC) with well-defined geometric structure and electronic configuration designed to emulate peroxidase glutathione oxidase exceptional activities, enabling cascade catalysis. We demonstrate that the formation of Ga-Zn metal bonding essential accelerating electron transfer reducing reaction energy barrier, thus enhancing performance. Within tumor microenvironment, actions Ga/Zn-NC induce oxidative damage sensitize breast cells ferroptosis. Concurrently, release gallium from "pseudo-iron" activity disrupts iron metabolism activates self-amplifying ferroptosis pathway, synergizing enzyme's potentiate apoptosis, thereby achieving remarkable efficacy against tumors.

Language: Английский

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Light-activatable manganese carbonate nanocubes elicit robust immunotherapy by amplifying endoplasmic reticulum stress-meditated pyroptotic cell death

Journal of Experimental & Clinical Cancer Research, Journal Year: 2025, Volume and Issue: 44(1)

Published: May 16, 2025

Although tumor immunotherapy has emerged as a promising treatment modality, it faces significant challenges stemming from the immunosuppressive characteristics of microenvironment (TME), low immunogenicity tumors, and poor specificity immunoactivation. These factors can hinder efficacy immunotherapeutic approaches lead to immune-related adverse events. This study reports multifunctional nanocube (Mn-ER-Cy) that integrates Mn carbonate (MnCO3) photosensitizer (ER-Cy) by targeting tumor-cell endoplasmic reticulum (ER). The results demonstrate Mn-ER-Cy preferentially accumulates in tissues is retained within ER organelles, facilitating photothermal therapy (PTT) photodynamic (PDT) upon exposure 808 nm light irradiation. Triggered acidic TME irradiation, MnCO3 rapidly degraded Mn2+, which turn promotes generation reactive oxygen species through Mn2+-mimic Fenton reaction, enabling chemical dynamics (CDT). Triple-modal synergistic simultaneously happens induce excessive stress, subsequently amplify highly immunogenic pyroptotic cell death activating NLRP3 inflammasome, caspase-1, gasdermin D (GSDMD) pathway. Meanwhile, decomposition consumes H+ contributes an increased intracellular pH regulating lactic acid levels, thereby counteracting TME. Furthermore, serves inherent dual-modality imaging contrast agent for near-infrared fluorescence photoacoustic imaging, imaging-guided precision therapy. findings underscore potential substantially enhance immunotherapy, portraying bright prospect improve clinical outcomes patients with cancer.

Language: Английский

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Dendrimer-Entrapped CuPt Bimetallic Nanozymes for Tumor Microenvironment-Regulated Photothermal/Catalytic Therapy

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: May 19, 2025

Noble metal nanozymes have attracted extensive attention in tumor therapy due to their multiple enzyme-like activities for catalytic and unique optical properties photothermal (PTT). However, therapeutic efficiency may be compromised by the intricate microenvironment (TME). Herein, copper-platinum (CuPt) bimetallic were synthesized entrapped poly(amidoamine) dendrimers, with p-carboxybenzenesulfonamide (BS, a carbonic anhydrase IX (CA IX) inhibitor) modified on surface lonidamine (Lon) loaded inside regulate TME enhanced PTT. The formed CPL@G5-BS could specifically target CA IX-overexpressed cells activate cascade reaction continuous •OH generation peroxidase-like property, O2 supply catalase-like H2O2 replenishing superoxide dismutase-like thereby alleviating hypoxia achieving chemodynamic (CDT). In TME, BS-mediated inhibition would normalize extracellular pH suppress metastasis while reducing intracellular boost efficiency, Lon-mediated mitochondrial respiration energy metabolic disruption elevate oxygen accumulation downregulate heat shock protein (HSP) expression, further enhancing PTT efficacy. Meanwhile, excellent performance of amplify multienzyme activities, Cu2+-mediated glutathione depletion improved CDT efficiency. Overall, can efficiently inhibit growth TME-regulated

Language: Английский

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