Chinese Journal of Natural Medicines, Journal Year: 2024, Volume and Issue: 22(12), P. 1177 - 1192
Published: Dec. 1, 2024
Language: Английский
Small, Journal Year: 2024, Volume and Issue: 20(26)
Published: Jan. 12, 2024
Abstract Although bioactive compounds (BCs) have many important functions, their applications are greatly limited due to own defects. The development of nanocarriers (NCs) technology has gradually overcome the defects BCs. NCs equally as BCs some extent. Self‐assembly (SA) methods build advantages than chemical methods, and SA significant impact on structure function NCs. However, relationship among mechanism, structure, not been given enough attention. Therefore, from perspective bottom‐up building concept SA‐structure‐function is emphasized promote SA‐based First, conditions forces for occurring introduced, then basis molecular mechanism protein, polysaccharide, lipid summarized. Then, varieties structures formed based introduced in detail. Finally, facing how be well solved by also elaborated. This review attempts describe great significance constructing artificial deliver aspects SA‐structure‐function, so wide application
Language: Английский
Citations
18
Journal of Polymers and the Environment, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 11, 2025
Language: Английский
Citations
3
Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 14(11), P. 4683 - 4716
Published: Sept. 2, 2024
About 40% of approved drugs and nearly 90% drug candidates are poorly water-soluble drugs. Low solubility reduces the drugability. Effectively improving bioavailability is a critical issue that needs to be urgently addressed in development application. This review briefly introduces conventional solubilization techniques such as solubilizers, hydrotropes, cosolvents, prodrugs, salt modification, micronization, cyclodextrin inclusion, solid dispersions, details crystallization strategies, ionic liquids, polymer-based, lipid-based, inorganic-based carriers bioavailability. Some most commonly used carrier materials for presented. Several using summarized. Furthermore, this summarizes mechanism each technique, reviews latest research advances challenges, evaluates potential clinical translation. could guide selection approach, dosage form, administration route Moreover, we discuss several promising attracting increasing attention worldwide.
Language: Английский
Citations
14
Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(4), P. 439 - 439
Published: March 22, 2024
Over the last few years, development of nanotechnology has allowed for synthesis many different nanostructures with controlled sizes, shapes, and chemical properties, dendrimers being best-characterized them. In this review, we present a succinct view structure synthetic procedures used dendrimer synthesis, as well cellular uptake mechanisms by these nanoparticles to gain access cell. addition, manuscript reviews reported in vivo applications drug carriers drugs treatment cancer, neurodegenerative diseases, infections, ocular diseases. The dendrimer-based formulations that have reached phases clinical trials, including safety pharmacokinetic studies, or delivery agents therapeutic compounds are also presented. continuous which makes it possible produce increasingly sophisticated complex indicates fascinating family wide potential pharmaceutical industry, especially systems, number entering trials will markedly increase during coming years.
Language: Английский
Citations
12
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 495, P. 153438 - 153438
Published: June 25, 2024
Language: Английский
Citations
12
Research, Journal Year: 2024, Volume and Issue: 7
Published: Jan. 1, 2024
Photochromic polymer is defined as a series of materials based on photochromic units in chains, which produces reversible color changes under irradiation with particular wavelength. Currently, the research progresses, it shows increasing potential applications various fields, such anti-counterfeiting, information storage, super-resolution imaging, and logic gates. However, there paucity published reviews topic polymers. Herein, this review discusses summarizes progress prospects materials, mainly summarizing basic mechanisms, classification, azobenzene, spiropyran, diarylethene Moreover, 3-dimensional (3D) printable polymers are worthy to be summarized specifically because its innovative approach for practical application; meanwhile, developing 3D printing technology has shown opportunities better applications. Finally, current challenges future directions summarized.
Language: Английский
Citations
8
Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: 505, P. 159183 - 159183
Published: Jan. 5, 2025
Language: Английский
Citations
1
Heliyon, Journal Year: 2024, Volume and Issue: 10(9), P. e29726 - e29726
Published: April 16, 2024
Hybrid nanostructures exhibit a synergistic combination of features derived from their individual components, showcasing novel characteristics resulting distinctive structure and chemical/physical properties. Surface modifiers play pivotal role in shaping INPs' primary attributes, influencing physicochemical properties, stability, functional applications. Among these modifiers, dendrimers have gained attention as highly effective multifunctional agents for INPs, owing to unique structural qualities, dendritic effects, Dendrimers can be seamlessly integrated with diverse inorganic nanostructures, including metal NPs, carbon silica QDs. Two viable approaches achieving this integration involve either growing or grafting dendrimers, nanostructure-cored dendrimers. The initial step involves functionalizing the nanostructures' surface, followed by generation through stepwise growth attachment pre-synthesized dendrimer branches. This hybridization imparts superior qualities structure, biocompatibility, solubility, high cargo loading capacity, substantial functionalization potential. Combining properties those nanostructure cores creates system suitable applications such theranostics, bio-sensing, component isolation, chemotherapy, cargo-carrying review summarizes recent developments, specific focus on last five years, within realm It delves into INPs explores potential INP-cored biomedical
Language: Английский
Citations
8
International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 1723 - 1748
Published: Feb. 1, 2024
Given the unique physiological and pathological characteristics of lung, direct, inhalable route is more conducive to pulmonary drug delivery disease control than traditional systemic delivery, significantly circumventing loss, off-target effects, organ toxicity, etc., widely regarded as preferred regimen for delivery.However, very few lung diseases are currently treated with inhaled formulations, such asthma, chronic obstructive hypertension.And there a lack appropriate formulations other critical diseases, cancer fibrosis, due fact that physicochemical properties drugs their pharmacokinetic profiles do not match physiology conventional inhalation devices unable deliver them specific parts lung.Phytochemicals natural origin, wide availability clear safety profile, hold great promise preparation improve current dilemma in treatment diseases.In particular, based on nano-and microparticulate carriers deep tissues, which overcome shortcomings therapies while targeting activity directly part may be best approach change treatment.In this review, we discuss recent advances micron-carrier-based products represent an opportunity practical clinical translation products.
Language: Английский
Citations
6
Nano Today, Journal Year: 2024, Volume and Issue: 57, P. 102386 - 102386
Published: July 13, 2024
Language: Английский
Citations
6