Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 378, P. 814 - 830
Published: Dec. 31, 2024
Language: Английский
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: April 26, 2024
CD44 is a ubiquitous leukocyte adhesion molecule involved in cell-cell interaction, cell adhesion, migration, homing and differentiation. can mediate the interaction between leukemic stem cells surrounding extracellular matrix, thereby inducing cascade of signaling pathways to regulate their various behaviors. In this review, we focus on impact CD44s/CD44v as biomarkers leukemia development discuss current research prospects for CD44-related interventions clinical application.
Language: Английский
Citations
14
Small Methods, Journal Year: 2024, Volume and Issue: unknown
Published: July 23, 2024
Abstract Hyaluronic acid (HA) is a naturally occurring polysaccharide found in the extracellular matrix with broad applications disease treatment. HA possesses good biocompatibility, biodegradability, and ability to interact various cell surface receptors. Its wide range of molecular weights modifiable chemical groups make it an effective drug carrier for delivery. Additionally, overexpression specific receptors on surfaces many states enhances accumulation drugs at pathological sites through receptor binding. In this review, modification drugs, major proteins, latest advances receptor‐targeted nano delivery systems (DDS) treatment tumors inflammatory diseases are summarized. Furthermore, functions varying vivo selection methods different discussed.
Language: Английский
Citations
14
Advances in Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 333, P. 103301 - 103301
Published: Sept. 6, 2024
Language: Английский
Citations
9
Biomacromolecules, Journal Year: 2024, Volume and Issue: 25(3), P. 1959 - 1971
Published: Feb. 20, 2024
Triple-negative breast cancer (TNBC) presents treatment challenges due to a lack of detectable surface receptors. Natural killer (NK) cell-based adaptive immunotherapy is promising because the characteristic anticancer effects killing malignant cells directly by secreting cytokines and lytic granules. To maximize recognition ability NK cells, biomaterial-mediated ex vivo cell engineering has been developed for sufficient membrane immobilization tumor-targeting ligands via hydrophobic anchoring. In this study, we optimized amphiphilic balances coating materials composed CD44-targeting hyaluronic acid (HA)-poly(ethylene glycol) (PEG)-lipid improve TNBC effect. Changes in modular design our material differentiating hydrophilic PEG length incorporating lipid amount into HA backbones precisely regulated nature HA-PEG-lipid conjugates. The biomaterial demonstrated improved anchoring membranes facilitating presentation level onto surfaces. This led enhanced targeting increasing formation immune synapse, thereby augmenting capability specifically toward CD44-positive cells. Our approach addresses solid tumors with deficiency tumor-specific antigens while offering valuable strategy using balance techniques.
Language: Английский
Citations
6
Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 340, P. 122311 - 122311
Published: May 23, 2024
Language: Английский
Citations
5
ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(22), P. 28193 - 28208
Published: May 22, 2024
Ferroptosis therapy and immunotherapy have been widely used in cancer treatment. However, nonselective induction of ferroptosis tumors is prone to immunosuppression, limiting the therapeutic effect To address this issue, study reports a customized hybrid nanovesicle composed NK cell-derived extracellular versicles RSL3-loaded liposomes (hNRVs), aiming establish positive cycle between immunotherapy. Thanks enhanced permeability retention tumor homing characteristics exosomes, our data indicate that hNRVs can actively accumulate enhance cellular uptake. FASL, IFN-γ, RSL3 are released into microenvironment, where FASL derived from cells effectively lyses cells. downregulates expression GPX4 tumor, leading accumulation LPO ROS, promotes The IFN-γ TNF-α stimulates maturation dendritic induces inactivation GPX4, promoting lipid peroxidation, making them sensitive indirectly occurrence ferroptosis. This highlights role hNRV platform enhancing effectiveness synergistic treatment with selective delivery inducers immune activation against glioma without causing additional side effects on healthy organs.
Language: Английский
Citations
4
Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)
Published: Dec. 19, 2024
Radiotherapy (RT) is a primary clinical approach for cancer treatment, but its efficacy often hindered by various challenges, especially radiation resistance, which greatly compromises the therapeutic effectiveness of RT. Mitochondria, central to cellular energy metabolism and regulation cell death, play critical role in mechanisms radioresistance. In this context, cuproptosis, novel copper-induced mitochondria-respiratory-dependent death pathway, offers promising avenue radiosensitization. study, an innovative theranostic nanoplatform was designed induce cuproptosis synergy with low-dose therapy (LDRT, i.e., 0.5–2 Gy) treatment situ hepatocellular carcinoma (HCC). This aims reverse hypoxic tumor microenvironment, promoting shift from glycolysis oxidative phosphorylation (OXPHOS), thereby enhancing sensitivity cuproptosis. Concurrently, Fenton-like reaction ensures sustained supply copper depletion glutathione (GSH), inducing disrupting mitochondrial function, interrupting supply. strategy effectively overcomes radioresistance enhances against tumors. conclusion, study elucidates intricate interactions among hypoxia reversal, metabolic reprogramming, radiosensitization, particularly context treating carcinoma, providing paradigm radiotherapy.
Language: Английский
Citations
4
OncoTargets and Therapy, Journal Year: 2025, Volume and Issue: Volume 18, P. 87 - 106
Published: Jan. 1, 2025
NK cells are a type of antitumor immune cell with promising clinical application, following T cells. The activity is primarily regulated by their surface receptors and microenvironment. In gliomas, the tumor microenvironment exerts strong immunosuppressive effect, which significantly reduces efficacy immunotherapy. Therefore, this review aims to discuss latest research on role in glioma immunotherapy, focusing aspects such as development, function, localization. It summarizes information compounds, monoclonal antibodies, cytokine therapies targeting while emphasizing current status trends gene-modified treatment. Additionally, it explores molecular mechanisms underlying escape cells, providing theoretical foundation new perspectives for cell-based immunotherapy gliomas.
Language: Английский
Citations
0
Biomaterials Research, Journal Year: 2025, Volume and Issue: 29
Published: Jan. 1, 2025
Effective drug delivery relies on the selection of suitable carriers, which is crucial for protein-based therapeutics such as tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). One key advantages TRAIL its ability to selectively induce apoptosis in cancer cells excluding healthy tissues by binding death receptors DR4 and DR5, are highly expressed various cells. Despite this promise, clinical application has been limited short half-life, stability, inefficient sites. To overcome currently available engineering approaches, a series sophisticated strategies required: (a) design biomaterial-mediated carriers enhanced targeting efficacy, particularly via optimizing selected materials, composition, formulation, surface modulation. Moreover, (b) development genetically modified cellular products augmented secretion toward microenvironments (c) cell techniques immobilization onto infusible populations also discussed present review. Among these living cell-based offer distinct advantage systemically administered TRAIL-functionalized capturing circulating bloodstream, thereby preventing secondary formation. This review provides insight into novel platforms, discusses considerations translation, suggests future directions complementary advance field TRAIL-based therapeutics.
Language: Английский
Citations
0
Asian Journal of Pharmaceutical Sciences, Journal Year: 2025, Volume and Issue: unknown, P. 101061 - 101061
Published: April 1, 2025
Language: Английский
Citations
0