iScience, Journal Year: 2024, Volume and Issue: 28(1), P. 111602 - 111602
Published: Dec. 14, 2024
Language: Английский
Journal of Hematology & Oncology, Journal Year: 2024, Volume and Issue: 17(1)
Published: April 2, 2024
Abstract Cancer immunotherapy and vaccine development have significantly improved the fight against cancers. Despite these advancements, challenges remain, particularly in clinical delivery of immunomodulatory compounds. The tumor microenvironment (TME), comprising macrophages, fibroblasts, immune cells, plays a crucial role response modulation. Nanoparticles, engineered to reshape TME, shown promising results enhancing by facilitating targeted These nanoparticles can suppress fibroblast activation, promote M1 macrophage polarization, aid dendritic cell maturation, encourage T infiltration. Biomimetic further enhance increasing internalization agents cells such as cells. Moreover, exosomes, whether naturally secreted body or bioengineered, been explored regulate TME immune-related affect cancer immunotherapy. Stimuli-responsive nanocarriers, activated pH, redox, light conditions, exhibit potential accelerate co-application with checkpoint inhibitors is an emerging strategy boost anti-tumor immunity. With their ability induce long-term immunity, nanoarchitectures are structures development. This review underscores critical overcoming current driving advancement modification.
Language: Английский
Citations
131
Cancer Nanotechnology, Journal Year: 2025, Volume and Issue: 16(1)
Published: Jan. 17, 2025
Emphasizing the significance of cancer-associated fibroblasts (CAFs), non-malignant yet pivotal players within tumor microenvironment (TME), this review illuminates role inflammatory subtype (iCAF) as catalysts in cancer proliferation, metastasis, and therapeutic resistance. Given their paramount importance, targeting CAFs emerges a robust strategy evolving landscape immunotherapy. Nanomaterials, distinguished by unique features malleability, hold considerable promise biomedicine, especially precision-oriented domain therapy. Their aptitude for modulating immune responses, amplifying drug efficacy through precise delivery, discerningly focusing on cells TME situates nanomaterials formidable tools to transcend boundaries set conventional treatments. This scrutinizes convoluted interplay among CAFs, cells, TME. It further showcases widely utilized management. We underscore potential nanoscale delivery systems directed at underscoring transformative power revolutionizing therapies, enhancing precision, culminating improved patient outcomes.
Language: Английский
Citations
2
Advanced Science, Journal Year: 2024, Volume and Issue: 11(29)
Published: June 3, 2024
Abstract Exploring efficient and low‐toxicity radiosensitizers to break through the bottleneck of radiation tolerance, immunosuppression poor prognosis remains one critical developmental challenges in radiotherapy. Nanoheterojunctions, due their unique physicochemical properties, have demonstrated excellent radiosensitization effects energy deposition lifting tumor radiotherapy inhibition. Herein, they doped selenium (Se) into prussian blue (PB) construct a nano‐heterojunction (Se@PB), which could promote increase Fe 2+ /Fe 3+ ratio conversion Se high valence state with introduction. The ‐Se‐Fe electron transfer chain accelerates rate on surface nanoparticles, turn endows it X‐ray transport capability, enhances physical sensitivity. Furthermore, Se@PB induces glutathione (GSH) depletion accumulation pro‐Fenton reaction, thereby disturbs redox balance cells biochemical sensitivity As an radiosensitizer, effectively induced mitochondrial dysfunction DNA damage, promotes cell apoptosis synergistic cervical cancer This study elucidates mechanism Se‐doped nanoheterojunction from perspective biochemistry provides low‐toxic strategy
Language: Английский
Citations
13
Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)
Published: Aug. 19, 2024
Drug resistance remains a significant challenge in cancer treatment. Recently, the interactions among various cell types within tumor microenvironment (TME) have deepened our understanding of mechanisms behind treatment resistance. Therefore, this review aims to synthesize current research focusing on infiltrating cells and drug suggesting that targeting TME could be viable strategy combat issue. Numerous factors, including inflammation, metabolism, senescence, hypoxia, angiogenesis, contribute Overexpression STAT3 is commonly associated with drug-resistant or stromal cells. Current often generalizes impact resistance, lacking specificity statistical robustness. Thus, future should take notice issue aim provide high-quality evidence. Despite existing limitations, overcome therapy hold promising valuable potential.
Language: Английский
Citations
9
Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(25), P. 6091 - 6101
Published: Jan. 1, 2024
Due to the rapid progression and aggressive metastasis of breast cancer, its diagnosis treatment remain a great challenge. The simultaneous inhibition tumor growth is necessary for cancer obtain ideal therapeutic outcomes. We herein report development radioactive hybrid semiconducting polymer nanoparticles (SPNH) imaging-guided tri-modal therapy cancer. Two polymers are used form SPNH with diameter around 60 nm via nano-coprecipitation they also labeled iodine-131 (131I) enhance imaging functions. formed show good radiolabeling stability excellent photodynamic photothermal effects under 808 laser irradiation produce singlet oxygen (1O2) heat. Moreover, can generate 1O2 ultrasound their sonodynamic properties. After intravenous tail vein injection, effectively accumulate in subcutaneous 4T1 tumors living mice as verified fluorescence single photon emission computed tomography (SPECT) imaging. With using an US, mediate (PDT), (PTT) (SDT) kill cells. Such leads improved efficacy inhibiting suppressing compared sole SDT combinational PDT-PTT. This study thus demonstrates applications diagnose combine different therapies effective treatment.
Language: Английский
Citations
4
International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: 670, P. 125190 - 125190
Published: Jan. 7, 2025
Language: Английский
Citations
0
Molecular Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 17, 2025
Malignant tumors pose a considerable threat to human life and health. Traditional treatments, such as radiotherapy chemotherapy, often lack specificity, leading collateral damage normal tissues. Tumor microenvironment (TME) is characterized by hypoxia, acidity, redox imbalances, elevated ATP levels factors that collectively promote tumor growth metastasis. This review provides comprehensive overview of the nanoparticles developed in recent years for TME-responsive strategies or TME-modulating methods therapy. The focus on designing synthesizing can interact with achieve precisely controlled drug release. These activate release under specific conditions within environment, thereby enhancing efficacy drugs while reducing toxicity cells. Moreover, simply eliminating cells does not fundamentally solve problem. Only comprehensively regulating TME make it unsuitable cell survival proliferation we more thorough therapeutic effects reduce risk recurrence. regulation aim suppress metastasis modulating various components TME. only improve treatment outcomes but also have potential lay foundation future personalized cancer therapies.
Language: Английский
Citations
0
Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)
Published: March 4, 2025
The tumor microenvironment (TME) is a complex and dynamic ecosystem that plays critical role in cancer progression. It comprises various cell types, including immune cells, stromal cells. Among these, cancer-associated fibroblasts (CAFs) represent heterogeneous population with diverse origins, phenotypes, functions. Activated CAFs secrete multiple factors promote growth, migration, angiogenesis, contribute to chemoresistance. Additionally, extracellular matrix (ECM) components, such as collagen, which form physical barrier hinders the penetration of chemotherapeutic immunotherapeutic agents. This ECM also influences infiltration, impeding their ability effectively target As result, modulating activity has emerged promising strategy enhance efficacy immunotherapy. Nano-delivery systems, constructed from nanomaterials high targeting specificity biocompatibility, offer compelling approach deliver therapeutic agents or immunomodulatory directly CAFs. modulation can alter CAF function, reduce tumor-promoting effects, thereby improve outcomes review provides an in-depth exploration functions, interactions within TME, particularly context suppression. Furthermore, it discusses potential applications functional nanocarrifers enhancing effectiveness immunotherapy, highlighting significant progress nanotechnology this area.
Language: Английский
Citations
0
Acta Pharmaceutica Sinica B, Journal Year: 2025, Volume and Issue: unknown
Published: March 1, 2025
Language: Английский
Citations
0
Critical Reviews in Oncology/Hematology, Journal Year: 2025, Volume and Issue: unknown, P. 104705 - 104705
Published: March 1, 2025
Language: Английский
Citations
0