Oxygen‐Independent Photodynamic Therapy‐Mediated Selective Consumption of M1 Macrophage Against Ventricular Arrhythmias via Sympathetic Neuromodulation DOI Open Access
Heng Lin, Hengyang Liu,

Haosong Xi

et al.

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 23, 2024

Abstract The occurrence of myocardial infarction (MI)‐induced malignant ventricular arrhythmias (VAs) is closely associated with the hyperactivation left stellate ganglion (LSG). Proinflammatory M1 macrophage reported to aggravate sympathetic overactivation and cause VAs. Therefore, depletion anticipated inhibit LSG alleviate MI‐induced Herein, oxygen‐independent photodynamic therapy (Oi‐PDT) combined targeting applied selectively deplete in further treat Oi‐PDT, which overcomes limitation extremely dependence on oxygen content traditional PDT, constructed through generation oxidizing photogenerated holes (h + ) under irradiation near‐infrared (NIR) light prepared Oi‐PDT agent (PPSCD). Meanwhile, PPSCD targets conjunction SR‐A receptor. selective consumption attributed both apoptosis ferroptosis induced by h , 1 O 2 •− generated Oi‐PDT. In vivo tests indicated neural activity experienced a notable reduction from 104.5 ± 2.9 51.5 6.7 after MI treatment, thereby significantly inhibited implementation this study provides promising strategy for macrophages treatment VAs MI.

Language: Английский

Photothermal Fe3O4 nanoparticles induced immunogenic ferroptosis for synergistic colorectal cancer therapy DOI Creative Commons
Yue Li, Jia Chen, Qi Xia

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Oct. 16, 2024

Photothermal therapy (PTT) is a promising non-invasive treatment that has shown great potential in eliminating tumors. It not only induces apoptosis of cancer cells but also triggers immunogenic cell death (ICD) which could activate the immune system against cancer. However, immunosuppressive tumor microenvironment (TIME) poses challenge to triggering strong responses with single treatment, thus limiting therapeutic effect immunotherapy. In this study, dual-targeted nano delivery (GOx@FeNPs) combined αPD-L1 checkpoint blocker inhibit colorectal (CRC) progression by mediating PTT, ferroptosis and anti-tumor response. Briefly, specific was achieved cyclic arginine glycyl aspartate (cRGD) peptide anisamide (AA) GOx@FeNPs had good photothermal realize PTT induce ICD, deplete glutathione (GSH) catalyze production reactive oxygen species (ROS) from endogenous H

Language: Английский

Citations

12
A novel silkworm excrement-derived nanomedicine integrating ferroptosis and photodynamic therapy, well-suitable for PD-L1-mediated immune checkpoint blockade DOI
Yujun Bao, Guanghao Li, Mingyang Liu

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: 505, P. 159676 - 159676

Published: Jan. 17, 2025

Language: Английский

Citations

1
Biodegradable Long-Circulating Nanoagonists Optimize Tumor-Tropism Chemo-Metalloimmunotherapy for Boosted Antitumor Immunity by Cascade cGAS-STING Pathway Activation DOI
Hao Li, Cheng Zhang, Yue Chen

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(34), P. 23711 - 23726

Published: Aug. 16, 2024

The activation of cyclic GMP-AMP synthase (cGAS) and stimulator interferon genes (STING) has been recognized as one the most promising immunotherapeutic strategies to induce innate antitumor immune responses. However, it is far from effective just activate cGAS-STING pathway, owing abundant immunosuppressive cells that infiltrate tumor microenvironment (TME) impair immunity. Here, we present smart design biodegradable Mn-doped mesoporous silica (MM) nanoparticles with metal–organic framework (MOF) gating hyaluronic acid (HA)-modified erythrocyte membrane (eM) camouflaging coload cisplatin (CDDP) SR-717 (a STING agonist) for long-circulating tumor-tropism synergistic chemo-metalloimmunotherapy by cascade activation. Once internalized cells, acidity/redox-responsive gated MOF rapidly disintegrates release exposes dual-responsive MM decompose CDDP release, thus inducing damage double-stranded DNA (dsDNA) in cancer cells. As tumor-specific antigens, these dsDNA fragments released can trigger enhance dendritic cell (DC) maturation cytotoxic T (CTL) infiltration, giving rise excellent therapeutic effects efficient regression. Overall, this custom-designed nanoagonist represents a paradigm nanotechnology realizing cooperation chemotherapy metalloimmunotherapy based on future oncological applications.

Language: Английский

Citations

7
Disulfidptosis, A Novel Cell Death Pathway: Molecular Landscape and Therapeutic Implications DOI Creative Commons

Qiuyang Gu,

Yumei An,

Mingyuan Xu

et al.

Aging and Disease, Journal Year: 2024, Volume and Issue: unknown, P. 0 - 0

Published: Jan. 1, 2024

Programmed cell death is pivotal for several physiological processes, including immune defense. Further, it has been implicated in the pathogenesis of developmental disorders and onset numerous diseases. Multiple modes programmed death, apoptosis, pyroptosis, necroptosis, ferroptosis, have identified, each with their own unique characteristics biological implications. In February 2023, Liu Xiaoguang his team discovered "disulfidptosis," a novel pathway death. Their findings demonstrated that disulfidptosis triggered glucose-starved cells exhibiting high expression protein called SLC7A11. Furthermore, marked by drastic imbalance NADPH/NADP+ ratio abnormal accumulation disulfides like cystine. These changes ultimately lead to destabilization F-actin network, causing Given SLC7A11 key feature certain cancers, these indicate could serve as basis innovative anti-cancer therapies. Hence, this review delves into discovery disulfidptosis, its underlying molecular mechanisms metabolic regulation, prospective applications disease treatment.

Language: Английский

Citations

6
Biodegradable Vanadium-Based Nanomaterials for Photothermal-Enhanced Tumor Ferroptosis and Pyroptosis DOI

Jinzha Zhang,

Ming Shi, Jiawen Sun

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 17, 2025

The designability and high reactivity of nanotechnology provide strategies for antitumor therapy by regulating the redox state in tumor cells. Here, we synthesize a kind vanadium dioxide nanoparticle encapsulated bovine serum albumin containing disulfide bonds (VSB NPs) photothermal-enhanced ferroptosis pyroptosis effects. Mechanism studies show that can effectively consume overexpressed glutathione (GSH) microenvironment, leading to decrease peroxidase 4 (GPX4) activity. Simultaneously, tetravalent induce catalytic reaction H2O2, producing plenty toxic hydroxyl radicals (·OH) singlet oxygen (1O2), cell ferroptosis. In addition, consumption also lead degradation nanoparticles into high-valent vanadates, activating thermal protein domain-associated 3 (NLRP3) inflammasomes causing pyroptosis. It is worth mentioning VSB NPs not only ablate cells under near-infrared light irradiation but further disrupt homeostasis thereby enhancing induced biodegradable vanadium-based nanomaterials. This strategy, based on biological effects regulate cells, provides possibilities cancer treatment.

Language: Английский

Citations

0
Biologically Logic-Gated Trojan-Horse Strategy for Personalized Triple-Negative Breast Cancer Precise Therapy by Selective Ferroptosis and STING Pathway Provoking DOI
Shuai Guo, Tianwang Guan,

Yushen Ke

et al.

Biomaterials, Journal Year: 2024, Volume and Issue: 315, P. 122905 - 122905

Published: Oct. 21, 2024

Language: Английский

Citations

4
From detection to elimination: iron-based nanomaterials driving tumor imaging and advanced therapies DOI Creative Commons
Dongyue Xie,

Linglin Sun,

Manxiang Wu

et al.

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: Feb. 7, 2025

Iron-based nanomaterials (INMs), due to their particular magnetic property, excellent biocompatibility, and functionality, have been developed into powerful tools in both tumor diagnosis therapy. We give an overview here on how INMs such as iron oxide nanoparticles, element-doped nanocomposites, iron-based organic frameworks (MOFs) display versatility for imaging therapy improvement. In terms of imaging, improve the sensitivity accuracy techniques resonance (MRI) photoacoustic (PAI) support development multimodal platforms. Regarding treatment, play a key role advanced strategies immunotherapy, hyperthermia, synergistic combination therapy, which effectively overcome tumor-induced drug resistance reduce systemic toxicity. The integration with artificial intelligence (AI) radiomics further expands its capabilities precise identification, treatment optimization, amplifies monitoring. now link materials science computing clinical innovations enable next-generation cancer diagnostics therapeutics.

Language: Английский

Citations

0
Iron-Dependent Cell Death: Exploring Ferroptosis as a Unique Target in Triple-Negative Breast Cancer Management DOI Creative Commons

L. Tan,

Jiaxing Liu, C Ma

et al.

Cancer Management and Research, Journal Year: 2025, Volume and Issue: Volume 17, P. 625 - 637

Published: March 1, 2025

Triple-negative breast cancer (TNBC) is characterized by aggressive behavior, high metastatic potential, and frequent relapses, presenting significant treatment challenges. Ferroptosis, a unique form of programmed cell death marked iron-dependent lipid peroxidation, has emerged as crucial factor in biology. Recent studies indicate that TNBC cells possess distinct metabolic profile linked to iron glutathione, which may render them more susceptible ferroptosis than other subtypes. Moreover, plays role the interactions between immune tumor cells, suggesting its potential modulate microenvironment influence response against TNBC.Evidence reveals not only affects viability but also alters promoting release damage-associated molecular patterns (DAMPs), can recruit site. Specific ferroptosis-related genes biomarkers, such ACSL4 GPX4, demonstrate altered expression tissues, offering promising avenues for diagnostic prognostic applications. Furthermore, preclinical models, induction been shown enhance efficacy existing therapies, indicating synergistic effect could be harnessed therapeutic benefit. The compelling link underscores novel target. Future research should focus on developing strategies exploit conjunction with traditional including identification natural compounds efficacious inducers personalized regimens. This review elucidates multifaceted implications TNBC, providing valuable insights improving both diagnosis this formidable subtype.

Language: Английский

Citations

0
MOF-Supported Gold Nanozyme with Glutathione Consumption and Oxidative Stress Amplification against Cancer Cells DOI

Xinyu Chang,

Meng-Fan Feng,

Li-Miao Qin

et al.

ACS Applied Nano Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 27, 2025

Language: Английский

Citations

0
Synchronously Evoking Disulfidptosis and Ferroptosis via Systematical Glucose Deprivation Targeting SLC7A11/GSH/GPX4 Antioxidant Axis DOI

Mengsi Zhang,

Hao Zheng,

Xuanqi Zhu

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: April 3, 2025

Disulfidptosis and ferroptosis are recently identified programmed cell deaths for tumor therapy, both of which highly depend on the intracellular cystine/cysteine transformation cystine transporter solute carrier family 7 member 11/glutathione/glutathione peroxidase 4 (SLC7A11/GSH/GPX4) antioxidant axis. However, disulfidptosis usually asynchronous due to opposite effect transport them. Herein, systematic glucose deprivation, by inhibiting upstream uptake promoting downstream consumption, is proposed synchronously evoke ferroptosis. As an example, Au nanodots Fe-apigenin (Ap) complexes coloaded FeOOH nanoshuttles (FeOOH@Fe-Ap@Au NSs) employed regulate SLC7A11/GSH/GPX4 axis performing disulfidptosis- ferroptosis-mediated therapy synchronously. In this scenario, exhibit oxidase-like activity when consuming massive glucose. Meanwhile, Ap can inhibit downregulating 1, depriving fundamentally. The systematical deprivation limits supplement NADPH suppresses axis, thus solving contradiction addition, efficient delivery exogenous iron ions FeOOH@Fe-Ap@Au NSs self-supplied H2O2 through nanodots-catalytic oxidation facilitate Fenton reaction therewith help amplify a result synchronous occurrence ferroptosis, good efficacy in ovarian cancer therapeutic model.

Language: Английский

Citations

0