Polymer-based responsive structural color materials

Progress in Materials Science, Journal Year: 2023, Volume and Issue: 135, P. 101091 - 101091

Published: Feb. 10, 2023

Language: Английский

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Multi‐Bioinspired MOF Delivery Systems from Microfluidics for Tumor Multimodal Therapy

Advanced Science, Journal Year: 2023, Volume and Issue: 10(33)

Published: Oct. 18, 2023

Metal-organic framework (MOF)-based drug delivery systems have demonstrated values in oncotherapy. Current research endeavors are centralized on the functionality enrichment of featured MOF materials with designed versatility for synergistic multimodal treatments. Here, inspired by multifarious biological functions including ferroptosis pattern, porphyrins, and cancer cell membrane (CCM) camouflage technique, novel multi-biomimetic nanocarriers from microfluidics prepared. The Fe

Language: Английский

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Bio‐Inspired Porous Microneedles Dwelled Stem Cells for Diabetic Wound Treatment

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(28)

Published: Feb. 6, 2024

Abstract Diabetic wound healing is a serious, complex, and chronic process; one current promising focusing technology in this area stem cell treatment. Here, novel porous microneedle (MN) arrays fabricated, which can highly mimetic niches, through template filling, particle etching method. The human adipose‐derived cells (ADSCs) are encapsulated Matrigel then loaded into the MN by post‐perfusion. Because of extracellular matrix‐mimicking, biocompatible offers bionic microenvironment nest suitable for growth. Benefiting from numerous pore structures MNs, ADSCs have enough space to fully absorb nutrients, proliferate greatly exhibit prompted function. In addition, cell‐loaded mechanical strength penetrate skin, allowing get deep areas. Based on these features, performance resultant promoting tissue regeneration demonstrated, collagen deposition angiogenesis diabetes wounds rat models. Thus, it believe that bioinspired MNs act as excellent scaffolds will find many practical values clinic healing.

Language: Английский

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Vein-Like Ni-BTC@Ni₃S₄ with Sulfur Vacancy and Ni³⁺ Fabricated In Situ Etching Vulcanization Strategy for an Electrochemical Sensor of Dopamine

ACS Applied Materials & Interfaces, Journal Year: 2023, Volume and Issue: 15(10), P. 13319 - 13331

Published: March 2, 2023

In this study, a novel Ni-BTC@Ni3S4 composite was fabricated by solvothermal reaction using an in situ etching vulcanization strategy and characterized X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), high-resolution transmission (HRTEM), photoelectron (XPS), paramagnetic resonance (EPR), Brunauer-Emmett-Teller (BET) analyses. The existence of sulfur vacancy Ni3+ the as-prepared vein-like greatly promoted electrochemical sensing activity materials. Herein, simple sensor (Ni-BTC@Ni3S4/CPE) has been used for detection dopamine (DA). current signal Ni-BTC@Ni3S4/CPE-modified electrode linear with concentration DA range 0.05-750 μM (R2 = 0.9995) sensitivity 560.27 μA·mM-1·cm-2 limit 0.016 μM. At same time, good stability anti-interference ability. This study could provide new idea structural regulation electrode-modified materials sensitive small biological molecules.

Language: Английский

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Ultrasound-responsive matters for biomedical applications

The Innovation, Journal Year: 2023, Volume and Issue: 4(3), P. 100421 - 100421

Published: April 6, 2023

Ultrasound (US) is a biofavorable mechanical wave that has shown practical significance in biomedical fields. Due to the cavitation effect, sonoluminescence, sonoporation, pyrolysis, and other biophysical chemical effects, wide range of matters have been elucidated be responsive stimulus US. This review addresses discusses current developments US-responsive matters, including US-breakable intermolecular conjugations, US-catalytic sonosensitizers, fluorocarbon compounds, microbubbles, US-propelled micro- nanorobots. Meanwhile, interactions between US advanced create various biochemical products enhanced leading exploration potential applications, from US-facilitated biosensing diagnostic imaging US-induced therapeutic applications clinical translations. Finally, challenges are summarized future perspectives on translations proposed.

Language: Английский

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Hierarchical Spinning of Janus Textiles with Anisotropic Wettability for Wound Healing

Research, Journal Year: 2023, Volume and Issue: 6

Published: Jan. 1, 2023

Wound healing and tissue repair are recognized as basic human health problems worldwide. Attempts to accelerate the reparative process focused on developing functional wound dressings. Herein, we present novel Janus textiles with anisotropic wettability from hierarchical microfluidic spinning for healing. The hydrophilic hydrogel microfibers microfluidics woven into freeze-drying treatment, followed by deposition of electrostatic nanofibers composed hydrophobic polylactic acid (PLA) silver nanoparticles. electrospun nanofiber layer can be well coupled microfiber generate due roughness textile surface incomplete evaporation PLA solution when reaching surface. For treatment side contacting surface, exudate pumped based differential derived drainage force. During this process, prevent excess fluid infiltrating again, preventing excessive moisture preserving breathability wound. In addition, nanoparticles contained in could impart good antibacterial effect, which further promote efficiency. These features indicate that described fiber has great application potential field treatment.

Language: Английский

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Computer vision meets microfluidics: a label-free method for high-throughput cell analysis

Microsystems & Nanoengineering, Journal Year: 2023, Volume and Issue: 9(1)

Published: Sept. 21, 2023

In this paper, we review the integration of microfluidic chips and computer vision, which has great potential to advance research in life sciences biology, particularly analysis cell imaging data. Microfluidic enable generation large amounts visual data at single-cell level, while vision techniques can rapidly process analyze these extract valuable information about cellular health function. One key advantages integrative approach is that it allows for noninvasive low-damage characterization, important studying delicate or fragile microbial cells. The use provides a highly controlled environment growth manipulation, minimizes experimental variability improves accuracy analysis. Computer be used recognize target species within heterogeneous populations, understanding physiological status cells complex biological systems. As hardware artificial intelligence algorithms continue improve, expected become an increasingly powerful tool situ microelectromechanical devices combination with could development label-free, automatic, low-cost, fast recognition high-throughput responses different compounds, broad applications fields such as drug discovery, diagnostics, personalized medicine.

Language: Английский

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PETG: Applications in Modern Medicine

Engineered Regeneration, Journal Year: 2023, Volume and Issue: 5(1), P. 45 - 55

Published: Nov. 26, 2023

Polyethylene terephthalate glycol, PETG, is a miscible, transparent thermoplastic known to have strong tensile properties, high ductility, as well resistance heat and chemical insults. PETG may be manufactured in several ways, most notably 3D printing modalities. As such, has emerged viable biomaterial for variety of medical applications such tissue engineering, dentistry, optometry, vascular health, cardiology, orthopedics, neurology, gynecology, surgery. also serves valuable role biomedical research engineering by offering improvements cell studies, drug carriers, anti-bacterial measures. Further innovation utilizing will better characterize its value an inexpensive versatile biomaterial.

Language: Английский

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On‐Site Melanoma Diagnosis Utilizing a Swellable Microneedle‐Assisted Skin Interstitial Fluid Sampling and a Microfluidic Particle Dam for Visual Quantification of S100A1

Advanced Science, Journal Year: 2024, Volume and Issue: 11(16)

Published: Feb. 28, 2024

Abstract Malignant melanoma (MM) is the most aggressive form of skin cancer. The delay in treatment will induce metastasis, resulting a poor prognosis and even death. Here, two‐step strategy for on‐site diagnosis MM developed based on extraction direct visual quantification S100A1, biomarker melanoma. First, swellable microneedle utilized to extract S100A1 interstitial fluid (ISF) with minimal invasion. After elution, antibody‐conjugated magnetic microparticles (MMPs) polystyrene (PMPs) are introduced. A high expression level gives rise robust binding between MMPs PMPs reduces number free PMPs. By loading reacted solution into device microfluidic particle dam, quantity after separation displayed their accumulation length inversely proportional levels. limit detection 18.7 ng mL −1 achieved. animal experiment indicates that ISF‐based using proposed exhibits significantly higher sensitivity compared conventional serum‐based detection. In addition, result highly comparable gold standard enzyme‐linked immunosorbent assay Lin's concordance correlation coefficient, suggesting practicality routine monitoring

Language: Английский

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Hydrogel-based hollow microfibers for functional esophageal carcinoma remodeling

Cell Reports Physical Science, Journal Year: 2025, Volume and Issue: unknown, P. 102358 - 102358

Published: Jan. 1, 2025

Language: Английский

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