The Analyst,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
A
chemiluminescence
enzyme
immunoassay
based
on
microfluidic
magnetic
droplets
for
multiplex
sepsis
biomarker
screening,
which
has
great
potential
broader
applications
in
biomolecule
detection
and
early
disease
diagnosis,
is
reported.
Advanced Science,
Journal Year:
2023,
Volume and Issue:
10(33)
Published: Oct. 18, 2023
Metal-organic
framework
(MOF)-based
drug
delivery
systems
have
demonstrated
values
in
oncotherapy.
Current
research
endeavors
are
centralized
on
the
functionality
enrichment
of
featured
MOF
materials
with
designed
versatility
for
synergistic
multimodal
treatments.
Here,
inspired
by
multifarious
biological
functions
including
ferroptosis
pattern,
porphyrins,
and
cancer
cell
membrane
(CCM)
camouflage
technique,
novel
multi-biomimetic
nanocarriers
from
microfluidics
prepared.
The
Fe
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(28)
Published: Feb. 6, 2024
Abstract
Diabetic
wound
healing
is
a
serious,
complex,
and
chronic
process;
one
current
promising
focusing
technology
in
this
area
stem
cell
treatment.
Here,
novel
porous
microneedle
(MN)
arrays
fabricated,
which
can
highly
mimetic
niches,
through
template
filling,
particle
etching
method.
The
human
adipose‐derived
cells
(ADSCs)
are
encapsulated
Matrigel
then
loaded
into
the
MN
by
post‐perfusion.
Because
of
extracellular
matrix‐mimicking,
biocompatible
offers
bionic
microenvironment
nest
suitable
for
growth.
Benefiting
from
numerous
pore
structures
MNs,
ADSCs
have
enough
space
to
fully
absorb
nutrients,
proliferate
greatly
exhibit
prompted
function.
In
addition,
cell‐loaded
mechanical
strength
penetrate
skin,
allowing
get
deep
areas.
Based
on
these
features,
performance
resultant
promoting
tissue
regeneration
demonstrated,
collagen
deposition
angiogenesis
diabetes
wounds
rat
models.
Thus,
it
believe
that
bioinspired
MNs
act
as
excellent
scaffolds
will
find
many
practical
values
clinic
healing.
ACS Applied Materials & Interfaces,
Journal Year:
2023,
Volume and Issue:
15(10), P. 13319 - 13331
Published: March 2, 2023
In
this
study,
a
novel
Ni-BTC@Ni3S4
composite
was
fabricated
by
solvothermal
reaction
using
an
in
situ
etching
vulcanization
strategy
and
characterized
X-ray
diffraction
(XRD),
Fourier
transform
infrared
spectroscopy
(FT-IR),
scanning
electron
microscopy
(SEM),
high-resolution
transmission
(HRTEM),
photoelectron
(XPS),
paramagnetic
resonance
(EPR),
Brunauer-Emmett-Teller
(BET)
analyses.
The
existence
of
sulfur
vacancy
Ni3+
the
as-prepared
vein-like
greatly
promoted
electrochemical
sensing
activity
materials.
Herein,
simple
sensor
(Ni-BTC@Ni3S4/CPE)
has
been
used
for
detection
dopamine
(DA).
current
signal
Ni-BTC@Ni3S4/CPE-modified
electrode
linear
with
concentration
DA
range
0.05-750
μM
(R2
=
0.9995)
sensitivity
560.27
μA·mM-1·cm-2
limit
0.016
μM.
At
same
time,
good
stability
anti-interference
ability.
This
study
could
provide
new
idea
structural
regulation
electrode-modified
materials
sensitive
small
biological
molecules.
The Innovation,
Journal Year:
2023,
Volume and Issue:
4(3), P. 100421 - 100421
Published: April 6, 2023
Ultrasound
(US)
is
a
biofavorable
mechanical
wave
that
has
shown
practical
significance
in
biomedical
fields.
Due
to
the
cavitation
effect,
sonoluminescence,
sonoporation,
pyrolysis,
and
other
biophysical
chemical
effects,
wide
range
of
matters
have
been
elucidated
be
responsive
stimulus
US.
This
review
addresses
discusses
current
developments
US-responsive
matters,
including
US-breakable
intermolecular
conjugations,
US-catalytic
sonosensitizers,
fluorocarbon
compounds,
microbubbles,
US-propelled
micro-
nanorobots.
Meanwhile,
interactions
between
US
advanced
create
various
biochemical
products
enhanced
leading
exploration
potential
applications,
from
US-facilitated
biosensing
diagnostic
imaging
US-induced
therapeutic
applications
clinical
translations.
Finally,
challenges
are
summarized
future
perspectives
on
translations
proposed.
Wound
healing
and
tissue
repair
are
recognized
as
basic
human
health
problems
worldwide.
Attempts
to
accelerate
the
reparative
process
focused
on
developing
functional
wound
dressings.
Herein,
we
present
novel
Janus
textiles
with
anisotropic
wettability
from
hierarchical
microfluidic
spinning
for
healing.
The
hydrophilic
hydrogel
microfibers
microfluidics
woven
into
freeze-drying
treatment,
followed
by
deposition
of
electrostatic
nanofibers
composed
hydrophobic
polylactic
acid
(PLA)
silver
nanoparticles.
electrospun
nanofiber
layer
can
be
well
coupled
microfiber
generate
due
roughness
textile
surface
incomplete
evaporation
PLA
solution
when
reaching
surface.
For
treatment
side
contacting
surface,
exudate
pumped
based
differential
derived
drainage
force.
During
this
process,
prevent
excess
fluid
infiltrating
again,
preventing
excessive
moisture
preserving
breathability
wound.
In
addition,
nanoparticles
contained
in
could
impart
good
antibacterial
effect,
which
further
promote
efficiency.
These
features
indicate
that
described
fiber
has
great
application
potential
field
treatment.
Microsystems & Nanoengineering,
Journal Year:
2023,
Volume and Issue:
9(1)
Published: Sept. 21, 2023
In
this
paper,
we
review
the
integration
of
microfluidic
chips
and
computer
vision,
which
has
great
potential
to
advance
research
in
life
sciences
biology,
particularly
analysis
cell
imaging
data.
Microfluidic
enable
generation
large
amounts
visual
data
at
single-cell
level,
while
vision
techniques
can
rapidly
process
analyze
these
extract
valuable
information
about
cellular
health
function.
One
key
advantages
integrative
approach
is
that
it
allows
for
noninvasive
low-damage
characterization,
important
studying
delicate
or
fragile
microbial
cells.
The
use
provides
a
highly
controlled
environment
growth
manipulation,
minimizes
experimental
variability
improves
accuracy
analysis.
Computer
be
used
recognize
target
species
within
heterogeneous
populations,
understanding
physiological
status
cells
complex
biological
systems.
As
hardware
artificial
intelligence
algorithms
continue
improve,
expected
become
an
increasingly
powerful
tool
situ
microelectromechanical
devices
combination
with
could
development
label-free,
automatic,
low-cost,
fast
recognition
high-throughput
responses
different
compounds,
broad
applications
fields
such
as
drug
discovery,
diagnostics,
personalized
medicine.
Engineered Regeneration,
Journal Year:
2023,
Volume and Issue:
5(1), P. 45 - 55
Published: Nov. 26, 2023
Polyethylene
terephthalate
glycol,
PETG,
is
a
miscible,
transparent
thermoplastic
known
to
have
strong
tensile
properties,
high
ductility,
as
well
resistance
heat
and
chemical
insults.
PETG
may
be
manufactured
in
several
ways,
most
notably
3D
printing
modalities.
As
such,
has
emerged
viable
biomaterial
for
variety
of
medical
applications
such
tissue
engineering,
dentistry,
optometry,
vascular
health,
cardiology,
orthopedics,
neurology,
gynecology,
surgery.
also
serves
valuable
role
biomedical
research
engineering
by
offering
improvements
cell
studies,
drug
carriers,
anti-bacterial
measures.
Further
innovation
utilizing
will
better
characterize
its
value
an
inexpensive
versatile
biomaterial.
Advanced Science,
Journal Year:
2024,
Volume and Issue:
11(16)
Published: Feb. 28, 2024
Abstract
Malignant
melanoma
(MM)
is
the
most
aggressive
form
of
skin
cancer.
The
delay
in
treatment
will
induce
metastasis,
resulting
a
poor
prognosis
and
even
death.
Here,
two‐step
strategy
for
on‐site
diagnosis
MM
developed
based
on
extraction
direct
visual
quantification
S100A1,
biomarker
melanoma.
First,
swellable
microneedle
utilized
to
extract
S100A1
interstitial
fluid
(ISF)
with
minimal
invasion.
After
elution,
antibody‐conjugated
magnetic
microparticles
(MMPs)
polystyrene
(PMPs)
are
introduced.
A
high
expression
level
gives
rise
robust
binding
between
MMPs
PMPs
reduces
number
free
PMPs.
By
loading
reacted
solution
into
device
microfluidic
particle
dam,
quantity
after
separation
displayed
their
accumulation
length
inversely
proportional
levels.
limit
detection
18.7
ng
mL
−1
achieved.
animal
experiment
indicates
that
ISF‐based
using
proposed
exhibits
significantly
higher
sensitivity
compared
conventional
serum‐based
detection.
In
addition,
result
highly
comparable
gold
standard
enzyme‐linked
immunosorbent
assay
Lin's
concordance
correlation
coefficient,
suggesting
practicality
routine
monitoring