The Analyst, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
A chemiluminescence enzyme immunoassay based on microfluidic magnetic droplets for multiplex sepsis biomarker screening, which has great potential broader applications in biomolecule detection and early disease diagnosis, is reported.
Language: Английский
Advanced Materials, Journal Year: 2023, Volume and Issue: 35(32)
Published: April 15, 2023
Circadian clock disorder during tissue degeneration has been considered the potential pathogenesis for various chronic diseases, such as intervertebral disc (IVDD). In this study, circadian clock-regulating biomaterials (ClockMPs) that can effectively activate intrinsic of nucleus pulposus cells (NPCs) in IVDD and improve physiological function NPCs regeneration are fabricated via air-microfluidic technique chemical cross-linking between polyvinyl alcohol modified-phenylboronic acid. vitro experiments verified ClockMPs scavenge reactive oxygen species to maintain a stable microenvironment by promoting binding BMAL1 CLOCK proteins. regulate expression core genes activating PI3K-AKT pathway remodel promote extracellular matrix synthesis. Furthermore, vivo treated with proved regulating NPCs. conclusion, provided novel promising strategy regulation regeneration.
Language: Английский
Citations
23
Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 92, P. 105374 - 105374
Published: Jan. 21, 2024
Language: Английский
Citations
8
Proceedings of the National Academy of Sciences, Journal Year: 2024, Volume and Issue: 121(28)
Published: July 3, 2024
Directional transport of liquids is great importance in energy saving, chemical/biomedical engineering, and microfluidics applications. Despite considerable progress engineering different open surfaces to achieve liquid manipulation, the realization diode-like enclosed spaces still challenging. Here, a flexible diode microtube presented for directional within confined using pulsed microfluidics. The microtubes exhibit sophisticated microstructures on inner wall, replicated from precisely controlled flow configuration microfluidic channel. Under effect asymmetric pinning unbalanced Laplace pressure, such enable closed channels. More importantly, by integrating situ lithography with system, segmented diodes are fabricated as assembly units construction fluidic–electronic circuits that perform logic operations. These results demonstrate capacity present liquid-diode flexible, directional, programmable transport. We believe it can an avenue designing advanced fluidic circuit-based devices toward versatile practical
Language: Английский
Citations
8
Advanced Science, Journal Year: 2024, Volume and Issue: 11(28)
Published: May 20, 2024
Abstract The hyperglycemic pathophysiological environment in diabetic wounds is a major obstacle that impedes the healing process. Glucose‐responsive wound materials are promising approach to address this challenge. In study, complex coacervate‐based protocells introduced for healing. By employing microfluidic chip with an external mechanical vibrator, uniform coacervate microdroplets generated via electrostatic interactions between diethylaminoethyl‐dextran and double‐stranded DNA. spontaneous assembly of phospholipid membrane on droplet surface enhances its biocompatibility. Glucose oxidase copper peroxide nanodots integrated into microdroplets, enabling glucose‐responsive cascade produces hydroxyl radicals as antibacterial agents. These features contribute efficient activity mice. present facilitate intelligent management, design catalytic coacervates can development various smart vehicles drug delivery.
Language: Английский
Citations
7
Colloids and Surfaces A Physicochemical and Engineering Aspects, Journal Year: 2024, Volume and Issue: 698, P. 134486 - 134486
Published: June 20, 2024
Language: Английский
Citations
7
Trends in biotechnology, Journal Year: 2023, Volume and Issue: 41(11), P. 1343 - 1359
Published: June 9, 2023
Language: Английский
Citations
16
Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 13(6)
Published: Nov. 16, 2023
Premature ovarian failure (POF) features an upward incidence nowadays, and the human umbilical cord mesenchymal stem cells (hUC-MSCs)-derived exosomes (MSC-Exos) have shown applied values in recovery of function. Here, a novel exosome-encapsulated microcarrier prepared by microfluidic technology for repair after chemotherapy damage is presented. The derived from lipopolysaccharide (LPS)-preconditioned hUC-MSCs are encapsulated with hyaluronic acid methacryloyl (HAMA) via electrospray, which named HAMA/MSC-Exos. Attributing to biocompatibility semipermeable property HAMA, show great viability controllable release behavior HAMA. It demonstrated that situ transplantation HAMA/MSC-Exos can rescue functions cyclophosphamide-induced mice increasing volume, improving number antral follicles restoring fertility. believed will provide new concept treatment POF clinical practice.
Language: Английский
Citations
15
Biomaterials, Journal Year: 2024, Volume and Issue: 313, P. 122757 - 122757
Published: Aug. 16, 2024
Language: Английский
Citations
5
Advanced Science, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 19, 2024
Engineered liver lobule is highly practical in hepatic disease treatment, while constructing a 3D biomimetic with heterogeneous architecture on large scale challenging. Here, inspired by the natural architectural construction of lobules, lobules are proposed coaxially through-pores for nutrient exchange via microfluidic technology. This multi-channel chip made parallelly installing capillaries. Sodium alginate (Alg) pumped through its central channel, Ca
Language: Английский
Citations
5
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 156315 - 156315
Published: Sept. 1, 2024
Language: Английский
Citations
4