Regenerative Biomaterials,
Journal Year:
2024,
Volume and Issue:
11
Published: Jan. 1, 2024
Tendinopathy
is
a
common
disorder
that
causes
local
dysfunction
and
reduces
quality
of
life.
Recent
research
has
indicated
alterations
in
the
inflammatory
microenvironment
play
vital
role
pathogenesis
tendinopathy.
Herein,
injectable
methacrylate
gelatin
(GelMA)
microspheres
(GM)
were
fabricated
loaded
with
heparin-dopamine
conjugate
(HDC)
hepatocyte
growth
factor
(HGF).
GM@HDC@HGF
designed
to
balance
by
inhibiting
oxidative
stress
inflammation,
thereby
regulating
extracellular
matrix
(ECM)
metabolism
halting
tendon
degeneration.
Combining
factors
heparin
was
expected
improve
encapsulation
rate
maintain
long-term
efficacy
HGF.
In
addition,
catechol
groups
on
dopamine
have
adhesion
antioxidant
properties,
allowing
potential
attachment
at
injured
site,
better
function
synergized
injected
Journal of Materials Chemistry B,
Journal Year:
2024,
Volume and Issue:
12(5), P. 1271 - 1284
Published: Jan. 1, 2024
A
triphasic
GELMA
based
scaffold
was
used
for
osteochondral
repair.
The
upper
layer
bonded
with
chondroitin
sulfate,
the
middle
and
lower
layers
introduced
hydroxyapatite,
promoting
chondrogenic,
angiogenic
osteogenic
induction
capabilities.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 8, 2024
Abstract
Osteoarthritis
is
a
common
degenerative
disease
characterized
by
continuous
detachment
of
lubrication
factors
from
damaged
cartilage
matrix.
This
study
proposes
paradigm
that
combines
natural
polyanionic
polysaccharides
(hyaluronic
acid,
HA)
with
dopamine
(DA)
to
design
synovial
factors‐recruiting
biomimetic
polyphenolized
system.
The
lubricants
can
use
DA's
polarity
and
hydrophilic
groups
as
specific
binding
sites
type
II
collagen's
stably
bind
surface,
further
utilize
molecular
interaction
recruit
detached,
joint
endogenous
or
chondrocytes
expressed
factors,
continuously
forming
supramolecular
complex
onto
matrix
induce
lubrication.
Simultaneously,
the
biolubricants
also
catechol
eliminate
anionic
free
radicals
resist
reactive
oxygen
species
invasion
in
early
stages
failure.
prepared
exhibit
low
coefficient
friction
(µ
<
0.08),
which
attributed
fluid
hydration
provided
HA
DA
side
chains
through
dynamic
effect
interfacial
adsorption.
Cell
animal
experiments
demonstrate
polyphenolic
have
good
biocompatibility
promote
regeneration.
Therefore,
developed
lubricants‐recruiting
potential
for
treating
osteoarthritis,
provide
theoretical
basis
other
biological
tissues
problems.
Regenerative Biomaterials,
Journal Year:
2024,
Volume and Issue:
11
Published: Jan. 1, 2024
Tendinopathy
is
a
common
disorder
that
causes
local
dysfunction
and
reduces
quality
of
life.
Recent
research
has
indicated
alterations
in
the
inflammatory
microenvironment
play
vital
role
pathogenesis
tendinopathy.
Herein,
injectable
methacrylate
gelatin
(GelMA)
microspheres
(GM)
were
fabricated
loaded
with
heparin-dopamine
conjugate
(HDC)
hepatocyte
growth
factor
(HGF).
GM@HDC@HGF
designed
to
balance
by
inhibiting
oxidative
stress
inflammation,
thereby
regulating
extracellular
matrix
(ECM)
metabolism
halting
tendon
degeneration.
Combining
factors
heparin
was
expected
improve
encapsulation
rate
maintain
long-term
efficacy
HGF.
In
addition,
catechol
groups
on
dopamine
have
adhesion
antioxidant
properties,
allowing
potential
attachment
at
injured
site,
better
function
synergized
injected
