Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 527, P. 216419 - 216419
Published: Dec. 28, 2024
Language: Английский
JACS Au, Journal Year: 2025, Volume and Issue: 5(2), P. 675 - 683
Published: Jan. 22, 2025
Cationic amphiphiles have been demonstrated to be superior targeted antibacterial agents whose activity exhibits a close relationship with their alkyl chain substituents. However, systematic and deep investigation of the structure–property is still pending. Meanwhile, cationic risk accumulating in living mammalian cells, which poses great threat biosafety clinical applications. In this study, series amphiphilic aggregation-induced emission luminogens (AIEgens) different chains (TPD-4, TPD-6, TPD-12) developed selective variable against Gram-positive bacteria depending on length. Among them, TPD-6 intermediate length exhibited performance. addition, these AIEgens had negligible invasiveness cells. Molecular dynamics simulations revealed that binding deforming capabilities phospholipid bilayer are responsible for activity. vivo experiments indicated also significant wound-healing abilities bacteria.
Language: Английский
Citations
2
Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(47)
Published: July 31, 2024
Abstract Near‐infrared photosensitizers are valuable tools to improve treatment depth in photodynamic therapy (PDT). However, their low singlet oxygen ( 1 O 2 ) generation ability, indicated by quantum yield, presents a formidable challenge for PDT. To overcome this challenge, the heptamethine cyanine was decorated with biocompatible S Scy7 and Se Secy7 atom. We observe that exhibits redshift main absorption ~840 nm an ultra‐efficient capacity. The emergence of strong intramolecular charge transfer effect between atom polymethine chain considerably narrows energy gap (0.51 eV), heavy strengthens spin–orbit coupling (1.44 cm −1 ), both which greatly improved high triplet state yield (61 %), determines . Therefore, demonstrated excellent capacity, is ~24.5‐fold indocyanine green, ~8.2‐fold IR780, ~1.3‐fold methylene blue under low‐power‐density 850 irradiation (5 mW −2 ). considerable phototoxicity toward cancer cells buried 12 mm tissue. Nanoparticles formed encapsulating within amphiphilic polymers lecithin, promising antitumor anti‐pulmonary metastatic effects, exhibiting remarkable potential advancing PDT deep tissues.
Language: Английский
Citations
10
Advanced Materials, Journal Year: 2024, Volume and Issue: 36(29)
Published: May 12, 2024
The activation of sequential events in the cancer-immunity cycle (CIC) is crucial for achieving effective antitumor immunity. However, formidable challenges, such as innate and adaptive immune resistance, along with off-target adverse effects nonselective immunomodulators, persist. In this study, a tumor-selective nano-regulator named PNBJQ has been presented, focusing on targeting two nonredundant nodes: inducing immunogenic cancer cell death abrogating resistance to fully activate endogenous tumor obtained by encapsulating immunomodulating agent JQ1 within self-assembling system formed linking Type-I photosensitizer polyethylene glycol through hypoxia-sensitive azo bond. Benefiting from photosensitive mechanism, triggers hypoxic tumors under near-infrared (NIR) light irradiation. This process resolves stimulating sufficient cytotoxic T-lymphocytes. Simultaneously, smartly responds microenvironment precise drug delivery, adeptly addressing using downregulate programmed ligand 1 (PD-L1) sustaining response T lymphocytes. activatable synergic photoimmunotherapy promotes an immune-promoting activating iterative revolution CIC, which remarkably eradicates established suppresses distal lesions low dose
Language: Английский
Citations
8
Advanced Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 26, 2025
Abstract Photodynamic therapy (PDT) using traditional type II photosensitizers (PSs) has been limited in hypoxic tumors due to excessive oxygen consumption. The conversion from into a less oxygen‐dependent I PDT pathway shown the potential combat tumors. Herein, design of heterodimeric PS, NBSSe , by conjugating widely used PS NBS and NBSe via molecular dimerization, achieving aggregation‐regulated efficient photodynamic for first time is reported. Electrochemistry characterizations theoretical calculations elucidate that tends form S +· /Se −· radical pair intramolecular electron transfer co‐excited * aggregate, realizing 7.25‐fold O 2 generation compared 80% suppression 1 . enhanced enables excellent anti‐hypoxia efficiency inhibition pulmonary metastasis. Additionally, incorporation electron‐rich bovine serum albumin accelerates recycling cationic further boosting photostability generation. resultant BSA@NBSSe nanoparticles demonstrate successful tumor‐targeting capability. This work provides an appealing avenue convert ROS cancer phototherapy hypoxia.
Language: Английский
Citations
1
Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(41)
Published: July 4, 2024
Abstract The clinical application of photodynamic therapy (PDT) is limited by oxygen‐dependence and side effects caused photosensitizer residues. Photoinitiators based on the H‐abstraction reaction can address these challenges because they generate alkyl radical‐killing cells independently oxygen undergo rapid bleaching following H‐abstraction. Nonetheless, development photoinitiators for PDT has been impeded absence effective design strategies. Herein, we have developed aryl‐ketone substituted cyanine (ACy−R), first red‐light triggered hypoxic cancer therapy. These ACy−R molecules inherited near‐infrared absorption dye, modification imparted capability. Experimental quantum calculations revealed that modifying electron‐withdrawing groups aryl (e.g., ACy‐5F) improved contribution O atom to photon excitation process promoting intersystem crossing ability. Particularly, ACy‐5F rapidly penetrated enriched in endoplasmic reticulum. Even under severe hypoxia, initiated induced with intracellular biomolecules, inducing necroptosis ferroptosis. Moreover, was degraded after H‐abstraction, thus avoiding long‐term phototoxicity This study not only provides a crucial molecular tool tumors therapy, but also presents promising strategy multifunctional photosensitizers photoinitiators.
Language: Английский
Citations
4
Chinese Chemical Letters, Journal Year: 2025, Volume and Issue: unknown, P. 110897 - 110897
Published: Jan. 1, 2025
Language: Английский
Citations
0
Aggregate, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 2, 2025
ABSTRACT Prostate cancer is an epithelial malignancy with a high incidence among elderly men. Photochemistry‐based dye photodrugs (known as photosensitizers) offer promising clinical approach for treating tumors. These agents work by inducing immunogenic cell death (ICD), which activates antitumor immune response. This favored owing to its minimal invasiveness, low toxicity, and efficiency. However, the immunosuppressive microenvironment of characteristics “cold” tumors significantly restricts efficacy photodrugs. Developing advanced nanocarrier system deliver agonists efficient drug delivery tumor lesion sites reshape crucial in practice. Therefore, this study, we designed integrin‐targeted, activatable nano photodrug co‐assembly agonist (RPST@IMQ) enhancing photoimmunotherapy prostate via reprogramming tumor‐associated macrophages. The active‐targeted nanosystem enhanced dosage at site through systemic administration. High doses glutathione cleaved disulfide bonds RPST@IMQ, releasing imiquimod (IMQ). Under photoirradiation, generated significant singlet oxygen eliminate cells, thereby ICD activate responses. Simultaneously, released IMQ reprograms M2‐type macrophages (TAMs) into M1‐type TAMs tumor‐killing capabilities, converting “hot” conversion enhances therapeutic against primary distant vivo. study offers new insights development innovative, smart, enhance anticancer outcomes.
Language: Английский
Citations
0
ACS Nano, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 7, 2025
Only a minority of patients benefit from current T-cell-focused adaptive immunotherapies, underscoring the need to engage innate immune cells, particularly macrophages, for multilayered tumor control. However, high-efficacy therapeutics capable orchestrating multiple cells remain scarce. Herein, dual stimuli-responsive nanoimmunomodulator (6EPP@si) that caters specifically microenvironment (TME) is presented antitumor synergy macrophages and T cells. Using functional polymer-based carrier, we co-deliver endoplasmic reticulum (ER)-localized photosensitizer 6E small interfering RNA targeting CD47 (siCD47) into breast tumors. Within acidic high-glutathione TME, 6EPP@si undergoes self-lysosome escape nanocleavage precise, on-demand drug release. Consequently, siCD47 released cytoplasm enables potent silencing, while ER-targeted induces immunogenic cell death through reactive oxygen species-based ER stress, triggering release damage-associated molecular patterns, including calreticulin surface translocation. enhances macrophage phagocytosis by modulating both antiphagocytic prophagocytic signals also promotes antigen presentation activate In orthotopic spontaneous lung metastatic models, this combined approach demonstrates robust effects effective antimetastatic immunity, offering meaningful strategy simultaneously enhancing cancer immunotherapy.
Language: Английский
Citations
0
Small, Journal Year: 2025, Volume and Issue: unknown
Published: March 4, 2025
Abstract Activatable combined therapeutic strategy exhibits significant potential for the management of malignant tumors. Ensuring timely and spatially effective release different agents is a great challenge maximizing efficacy combination therapy. Herein, based on 1,4‐and 1,6‐elimination behaviors, study proposes novel universal single‐activated‐dual‐release platform that can be triggered by various stimulants interest. As proof‐of‐concept, develops an example synergistic therapy called CyI‐Cbl‐NTR , which selectively activated nitroreductase (NTR) to photosensitizer ( CyI‐OH ) DNA alkylating agent chlorambucil (Cbl), thereby enabling chemo‐ photodynamic Both in vitro vivo experiments fully demonstrate remarkable effect Cyl‐Cbl‐NTR feasibility this strategy. This work provides promising future development activatable
Language: Английский
Citations
0
Science China Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: March 10, 2025
Language: Английский
Citations
0