ACS Applied Materials & Interfaces,
Journal Year:
2023,
Volume and Issue:
15(8), P. 10414 - 10425
Published: Feb. 20, 2023
Atherosclerosis
is
a
common
cardiovascular
disease
with
increasing
morbidity
and
mortality.
The
pathogenesis
of
atherosclerosis
strongly
related
to
endothelial
dysfunction,
which
induced
by
severe
oxidative
stress
damage
derived
from
reactive
oxygen
species
(ROS).
Thus,
ROS
plays
critical
role
in
the
progression
atherosclerosis.
In
this
work,
we
demonstrated
that
gadolinium
doping
CeO2
(Gd/CeO2)
nanozymes
as
effective
scavengers
delivered
high
performance
for
antiatherosclerosis.
It
was
found
chemical
Gd
promoted
surface
proportion
Ce3+
thereby
enhanced
overall
scavenging
ability.
vitro
vivo
experiments
unambiguously
showed
Gd/CeO2
efficiently
scavenged
harmful
at
cellular
histological
levels.
Further,
were
significantly
reduce
vascular
lesions
reducing
lipid
accumulation
macrophage
decreasing
inflammatory
factor
levels,
inhibiting
exacerbation
Moreover,
can
serve
T1-weighted
magnetic
resonance
imaging
contrast
agents,
generate
sufficient
distinguish
location
plaque
during
living
imaging.
Through
those
efforts,
may
potential
diagnostic
treatment
nanomedicine
ROS-induced
Chemical Society Reviews,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 1, 2024
This
review
provides
a
comprehensive
summary
of
the
dysregulation
redox
metabolism
in
cancer
cells
and
advantages
latest
advances
nanomaterial-assisted
metabolic
regulation
therapy.
Theranostics,
Journal Year:
2023,
Volume and Issue:
13(8), P. 2492 - 2514
Published: Jan. 1, 2023
Nanozymes
are
a
class
of
nanomaterials
with
enzyme-like
catalytic
activities.Due
to
their
multiple
activities,
as
well
good
stability,
modifiable
activity
and
other
advantages
over
natural
enzymes,
they
have
wide
range
application
prospects
in
sterilization,
the
treatment
inflammation,
cancer,
neurological
diseases,
fields.In
recent
years,
it
has
been
found
that
various
nanozymes
antioxidant
activity,
allowing
them
simulate
endogenous
system
play
an
important
role
cell
protection.Therefore,
can
be
applied
reactive
oxygen
species
(ROS)-related
diseases.Another
advantage
is
customized
modified
variety
ways
increase
beyond
classical
enzymes.In
addition,
some
unique
properties,
such
ability
effectively
penetrate
blood-brain
barrier
(BBB)
or
depolymerize
otherwise
eliminate
misfolded
proteins,
making
potentially
useful
therapeutic
tools
for
diseases.Here,
we
review
mechanisms
antioxidant-like
nanozymes,
latest
research
progress
strategies
designing
aiming
promote
development
more
effective
diseases
future.
Nano Convergence,
Journal Year:
2023,
Volume and Issue:
10(1)
Published: Sept. 11, 2023
Abstract
Nanozymes
mimic
the
function
of
enzymes,
which
drive
essential
intracellular
chemical
reactions
that
govern
biological
processes.
They
efficiently
generate
or
degrade
specific
biomolecules
can
initiate
inhibit
processes,
regulating
cellular
behaviors.
Two
approaches
for
utilizing
nanozymes
in
chemistry
have
been
reported.
Biomimetic
catalysis
replicates
identical
natural
and
bioorthogonal
enables
chemistries
inaccessible
cells.
Various
based
on
nanomaterials
catalytic
metals
are
employed
to
attain
intended
cells
either
enzymatic
mechanism
kinetics
expand
chemistries.
Each
nanozyme
approach
has
its
own
intrinsic
advantages
limitations,
making
them
complementary
diverse
applications.
This
review
summarizes
strategies
applications
biomimetic
nanozymes,
including
a
discussion
their
limitations
future
research
directions.
Angewandte Chemie International Edition,
Journal Year:
2023,
Volume and Issue:
62(26)
Published: April 21, 2023
Hypertension,
as
a
leading
risk
factor
for
cardiovascular
diseases,
is
associated
with
oxidative
stress
and
impairment
of
endogenous
antioxidant
mechanisms,
but
there
still
tremendous
knowledge
gap
between
hypertension
treatment
nanomedicines.
Herein,
we
report
specific
nanozyme
based
on
ultrathin
two-dimensional
(2D)
niobium
carbide
(Nb2
C)
MXene,
termed
Nb2
C
MXenzyme,
to
fight
against
by
achieving
highly
efficient
reactive
oxygen
species
elimination
inflammatory
factors
inhibition.
The
biocompatible
MXenzyme
displays
multiple
enzyme-mimicking
activities,
involving
superoxide
dismutase,
catalase,
glutathione
peroxidase,
inducing
cytoprotective
effects
resisting
stress,
thereby
alleviating
response
reducing
blood
pressure,
which
systematically
demonstrated
in
stress-induced
rat
model.
This
strategy
not
only
opens
new
opportunities
nanozymes
treat
also
expands
the
potential
biomedical
applications
2D
MXene
nanosystems.
ACS Applied Materials & Interfaces,
Journal Year:
2023,
Volume and Issue:
15(8), P. 10414 - 10425
Published: Feb. 20, 2023
Atherosclerosis
is
a
common
cardiovascular
disease
with
increasing
morbidity
and
mortality.
The
pathogenesis
of
atherosclerosis
strongly
related
to
endothelial
dysfunction,
which
induced
by
severe
oxidative
stress
damage
derived
from
reactive
oxygen
species
(ROS).
Thus,
ROS
plays
critical
role
in
the
progression
atherosclerosis.
In
this
work,
we
demonstrated
that
gadolinium
doping
CeO2
(Gd/CeO2)
nanozymes
as
effective
scavengers
delivered
high
performance
for
antiatherosclerosis.
It
was
found
chemical
Gd
promoted
surface
proportion
Ce3+
thereby
enhanced
overall
scavenging
ability.
vitro
vivo
experiments
unambiguously
showed
Gd/CeO2
efficiently
scavenged
harmful
at
cellular
histological
levels.
Further,
were
significantly
reduce
vascular
lesions
reducing
lipid
accumulation
macrophage
decreasing
inflammatory
factor
levels,
inhibiting
exacerbation
Moreover,
can
serve
T1-weighted
magnetic
resonance
imaging
contrast
agents,
generate
sufficient
distinguish
location
plaque
during
living
imaging.
Through
those
efforts,
may
potential
diagnostic
treatment
nanomedicine
ROS-induced
