Human Vaccines & Immunotherapeutics,
Journal Year:
2024,
Volume and Issue:
20(1)
Published: Dec. 10, 2024
Immunogenic
cell
death
(ICD)
is
a
distinct
type
of
stress-induced
regulated
that
can
lead
to
adaptive
immune
responses
and
the
establishment
immunological
memory.
ICD
exhibits
both
similarities
differences
when
compared
apoptosis
other
non-apoptotic
forms
(RCD).
The
interplay
between
ICD-mediated
immunosurveillance
against
cancer
ability
cells
evade
influences
host-tumor
interaction.
Consequently,
restoration
development
effective
strategies
induce
have
emerged
as
crucial
considerations
in
treatment
within
context
immunotherapy.
To
enhance
comprehension
setting
cancer,
this
paper
examines
interconnected
responsive
pathways
associated
with
ICD,
corresponding
biomarkers
indicative
mechanisms
through
which
tumors
subvert
ICD.
Additionally,
review
explores
for
reinstating
therapeutic
potential
harnessing
Signal Transduction and Targeted Therapy,
Journal Year:
2024,
Volume and Issue:
9(1)
Published: Aug. 12, 2024
Cancer
remains
a
significant
risk
to
human
health.
Nanomedicine
is
new
multidisciplinary
field
that
garnering
lot
of
interest
and
investigation.
shows
great
potential
for
cancer
diagnosis
treatment.
Specifically
engineered
nanoparticles
can
be
employed
as
contrast
agents
in
diagnostics
enable
high
sensitivity
high-resolution
tumor
detection
by
imaging
examinations.
Novel
approaches
labeling
are
also
made
possible
the
use
nanoprobes
nanobiosensors.
The
achievement
targeted
medication
delivery
therapy
accomplished
through
rational
design
manufacture
nanodrug
carriers.
Nanoparticles
have
capability
effectively
transport
medications
or
gene
fragments
tissues
via
passive
active
targeting
processes,
thus
enhancing
treatment
outcomes
while
minimizing
harm
healthy
tissues.
Simultaneously,
context
radiation
sensitization
photothermal
enhance
therapeutic
efficacy
malignant
tumors.
This
review
presents
literature
overview
summary
how
nanotechnology
used
According
oncological
diseases
originating
from
different
systems
body
combining
pathophysiological
features
cancers
at
sites,
we
most
recent
developments
applications.
Finally,
briefly
discuss
prospects
challenges
cancer.
Biomedicine & Pharmacotherapy,
Journal Year:
2023,
Volume and Issue:
166, P. 115316 - 115316
Published: Aug. 10, 2023
Melanoma
is
a
highly
aggressive
form
of
skin
cancer
with
limited
therapeutic
options.
Chemo-photothermal
combination
therapy
has
demonstrated
potential
for
effectively
treating
melanoma,
and
transdermal
administration
considered
the
optimal
route
diseases
due
to
its
ability
bypass
first-pass
metabolism
enhance
drug
concentration.
However,
stratum
corneum
presents
formidable
challenge
as
significant
barrier
penetration
in
delivery.
Lipid-nanocarriers,
particularly
cubosomes,
have
been
possess
augmenting
permeation
across
corneum.
Herein,
cubosomes
co-loaded
doxorubicin
(DOX,
chemotherapeutic
drug)
indocyanine
green
(ICG,
photothermal
agent)
(DOX-ICG-cubo)
delivery
system
was
developed
efficiency
melanoma
by
improving
permeation.
The
DOX-ICG-cubo
showed
high
encapsulation
both
DOX
ICG,
exhibited
good
stability
under
physiological
conditions.
In
addition,
unique
cubic
structure
confirmed
through
transmission
electron
microscopy
(TEM)
images,
polarizing
microscopy,
small
angle
X-ray
scattering
(SAXS).
presented
conversion
efficiency,
well
pH
thermo-responsive
release.
Notably,
enhanced
biocompatibility,
improved
vivo
anti-melanoma
efficacy
synergistic
effects
chemo-photothermal
therapy.
conclusion,
promising
strategy
treatment.
Discover Nano,
Journal Year:
2024,
Volume and Issue:
19(1)
Published: Feb. 26, 2024
Abstract
Biomaterials
play
a
vital
role
in
targeting
therapeutics.
Over
the
years,
several
biomaterials
have
gained
wide
attention
treatment
and
diagnosis
of
diseases.
Scientists
are
trying
to
make
more
personalized
treatments
for
different
diseases,
as
well
discovering
novel
single
agents
that
can
be
used
prognosis,
medication
administration,
keeping
track
how
works.
Theranostics
based
on
nano-biomaterials
higher
sensitivity
specificity
disease
management
than
conventional
techniques.
This
review
provides
concise
overview
various
biomaterials,
including
carbon-based
materials
like
fullerenes,
graphene,
carbon
nanotubes
(CNTs),
nanofibers,
their
involvement
theranostics
In
addition,
imaging
techniques
applications
was
overviewed.
is
an
emerging
strategy
has
great
potential
enhancing
accuracy
efficacy
medicinal
interventions.
Despite
presence
obstacles
such
heterogeneity,
toxicity,
reproducibility,
uniformity,
upscaling
production,
regulatory
hurdles,
field
medical
research
development
promise
due
its
ability
provide
patients
with
personalised
care,
facilitate
early
identification,
enable
focused
treatment.
International Journal of Nanomedicine,
Journal Year:
2025,
Volume and Issue:
Volume 20, P. 2371 - 2394
Published: Feb. 1, 2025
Lung
cancer
is
the
leading
cause
of
cancer-related
mortality
globally,
with
non-small
cell
lung
(NSCLC)
constituting
85%
cases.
Immune
checkpoint
inhibitors
(ICIs)
represented
by
anti-programmed
death
protein
1
(PD-1)/
programmed
ligand
(PD-L1)
have
emerged
as
a
promising
frontier
in
treatment,
effectively
extending
survival
patients
NSCLC.
However,
efficacy
ICIs
exhibits
significant
variability
across
diverse
patient
populations,
substantial
proportion
showing
poor
responsiveness
and
acquired
resistance
those
initially
responsive
to
treatments.
With
advancement
nanotechnology,
nanoparticles
offer
unique
advantages
tumor
immunotherapy,
including
high
permeability
prolonged
retention(EPR)
effects,
enhanced
drug
delivery
stability,
modulation
inflammatory
microenvironment(TME).
This
review
summarizes
mechanisms
NSCLC,
focusing
on
antigens
loss
defective
antigen
processing
presentation,
failure
T
priming,
impaired
migration
infiltration,
immunosuppressive
TME,
genetic
mutations.
Furthermore,
we
discuss
how
nanoparticles,
through
their
intrinsic
properties
such
EPR
effect,
active
targeting
shielding
self-regulatory
synergistic
can
potentiate
reverse
resistance.
In
conclusion,
serve
robust
platform
for
ICIs-based
NSCLC
therapy,
aiding
overcoming
challenges.
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 26, 2024
Mild
photothermal
therapy
(MPTT)
has
emerged
as
a
promising
therapeutic
modality
for
attenuating
thermal
damage
to
the
normal
tissues
surrounding
tumors,
while
heat-induced
upregulation
of
heat
shock
proteins
(HSPs)
greatly
compromises
curative
efficacy
MPTT
by
increasing
cellular
thermo-tolerance.
Ferroptosis
been
identified
suppress
overexpression
HSPs
accumulation
lipid
peroxides
and
reactive
oxygen
species
(ROS),
but
is
restricted
overexpressed
glutathione
(GSH)
in
tumor
microenvironment
undesirable
ROS
generation
efficiency.
Herein,
synergistic
strategy
based
on
mutual
enhancement
ferroptosis
proposed
cleaving
recover
cell
sensitivity.
A
facile
method
fabricating
series
Fe-based
metal-quinone
networks
(MQNs)
coordinated
assembly
representative
FTP
MQNs
possess
high
conversion
efficiency
(69.3
%).
Upon
808
nm
laser
irradiation,
not
only
trigger
effective
induce
apoptosis
more
significantly,
potentiate
Fenton
reaction
marked
GSH
consumption
boost
ferroptosis,
reinforced
effect
turn
can
alleviate
resistance
declining
HSP70
defense
reducing
ATP
levels.
This
study
provides
valuable
rationale
constructing
large
library
achieving
ferroptosis.
ACS Applied Bio Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 21, 2025
Melanoma
is
a
severe
malignant
skin
tumor.
It
crucial
to
effectively
eliminate
melanoma
and
promote
rapid
healthy
regeneration
of
postoperative
tissue
defects.
Herein,
hesperidin
derivatives
(HD)
have
been
developed
as
the
bioactive
components
hydrogels
that
are
capable
ablating
via
photothermal
therapy
(PTT)
promoting
regeneration.
HD
prepared
by
heating
alkaline
solution
followed
dialysis
lyophilization,
GelMA
encapsulating
kill
cancer
cells
bacteria
under
near-infrared
(NIR)
irradiation.
The
in
vitro
test
vivo
transcriptomic
analysis
confirmed
containing
induce
immunogenic
cell
death
(ICD)
effect
tumor
significantly
upregulating
chemokine-related,
cytokine-related,
apoptosis-related
genes,
thereby
enhancing
therapeutic
efficacy.
In
mouse
model
infected
wounds,
808
nm
light
irradiation
promoted
wound
repair.
This
was
achieved
through
accelerated
closure
enhanced
regeneration,
mediated
increased
angiogenesis
collagen
deposition.
conclusion,
provide
new
strategy
for
clinical
treatment
defect
repair
following
operative
resection
cancer.
