An antibacterial, antioxidant and hemostatic hydrogel accelerates infectious wound healing DOI Creative Commons
Ziyi Zhou, Dengjun Zhang, Xuchao Ning

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 12, 2024

Abstract Hydrogel drug-delivery system that can effectively load antibacterial drugs, realize the in-situ drug release in microenvironment of wound infection to promote healing. In this study, a multifunctional hydrogel delivery (HA@TA-Okra) was constructed through integration hyaluronic acid methacrylate (HAMA) matrix with tannic (TA) and okra extract. The composition structural characteristics HA@TA-Okra its unique advantages treatment diverse wounds were systematically evaluated. TA, due chemical structure, is able anchor within HAMA network interactions cross-linking, conferring exceptional mechanical strength stability hydrogel. Both TA extract possess antioxidant properties, when they two acts synergistically scavenge free radicals, enhance action, diminishing risk infection. In vitro experiments revealed has superior such as rapid gel response, remarkable swelling regulation, potent ability. Furthermore, significantly outperformed conventional dressings terms hemostatic performance rat hemorrhage model. We further evaluated repair role in vivo by establishing an animal model full-thickness skin defects infected total defects. results confirmed positive effects fighting bacterial infection, reducing inflammation promoting summary, exhibits comprehensive properties antibacterial, which potential application field tissue medicine.

Language: Английский

Oral microsphere formulation of M2 macrophage-mimetic Janus nanomotor for targeted therapy of ulcerative colitis DOI Creative Commons
Ruifeng Luo, J. Liu, Qian Cheng

et al.

Science Advances, Journal Year: 2024, Volume and Issue: 10(26)

Published: June 28, 2024

Oral medication for ulcerative colitis (UC) is often hindered by challenges such as inadequate accumulation, limited penetration of mucus barriers, and the intricate task mitigating excessive ROS inflammatory cytokines. Here, we present a strategy involving sodium alginate microspheres (SAMs) incorporating M2 macrophage membrane (M2M)-coated Janus nanomotors (denominated Motor@M2M) targeted treatment UC. SAM provides protective barrier, ensuring that Motor@M2M withstands harsh gastric milieu exhibits controlled release. M2M enhances targeting precision to tissues acts decoy neutralization Catalytic decomposition H

Language: Английский

Citations

29
Macrophage based drug delivery: Key challenges and strategies DOI Creative Commons
Qian Guo, Zhong‐Ming Qian

Bioactive Materials, Journal Year: 2024, Volume and Issue: 38, P. 55 - 72

Published: April 23, 2024

As a natural immune cell and antigen presenting cell, macrophages have been studied engineered to treat human diseases. Macrophages are well-suited for use as drug carriers because of their biological characteristics, such excellent biocompatibility, long circulation, intrinsic inflammatory homing phagocytosis. Meanwhile, macrophages' uniquely high plasticity easy re-education polarization facilitates part efficacious therapeutics the treatment diseases or tumors. Although recent studies demonstrated promising advances in macrophage-based delivery, several challenges currently hinder further improvement therapeutic effect clinical application. This article focuses on main utilizing from selection macrophage sources, loading, maintenance phenotypes, migration release at target sites. In addition, corresponding strategies insights related these described. Finally, we also provide perspective shortcomings road translation production.

Language: Английский

Citations

23
An antibacterial, antioxidant and hemostatic hydrogel accelerates infectious wound healing DOI Creative Commons
Ziyi Zhou, Dengjun Zhang, Xuchao Ning

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 28, 2025

Abstract Hydrogel drug-delivery system that can effectively load antibacterial drugs, realize the in-situ drug release in microenvironment of wound infection to promote healing. In this study, a multifunctional hydrogel delivery (HA@TA-Okra) was constructed through integration hyaluronic acid methacrylate (HAMA) matrix with tannic (TA) and okra extract. The composition structural characteristics HA@TA-Okra its unique advantages treatment diverse wounds were systematically evaluated. TA, due chemical structure, is able anchor within HAMA network interactions cross-linking, conferring exceptional mechanical strength stability hydrogel. Both TA extract possess antioxidant properties, when they two acts synergistically scavenge free radicals, enhance action, diminishing risk infection. vitro experiments revealed has superior such as rapid gel response, remarkable swelling regulation, potent ability. Furthermore, significantly outperformed conventional dressings terms hemostatic performance rat hemorrhage model. We further evaluated repair role vivo by establishing an animal model full-thickness skin defects infected total defects. results confirmed positive effects fighting bacterial infection, reducing inflammation promoting summary, exhibits comprehensive properties antibacterial, which potential application field tissue medicine. Graphical

Language: Английский

Citations

3
Ros-responsive hydrogel with size-dependent sequential release effects for anti-bacterial and anti-inflammation in diabetic wound healing DOI
Zhipeng Sun,

Yilin Ding,

Zetao Wang

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 493, P. 152511 - 152511

Published: May 23, 2024

Language: Английский

Citations

17
Inflammation-modulating elastic decellularized extracellular matrix scaffold promotes meniscus regeneration DOI
Yangfan Ding, Moran Huang, Pengfei Cai

et al.

Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

1
Macrophage membrane-coated nanoparticles for the treatment of infectious diseases DOI
Chenguang Wang,

Chuyu Li,

Ruoyu Zhang

et al.

Biomedical Materials, Journal Year: 2024, Volume and Issue: 19(4), P. 042003 - 042003

Published: May 13, 2024

Abstract Infectious diseases severely threaten human health, and traditional treatment techniques face multiple limitations. As an important component of immune cells, macrophages display unique biological properties, such as biocompatibility, immunocompatibility, targeting specificity, immunoregulatory activity, play a critical role in protecting the body against infections. The macrophage membrane-coated nanoparticles not only maintain functions inner but also inherit characteristics macrophages, making them excellent tools for improving drug delivery therapeutic implications infectious (IDs). In this review, we describe their advantages challenges ID therapy. We first summarize pathological features IDs, providing insight into how to fight them. Next, focus on classification, characteristics, preparation nanoparticles. Finally, comprehensively progress combating including delivery, inhibition killing pathogens, modulation. At end look forward aspect is presented.

Language: Английский

Citations

6
Macrophage‐Mimicking Cellular Nanoparticles Scavenge Proinflammatory Cytokines in Specimens of Patients with Inflammatory Disorders DOI Creative Commons
Zhidong Zhou, Nilesh Mukundan,

Jiayuan Alex Zhang

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(31)

Published: June 17, 2024

Abstract Effectively neutralizing inflammatory cytokines is crucial for managing a variety of disorders. Current techniques that target only subset often fall short due to the intricate nature redundant and compensatory cytokine networks. A promising solution this challenge using cell membrane‐coated nanoparticles (CNPs). These replicate complex interactions between cells observed in disease pathology, providing potential avenue multiplex scavenging. While development CNPs experimental animal models has shown great promise, their effectiveness scavenging multiple human diseases yet be demonstrated. To bridge gap, study selected macrophage (MФ‐CNPs) assessed ability scavenge serum samples from patients with COVID‐19, sepsis, acute pancreatitis, or type‐1 diabetes, along synovial fluid rheumatoid arthritis. The results show MФ‐CNPs effectively critical cytokines, including interleukin (IL)‐6, IL‐8, interferon (IFN)‐γ, tumor necrosis factor (TNF)‐α, dose‐dependent manner. Overall, demonstrates as formulation applications clinical settings treat range

Language: Английский

Citations

5
Advanced Nano-Drug Delivery Systems in the Treatment of Ischemic Stroke DOI Creative Commons
Jiangjun Zhang, Zhong Chen, Qi Chen

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(8), P. 1848 - 1848

Published: April 18, 2024

In recent years, the frequency of strokes has been on rise year by and become second leading cause death around world, which is characterized a high mortality rate, recurrence disability rate. Ischemic account for large percentage strokes. A reperfusion injury in ischemic complex cascade oxidative stress, neuroinflammation, immune infiltration, mitochondrial damage. Conventional treatments are ineffective, presence blood–brain barrier (BBB) leads to inefficient drug delivery utilization, so researchers turning their attention nano-drug systems. Functionalized systems have widely studied applied study cerebral diseases due favorable biocompatibility, efficiency, strong specificity, specific targeting ability. this paper, we briefly describe pathological process injuries focus therapeutic research progress strokes, aiming provide certain references understand (NDDSs).

Language: Английский

Citations

4
Macrophage membrane‒biomimetic nanoparticles target inflammatory microenvironment for epilepsy treatment DOI Creative Commons

Chao Geng,

Xing‐Hui Ren,

Peipei Cao

et al.

Theranostics, Journal Year: 2024, Volume and Issue: 14(17), P. 6652 - 6670

Published: Jan. 1, 2024

The clinical treatment of epilepsy is faced with challenges. On the one hand, effectiveness existing antiepileptic drugs (AEDs) limited by blood‒brain barrier (BBB); on other changes in inflammatory microenvironment during epileptogenesis are often neglected.

Language: Английский

Citations

4
Macrophage membrane-biomimetic ROS-responsive platinum nanozyme clusters for acute kidney injury treatment DOI

Hanzhi Deng,

Ying Qu, Bingyang Chu

et al.

Biomaterials, Journal Year: 2024, Volume and Issue: 317, P. 123072 - 123072

Published: Dec. 30, 2024

Language: Английский

Citations

4