Advanced Optical Materials,
Journal Year:
2024,
Volume and Issue:
13(1)
Published: Sept. 24, 2024
Abstract
Dye‐sensitized
down‐conversion
nanoparticles
(DCNPs)
can
significantly
enhance
photon
absorption,
bridging
the
gap
of
narrow
and
weak
absorption
cross‐section
lanthanide
(Ln)
ions,
thus
fundamentally
prompting
their
near‐infrared
(NIR)
emission.
However,
ideal
strategy
for
utilization
both
singlet
triplet
energy
dyes
is
hindered
by
nanostructures
dependence
on
heavy
atom
effect.
Herein,
thermally
activated
delayed
fluorescence
(TADF)
dye
utilized
with
a
small
singlet‐triplet
as
antenna,
achieving
733
fold
emission
enhancement.
This
facilitates
efficient
intersystem
crossing
(ISC)
reverse
(RISC)
processes,
enabling
effective
transfer
from
(S
1
)
(T
excitons
to
emitted
levels
Er
3+
.
Combining
highly
Erbium‐doped
nanoparticles,
water‐dispersed
AD‐sensitized
system
shows
excellent
hydrodynamic
stability
photostability.
innovative
approach
marks
first
report
TADF
dye‐sensitized
Ln
nanosystems,
offering
new
direction
photo
conversion
technology.
Smart Molecules,
Journal Year:
2024,
Volume and Issue:
2(3)
Published: July 4, 2024
Abstract
Prostate‐specific
membrane
antigen
(PSMA)
is
known
to
be
overexpressed
in
prostate
cancer
(PCa).
The
development
of
precise
and
rapid
imaging
technologies
monitor
PSMA
crucial
for
early
diagnosis
therapy.
Fluorescence
the
second
near‐infrared
window
(NIR‐II)
has
emerged
as
a
powerful
tool
real‐time
tracking
vivo
visualization,
offering
high
sensitivity
resolution.
However,
there
lack
stable,
bright
easy‐to‐implement
NIR‐II
fluorescent
probes
targeting.
Herein,
we
presented
PSMA‐targeting
probe
FC‐PSMA
based
on
π‐conjugated
crossbreeding
dyed
strategy
that
affords
stability,
large
extinction
coefficient,
good
brightness.
As
demonstrated,
displayed
fluorescence
quantum
yield
fetal
bovine
serum
(FBS).
Following
intravenous
injection
FC‐PSMA,
tumor‐to‐normal
ratio
intensity
steadily
increased
over
time,
reaching
peak
at
48
h
(tumor‐to‐leg
=
12.16
±
0.90).
This
advancement
enables
identification
PC
through
imaging,
facilitating
high‐performance
guidance
resection
surgery.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(41), P. 28178 - 28188
Published: Oct. 3, 2024
Conjugated
polymers
are
becoming
popular
near-infrared
II
(NIR-II)
phototheranostic
agents
(PTAs)
due
to
their
numerous
advantages,
such
as
high
photostability,
large
molar
extinction
coefficients,
and
excellent
photothermal
properties.
However,
the
strong
π-π
interactions
between
chains
of
conjugated
resulted
in
generally
low
NIR-II
emission
quantum
yields
(QY).
Therefore,
synthesis
with
QY
is
an
interesting
but
challenging
task.
Herein,
we
proposed
a
spacer
twisting
strategy
realize
ultrabright
polymer
nanoparticles
for
fluorescence
imaging-guided
tumor
phototheranostics.
Theoretical
calculations
indicated
that
PY-IT
has
largest
dihedral
angle
largely
π-conjugated
skeleton
spacer,
which
can
effectively
inhibit
intermolecular
stacking,
resulting
improved
16.5%
nanoparticles.
In
addition,
NPs
perform
imaging
treatment
tumors.
The
work
presents
some
valuable
guides
achieving
polymeric
PTAs
QY.
Analytical Chemistry,
Journal Year:
2025,
Volume and Issue:
97(1), P. 1003 - 1009
Published: Jan. 1, 2025
At
present,
some
progress
has
been
made
in
developing
NIR
light-responsive
free
radical
generators.
However,
the
efficacy
of
theranostics
continues
to
be
hindered
by
tumor-associated
inflammatory
reactions.
Hence,
fulfilling
situ
release
radicals
upon
light
excitation
specifically
activated
inflammation
microenvironment
would
an
ideal
strategy
for
efficient
eradication
and
tumor
suppression
but
remains
a
challenge.
Herein,
SO2
(overexpressed
reactive
sulfur
species
inflamed
site)-stimulated
phototheranostic
agent
(CVS)
is
successfully
developed.
Through
specific
response
both
endogenous
exogenous
with
low
LOD
(31.7
nM),
CVS
demonstrates
"switch
on"
two-photon
activity
as
well
OH·
generation.
Remarkably,
CVS-treated
H22-tumor-bearing
mice,
light-activated
accurate
are
accomplished.
This
platform
not
only
facilitates
quantification
during
also
renders
it
potent
antihypoxic
agent.
Small,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 12, 2025
Abstract
Although
classical
fluorescent
dyes
feature
advantages
of
high
quantum
yield,
tunable
“OFF‐ON”
fluorescence,
and
modifiable
chemical
structures,
etc.,
their
bio‐applications
in
deep
tissue
remains
challenging
due
to
excessively
short
emission
wavelength
(that
may
lead
superficial
penetration
depth).
Therefore,
there
is
a
pressing
need
for
pushing
the
from
visible
region
NIR‐II
window.
As
representative
dye,
2′,7′‐Dichlorofluorescein
(
DCF
),
derivative
Fluorescein,
selected
rationally
engineered
develop
novel
platform,
CR‐OH
,
which
exhibits
substantial
red‐shift
region.
This
achievement
attributed
molecular
modification
strategies
that
include
extending
π‐conjugation,
enhancing
rigidity,
incorporating
strong
electron‐withdrawing
groups.
Furthermore,
based
on
this
developed
fluorescence
probe
photothermal
nanoagent
are
successfully
constructed
unlock
its
bio‐application
imaging
endogenous
O
2
·–
fluctuations
CIRI
model
first
time,
as
well
effective
therapy
4T1
tumors
with
conversion
efficiency
(44.0%).
Significantly,
work
overcomes
limitation
dyes,
effectively
unlocking
applications
diagnosis
treatment
early
disease
Journal of Materials Chemistry B,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 1, 2024
Fluorescence
imaging
in
the
second
near-infrared
region
(NIR-II,
1000-1700
nm)
enables
high-resolution
visualization
of
deep-tissue
biological
architecture
and
physiopathological
events,
due
to
reduced
light
absorption,
scattering
tissue
autofluorescence.
Numerous
versatile
NIR-II
fluorescent
probes
have
been
reported
over
past
decades.
In
this
review,
we
first
provide
a
detailed
account
advantages
fluorescence
region.
Following
this,
classification,
design
performance
optimization
strategies
are
systematically
discussed,
along
with
broad
range
biomedical
applications
