Journal of advanced Biomedical and Pharmaceutical Sciences,
Journal Year:
2023,
Volume and Issue:
6(4), P. 184 - 187
Published: Oct. 1, 2023
Cannabinoids
have
many
important
properties,
such
as
anti-inflammatory,
antioxidant,
and
neuroprotective
effects
that
make
cannabinoids
promising
to
reduce
kidney
liver
toxicity.There
are
some
conditions,
oxidative
stress
fibrosis,
well
inflammation,
associated
with
nephrotoxicity
hepatotoxicity.Cannabinoids
showed
the
ability
these
effects.According
numerous
experimental
investigations
preclinical
models,
compounds
appear
play
a
part
in
controlling
inflammation
cell
death
by
activating
certain
receptors
regulating
cellular
pathways.However,
assure
safety
effectiveness
of
cannabinoids,
further
research
is
required
develop
dose
regimens
comprehend
medication
interactions.Measurements
cannabinoid
optimal
dosages,
frequency,
duration
treatment
need
be
addressed
carefully.
Ecotoxicology and Environmental Safety,
Journal Year:
2023,
Volume and Issue:
262, P. 115320 - 115320
Published: July 31, 2023
Tetrabromobisphenol
A
(TBBPA)
is
a
common
brominated
flame
retardant
that
has
wide
range
of
toxic
effects
on
organisms.
However,
the
mechanism
TBBPA
digestive
system
rarely
been
studied.
The
purpose
this
study
was
to
investigate
toxicity
gastric
mucosa.
In
study,
(mixed
with
corn
oil)
administered
by
gavage
at
doses
0
mg/kg
(CG),
10
and
20
mg/kg.
results
showed
levels
ROS,
MDA
LPO
were
increased,
activities
antioxidant
enzymes
decreased.
Large
amounts
ROS
activated
NF-κB
pathway,
leading
development
an
inflammatory
response.
expression
BCL
family
Caspase
(Cas)
genes
inducing
apoptosis.
RIP3/MLKL
pathway
activated,
cell
necrosis.
summary,
can
cause
damage
mucosa
through
oxidative
stress,
increased
activation
pathway.
Treatment
NAC
alleviated
caused
TBBPA.
