Deconstructing the Posterior Medial Episodic Network

Trends in Cognitive Sciences, Journal Year: 2020, Volume and Issue: 24(6), P. 451 - 465

Published: April 24, 2020

Language: Английский

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Transcending time in the brain: How event memories are constructed from experience

Hippocampus, Journal Year: 2019, Volume and Issue: 29(3), P. 162 - 183

Published: Feb. 7, 2019

Our daily lives unfold continuously, yet when we reflect on the past, remember those experiences as distinct and cohesive events. To understand this phenomenon, early investigations focused how individuals perceive natural breakpoints, or boundaries, in ongoing experience. More recent research has examined these boundaries modulate brain mechanisms that support long-term episodic memory. This work revealed a complex interplay between hippocampus prefrontal cortex promotes integration separation of sequential information to help organize our into mnemonic Here, discuss both temporal stability change one's thoughts, goals, surroundings may provide scaffolding for neural processes link separate memories across time. When learning novel familiar sequences information, dynamic hippocampal independently from concert with other regions bind representations together The formation storage discrete occur proactively an experience unfolds. They also retroactively, either during context shift reactivation bring past present allow integration. We describe conditions factors shape construction event different timescales. Together findings shed new light transcends time transform everyday meaningful memory representations.

Language: Английский

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Cortico-hippocampal network connections support the multidimensional quality of episodic memory

eLife, Journal Year: 2019, Volume and Issue: 8

Published: March 22, 2019

Episodic memories reflect a bound representation of multimodal features that can be reinstated with varying precision. Yet little is known about how brain networks involved in memory, including the hippocampus and posterior-medial (PM) anterior-temporal (AT) systems, interact to support quality content recollection. Participants learned color, spatial, emotion associations objects, later reconstructing visual using continuous color spectrum 360-degree panorama scenes. Behaviorally, dependencies memory were observed for gist but not precision event associations. Supporting this integration, hippocampus, AT, PM regions showed increased connectivity reduced modularity during retrieval compared encoding. These inter-network connections tracked multidimensional, objective measure quality. Moreover, distinct patterns item spatial findings demonstrate hippocampal-cortical reconfigure episodic retrieval, such dynamic interactions might flexibly multidimensional remembered events.

Language: Английский

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Eye Movements Actively Reinstate Spatiotemporal Mnemonic Content

Vision, Journal Year: 2019, Volume and Issue: 3(2), P. 21 - 21

Published: May 18, 2019

Eye movements support memory encoding by binding distinct elements of the visual world into coherent representations. However, role eye in retrieval is less clear. We propose that play a functional reinstating context. By overtly shifting attention manner broadly recapitulates spatial locations and temporal order encoded content, facilitate access to, reactivation of, associated details. Such mnemonic gaze reinstatement may be obligatorily recruited when task demands exceed cognitive resources, as often observed older adults. review research linking to retrieval, describe neural integration between oculomotor systems, discuss implications for models control, memory, aging.

Language: Английский

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Systems consolidation, transformation and reorganization: Multiple Trace Theory, Trace Transformation Theory and their Competitors

Published: May 10, 2021

We review the literature on systems consolidation by providing a brief history of field to place current research in proper perspective. cover both humans and non-humans, which are highly related despite differences techniques tasks that used. argue understanding interactions between hippocampus neocortex (and other structures) underlie consolidation, depend appreciating close correspondence psychological neural representations memory, as postulated Multiple Trace Theory Transformation Theory. end evaluating different theories light evidence we reviewed suggest concept with its central concern time-limited role plays may have outlived usefulness. replacing it program processes mechanisms changes memory across lifetime – natural change.

Language: Английский

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A Posterior–Anterior Distinction between Scene Perception and Scene Construction in Human Medial Parietal Cortex

Journal of Neuroscience, Journal Year: 2018, Volume and Issue: 39(4), P. 705 - 717

Published: Nov. 30, 2018

Human retrosplenial complex (RSC), located in medial parietal cortex, has been implicated numerous cognitive functions, including scene perception, spatial navigation, and autobiographical memory retrieval. Recently, a posterior-anterior distinction within RSC was proposed, such that posterior aspects process scene-related visual information (constituting place area [MPA]), whereas anterior is vividly retrieved from memory, thereby supporting remembering potentially navigation. Here, we tested this proposed single group of participants (both male female) using fMRI with both perceptual mnemonic tasks. After completing resting-state scan, performed task required constructing scenes completed selectivity localizer task. We directly responses MPA an anterior, connectivity-defined region (CON), which showed strong functional connectivity parahippocampal area. A double dissociation observed, CON more strongly activated during construction than MPA, perceptually responsive CON. Further, peak the were to peaks all but 1 participant hemisphere. Finally, through analyses response profiles, identify fundus parieto-occipital sulcus as potential location for crossover representations highlight left-hemisphere advantage representations. Collectively, our results support between RSC, suggesting specific functional-anatomic terms should be used its future work.SIGNIFICANCE STATEMENT The (RSC) vision, cognition, memory. previously speculated on perception memory-based construction/navigation. combination resting-state, perceptual, data. Consistent predictions, demonstrate consistently those elicited by broader RSC. (1) landmark transition these representations, (2) bank point maximal separation (3) hemispheric asymmetry These data dissociations

Language: Английский

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Precuneus stimulation alters the neural dynamics of autobiographical memory retrieval

NeuroImage, Journal Year: 2020, Volume and Issue: 210, P. 116575 - 116575

Published: Jan. 20, 2020

Autobiographical memory (AM) unfolds over time, but little is known about the dynamics of its retrieval. Space-based models implicate hippocampus, retrosplenial cortex, and precuneus in early computations. Here we used transcranial magnetic stimulation (TMS) magnetoencephalography (MEG) to investigate causal role AM During search construction, compared vertex led delayed evoked neural activity within 1000 ​ms after cue presentation. later elaboration, decreased sustained positivity. We further identified a parietal late positive component during amplitude which was associated with spatial perspective recollection. This association disrupted following stimulation, suggesting that this region plays an important representation AM. These findings demonstrate for retrieval, before specific accessed, context reinstatement initial stages elaboration re-experiencing. By utilizing high temporal resolution MEG causality TMS, study helps clarify correlates naturalistic

Language: Английский

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The role of oxytocin and vasopressin dysfunction in cognitive impairment and mental disorders

Neuropeptides, Journal Year: 2020, Volume and Issue: 83, P. 102079 - 102079

Published: Aug. 15, 2020

Language: Английский

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Building up and wearing down episodic memory: Mnemonic discrimination and relational binding.

Journal of Experimental Psychology General, Journal Year: 2019, Volume and Issue: 148(9), P. 1463 - 1479

Published: March 21, 2019

Our capacity to form and retrieve episodic memories improves over childhood but declines in old age. Understanding these changes requires decomposing memory into its components. Two such components are (a) mnemonic discrimination of similar people, objects, contexts, (b) relational binding elements. We designed novel tasks assess component processes using animations that appropriate across the life span (ages 4-80 our sample). In Experiment 1, we assessed objects as well binding, a common task format. Both follow an inverted U-shaped curve age were positively correlated only aging group. 2, examined context effect on binding. Relational low-similarity contexts showed robust gains between ages 4 6, whereas 6-year-olds performed similarly adults. contrast, high-similarity more protracted development, with 4- both performing worse than young adults not differing from each other. conditions declined aging. This multiprocess approach provides important theoretical insights memory. (PsycINFO Database Record (c) 2019 APA, all rights reserved).

Language: Английский

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Brain Mechanisms Underlying the Subjective Experience of Remembering

Annual Review of Psychology, Journal Year: 2021, Volume and Issue: 73(1), P. 159 - 186

Published: Sept. 30, 2021

The ability to remember events in vivid, multisensory detail is a significant part of human experience, allowing us relive previous encounters and providing with the store memories that shape our identity. Recent research has sought understand subjective experience remembering, is, what it feels like have memory. Such remembering involves reactivating sensory-perceptual features an event thoughts feelings we had when occurred, integrating them into conscious first-person experience. It allows reflect on content make judgments about them, such as distinguishing actually occurred from those might imagined or been told about. In this review, consider recent evidence functional neuroimaging healthy participants studies neurological psychiatric conditions, which shedding new light how subjectively remembering.

Language: Английский

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