Differential Functional Connectivity along the Long Axis of the Hippocampus Aligns with Differential Role in Memory Specificity and Generalization DOI Open Access
Lea E. Frank, Caitlin R. Bowman, Dagmar Zeithamová

et al.

Journal of Cognitive Neuroscience, Journal Year: 2019, Volume and Issue: 31(12), P. 1958 - 1975

Published: Aug. 9, 2019

The hippocampus contributes to both remembering specific events and generalization across events. Recent work suggests that information may be represented along the longitudinal axis of at varied levels specificity: detailed representations in posterior generalized anterior hippocampus. Similar distinctions are thought exist within neocortex, with lateral prefrontal parietal regions supporting memory specificity ventromedial temporal cortices memory. Here, we tested whether functional connectivity cortical is consistent these proposed dissociations. We predicted greater putative regions. Furthermore, differences stable under varying task engagement. Participants learned categorize a set stimuli outside scanner, followed by an fMRI session included rest scan, passive viewing runs, category runs. Analyses revealed stronger pFC angular gyrus inferior frontal These remained relatively three phases (rest, viewing, generalization). Whole-brain analyses further widespread hippocampus, little overlap. results contribute our understanding organization long suggest distinct hippocampal–cortical connections one mechanism which represents individual experiences knowledge.

Language: Английский

20 years of the default mode network: A review and synthesis DOI Open Access
Vinod Menon

Neuron, Journal Year: 2023, Volume and Issue: 111(16), P. 2469 - 2487

Published: May 10, 2023

Language: Английский

Citations

284
Medial temporal lobe connectivity and its associations with cognition in early Alzheimer’s disease DOI Creative Commons
David Berron, Danielle van Westen, Rik Ossenkoppele

et al.

Brain, Journal Year: 2020, Volume and Issue: 143(4), P. 1233 - 1248

Published: Feb. 25, 2020

Abstract Human episodic memory critically depends on subregions of the medial temporal lobe, which are part functional brain systems such as anterior-temporal and posterior-medial system. Here we analysed how Alzheimer’s pathology affects connectivity within these systems. Data from 256 amyloid-β-negative cognitively unimpaired, 103 amyloid-β-positive 83 individuals with mild cognitive impairment were analysed. Amyloid-β tau measured using CSF amyloid-β42/40 ratio phosphorylated tau, respectively. We found that unimpaired mainly characterized by decreased between lobe regions in system, most prominently left perirhinal/entorhinal cortices prefrontal cortex. Furthermore, correlation analysis this group revealed decreasing bilateral cortices, anterior hippocampus increasing levels tau. The mostly exhibited reduced regions, predominantly posterior cingulate In addition, they showed hyperconnectivity its immediate proximity. Lower temporal-cortical networks resulting comparisons associated performance more rapid longitudinal decline shown linear mixed-effects regression analysis. Finally, mildly impaired was related to entorhinal thickness white matter integrity parahippocampal cingulum fornix. No relationships individuals. conclusion, our findings show earliest changes preclinical disease might involve early be impairment, but not structural changes. With progression increased pathology, seems increasingly impaired. is well emergence locally patterns. Thus, system could serve stage-specific markers disease.

Language: Английский

Citations

237
Deconstructing the Posterior Medial Episodic Network DOI
Maureen Ritchey, Rose A. Cooper

Trends in Cognitive Sciences, Journal Year: 2020, Volume and Issue: 24(6), P. 451 - 465

Published: April 24, 2020

Language: Английский

Citations

209
Intrinsic connectivity reveals functionally distinct cortico-hippocampal networks in the human brain DOI Creative Commons
Alexander J. Barnett, Walter Reilly, Halle R. Dimsdale-Zucker

et al.

PLoS Biology, Journal Year: 2021, Volume and Issue: 19(6), P. e3001275 - e3001275

Published: June 2, 2021

Episodic memory depends on interactions between the hippocampus and interconnected neocortical regions. Here, using data-driven analyses of resting-state functional magnetic resonance imaging (fMRI) data, we identified networks that interact with hippocampus-the default mode network (DMN) a "medial temporal network" (MTN) included regions in medial lobe (MTL) precuneus. We observed MTN plays critical role connecting visual to DMN hippocampus. The could be further divided into 3 subnetworks: "posterior medial" (PM) subnetwork comprised posterior cingulate lateral parietal cortices; an "anterior temporal" (AT) temporopolar dorsomedial prefrontal cortex; prefrontal" (MP) primarily cortex (mPFC). These vary their connectivity (FC) along hippocampal long axis represent different kinds information during memory-guided decision-making. Finally, Neurosynth meta-analysis fMRI studies suggests new hypotheses regarding functions subnetworks, providing framework guide future research neural architecture episodic memory.

Language: Английский

Citations

106
Non-invasive temporal interference electrical stimulation of the human hippocampus DOI Creative Commons
Inês R. Violante,

Ketevan Alania,

Antonino M. Cassarà

et al.

Nature Neuroscience, Journal Year: 2023, Volume and Issue: 26(11), P. 1994 - 2004

Published: Oct. 19, 2023

Deep brain stimulation (DBS) via implanted electrodes is used worldwide to treat patients with severe neurological and psychiatric disorders. However, its invasiveness precludes widespread clinical use deployment in research. Temporal interference (TI) a strategy for non-invasive steerable DBS using multiple kHz-range electric fields difference frequency within the range of neural activity. Here we report validation concept humans. We field modeling measurements human cadaver verify that locus transcranial TI can be steerably focused hippocampus minimal exposure overlying cortex. then functional magnetic resonance imaging behavioral experiments show focally modulate hippocampal activity enhance accuracy episodic memories healthy Our results demonstrate targeted, electrical deep structures brain.

Language: Английский

Citations

100
Flexible reuse of cortico-hippocampal representations during encoding and recall of naturalistic events DOI Creative Commons
Zachariah M. Reagh, Charan Ranganath

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: March 8, 2023

Abstract Although every life event is unique, there are considerable commonalities across events. However, little known about whether or how the brain flexibly represents information different components at encoding and during remembering. Here, we show that cortico-hippocampal networks systematically represent specific of events depicted in videos, both online experience episodic memory retrieval. Regions an Anterior Temporal Network represented people, generalizing contexts, whereas regions a Posterior Medial context information, people. prefrontal cortex generalized videos depicting same schema, hippocampus maintained event-specific representations. Similar effects were seen real-time recall, suggesting reuse overlapping memories. These representational profiles together provide computationally optimal strategy to scaffold for high-level components, allowing efficient comprehension, recollection, imagination.

Language: Английский

Citations

53
Spatial navigation and memory: A review of the similarities and differences relevant to brain models and age DOI Creative Commons
Arne D. Ekstrom, Paul F. Hill

Neuron, Journal Year: 2023, Volume and Issue: 111(7), P. 1037 - 1049

Published: April 1, 2023

Language: Английский

Citations

44
The Margins of the Language Network in the Brain DOI Creative Commons
Ingo Hertrich, Susanne Dietrich, Hermann Ackermann

et al.

Frontiers in Communication, Journal Year: 2020, Volume and Issue: 5

Published: Nov. 6, 2020

This review paper summarizes the various brain modules that are involved in speech and language communication addition to a left-dominant "core" network that, for present purpose, has been restricted elementary formal-linguistic largely disembodied functions such as abstract phonology, syntax, very basic lexical functions. perisylvian comprises parts of inferior frontal gyrus, premotor cortex, upper temporal lobe, temporoparietal interface. After introducing this network, first, roles neighboring functionally connected regions discussed. As second approach, entire additional networks were considered rather than single regions, mainly motivated by resting-state studies indicating more or less stable connectivity patterns within these networks. Thirdly, some examples provided tasks with functional demands exceeding operating domain core network. The rationale behind approach is outline how produces perceives language, accounting, bulk clinical showing typical forms aphasia case left-hemispheric lesions second, wide-spread activation beyond experimental tasks. Roughly, resources complement system task-specific way can be described number structures related (1) motor representations, (2) sensory-related (3) nonverbal memory structures, (4) affective/emotional processing, (5) social cognition theory mind, (6) meaning context, (7) cognitive control. taking into account all aspects, it seems clear natural cannot really work without systems. Second, also becomes evident during acquisition built up from outside, is, neuronal activations sensory input, imitation, nursing, pre-linguistic sound communication, pragmatics. Furthermore, might worth considering cases restored being trained outside.

Language: Английский

Citations

112
Precision, binding, and the hippocampus: Precisely what are we talking about? DOI
Arne D. Ekstrom, Andrew P. Yonelinas

Neuropsychologia, Journal Year: 2020, Volume and Issue: 138, P. 107341 - 107341

Published: Jan. 13, 2020

Language: Английский

Citations

74
Amyloid-β and tau pathologies relate to distinctive brain dysconnectomics in preclinical autosomal-dominant Alzheimer’s disease DOI Creative Commons
Edmarie Guzmán‐Vélez, Ibai Díez, Dorothée Schoemaker

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2022, Volume and Issue: 119(15)

Published: April 5, 2022

SIGNIFICANCE Amyloid-β and tau, hallmark pathologies of Alzheimer’s disease (AD), are hypothesized to spread through brain functional networks that critical for neural communication. Using high-resolution network analyses positron emission tomography, we showed greater tau burden was related dysconnectivity regions associated with memory function increased connectivity structures important integrating information in cognitively unimpaired Presenilin-1 E280A carriers, who will develop early-onset AD dementia. These findings enlighten how pathology relates distinct patterns essential processing. Elucidating alters connections before individuals experience cognitive impairment could help detect early predict progression dementia risk.

Language: Английский

Citations

58