Emerging Nanoagents for Medical X-ray Imaging

Analytical Chemistry, Journal Year: 2023, Volume and Issue: 95(1), P. 33 - 48

Published: Jan. 10, 2023

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTEmerging Nanoagents for Medical X-ray ImagingQinxia WuQinxia WuMOE Key Laboratory Analytical Science of Food Safety and Biology, College Chemistry, Fuzhou University, 350002, ChinaMore by Qinxia WuView Biography, Qianyu ZhengQianyu ZhengMOE ZhengView Yu HeYu HeMOE HeView Qiushui Chen*Qiushui ChenMOE ChinaFujian & Technology Innovation Optoelectronic Information China, 350108, P. R. China*Email: [email protected]More ChenView Huanghao Yang*Huanghao YangMOE YangView Biographyhttps://orcid.org/0000-0001-5894-0909Cite this: Anal. Chem. 2023, 95, 1, 33–48Publication Date (Web):January 10, 2023Publication History Published online10 January 2023Published inissue 10 2023https://pubs.acs.org/doi/10.1021/acs.analchem.2c04602https://doi.org/10.1021/acs.analchem.2c04602review-articleACS PublicationsCopyright © 2023 American Chemical SocietyRequest reuse permissionsArticle Views1264Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum full text article downloads since November 2008 (both PDF HTML) across all institutions individuals. These metrics regularly updated to reflect usage leading up last few days.Citations number other articles citing this article, calculated Crossref daily. Find more information about citation counts.The Altmetric Attention Score is a quantitative measure attention that research has received online. Clicking on donut icon will load page at altmetric.com with additional details score social media presence given article. how calculated. Share Add toView InAdd Full Text ReferenceAdd Description ExportRISCitationCitation abstractCitation referencesMore Options onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Biological imaging,Imaging agents,Luminescence,Nanoparticles,X-rays Get e-Alerts

Language: Английский

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Gold nanoparticle-enhanced X-ray microtomography of the rodent reveals region-specific cerebrospinal fluid circulation in the brain

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Jan. 27, 2023

Abstract Cerebrospinal fluid (CSF) is essential for the development and function of central nervous system (CNS). However, brain its interstitium have largely been thought as a single entity through which CSF circulates, it not known whether specific cell populations within CNS preferentially interact with CSF. Here, we develop technique tracking, gold nanoparticle-enhanced X-ray microtomography, to achieve micrometer-scale resolution visualization circulation patterns during development. Using this method subsequent histological analysis in rodents, identify previously uncharacterized pathways from subarachnoid space (particularly basal cisterns) that mediate CSF-parenchymal interactions involving 24 functional-anatomic groupings spinal cord. distribution these areas restricted early altered posthemorrhagic hydrocephalus. Our study also presents particle size-dependent including interaction between neurons small tracers, but large tracers. These findings implications understanding biological basis normal pathogenesis broad range disease states,

Language: Английский

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Supramolecular metal-organic frameworks as host-guest nanoplatforms for versatile and customizable biomedical applications

Acta Biomaterialia, Journal Year: 2023, Volume and Issue: 168, P. 617 - 627

Published: July 22, 2023

Language: Английский

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Comparison of the Medical Uses and Cellular Effects of High and Low Linear Energy Transfer Radiation

Toxics, Journal Year: 2022, Volume and Issue: 10(10), P. 628 - 628

Published: Oct. 21, 2022

Exposure to ionizing radiation can occur during medical treatments, from naturally occurring sources in the environment, or as result of a nuclear accident thermonuclear war. The severity cellular damage exposure is dependent upon number factors including absorbed dose (energy per unit mass exposure), rate, area and volume tissue exposed, type (e.g., X-rays, high-energy gamma rays, protons, neutrons) linear energy transfer. While dose, distribution are aspects that be varied experimentally LET eV inherent characteristics radiation. High-LET deposits higher concentration shorter distance when traversing compared with low-LET different biological effects high low similar energies have been documented vivo animal models cultured cells. results intense macromolecular more cell death. Findings indicate while both low- high-LET activate non-homologous end-joining DNA repair activity, efficient requires homologous recombination pathway. Low- p53 transcription factor activity most cells, but activates NF-kB at lower doses than Here we review development, uses, current understanding exposure.

Language: Английский

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Advances of hafnium based nanomaterials for cancer theranostics

Frontiers in Chemistry, Journal Year: 2023, Volume and Issue: 11

Published: Nov. 24, 2023

Hafnium-based nanomaterials (Hf-NMs) have attracted the interest of numerous biomedical researchers by their unique properties. Recent years witnessed significant advancements in field nanomaterials, particularly context cancer diagnosis and treatment. However, research this area, especially concerning clinical application has not been thoroughly reviewed. This review will cover: 1) Classification synthesis including Hafnium oxide Metal-Organic Frameworks/nanoscale coordination polymers (MOFs/NCPs); 2) act as contrast enhancement agent for imaging, hafnium-based used liquid biopsy; 3) therapy, radiotherapy, photodynamic various combined therapy; 4) Translation, toxicity, safety Hf-NMs human preclinical animal models. More attention be given to translation cancer.

Language: Английский

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